Publications by authors named "Xiaohua Ren"

50 Publications

Peroxydisulfate activation by LaNiO nanoparticles with different morphologies for the degradation of organic pollutants.

Water Sci Technol 2022 Jan;85(1):39-51

School of Water Conservancy and Environment, University of Jinan, Jinan 250022, China E-mail:

A series of LaNiO perovskite nanoparticles with different morphologies, such as spheres, rods and cubes, were prepared through co-precipitation and hydrothermal methods, and used as the catalysts for peroxydisulfate (PDS) activation. The physical and chemical characterization of LaNiO perovskites was performed, including X-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen isotherm absorption (BET), electrochemical impedance spectroscopy (EIS), and X-ray photoelectron spectroscopy (XPS). The LaNiO with different shapes showed different activities in Acid Orange 7 (AO7) degradation. Sphere-like LaNiO exhibited the highest catalytic activity, which is probably due to the largest specific surface area, higher proportion of reductive Ni and the higher electron transfer ability. The radical scavenging experiments and electron paramagnetic resonance (EPR) revealed the production of massive sulfate radicals (SO) and hydroxyl radicals (OH) during the oxidation. Finally, the possible mechanisms of PDS activation and AO7 degradation were proposed. The prepared LaNiO perovskites also showed excellent reusability and stability.
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http://dx.doi.org/10.2166/wst.2021.504DOI Listing
January 2022

Persulfate activation by ferrocene-based metal-organic framework microspheres for efficient oxidation of orange acid 7.

Environ Sci Pollut Res Int 2022 May 17;29(23):34464-34474. Epub 2022 Jan 17.

School of Water Conservancy and Environment, University of Jinan, Jinan, 250022, China.

Ferrocene-based metal-organic framework with different transition metals (M-Fc-MOFs, M = Fe, Mn, Co) was synthesized by a simple hydrothermal method and used as a heterogeneous catalyst for persulfate activation. The samples were characterized by X-ray diffraction, transmission electron microscopy, X-ray electron spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. Meanwhile, the influences of factors such as catalyst dosage, persulfate concentration, and pH on the degradation of acid orange 7 (AO7) were studied in detail. The results showed that hollow cobalt-based ferrocenyl metal-organic framework microspheres (Co-Fc-MOFs) exhibited the best catalytic performance, which is closely related to the synergy of Fc/Fc and Co(II)/Co(III) cycles in persulfate activation. Free radical quenching studies indicated that both sulfate and hydroxyl appeared to contribute to the degradation of AO7.
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http://dx.doi.org/10.1007/s11356-022-18669-2DOI Listing
May 2022

Peroxisome Proliferator-Activated Receptor α Activation Protects Retinal Ganglion Cells in Ischemia-Reperfusion Retinas.

Front Med (Lausanne) 2021 23;8:788663. Epub 2021 Dec 23.

Eye Center of Xiangya Hospital, Central South University, Changsha, China.

Retinal ischemia-reperfusion (IR) leads to massive loss of retinal ganglion cells (RGC) and characterizes several blind-causing ophthalmic diseases. However, the mechanism related to retinal IR is controversial, and a drug that could prevent the RGC loss caused by IR is still lacking. This study aimed to investigate the role of endogenous retinal peroxisome proliferator-activated receptor (PPAR)α and the therapeutic effect of its agonist, fenofibric acid (FA), in IR-related retinopathy. Fenofibric acid treatment was applied to the Sprague-Dawley rats with IR and retinal cell line 28 cells with oxygen-glucose deprivation (OGD) (an model of IR). Western blotting, real-time PCR, and immunofluorescence were used to examine the expression levels of PPARα, glial fibrillary acidic protein (GFAP), and cyclooxygenase-2 (COX2). Hematoxylin and eosin (HE) staining, propidium iodide (PI) staining, retrograde tracing, and flash visual-evoked potential (FVEP) were applied to assess RGC injury and visual function. Retinal IR down-regulated PPARα expression and . Peroxisome proliferator-activated receptor α activation by FA promoted survival of RGCs, mitigated thinning of the ganglion cell complex, and decreased the latency of positive waves of FVEPs after IR injury. Further, FA treatment enhanced the expression of endogenous PPARα and suppressed the expression of GFAP and COX2 significantly. Peroxisome proliferator-activated receptor α activation by FA is protective against RGC loss in retinal IR condition, which may occur by restoring PPARα expression, inhibiting activation of glial cells, and suppressing retinal inflammation. All these findings indicate the translational potential of FA in treating IR-related retinopathy.
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http://dx.doi.org/10.3389/fmed.2021.788663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732875PMC
December 2021

Osteogenic ability using porous hydroxyapatite scaffold-based delivery of human placenta-derived mesenchymal stem cells.

Exp Ther Med 2021 Oct 2;22(4):1091. Epub 2021 Aug 2.

Stomatology Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.

