Publications by authors named "Xiaohua Gong"

70Publications

Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism.

Cell Death Dis 2020 12 7;11(12):1040. Epub 2020 Dec 7.

Department of Endocrinology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

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December 2020

Mild formation of core-shell hydrogel microcapsules for cell encapsulation.

Biofabrication 2020 Dec 3. Epub 2020 Dec 3.

Mechanical and Energy Eningeering, Southern University of Science and Technology, NoNo. 1088 Xueyuan Avenue, Nanshan District, China., Shenzhen, 518000, CHINA.

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December 2020

Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism.

Endocrine 2020 Oct 6. Epub 2020 Oct 6.

Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, Zhejiang, China.

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October 2020

CP49 and filensin intermediate filaments are essential for formation of cold cataract.

Mol Vis 2020 23;26:603-612. Epub 2020 Aug 23.

Vision Science and Optometry, University of California, Berkeley, Berkeley, CA.

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August 2020

Modification of the second translation initiation site restricts the replication of foot-and-mouth disease virus in PK-15 cells.

Appl Microbiol Biotechnol 2020 Oct 21;104(19):8455-8466. Epub 2020 Aug 21.

State Key Laboratory of Veterinary Etiological Biology, OIE/China Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 1 Xujiaping, Yanchangbao, Lanzhou, Gansu, 730046, People's Republic of China.

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October 2020

3D printed microfluidic devices for circulating tumor cells (CTCs) isolation.

Biosens Bioelectron 2020 Feb 16;150:111900. Epub 2019 Nov 16.

Department of Mechanical Engineering, University of California, Berkeley, USA; Berkeley Sensor and Actuators Center, USA. Electronic address:

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February 2020

Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037).

J Clin Oncol 2018 Nov 28;36(32):3223-3230. Epub 2018 Sep 28.

Tara C. Mitchell, University of Pennsylvania; Anthony J. Olszanski, Fox Chase Cancer Center, Philadelphia, PA; Omid Hamid and Ani S. Balmanoukian, The Angeles Clinic and Research Institute, Los Angeles, CA; David C. Smith, University of Michigan, Ann Arbor, MI; Todd M. Bauer, Tennessee Oncology, Nashville, TN; Jeffrey S. Wasser, University of Connecticut School of Medicine, Farmington, CT; Jason J. Luke and Thomas F. Gajewski, University of Chicago Medicine, Chicago, IL; Emmett V. Schmidt, Merck & Co, Kenilworth, NJ; and Yufan Zhao, Xiaohua Gong, Janet Maleski, and Lance Leopold, Incyte Corporation, Wilmington, DE.

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November 2018

Essential function of NHE8 in mouse retina demonstrated by AAV-mediated CRISPR/Cas9 knockdown.

Exp Eye Res 2018 11 26;176:29-39. Epub 2018 Jun 26.

School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA, USA. Electronic address:

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November 2018

Ultrasound-Guided Percutaneous Microwave Ablation for Solid Benign Thyroid Nodules: Comparison of MWA versus Control Group.

Int J Endocrinol 2017 23;2017:9724090. Epub 2017 Nov 23.

Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, China.

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November 2017

Comparison of Ultrasound-Guided Percutaneous Polidocanol Injection Versus Percutaneous Ethanol Injection for Treatment of Benign Cystic Thyroid Nodules.

J Ultrasound Med 2018 Jun 8;37(6):1423-1429. Epub 2017 Dec 8.

Department of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University, Suzhou, China.

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June 2018

US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules.

Endocr J 2017 Nov 29;64(11):1079-1085. Epub 2017 Aug 29.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

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November 2017

Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro.

Sci Rep 2017 08 4;7(1):7274. Epub 2017 Aug 4.

School of Optometry and Vision Science Program, University of California Berkeley, California, 94720, USA.

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August 2017

Growth of hollow cell spheroids in microbead templated chambers.

Biomaterials 2017 Oct 26;143:57-64. Epub 2017 Jul 26.

School of Optometry and Vision Science Program, University of California, Berkeley, CA, USA; UC Berkeley - UCSF Bioengineering Graduate Program, Berkeley, CA, USA. Electronic address:

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October 2017

Sox10 Cells Contribute to Vascular Development in Multiple Organs-Brief Report.

Arterioscler Thromb Vasc Biol 2017 09 27;37(9):1727-1731. Epub 2017 Jul 27.

