Publications by authors named "Xiaoming Duan"

46 Publications

Design and synthesis of novel substituted benzyl pyrrolopyrimidine derivatives as selective BTK inhibitors for treating mantle cell lymphoma.

Bioorg Chem 2021 Jul 7;112:104968. Epub 2021 May 7.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, PR China. Electronic address:

Ibrutinib, a potent irreversible Bruton's tyrosine kinase (BTK) inhibitor, was approved by the FDA for treating mantle cell lymphoma (MCL). Although ibrutinib exhibited excellent antitumor activity, it was associated with certain adverse reactions, with off-target effects against EGFR, Itk and Src family kinases. Our studies yielded a novel series of substituted benzyl pyrrolopyrimidine derivatives capable of potent inhibition of BTK. Compared with ibrutinib, compound 15c exhibited potent BTK inhibitory activity and enhanced antiproliferative activity, a 12-24-fold increase, against MCL cell lines, with IC values lower than 1 μM. Low micromolar doses of 15c inhibited the BCR signaling pathway and strongly induced the apoptosis of Z138 cells. Ibrutinib and 15c induced autophagy in a dose-dependent manner in Z138 cells. Moreover, compound 15c induced the production of reactive oxygen species (ROS), which may be a reason for its potent antiproliferative activity. Importantly, compound 15c showed greater BTK selectivity than ibrutinib, indicating a potentially safer treatment of MCL.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2021.104968DOI Listing
July 2021

High-power actively Q-switched Ho-doped gadolinium tantalate laser.

Opt Express 2021 Apr;29(8):12471-12477

In this paper, we present the acousto-optical (AO) Q-switched performance of a holmium (Ho):gadolinium tantalate (GdTaO) (Ho:GTO) laser pumped by a thulium (Tm)-fiber laser emitting at 1.94 µm. In the efficient continuous wave (CW) regime, a maximum output power of 30.5 W at 2068.8 nm was achieved, corresponding to a slope efficiency of 74.9% with respect to the absorbed pump power. In the Q-switching regime, pulse energies of 2.4 mJ, 1.2 mJ, and 0.9 mJ were obtained with pulse repetition frequencies of 10 kHz, 20 kHz, and 30 kHz, respectively. The minimum pulse widths were 18 ns, 23 ns, and 26 ns, corresponding to peak powers of approximately 133.3 kW, 52.2 kW, and 34.6 kW, respectively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.420706DOI Listing
April 2021

Design, Synthesis and Biological Evaluation of 1-methyl-1H-pyrazole-5-Carboxamide Derivatives as Novel Anti-Prostate Cancer Agents.

Anticancer Agents Med Chem 2021 Feb 2. Epub 2021 Feb 2.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong. China.

Background: The androgen receptor (AR) signaling functions is a critical driving force for the progression of prostate cancer (PCa) to bring about anti-prostate cancer agents, and AR has been proved to be an effective therapeutic target even for castration-resistant prostate cancer (CRPC).

Objective: In order to discover novel anti prostate cancer agents, we performed structural modifications based on the lead compounds T3 and 10e.

Methods: A set of 1-methyl- 1H-pyrazole-5-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against both expressions of prostate-specific antigen(PSA) and growth of PCa cell lines.

Results: Compound H24 was found to be able to completely block PSA expression at 10 µM, and showed prominent antiproliferative activity in both the LNCaP cell line (GI 50 = 7.73 µM) and PC-3 cell line (GI 50 = 7.07 µM).

Conclusions: These preliminary data supported a further evaluation of compound H24 as a potential agent to treat prostate cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871520621666210202162953DOI Listing
February 2021

Clinical characteristics, rates of blindness, and geographic features of PACD in China.

Can J Ophthalmol 2021 Jan 21. Epub 2021 Jan 21.

The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: To analyze the rates of blindness with the demographics and clinical characteristics of patients with primary angle-closure disease (PACD) to provide a comprehensive epidemiologic reference in China.

Methods: A retrospective analysis was conducted in the Chinese Glaucoma Study Consortium database, which is a national multicenter glaucoma research alliance of 111 hospitals participating between December 21, 2015 and September 9, 2018. The diagnosis of PACD was made by qualified physicians through examination. Comparison of sex, age, family history, subtypes of PACD, and blindness were analyzed.