Previous preliminary studies have suggested that hydroxyapatite with a grooved structure (HAG) scaffold has good osteogenic potential. This type of scaffold may aid osteogenesis during the repair of large maxillofacial bony defects. The ectopic osteogenic effect and underlying mechanism were further studied using porous HAG scaffold-based delivery of human placenta-derived mesenchymal stem cells (hPMSCs). A total of 18 dogs were randomly allocated into a HAG scaffold group and a HAG scaffold-based hPMSC (HAG/hPMSC) group, and three scaffolds were implanted into the dorsal muscle of each dog. Samples were taken for subsequent analysis and tested 4, 8 and 12 weeks following heterotopic implantation. H&E staining was used to study the osteogenic effect in dog dorsal muscles, and RNA sequencing (RNA-seq) was used for exploring the underlying osteogenic mechanism. The osteogenic ability and effector of the HAG/hPMSC group were significantly greater than those of the HAG scaffold group at 4 weeks after implantation. After 12 weeks, a mature bone plate structure was seen in the HAG/hPMSC group. RNA-seq demonstrated that various osteogenesis-related pathways participated at different stages of metabolism, and that the expression of collagen-1 and runt-related transcription factor 2 increased with implantation time. The present study preliminarily focused on the ectopic osteogenic effect of the porous HAG scaffold-based delivery of hPMSCs , which may be helpful for the improved application of HAG scaffolds in the future.
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http://dx.doi.org/10.3892/etm.2021.10525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383769PMC
October 2021

Hierarchical multi-active component yolk-shell nanoreactors as highly active peroxymonosulfate activator for ciprofloxacin degradation.

J Colloid Interface Sci 2022 Jan 29;605:766-778. Epub 2021 Jul 29.

School of Physics and Technology, University of Jinan, Shandong, 250022, China. Electronic address:

The reasonable design of the structure and composition of catalysts was essential to improve the catalytic performance of advanced oxidation processes (AOPs). Herein, we reported a simple strategy to synthesize hierarchical [email protected] yolk-shell nanoreactors with multiple active components by using metal-organic frameworks (MOFs). The novel nanoreactors are further used to activate peroxymonosulfate (PMS) for ciprofloxacin (CIP) degradation. The effects of reaction parameters (pH value, co-existing ions, reaction temperature, etc.) on CIP degradation were systematically investigated. Especially, ∼98.2% of CIP was degraded within 17 min under the optimal conditions, together with the low cobalt leaching and excellent reusability. The appreciable catalytic performance improvement might be due to the synergistic effect of the structure and component design: (1) the hierarchical yolk-shell structure endowed the catalyst with high surface area (∼232.47 m/g) and fully exposed active sites; (2) abundant highly active ≡Co-OH were formed on the surface of CoSiO; (3) the presence of oxygen vacancies and nitrogen-doped carbon promoted the decomposition of PMS through a non-radical process. The results revealed both the radical (SO, ∙OH and O) and non-radical (O and direct charge transfer) should be responsible for the CIP degradation. Moreover, the possible degradation pathways of CIP were proposed through the identification of intermediates using LC-MS/MS techniques and density functional theory (DFT) calculation. Our work highlights that multi-component catalysts derived from MOFs with novel structure have broad application prospects in AOPs.
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http://dx.doi.org/10.1016/j.jcis.2021.07.130DOI Listing
January 2022

Disordered Eating Attitudes Among University Students: The Role of Psychological Distress.

Altern Ther Health Med 2021 Sep;27(5):58-60

Objective: The aim of this study was to explore the relationship between psychological distress and disordered eating attitudes.

Methods: The study design was cross-sectional study. The 12-item General Health Questionnaire (ghq-12) and Eating Attitude Test-26 (eat-26) were used to measure psychological distress and disordered eating attitudes, respectively. The data were analyzed using spss version 20.0 Software (spss Inc, ii, Chicago, il, usa). Description statistics were used for height, weight, bmi), age, eat-26 scores and ghq-12 scores. Pearson's correlation analysis was performed to explore the relationship between the eat-26 scores and the ghq-12 scores.

Results: The overall prevalence of disordered eating attitudes was 4.6%. The mean ghq-12 score in subjects with disordered eating attitude was higher than that of the control group (P < .05) in both the male and female groups.

Conclusion: Our study suggested that psychological distress is associated with disordered eating attitudes. Bmi and gender turned out to not be correlated with disordered eating attitude. The findings of this study revealed that university students who have psychological distress also have a tendency toward disordered eating attitudes.
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September 2021

Knowledge, attitude, and practice of obesity among university students.

Ann Palliat Med 2021 Apr;10(4):4539-4546

School of Public Health and Management, Binzhou Medical University, Yantai, China.

Background: Obesity, as an epidemic disease, is distributed among all age groups, including children, adolescents, adults, and the elderly. The goal of this study was to investigate the knowledge, attitude, and practice (KAP) concerning obesity among university students.

Methods: In total, 1,317 questionnaires were filled out by 1,317 (466 male and 851 female) randomly selected students aged range from 16 to 24. All participants agreed to provide personal information in this study. A self-designed questionnaire was applied to collect demographic characteristics and assess the KAP of obesity. Gender, height, weight, grade, sleep and income were included in the population questionnaire. Descriptive statistics was used to analyze the respondent rate of KAP among students.

Results: In the survey, 64.9% of respondents believed that obesity was a disease. Only a few people cared about their body shape. Most of the participants in the study had practices that were detrimental to their health, including irregular dieting (52.9%), surfing the internet, and playing games (58.5%) in their spare time.

Conclusions: This study identified that lacking knowledge of obesity was common among college students. Most respondents had a positive attitude about preventing obesity by focusing on dieting and exercise. Thus, education related to obesity should be strengthening among university students to translate attitude into practice.
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http://dx.doi.org/10.21037/apm-21-573DOI Listing
April 2021

Poor sleep quality and its related risk factors among university students.

Ann Palliat Med 2021 Apr;10(4):4479-4485

Department of Oncology, Taizhou Municipal Hospital, Taizhou, China.

Background: Poor sleep quality is a major health problem worldwide. In universities, poor sleep quality can effect student's ability to study and have a serious impact on their psychological and physical well-being. The aim of this study was to explore the quality of sleep among university students and identify risk factors associated with poor sleep quality.

Methods: A cross-sectional study was conducted and the Pittsburgh sleep quality index scale was used to measure sleep quality. The overall score of the PSQI ranges from 0 to 21, with a score of 4 or less indicating good sleep quality, a score of 5-10 indicating fairly good sleep quality, 11-15 indicating fairly bad sleep quality, and a score of 16-21 indicating poor sleep quality.

Results: A total of 1,317 subjects were enrolled in the study. Most subjects were female (64.6%) and rural based (69.2%). Low intensity sports activity more than once per week was reported by 81.9% of subjects and 59.8% reported they participated in high-intensity sports more than once a week. In addition, 72.8% of subjects took a nap more than three times per week.

Conclusions: We found that physical activity and taking a nap may be important factors in improving sleep quality and preventing sleep disorders among university students.
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http://dx.doi.org/10.21037/apm-21-472DOI Listing
April 2021

Insights into the facet-dependent adsorption of antibiotic ciprofloxacin on goethite.

Environ Sci Pollut Res Int 2021 Mar 29;28(9):11486-11497. Epub 2020 Oct 29.

School of Water Conservancy and Environment, University of Jinan, Jinan, 250022, China.

Goethite is the most ubiquitous iron oxide mineral in soils, and adsorption of organic pollutants on goethite dominates the fate and transportation in the environment. In this study, the facet-dependent adsorption behavior of ciprofloxacin (CIP) on goethite was systematically investigated with in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectra and two-dimensional correlation analysis (2D-COS). The experimental results indicated that the goethite samples with higher facet proportion of {021}/{110} exhibited the better adsorption capacity compared to goethite with lower facet proportion of {021}/{110}. The reason is the more existence of singly coordinated sites with higher reactivity on the {021} facet. Moreover, CIP was found to be adsorbed on {021} and {110} facets by forming a tridentate complex involving the bridge coordination of bidentate ligands, H-bonding, and a bidentate chelate complex.
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http://dx.doi.org/10.1007/s11356-020-11422-7DOI Listing
March 2021

The theoretical investigation of OH-induced degradation mechanisms of isoproturon.

J Mol Model 2020 Aug 15;26(9):232. Epub 2020 Aug 15.

Shandong Institute of Land Survey and Mapping, Jinan, 250100, People's Republic of China.

Herbicides are widely applied in agriculture, which causes emerging concern for contaminating surface water and groundwater. The degradation of isoproturon, being a typical phenylurea herbicide, has been studied much with advanced oxidation processes. However, little information on the detailed degradation mechanism from the theoretical level is available. In the present work, the degradation mechanisms of OH-initiated reactions of isoproturon were studied at the MPWB1K/6-311+G(3df, 2p)//MPWB1K/6-31+G(d, p) level. The calculation results display that H-atom abstraction, ·OH addition, and ·OH substitution pathways are found for ·OH and isoproturon reactions. For H-atom abstractions, the results show that aliphatic H atoms are more easily abstracted by ·OH than the aromatic H atoms, and the pathway R6 has the lowest energy barrier of 6.65 kcal mol, indicating that H in the -CH group attached to the N2 atom could be most favorably abstracted. Six pathways for ·OH addition to the six sites of the phenyl ring are identified with low energy barriers, which are in good accordance with the fact that the additions of ·OH to the phenyl ring were the important steps from experimental results. For ·OH substitution reactions, two pathways with high activation energies are found, and the corresponding products have been also detected from previous experimental studies, suggesting that the substitution reactions could also occur.
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http://dx.doi.org/10.1007/s00894-020-04503-4DOI Listing
August 2020

Grooved hydroxyapatite scaffold modulates mitochondria homeostasis and thus promotes osteogenesis in bone mesenchymal stromal cells.

Mol Med Rep 2020 10 23;22(4):2801-2809. Epub 2020 Jul 23.

Department of Stomatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.

Hydroxyapatite scaffolds (HASs) are widely studied as suitable materials for bone replacement scaffolds due to their chemical similarities to organic materials. In our previous study, a novel HAS with a 25‑30‑µm groove structure (HAS‑G) exhibited enhanced osteogenesis of bone mesenchymal stromal cells (BMSCs) compared with HAS, potentially by modulating the macrophage‑induced immune microenvironment. However, the exact effects of different surface patterns on the physiological processes of attached cells is not known. The present study aimed to determine the effects of HAS‑G on the osteogenesis and physiological processes in BMSCs. Cell counting kit‑8 assays and propidium iodide staining followed by flow cytometry were performed, and the results demonstrated that both in normal medium and differentiating medium, HAS‑G promoted cell proliferation by decreasing the proportion of G1/G0 cells and decreased reactive oxygen species (ROS) accumulation in BMSCs compared with HAS. Detection markers of osteogenesis revealed that compared with HAS, HAS‑G increased runt‑related transcription factor 2, osteocalcin and osteopontin protein levels and promoted osteogenesis, which was further confirmed by Alizarin Red S staining. Following JC‑1 staining, it was observed that HAS‑G maintained the mitochondrial membrane potential, similar to that achieved by N‑acetylcysteine pretreatment. In addition, compared with those of HAS, HAS‑G decreased mitochondrial ROS levels, which potentially contributed to the promotion of osteogenesis. The results also demonstrated that HAS‑G inhibited mitophagy induced by ROS accumulation and ATP synthesis compared with HAS. In conclusion, HAS‑G decreased ROS accumulation and mitophagy and thus promoted osteogenesis of BMSCs, indicating that ROS modulation of HAS‑G may serve a key role in osteogenesis.
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http://dx.doi.org/10.3892/mmr.2020.11352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453552PMC
October 2020

Enhanced catalytic activity of MIL-101(Fe) with coordinatively unsaturated sites for activating persulfate to degrade organic pollutants.