Results: A total of 5762 glaucoma patients were included, of which 4588 (79.6%) had PACD. Of PACD patients, 72.1% were female with the sex ratio (F/M) of 2.6, and the average age of patients was 63.8±9.3 years with the majority between 60 and 70 years. Additionally, 30% of these patients had low vision in one eye, 8.8% had low vision in both eyes, 1.7% had blindness in one eye, and 0.3% had blindness in both eyes. There were statistical differences with regards to age between male and female patients with PACD, with male patients being older on average. Primary angle-closure glaucoma was more commonly diagnosed in males (60%) compared to females (35.9%), whereas acute primary angle closure (APAC) was more commonly diagnosed in females (54.3%) compared to males (37.7%). The visual acuity in APAC patients was lower and the rate of low vision and blindness was higher than other subtypes.

Conclusion: PACD was the major type of glaucoma in Chinese hospitals. There were more female patients with PACD, mostly between 60 and 70 years old, with higher rates of APAC in women. APAC resulted in the worst visual outcomes of all PACD subtypes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2020.12.010DOI Listing
January 2021

161  W middle infrared ZnGeP MOPA system pumped by 300  W-class Ho:YAG MOPA system.

Opt Lett 2021 Jan;46(1):82-85

We demonstrated a high-power -switched two-stage Ho:YAG master-oscillator power-amplifier (MOPA) system dual-end pumped by Tm:YLF lasers. A new method was introduced by rotating and swapping spatial axial directions of pump beams to improve the beam quality of the Ho:YAG oscillator and first-stage amplifier. Two parallel second-stage Ho:YAG amplifiers were employed to output high power. A total maximum average output power of 332 W at 2091 nm with pulse repetition frequency of 20 kHz was achieved. Then a MOPA system was demonstrated using the Ho:YAG MOPA as the pump source. A maximum average output power of 161 W at 3-5 µm was obtained with 290 W incident Ho pump power, corresponding to beam quality factors of 3.42 and 3.83 for horizontal and vertical directions, respectively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.413755DOI Listing
January 2021

Continuously tunable high-power single-longitudinal-mode Ho:YLF laser around the P12 CO absorption line.

Opt Lett 2020 Dec;45(24):6691-6694

A continuously tuned single-longitudinal-mode (SLM) Ho:YLF laser around the P12 absorption line was demonstrated. The continuous tuning range of 5.75 pm within one longitudinal mode spacing of the Ho:YLF resonator was realized by using a novel intra-cavity wedge prism device fixed on the piezoelectric transducer (PZT) as the cavity length controller. High SLM power of 11.3 W was obtained from a Ho:YLF amplifier with three crystals at the pump power of 31.8 W and master oscillator power of 323 mW, corresponding to a gain of 15.44 dB and an optical-to-optical conversion efficiency of 34.5%. The beam quality factors of the SLM Ho:YLF amplifier in the and directions were estimated to be 1.04 and 1.05, respectively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.412617DOI Listing
December 2020

Research on performance improvement technology of a BaGaSe mid-infrared optical parametric oscillator.

Opt Lett 2020 Dec;45(23):6418-6421

In this Letter, we demonstrate an average output power of 5.12 W at 3-5 µm from a type-I phase-matching (BGSe) optical parametric oscillator (OPO), which is pumped by a 2090 nm -switched Ho:YAG laser with pulse repetition frequency of 1 kHz. At maximum output level, the corresponding slope efficiency and optical-to-optical conversion efficiency are 30.0% and 18.3%, respectively. Moreover, under ring cavity conditions, the BGSe OPO produced a 3.04 W mid-infrared laser with high beam quality factors of 1.47 in the horizontal direction and 1.51 in the vertical direction. Besides, the wavelength-tuning curve for type-I BGSe was also investigated, corresponding to an idler wavelength-tuning range of 4.5-5.3 µm, and the signal light wavelength was 4.5 to 4.1 µm.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.403759DOI Listing
December 2020

Tunable twisted-mode Ho:YAG laser at continuous-wave and pulsed operation.