Environ Sci Pollut Res Int 2020 May 9;27(14):17194-17204. Epub 2020 Mar 9.

School of Water Conservancy and Environment, University of Jinan, Jinan, 250022, China.

In this work, four novel defective MIL-101(Fe) catalysts with coordinatively unsaturated sites were successfully prepared via a facile synthesis strategy by employing benzoic acid, acetic acid, oxalic acid, or citric acid as a modulator. The modified catalysts were demonstrated the existence of defects in the parent framework by a series of characterizations. As compared to the initial MIL-101(Fe), the electronic structure of defective MIL-101(Fe) catalyst was effectively adjusted; meanwhile, the coordinatively unsaturated Fe sites were efficiently generated and the pore sizes were enlarged. Besides, the defective MIL-101(Fe) catalysts exhibited excellent catalytic performance for rhodamine B degradation by persulfate activation. To be specific, the degradation rates of rhodamine B increased from 58.70 to 94.05%, 86.11%, 78.70%, and 82.62%, respectively. The defective MIL-101(Fe) with coordinatively unsaturated sites showed good reusability and stability, and the probable catalytic mechanism was also investigated.
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http://dx.doi.org/10.1007/s11356-020-08316-zDOI Listing
May 2020

Quinone-modified metal-organic frameworks MIL-101(Fe) as heterogeneous catalysts of persulfate activation for degradation of aqueous organic pollutants.

Water Sci Technol 2019 Jun;79(12):2357-2365

School of Water Conservancy and Environment, University of Jinan, Jinan 250022, China E-mail:

In this work, quinone-modified metal-organic framework MIL-101(Fe)(Q-MIL-101(Fe)), as a novel heterogeneous Fenton-like catalyst, was synthesized for the activation of persulfate (PS) to remove bisphenol A (BPA). The synthetic Q-MIL-101(Fe) was characterized via X-ray diffraction, scanning electron microscope, Fourier transform infrared, electrochemical impedance spectroscopy, cyclic voltammetry and X-ray photoelectron spectroscopy. As compared to the pure MIL-101(Fe), Q-MIL-101(Fe) displayed better catalytic activity and reusability. The results manifested that the Q-MIL-101(Fe) kept quinone units, which successfully promoted the redox cycling of Fe/Fe and enhanced the removal efficiency. In addition, the reaction factors of Q-MIL-101(Fe) were studied (e.g. pH, catalyst dosage, PS concentration and temperature), showing that the optimum conditions were [catalyst] = 0.2 g/L, [BPA] = 60 mg/L, [PS] = 4 mmol/L, pH = 6.79, temperature = 25 °C. On the basis of these findings, the probable mechanism on the heterogeneous activation of PS by Q-MIL-101(Fe) was proposed.
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http://dx.doi.org/10.2166/wst.2019.239DOI Listing
June 2019

Groove structure of porous hydroxyapatite scaffolds (HAS) modulates immune environment via regulating macrophages and subsequently enhances osteogenesis.

J Biol Inorg Chem 2019 08 19;24(5):733-745. Epub 2019 Jul 19.

Stomatology department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32 West Second Section, First Ring Road, Chengdu, 610072, Sichuan, China.

Researches have revealed the vital roles of the generated immune environment via the response of immune cells growing on biomaterial surfaces in the bone healing process. HAS and novel constructed microgrooved patterns of HAS (HAS-G) are widely used as biocompatible ceramic, especially as a mimic of the natural bone matrix. However, it is unclear whether osteoimmune response induced by HAS and HAS-G affects the osteogenic differentiation of bone marrow stromal cells (BMSCs). RAW264.7 cells were seeded on different surface of materials and cytokines released by macrophages were detected by enzyme-linked immunosorbent assay. The cell viability and mitochondrial function of macrophages seeded on different surface of materials were detected. Then, the effects of modified inflammatory microenvironment by macrophages on osteogenesis of BMSCs were measured by performing ALP staining, Alizarin Red S staining, and western blot. We confirmed that HAS-G is more favorable for RAW cell attaching and subsequently regulated the expression and release of cytokines/chemokines. Decrease in interleukin-6 (IL-6) release was further confirmed for contributing significantly to improve mitochondrial function in RAW cells. HAS-G-conditioned medium promoted osteogenic differentiation in BMSCs and was reversed by IL-6 addition. Decrease in IL-6 contributes to downregulation of miR-214 and subsequently upregulated p38/JNK pathway, which is potentially contributes to osteogenic promotion by HAS-G. This study is the first report to reveal the effects of HAS-G on osteogenesis via immune response, which could lead to a new insight into novel material for the advantage of biomaterials for tissue engineering applications.
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http://dx.doi.org/10.1007/s00775-019-01687-wDOI Listing
August 2019

Microfluidic Fabrication of Bubble-Propelled Micromotors for Wastewater Treatment.

ACS Appl Mater Interfaces 2019 Jun 15;11(25):22761-22767. Epub 2019 Jun 15.

School of Water Conservancy and Environment , University of Jinan , Jinan 250022 , China.