Opt Express 2020 Oct;28(21):31775-31780

A single-longitudinal-mode Ho:YAG laser with a twisted-mode cavity under the continuous-wave and pulsed operation was demonstrated. The maximum continuous-wave single-longitudinal-mode output power of 0.76 W was obtained at the wavelength of 2097.46 nm, corresponding to a slope efficiency of 28.9%. The output wavelength was tuned from 2096.94 nm to 2098.48 nm by utilizing a 0.5-mm-thick etalon. Furthermore, the single-frequency pulsed operation of the twisted-mode Ho:YAG laser was realized by the electro-optic switch. For the 2 kHz pulse repetition frequency, the single-frequency pulse energy reached 0.2 mJ with the pulse width of 116.5 ns. The beam quality factors M of the pulsed twisted-mode Ho:YAG laser in the x and y directions were 1.15 and 1.10, respectively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.405153DOI Listing
October 2020

570 MHz harmonic mode-locking in an all polarization-maintaining Ho-doped fiber laser.

Opt Express 2020 Oct;28(22):33028-33034

In this paper, we demonstrate a 570.0 MHz harmonically mode-locked all-polarization-maintaining Ho-doped fiber laser based on semiconductor saturable absorbed mirror. Firstly, the laser operates in the 15.4 MHz fundamental mode-locked soliton regime, emitting 2051.5 nm, 1.62 ps soliton pulse without Kelly sidebands. And then, the stable 37th-order harmonic mode-locked soliton with maximum repetition rate up to 570.0 MHz at 2053nm is generated. Moreover, colorful soliton rain behaviors are also discussed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.403518DOI Listing
October 2020

Atomically Thin Hexagonal Boron Nitride and Its Heterostructures.

Adv Mater 2021 Feb 16;33(6):e2000769. Epub 2020 Aug 16.

School of Materials Science and Engineering, Harbin Institute of Technology, No. 92, Dazhi Street, Harbin, 150001, China.

Atomically thin hexagonal boron nitride (h-BN) is an emerging star of 2D materials. It is taken as an optimal substrate for other 2D-material-based devices owing to its atomical flatness, absence of dangling bonds, and excellent stability. Specifically, h-BN is found to be a natural hyperbolic material in the mid-infrared range, as well as a piezoelectric material. All the unique properties are beneficial for novel applications in optoelectronics and electronics. Currently, most of these applications are merely based on exfoliated h-BN flakes at their proof-of-concept stages. Chemical vapor deposition (CVD) is considered as the most promising approach for producing large-scale, high-quality, atomically thin h-BN films and heterostructures. Herein, CVD synthesis of atomically thin h-BN is the focus. Also, the growth kinetics are systematically investigated to point out general strategies for controllable and scalable preparation of single-crystal h-BN film. Meanwhile, epitaxial growth of 2D materials onto h-BN and at its edge to construct heterostructures is summarized, emphasizing that the specific orientation of constituent parts in heterostructures can introduce novel properties. Finally, recent applications of atomically thin h-BN and its heterostructures in optoelectronics and electronics are summarized.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.202000769DOI Listing
February 2021

High-beam-quality 2.1  µm pumped mid-infrared type-II phase-matching BaGaSe optical parametric oscillator with a ZnGeP amplifier.

Opt Lett 2020 Jul;45(13):3805-3808

We firstly demonstrated a tunable 2.1 µm pumped mid-infrared type-II phase-matching (BGSe) optical parametric oscillator (OPO). A signal tuning range of 3.82-3.99 µm was achieved. With a signal light produced by the BGSe OPO serving as seed, the (ZGP) optical parametric amplifier (OPA) was first introduced. A 4.35 W mid-infrared laser was obtained in the novel type-II BGSe OPO with a ZGP OPA system, which was pumped by a 24 W 1 kHz -switched Ho:YAG laser. The beam quality factor of the whole system is ∼2.3, which is over a 50% promotion on the previous results of single BGSe OPO.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.398588DOI Listing
July 2020

Measurement of optical homogeneity of ZnGeP crystal using a 2.02 µm single-longitudinal-mode Tm:LuAG ring laser.

Appl Opt 2020 Jul;59(19):5864-5869

We demonstrate a single-longitudinal-mode Tm:LuAG unidirectional ring laser based on the Faraday effect and its application in measuring the optical homogeneity of (ZGP) crystal. The maximum single-longitudinal-mode power was 511 mW at 2022.4 nm, with a slope efficiency of 9.7%, and the factors were 1.13 and 1.23 in the and directions, respectively. The laser was polarized with a polarization degree of 30 dB. Also, the optical homogeneity of ZGP crystal was measured by the Mach-Zehnder interference method, which adopts the single-longitudinal-mode laser as the monochrome source. According to the interference fringes, the quantitative calculation or qualitative analysis of the optical homogeneity of ZGP crystal was achieved, which could quickly and conveniently judge the quality of ZGP crystal, and provided high-quality crystals for high-power mid-infrared lasers. To our knowledge, it is the first report of the optical homogeneity measurement of ZGP crystal by a 2 µm single-longitudinal-mode laser.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/AO.394801DOI Listing
July 2020

11 µm, high beam quality idler-resonant CdSe optical parametric oscillator with continuous-wave injection-seeded at 2.58 µm.

Opt Express 2020 May;28(11):17056-17063

We report an idler-resonant, continuous-wave (CW) seed injected, optical parametric oscillator (OPO) based on cadmium selenide (CdSe). The CdSe OPO was pumped by a 2.09 µm ns-pulsed laser and injection-seeded by a 2.58 µm CW laser. The idler-resonant oscillator was designed to maximize the optical-to-optical conversion efficiency and optimize the beam quality. The injected seed laser was designed to reduce the pump threshold. With this setup, the average idler output power of 802 mW was obtained corresponding to a pulse energy of 0.8 mJ at the wavelength of 11.01 µm and linewidth (FWHM) of 0.6 cm, optical-to-optical conversion efficiency of 4.4%, quantum conversion efficiency of 23.3%, beam quality of M = 1.23, M = 1.12, and pulse width of 21 ns. In addition, by turning the angle of the CdSe, wavelength tuning of 10.55-11.98 µm was achieved.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.393436DOI Listing
May 2020

Broadband second-harmonic and sum-frequency generation with a long-wave infrared laser in AgGaGeSe.

Appl Opt 2020 Jun;59(17):5247-5251

Using an 8 µm long-wave infrared laser as the fundamental wave, we achieved second-harmonic generation (SHG) and sum-frequency generation simultaneously in and obtained a 4 µm laser output. Among them, SHG was achieved in the 173 nm spectral range of the fundamental wave, which was consistent with theoretical calculations. The average power of the obtained 4 µm laser was 41 mW, corresponding to an optical-to-optical conversion efficiency of 3.2%. The measured temperature acceptance bandwidth () (FWHM) was 50 K·cm; the angular acceptance bandwidth () (FWHM) was 13.3 mrad·cm; and the average absorption coefficient in the wavelength range of 0.86-11.30 µm was 0.07. In addition, the spectral acceptance bandwidth () of fundamental wave in SHG and the spectral gain bandwidth of frequency downconversion in were calculated. In view of the small absorption coefficient, the large temperature acceptance bandwidth, and the large spectral gain bandwidth, we conclude that is a suitable nonlinear crystal for high-power short/mid/long-wave infrared lasers and frequency conversions of nanosecond-femtosecond infrared lasers. These results are conducive to the further development of lasers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/AO.394970DOI Listing
June 2020

Coding Variants in and May Contribute to Risk of Primary Angle Closure Glaucoma.

DNA Cell Biol 2020 Jun 12;39(6):949-957. Epub 2020 May 12.

Beijing Ophthalmology and Visual Science Key Lab, Beijing, P.R. China.