Bubble-propelled micromotors with controllable shapes and sizes have been developed by a microfluidic method, which serves for effective wastewater treatment. Using the emulsion from microfluidics as the template, monodisperse micromotors can be fabricated in large quantities based on phase separation and UV-induced monomer polymerization. By adjusting the volume ratio of the two immiscible oils (ethoxylated trimethylolpropane triacrylate/paraffin oil) in the initial emulsion, the geometry of the resulting micromotor can be precisely controlled from nearly spherical, hemispherical to crescent-shaped. The size of the micromotor can be manipulated by varying the fluid flow parameters. In addition, by incorporating functional nanoparticles into the asymmetric structure, the micromotor can be functionalized flexibly for water remediation. In this research, FeO and MnO nanoparticles were successfully loaded on Janus micromotors. FeO nanoparticles can act as catalysts for pollutant degradation and also control the movement direction of micromotors. MnO nanoparticles on the concave of the micromotor catalyzed HO to produce bubble propulsion motion in solution, which further enhanced the degradation of pollutants. Consequently, the obtained micromotor demonstrated effective degradation of methylene blue and can be easily recovered by magnets. Furthermore, this simple and flexible strategy offers a synthetic way for anisotropic Janus particles, which will broaden their potential application.
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http://dx.doi.org/10.1021/acsami.9b05925DOI Listing
June 2019

High efficient adsorption and storage of iodine on S, N co-doped graphene aerogel.

J Hazard Mater 2019 Jul 3;373:705-715. Epub 2019 Apr 3.

SDU& Rice Joint Center for Carbon Nanomaterials, Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, 250061, China. Electronic address:

High efficient adsorption of radioiodine in nuclear waste has attracted extensive attentions all over the world. In this work, we fabricated sulfur and nitrogen co-doped graphene aerogels (SN-GA) through one-step hydrothermal method, and investigated its iodine adsorption behavior including adsorption kinetics and isotherms in water. Our results reveal that SN-GA exhibits a 3D porous architecture with thiophene-S, oxidized-S, pyridine-N, pyrrole-N and graphite-N co-doped into the sp carbon frameworks. The adsorption experiment showed SN-GA has a maximum iodine adsorption capacity of 999 mg g determined by Langmuir isotherm, and the adsorption process could be better described by the pseudo-second-order model.
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http://dx.doi.org/10.1016/j.jhazmat.2019.04.005DOI Listing
July 2019

Sexual Activity and HIV-Related Knowledge among Secondary School Students in China.

Eurasian J Med 2019 Feb;51(1):49-52

Wannan Medical College School of Public Health, Wuhu, Anhui, China.

Objective: The aim of this study was to assess the level of HIV/AIDS knowledge and sexual activity among secondary school students, and to offer specific intervention strategies.

Materials And Methods: Random sampling technique was used and cross-sectional study was conducted among 6347 students using self-administered questionnaire.

Results: The ages of participants range from 9 to 21 years with a mean of 14.83±1.63 years. Of 6347 students, 3214 (50.6%) were female. Results showed that 65% of male and 71% of female had been pornography reader. Overall, the prevalence of knowledge on HIV caused by virus was high for male and female. On intimate contact, 25.7% of the male and 17.7% of the female students reported that they had a history of hugging; 11.3% of male and 5.6% of female students reported that they had an experience of kissing; 11.3% of male and 4.0% of female students reported that they had an experience of caressing, 27% of male and 18% of female students reported that they had an experience of sexual intercourse; and 49.5% of male and 58.4% of female students reported to have been forced to have sex. Accordingly, 75.1% of male and 90% of female students heard of HIV.

Conclusion: Education of the students on HIV/AIDS seems poorer at the secondary school in certain areas of China; more attention should be paid to those of senior grade students and students from divorced families.
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http://dx.doi.org/10.5152/eurasianjmed.2015.15057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422611PMC
February 2019

Enhanced heterogeneous activation of peroxydisulfate by S, N co-doped graphene via controlling S, N functionalization for the catalytic decolorization of dyes in water.

Chemosphere 2018 Nov 3;210:120-128. Epub 2018 Jul 3.

SDU& Rice Joint Center for Carbon Nanomaterials, Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan 250061, China. Electronic address:

3D porous sulfur and nitrogen co-doped graphene aerogel has been fabricated by a facile one-pot process. Both experimental and theoretical studies have demonstrated that sulfur and nitrogen co-doping could synergistically enhance the catalytic performance for activating peroxydisulfate (PDS) compared to the original and N doped graphene aerogels. The ratio of sulfur/nitrogen in the aerogel can be controlled by regulating the additions of thiourea and urea sources, and the aerogel with the S/N ratio of about 1:2.5 shows a better catalytic effect due to more significant changes in the electrostatic potential and the surface charge distribution, as revealed by the theoretical simulations. The radical quenching tests indicated that both SO· and ·OH radicals could be formed in the SN-rGO aerogel + PDS system and contribute most to RhB degradation.
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http://dx.doi.org/10.1016/j.chemosphere.2018.07.011DOI Listing
November 2018

HSP27 associates with epithelial-mesenchymal transition, stemness and radioresistance of salivary adenoid cystic carcinoma.

J Cell Mol Med 2018 04 9;22(4):2283-2298. Epub 2018 Feb 9.