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. This study proposed to screen candidate PACG-associated variants in Chinese Han people. Whole exome sequencing was applied to five confirmed PACG patients and two primary angle closure suspect individuals within a PACG-enriched Chinese Han family. A series of bioinformatics analyses were implemented to obtain high-risk single nucleotide variant (SNV) loci for PACG, which were subsequently used for linkage analysis for identifying linkage genome regions. In addition, MassARRAY SNV genotyping was applied to high-risk PACG loci as well as those within linkage regions in another independent cohort including 251 PACG and 251 normal samples to further screen high-confidence SNVs. A total of 27 loci in 19 genes remained after linkage analysis. The 19 genes were significantly enriched in biological processes tightly related to PACG, including retinol metabolism and salmonella infection. Two nonsynonymous SNV loci, rs897804 in exon15 of and rs3745193 in exon7 of were recognized with higher variant frequency in PACG samples than that in control samples after association analysis of MassARRAY SNV genotyping data. This study sheds new light on the understanding of PACG incidence among Chinese Han people.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2019.5079DOI Listing
June 2020

1  W, 10.1  µm, CdSe optical parametric oscillator with continuous-wave seed injection.

Opt Lett 2020 Apr;45(7):2119-2122

We demonstrated a 2.1 µm nanosecond laser pumped, 2.6 µm continuous-wave (CW) seed injected, cadmium selenide (CdSe) signal singly resonant optical parametric oscillator (OPO). A maximum average power of 1.05 W was obtained corresponding to a pulse energy of 1.05 mJ at the idler wavelength of 10.1 µm and optical-to-optical conversion efficiency of 4.69%, beam quality of $M_x^2={2.25}$Mx2=2.25, $M_y^2={2.12}$My2=2.12 and pulse width of 24.4 ns. To the best of our knowledge, this is the first time to achieve 10-12 µm laser with watt-level average power using OPO technology.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.391547DOI Listing
April 2020

Single-longitudinal-mode Ho:YVO MOPA system with a passively Q-switched unidirectional ring oscillator.

Opt Express 2019 Nov;27(24):34618-34625

A 2052.96 nm single-longitudinal-mode pulsed Ho:YVO MOPA system was demonstrated for the first time. The pulsed Ho:YVO MOPA system consisted of a unidirectional ring passively Q-switched oscillator and a single-pass amplifier. By inserting an isolator, a half-wave plate and a Cr:ZnS plate into the ring Ho:YVO oscillator cavity, the single-longitudinal-mode pulsed laser was achieved with an average output power of 1.02 W with pulse width of 910 ns and pulse repetition frequency (PRF) of 67 kHz. Using the residual (non-absorbed) pump power of the oscillator as pump, the single-pass pulsed Ho:YVO amplifier obtained an average output power of 1.67 W. The total optical-to-optical efficiency of the pulsed Ho:YVO MOPA system was 14.3%. Single-longitudinal-mode pulsed MOPA system based on isolator and Cr:ZnS around 2 µm has not been reported yet to the best of our knowledge.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.27.034618DOI Listing
November 2019

High efficiency single-longitudinal-mode resonantly-pumped Ho:GdTaO laser at 2068nm.

Opt Express 2019 Nov;27(23):34204-34210

Based on Faraday effect we demonstrate a thulium fiber pumped continuous-wave single-longitudinal-mode laser with a new Ho:GdTaO crystal. By inserting a faraday rotator and a half-wave plate into the laser cavity, the single-longitudinal-mode output power of 392 mW at wavelength of 2068.33 nm was obtained in unidirectional Ho:GdTaO ring laser, corresponding to a slope efficiency of 60.2% respect to the absorbed pump power. Furthermore, utilizing the Ho:GdTaO power amplifier, the maximum single-longitudinal- mode output power of 1.02 W was achieved.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.27.034204DOI Listing
November 2019

Resonantly pumped high efficiency Ho:GdTaO laser: erratum.

Opt Express 2019 Oct;27(22):31362

An erratum is presented to correct the wrong picture in our paper.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.27.031362DOI Listing
October 2019

High-repetition-rate laser ultrasonic generation in carbon-fiber-reinforced plastics excited by a 3.2-3.4  μm ZGP master oscillator power amplifier system.