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Epithelial-mesenchymal transition (EMT) has been shown to associate with cancer stem cells and radioresistance. However, it is obscure whether EMT itself or specific EMT regulators play causal roles in these properties of salivary adenoid cystic carcinoma (SACC). Here, we exhibited that overexpression of HSP27 drove the migration and invasion, induced EMT, as well as mediated TGF-β1-induced EMT in SACC cells, accompanying the up-regulation of Snail1 and Prrx1. Conversely, HSP27 silencing reduced the migration and invasion and contributed to MET of SACC cells. HSP27 indirectly down-regulates the expression of E-cadherin through activating Snail1 and Prrx1 expressions. Overexpression of Snail1 or Prrx1 restored the migration and invasion in HSP27 knockdown cells. Enforced expression of HSP27 enhanced colony formation, CD133 /CD44 population and radioresistance of SACC cell lines. In addition, HSP27 expression was positively associated with radioresistance and poor prognosis of SACC patients as well as with the expression of Prrx1 or Snail1 in SACC tissues. The data confirm an important function for HSP27 in SACC progression through regulating EMT and stemness, and they imply the possible association between EMT and radioresistance of SACC.
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http://dx.doi.org/10.1111/jcmm.13510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867171PMC
April 2018

A new four-step hierarchy method for combined assessment of groundwater quality and pollution.

Environ Monit Assess 2017 Dec 28;190(1):50. Epub 2017 Dec 28.

Shandong Institute of Geological Survey, Jinan, Shandong Province, China.

A new four-step hierarchy method was constructed and applied to evaluate the groundwater quality and pollution of the Dagujia River Basin. The assessment index system is divided into four types: field test indices, common inorganic chemical indices, inorganic toxicology indices, and trace organic indices. Background values of common inorganic chemical indices and inorganic toxicology indices were estimated with the cumulative-probability curve method, and the results showed that the background values of Mg (51.1 mg L), total hardness (TH) (509.4 mg L), and NO (182.4 mg L) are all higher than the corresponding grade III values of Quality Standard for Groundwater, indicating that they were poor indicators and therefore were not included in the groundwater quality assessment. The quality assessment results displayed that the field test indices were mainly classified as grade II, accounting for 60.87% of wells sampled. The indices of common inorganic chemical and inorganic toxicology were both mostly in the range of grade III, whereas the trace organic indices were predominantly classified as grade I. The variabilities and excess ratios of the indices were also calculated and evaluated. Spatial distributions showed that the groundwater with poor quality indices was mainly located in the northeast of the basin, which was well-connected with seawater intrusion. Additionally, the pollution assessment revealed that groundwater in well 44 was classified as "moderately polluted," wells 5 and 8 were "lightly polluted," and other wells were classified as "unpolluted."
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http://dx.doi.org/10.1007/s10661-017-6403-7DOI Listing
December 2017

Synergic mechanism of adsorption and metal-free catalysis for phenol degradation by N-doped graphene aerogel.

Chemosphere 2018 Jan 15;191:389-399. Epub 2017 Oct 15.

SDU & Rice Joint Center for Carbon Nanomaterials, Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan 250061, China. Electronic address:

3D porous N-doped reduced graphene oxide (N-rGO) aerogels were synthesized by a hydrothermal reduction of graphene oxide (GO) with urea and following freeze-drying process. N-rGO aerogels have a high BET surface of 499.70 m/g and a high N doping content (5.93-7.46 at%) including three kinds of N (graphitic, pyridinic and pyrrolic). Their high catalytic performance for phenol oxidation in aqueous solution was investigated by catalytic activation of persulfate (PS). We have demonstrated that N-rGO aerogels are promising metal-free catalysts for phenol removal. Kinetics studies indicate that phenol degradation follows first-order reaction kinetics with the reaction rate constant of 0.16799 min for N-rGO-A(1:30). Interestingly, the comparison of direct catalytic oxidation with adsorption-catalytic oxidation experiments indicates that adsorption plays an important role in the catalytic oxidation of phenol by decreasing the phenol degradation time. Spin density and adsorption modeling demonstrates that graphitic N in N-rGO plays the most important role for the catalytic performance by inducing high positive charge densities to adjacent carbon atoms and facilitating phenol adsorption on these carbon sites. Furthermore, the activation mechanism of persulfate (PS) on N-rGO was first investigated by DFT method and PS can be activated to generate strongly oxidative radical (SO·) by transferring electrons to N-rGO.
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http://dx.doi.org/10.1016/j.chemosphere.2017.10.076DOI Listing
January 2018

[Study of human leucine-rich amelogenin peptide and its regulation of mineralization by cryogenic transmission electron microscopy].

Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Feb;35(1):63-67

Dept. of Stomatology, Hospital of University of Electronic Science and Technology of China UESTC & Sichuan Provincial People's Hosptial, Chengdu 610072, China.

Objective: Recombinant human leucine-rich amelogenin peptide (LRAP) was studied by cryogenic transmission electron microscopy (TEM); evaluation focused on its self-assembly and crystal growth in vitro.

Methods: Human LRAP was recombined through prokaryotic expression vector pCold-SUMO and transformed into Escherichia coli BL21plys to acquire purified proteins. Cryogen TEM recorded assembly and self-assembling of LRAP from pH 3.5 to pH 8.0, and the hydroxyapatite crystal growth in the mixture of LRAP protein solution and artificial saliva was observed using TEM and selected area electron diffraction.

Results: More than 90% purity LRAP was expressed, purified and identified as described in methods. LRAP linked into oligomers, nanospheres, nanochains, and microribbons, whereas pH value increased from 3.5 to 8.0. Mature hydroxyapatite crystal growth was guided in artificial saliva filled with calcium phosphate.

Conclusions: LRAP is simplified amelogenin functional domain and conserved the basic characters of amelogenin such as self-assembling and inducing crystallization along c axis. In the area of acellular synthesis of hydroxyapatite using extracellular enamel matrix protein, LRAP is one of candidate repair materials for irregular hard tissue defection.
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http://dx.doi.org/10.7518/hxkq.2017.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030201PMC
February 2017

Local hyperthermia in head and neck cancer: mechanism, application and advance.