Appl Opt 2019 Sep;58(27):7655-7660

In this paper, we demonstrate 1-kHz-repetition-rate laser ultrasound in carbon-fiber-reinforced plastics (CFRPs). A ZGP master oscillator and power amplifier (MOPA) system was used to generate high-repetition-rate laser radiation in the spectral range 3.2-3.4 μm. At the output wavelength of 3.4 μm, the maximum output energy of the ZGP MOPA system is 5.62 mJ with a pulse width of 24 ns, corresponding to a peak power of approximately 233.9 kW. The ultrasound was generated by the laser converted from 3.2 to 3.4 μm in the graphite/epoxy composite. The maximum ultrasonic signal amplitude in the CFRP sample was 36.2 mV in the condition of thermoelastic excitation at 3.4 μm. Ablation occurred in the CFRP sample when the energy fluence was over 90  mJ/cm. Compared in different samples, laser-ultrasound generation was influenced by the wavelength of the laser.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/AO.58.007655DOI Listing
September 2019

Interplay between storage temperature, medium and leaching kinetics of hazardous wastes in Metakaolin-based geopolymer.

J Hazard Mater 2020 02 6;384:121377. Epub 2019 Oct 6.

Institute for Advanced Ceramics, School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, PR China; Key Laboratory of Advanced Structural-Functional Integration Materials & Green Manufacturing Technology, Harbin Institute of Technology, Harbin, 150001, PR China.

Notwithstanding the success of carbon-free nuclear power in the new energy industry, an effective way to address nuclear contamination is still lacking. As a generally accepted method to date, immobilization of radioactive nuclear wastes with inexpensive and environment-friendly matrix such as geopolymer has attracted extensive attention. In this contribution, Na-based and K-based metakaolin geopolymer were prepared to encapsulate simulated radioactive Cs and Sr under different temperatures and environments during long-term leaching tests. The temperature-dependent and environmental-dependent leaching kinetics as well as their dominant leaching mechanisms have been revealed. The results showed that Na-based and K-based geopolymer exhibited better immobilization performance than that of Portland cement, ceteris paribus. For the immobilization of Cs, Na-based geopolymer showed lower leaching rate than K-based geopolymer under the same leaching conditions. Both higher temperature and salt solution accelerated the leaching behaviors of Sr and Cs from the encapsulation matrix. This contribution sheds light on understanding the dominant leaching mechanisms of hazardous elements under different storage environments and highlights the significance of salt-tolerant matrix for the immobilization of nuclear wastes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2019.121377DOI Listing
February 2020

The Chinese Glaucoma Study Consortium for Patients With Glaucoma: Design, Rationale and Baseline Patient Characteristics.

J Glaucoma 2019 11;28(11):974-978

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University.

Precis: Chinese Glaucoma Study Consortium (CGSC) as the first nationwide glaucoma registry in China, we describe its design, rationale, the geographic distribution of the hospitals, and baseline patient characteristics.

Aim: As a leading cause of blindness in China, glaucoma affects 2% to 4% of adults over the age of 40 and will become increasingly prevalent as the population ages. At the national level, there are few reports on the current medical practice for glaucoma patients. CGSC will be considered as the first nationwide glaucoma registry in China. Here we describe its design, rationale, the geographic distribution of the hospitals, and baseline patient characteristics.

Methods: From December 21, 2015 to September 9, 2018, CGSC recruited patients with the diagnoses of primary angle-closure suspect, primary angle-closure, primary angle-closure glaucoma, acute primary angle closure, primary open-angle glaucoma (POAG), pigmentary glaucoma (PG), and pseudoexfoliative glaucoma (PXG) from 111 hospitals covering 67 cities from 22 provinces, 4 municipalities, and 5 autonomous regions in mainland China. Clinical data were collected using an Electronic Data Capture System designed by Tongren hospital and Gauss informed Ltd. Blood samples were collected from every patient for further genetic analysis.

Results: Medical records of 10,892 patients were collected, of which 5762 patients have complete information. The average age of those with complete information (n=5762) was 62.05±11.26 years old, and 35.25% were males. Primary angle-closure disease, including primary angle-closure suspect/primary angle-closure/primary angle-closure glaucoma/acute primary angle closure, was predominant (4588, 79.63%), and the distribution for others is as follows: POAG (1116, 19.37%), PXG (41, 0.71%) and PG (17, 0.30%). A total of 16,684 blood samples were collected, of which 9917 (82.68%) were primary angle-closure disease, 1987 (16.57%) were POAG, 69 (0.58%) were PXG, 22 (0.18%) were PG, and 4689 were normal controls.

Conclusions: The CGSC is the first national-level glaucoma registry study in China. Clinical data and blood samples will provide the opportunity to study the epidemiology of glaucoma in Chinese hospitals, to evaluate the level of medical diagnosis and treatment of glaucoma in China, and to identify the susceptibility loci for glaucoma.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028307PMC
November 2019

Resonantly pumped high efficiency Ho:GdTaO laser.

Opt Express 2019 Jun;27(13):18273-18281

We demonstrate a continuous-wave 2.1-µm laser with a new Ho:GdTaO crystal pumped by a 1940.3-nm Tm fiber laser at room temperature. The maximum output power of 11.2 W at 2068.39 nm was achieved, corresponding to a slope efficiency of 72.9%. Moreover, the beam quality factor was measured to be about 1.4 at the maximum output level.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.27.018273DOI Listing
June 2019

Comparison of mid-infrared ZnGeP rectangle ring optical parametric oscillators of three types of resonant regimes.

Appl Opt 2019 May;58(15):4163-4169

We experimentally demonstrated doubly resonant oscillator (DRO), signal singly resonant oscillator (SSRO), and idler singly resonant oscillator (ISRO) ZnGeP (ZGP) optical parametric oscillators (OPOs), respectively, pumped by a 1 kHz Q-switched Ho:YAG laser. At the full incident pump energy, the ISRO got the highest output pulse energy of 8.38 mJ and the best beam quality factors Mx2 of 2.3 for idler (4.6 μm) and 2.7 for signal (3.8 μm) but got the highest threshold of 3.97  MW/cm. The DRO had the lowest threshold of 3.12  MW/cm but had the lowest output energy of 8.29 mJ and the worst Mx2 of 3.9 for idler and 4.1 for signal. The output laser characteristics of the SSRO were slightly worse than those of the ISRO. The experimental results show that the ISRO is the most suitable resonant regime for high brightness mid-infrared ZGP planar ring OPOs pumped by 2 μm nanosecond lasers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/AO.58.004163DOI Listing
May 2019

Active Q-switching operation of slab Ho:SYSO laser wing-pumped by fiber coupled laser diodes.

Opt Express 2019 Apr;27(8):11455-11461

In this paper, we demonstrate the continuous-wave and acousto-optical Q-switched performance of diode-pumped slab Ho:(ScY)SiO (Ho:SYSO) laser at 2.1 µm for the first time. Two 1.91-µm laser diodes were used to pump the Ho:SYSO crystal. With a wing-pumping structure, at absorbed pump power of 44.7 W, the continuous wave slab Ho:SYSO laser produced 20.7 W maximum output power at 2097.9 nm, resulting in a slope efficiency of 53.1% with respect to the absorbed pump power. In the Q-switched regime, the slab Ho:SYSO laser produced up to 3.4 mJ pulse energy with 20 ns minimum pulse width at pulse repetition frequency of 5 kHz, corresponding to a peak power of 170 kW.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.27.011455DOI Listing
April 2019

High-beam-quality operation of a 2  μm passively Q-switched solid-state laser based on a boron nitride saturable absorber.

Appl Opt 2019 Apr;58(10):2546-2550

Boron nitride (BN) nanosheets were used as the material sources which were coated on a calcium fluoride mirror to achieve a saturable absorber (SA). A passively -switched solid-state laser at 2000.5 nm was demonstrated with a ,: (Tm,Ho:YAP) crystal and a SA based on BN. An average output power of 650 mW was obtained with a minimum pulse width of 6.3 μs at the pulsed repetition frequency of 41.7 kHz, corresponding to a per pulse energy of 13 μJ. The beam quality factor was measured to be 2=1.06 and 2=1.07 at the maximum output power.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/AO.58.002546DOI Listing
April 2019

Efficient Ho:(ScY)SiO laser at 2.1 µm in-band pumped by Tm fiber laser.