Oncotarget 2016 Aug;7(35):57367-57378

State Key Laboratory of Oral Diseases West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose control, target treatment regions and discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials to local HT of head and neck cancer that basically take advantage of various targeting approaches. The aim of this paper is to give a brief review of the mechanism, methods and clinical applications of local HT in head and neck cancer, mainly focusing on photothermal therapy (PTT) and nanoparticle-based hyperthermia.
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http://dx.doi.org/10.18632/oncotarget.10350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302995PMC
August 2016

Physiological interactions between the hypothalamic-pituitary-gonadal axis and spleen in rams actively immunized against GnRH.

Int Immunopharmacol 2016 Sep 18;38:275-83. Epub 2016 Jun 18.

Isotope Research Lab, Sichuan Agricultural University, Ya'an 625014, People's Republic of China. Electronic address:

Hypothalamic-pituitary-gonadal (HPG) axis is strongly implicated in the regulation of immune system. The objective was to determine the effects of immunocastration on splenic reproduction- and immunity-related gene expressions, and serum cytokine profiles in rams. Forty rams were randomly allocated into three groups: control (n=14); surgically castrated (n=13); or immunized (n=13) against 100μg D-Lys6-GnRH-tandem-dimer peptide conjugated to ovalbumin in Specol adjuvant at 6months of age (with a booster 2months later). Blood samples (for hormone and immune cytokine profiles) were collected at 1-month intervals until rams were slaughtered (10months). Compared to intact controls, anti-GnRH immunization reduced (P<0.05) serum concentrations of LH, FSH, and testosterone. Reduced testosterone abrogated its inhibitor feedback effect on the synthesis of GnRH in spleen, as evidenced by increased (P<0.05) protein content and mRNA expressions of GnRH, and simultaneously decreased (P<0.05) mRNA expressions of androgen receptor in spleen. In parallel with the increased GnRH production in spleen, the mRNA expressions of interleukin (IL)-2, IL-4, IL-6 and tumor necrosis factor alpha (TNF-α) as well as lymphocyte marker CD4, CD8 and CD19 molecules were increased (P<0.05) in spleen. Consistently, serum concentrations of IL-2, IL-4, IL-6, TNF-α were increased (P<0.05) in rams following immunization. Similarly, deprivation of testosterone by surgical castration also increased (P<0.05) GnRH and thus immune cytokine expressions in spleen. Collectively, our data suggested that immunocastration increased GnRH production in spleen by abrogating the inhibitory feedback effects from testosterone, consequently improving the immune markers of spleen and serum immune cytokines in rams.
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http://dx.doi.org/10.1016/j.intimp.2016.06.011DOI Listing
September 2016

[Comprehensive evaluation on the prescription behavior for outpatients in primary health care institutions of Yiyang].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2016 Feb;41(2):182-90

Department of Epidemiology and Medical Statistics, School of Public Health, Central South University, Changsha 410078, China.

Objective: To evaluate the prescription behavior for outpatients in primary health care institutions of Yiyang and to provide scientific basis for promoting the rational use of drugs.


Methods: A multi-stage random sampling method was conducted in 21 primary health care institutions from Yiyang. Fifteen prescriptions were randomly selected in every month from each institution and a total of 3780 prescriptions were eventually collected in a year.


Results: Both the number of drugs and percentage of injection in a prescription were greater than the international standards. Children were more likely to be prescribed by multiple prescriptions, antibiotics prescriptions, hormones and injections prescriptions. The utilization of essential drug was more frequent in female. Antibiotics and hormones were more frequently used in summer and autumn season. Polypharmacy, antibiotics, injections and essential drugs were more frequently used in hospitals of small town. The skin and subcutaneous tissue diseases were often treated with multiple prescriptions, while the respiratory diseases were often treated with antibiotics, hormones and injections. Most primary health care institutions were at the upper limit of rational drug use.


Conclusion: The usage of prescription drug in most primary health care is rational, but some still surpass international standards. Thus, primary health care physicians should strictly control their prescriptions behavior.
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http://dx.doi.org/10.11817/j.issn.1672-7347.2016.02.011DOI Listing
February 2016

Correlation of burnout with social support in hospital nurses.

Int J Clin Exp Med 2015 15;8(10):19144-9. Epub 2015 Oct 15.

School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.

Burnout is common in industrial countries. In this study, our aim is to investigate the relationship between burnout and social support (SS) among hospital nurses. A cross-sectional survey was conducted in 7 hospitals from three provinces of China. A total of 1212 registered hospital nurses were included, the respond rate is 94.4% (1144/1212). A self-administered questionnaire consisting of socio-demographic characteristics, burnout and SS was used in this study. A revised version of Maslach Burnout Inventory (MBI) was applied to evaluate the burnout and SS was measured by nine questions. Logistic regression analysis was used to explore the association between burnout and SS after controlling for age, gender, marital status, working years, income, educational level, and profession. According to the results obtained from the study, 66% of the staff suffered from emotional exhaustion (EE) in moderate or severe degree, 65% of them suffered from depersonalization (DP) and 63% feel lower personal achievements (PAs). It means that higher level of EE, DP and lower PAs were considered care providers in the hospital nurse. Further correlation analysis indicated that the score of EE, DP and PAs were negative associated with the score of SS (P<0.05). The univariate analysis and multivariate analysis results also revealed that the SS score negative associated with DP score and positively associated with PAs score after controlling for age, gender, marital status, working years, income, educational level and job title. SS have a significantly influences on depersonalization in hospitals nurse. This study also suggests that we should pay more attention to the relationship between burnout and reduced personal accomplishment in future studies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694446PMC
January 2016

[Satisfaction degree in outpatients and the influential factors at national essential medicine system in primary health care institutions of Yiyang].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2015 Dec;40(12):1377-83

Department of Social Medicine and Health Management, School of Public Health, Central South University, Changsha 410078; Department of Epidemiology and Medical Statistics, School of Public Health, Central South University, Changsha 410078, China.