Opt Express 2019 Feb;27(4):4522-4527

In this paper, we demonstrate a new 2.1-µm Ho:(ScY)SiO (Ho:SYSO) laser at room temperature. The absorption and emission spectra of Ho:SYSO crystal were studied at temperature of 300 K. The strongest absorption peak of I level of Ho ions in SYSO crystal is located at 1943 nm with cross section of 0.79 × 10 cm. The maximum emission cross section of 1.74 × 10 cm is located at 2032 nm. A 1940.3-nm narrow-linewidth Tm fiber was used to pump the Ho:SYSO crystal. At absorbed pump power of 20.4 W, the continuous wave Ho:SYSO laser yielded 10.3 W maximum output power at 2097.67 nm and 54.7% slope efficiency respect with absorbed pump power. In addition, we have estimated the beam quality factor (M) of Ho:SYSO laser to be 1.7 near maximum output level.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.27.004522DOI Listing
February 2019

110.4  mJ, 1  kHz repetition rate, Ho:YAG master oscillator power amplifier.

Appl Opt 2019 Feb;58(4):879-882

We reported a high-energy, high-pulse-repetition-frequency Ho:YAG master oscillator and power amplifier (MOPA), which was resonantly dual-end pumped by Tm:YLF lasers at room temperature. At a pulse repetition frequency of 1 kHz, the Ho:YAG MOPA laser system produced a maximum pulse energy of 110.4 mJ with a 28 ns pulse width, corresponding to a peak power of approximately 3.94 MW. The output wavelength of the Ho:YAG MOPA laser system was 2090.9 nm. In addition, a beam quality factor M of about 1.7 was achieved at maximum output level.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/AO.58.000879DOI Listing
February 2019

Modification of Residual Stresses in Laser Additive Manufactured AlSi10Mg Specimens Using an Ultrasonic Peening Technique.

Materials (Basel) 2019 Feb 1;12(3). Epub 2019 Feb 1.

College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China.

Ultrasonic peening treatment (UPT) has been proved to be an effective way of improving residual stresses distribution in weld structures. Thus, it shows a great potential in stress modification for metal parts fabricated by additive manufacturing technology. In this paper, an investigation into the ultrasonic treatment process of AlSi10Mg specimens fabricated by selective laser melting (SLM) process was conducted by means of experimental and numerical simulation. The specimens were prepared using a SLM machine, and UPT on their top surface was carried out. The residual stresses were measured with an X-ray stress diffraction device before and after UPT. Meanwhile, a finite element simulation method for analyzing the influence of UPT on the residual stress field of specimens was proposed and validated by experiments. Firstly, the thermal mechanical coupling numerical simulation of the SLM process of the specimen was carried out in order to obtain the residual stress distribution in the as-fabricated specimen. Then, the transient dynamic finite element simulation model of the UPT process of the specimen was established, and the UPT effect analysis was implemented. In the UPT simulation, the residual stress was applied as a pre-stress on the specimen, and the specimen's material mechanical property was described by the Johnson⁻Cook model, whose parameters were determined by Split Hopkinson Pressure Bar (SHPB) experiment. The residual stress distribution before and after UPT predicted by the finite element model agree well with the measurement results. This paper concludes with a discussion of the effects of ultrasonic peening time, as well as the frequency and amplitude of the peening needle on residual stress.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma12030455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384986PMC
February 2019

Safe trapping of cesium into doping-enhanced pollucite structure by geopolymer precursor technique.

J Hazard Mater 2019 04 10;367:577-588. Epub 2019 Jan 10.

Institute for Advanced Ceramics, School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, PR China; Key Laboratory of Advanced Structural-Functional Integration Materials & Green Manufacturing Technology, Harbin Institute of Technology, Harbin, 150001, PR China.

Safe trapping of radioactive nuclear waste such as Cs has become a grim issue with the popularity of nuclear power and the growing yield of nuclear waste. To address this intractable problem, pollucite has been screened out as an ideal material for the long-term storage of Cs due to its low leaching rate and good chemical and thermal stability. With an effort to further enhance its immobilization capability and practical values, we herein report a robust route to prepare pollucite from ion-doped geopolymer at low temperature (≤1000 °C), achieving high Cs content (33.37 wt.%) and the lowest leaching rate of Cs (2.51 × 10 g m d) to date. Meanwhile, the leaching mechanism of Cs in pollucite is revealed via leaching tests coupled with SEM-EDS analysis. Therefore, this contribution may provide an alternative route to preparing pollucite and open up new possibilities in the immobilization of Cs for real-world applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2019.01.013DOI Listing
April 2019