Objective: To analyze the satisfaction degree in outpatients and influential factors at national essential medicine system in primary health care institution of Yiyang and to provide useful information for the sustainable development of the national essential medicine system in China.


Methods: A multi-stage random sampling method was conducted. A total of 525 outpatients were randomly selected in 21 primary health care institution. Their satisfaction degree on national essential medicine system were investigated through anonymous survey.


Results: Categories of medical institutions, age, education, medicare categories and occupation were influential factors, with statistical significance (P<0.05). 


Conclusion: There's no difference among different class of outpatients' attitude on national essential medicine system. Categories of medical institutions, age, education, medicare categories and occupation are influential factors for outpatients' attitude.
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http://dx.doi.org/10.11817/j.issn.1672-7347.2015.12.015DOI Listing
December 2015

[The effect of paraquat on voltage-dependent anion channel and caspase-3, 8, 9 in the mitochondria of rat lung].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2015 May;33(5):363-5

Hangzhou Normal University Affiliated Hospital, Hangzhou 310015, China.

Objective: To investigate the effects of different concentrations of paraquat (PQ) poisoning on the expression of voltage-dependent anion channel (VDAC) and caspase family in the mitochondria of rat lung tissue, and to explore possible mechanisms of acute lung injury induced by acute PQ poisoning.

Methods: Two hundred healthy adult Wister rats with equal numbers of male and female ones were randomly and equally divided into control group and poisoned group. The control group received one-time gastric lavage with 1 ml of normal saline, and the poisoned group with PQ (50 mg/kg) diluted in 1 ml of normal saline. Twenty rats were collected at 1, 24, 72, 120, and 168 h after lavage with normal saline or PQ and dissected after anesthesia. Mitochondria were separated from rat lung tissue, and the content of VDAC and caspase-3, -8, and -9 were determined.

Results: The expression of VDAC and caspase-3, -8, and -9 in the poisoned rats were significantly higher than that in the control group (P < 0.001). At 1, 24, 72, 120, and 168 h after exposure, acute diffuse damages were found in alveolar capillary endothelial cells, alveolar epithelial cells, and pulmonary interstitial cells. Inflammatory cell infiltration in the pulmonary interstitium, alveolar structural disorder, and substantially increased fibroblasts were also found in rat lung tissue.

Conclusion: PQ poisoning can up-regulate the expression of VDAC and caspase-3, -8, and -9 in mitochondria of rat lung tissue to induce acute lung injury.
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May 2015

Correlation analysis of anxiety status and sub-health status among students of 13-26 years old.

Int J Clin Exp Med 2015 15;8(6):9810-4. Epub 2015 Jun 15.

School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.

The purpose of the survey is to investigate the relationship between anxiety statuses and suboptimal health status among students from south of Anhui in china. Our study was a population-based, cluster sampling method survey with a sample consisting of 5249 students, who come from a university, four high schools and four middle schools in Wannan Area in China. Sub-health status was measured by multidimensional sub-health questionnaire of adolescents, and anxious status was assessed using anxiety self-assessment scale. A total of 538 (10.25%) of the students were detected with anxiety status, the prevalence of anxiety status for boy and girl students were 11.8% and 16.5%,respectively, there are no significant difference between urban and rural for the anxiety score in physical and mental sub-health status (P > 0.05). The boys living in urban have a lower anxiety score than that of the girls, the no-only child and child living in rural in different sub-health status (P < 0.05). The results indicate that sub-health status and anxiety status are prevalent among students, especially in girls, no-only child and students who living in rural area, the school heads should pay more attention to the mental health of students.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537984PMC
August 2015

Prevalence of overweight and obesity among secondary school children aged 14 to 18 years (china).

Nutr Hosp 2015 May 1;31(5):2006-10. Epub 2015 May 1.

School of Public Health, Wannan Medical College. Wuhu,Anhui 241002 China..

Background: Prevalence of overweight and obesity in adolescents has been increasing during recent decades. The present study aimed to assess the prevalence of obesity in 14-18 years old Anhui Secondary school children, and provide more comprehensive guidelines for intervention programs.

Methods: This cross-sectional study was conducted among 4788 children in secondary school, and date from the routine health survey was analyzed. Trained health workers took anthropometric measures, height and weight, at the school. Definition of children overweight and obesity children was based on the international age-and sex-specific body mass index reference standards proposed by the International Obesity Task Force and National Center for Health Statistics.

Results: According to the IOTF standard the prevalence of overweight (including obesity) and obesity revealed decreasing trend with age in male (overweight, from 17.3% at 14-y to 5.3% at 18-y; obesity, from 3.8% at 14-y to 2.3% at 18-y). Depending on the NCHS references used, the overall prevalence of overweight (including obesity) and obesity in male aged 14 to 18 decreases from 16.4% to 11.7% and from 4.6% to 2.8%, respectively.

Conclusion: The overweight (including obesity) and obesity from 14 to 18 years old have a decreasing trend, and more attention should be taken to male students in China. These findings suggest secondary school and government need to design appropriate guidelines to keep healthy for adolescents in China.
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http://dx.doi.org/10.3305/nh.2015.31.5.8532DOI Listing
May 2015
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