From the Department of Bioengineering (D.W., F.W., A.W., S.L.) and School of Optometry and Vision Science Graduate Program (D.W., G.J.K., T.T., L.C., X.G.), University of California, Berkeley; Department of Bioengineering (D.W., H.Y., S.L.) and Department of Medicine (S.L.), University of California, Los Angeles; The Second Xiangya Hospital of Central South University (H.Y.); Surgical Bioengineering Laboratory, Department of Surgery, School of Medicine, University of California, Davis (A.W.); and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine (A.S.M).

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September 2017

EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens.

Exp Eye Res 2017 09 23;162:9-17. Epub 2017 Jun 23.

School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, United States.

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September 2017

Efficacy and Safety of Ultrasound-Guided Percutaneous Polidocanol Sclerotherapy in Benign Cystic Thyroid Nodules: Preliminary Results.

Int J Endocrinol 2017 31;2017:8043429. Epub 2017 May 31.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, Zhejiang 325015, China.

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May 2017

Screening, genetics, risk factors, and treatment of neonatal cataracts.

Birth Defects Res 2017 Jun 22;109(10):734-743. Epub 2017 May 22.

School of Optometry and Vision Science Program, University of California, Berkeley, California, USA.

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June 2017

Efficacy and safety of ultrasound-guided percutaneous polidocanol sclerotherapy in benign predominantly cystic thyroid nodules: a prospective study.

Curr Med Res Opin 2017 08 6;33(8):1505-1510. Epub 2017 Jun 6.

a Department of Endocrinology and Metabolism , the First Affiliated Hospital of Wenzhou Medical University , Ouhai District , Wenzhou 325015 , Zhejiang Province , PR China.

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August 2017

Knock-in of Cx46 partially rescues fiber defects in lenses lacking Cx50.

Mol Vis 2017 24;23:160-170. Epub 2017 Mar 24.

School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA.

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January 2018

Targeted Exome Sequencing of Congenital Cataracts Related Genes: Broadening the Mutation Spectrum and Genotype-Phenotype Correlations in 27 Chinese Han Families.

Sci Rep 2017 04 27;7(1):1219. Epub 2017 Apr 27.

Eye Center, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.

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April 2017

Sox10 adult stem cells contribute to biomaterial encapsulation and microvascularization.

Sci Rep 2017 01 10;7:40295. Epub 2017 Jan 10.

Department of Bioengineering, University of California, Berkeley, California 94720, USA.

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January 2017

Identification and functional analysis of two novel connexin 50 mutations associated with autosome dominant congenital cataracts.

Sci Rep 2016 05 24;6:26551. Epub 2016 May 24.

Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

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May 2016

Roles of phosphatidylinositol 3-kinase regulatory subunit alpha, activator protein-1, and programmed cell death 4 in diagnosis of papillary thyroid carcinoma.

Tumour Biol 2016 May 4;37(5):6519-26. Epub 2015 Dec 4.

Department of Endocrinology, First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, 325015, Zhejiang, People's Republic of China.

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May 2016

Differential connexin function enhances self-renewal in glioblastoma.

Cell Rep 2015 May 7;11(7):1031-42. Epub 2015 May 7.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44915, USA; Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA; Rose Ella Burkhardt Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Cleveland, OH 44106, USA. Electronic address:

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May 2015

NHE8 is essential for RPE cell polarity and photoreceptor survival.

Sci Rep 2015 Mar 20;5:9358. Epub 2015 Mar 20.

School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720, USA.

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March 2015

Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels.

Atherosclerosis 2015 Apr 23;239(2):566-70. Epub 2015 Feb 23.

Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan, Guangdong, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan, Guangdong, China. Electronic address:

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April 2015

A novel GJA8 mutation (p.V44A) causing autosomal dominant congenital cataract.

PLoS One 2014 17;9(12):e115406. Epub 2014 Dec 17.

Eye center, 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China; Key Laboratory of Ophthalmology of Zhejiang Province, Wenzhou, China.

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January 2016

Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization.

PLoS One 2013 13;8(9):e75186. Epub 2013 Sep 13.

School of Optometry and Vision Science Program, University of California Berkeley, Berkeley, California, United States of America.

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September 2014

EphA2 and Src regulate equatorial cell morphogenesis during lens development.

Development 2013 Oct 11;140(20):4237-45. Epub 2013 Sep 11.

School of Optometry and Vision Science Program, University of California Berkeley, Berkeley, CA 94720, USA.

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October 2013

Cataracts and microphthalmia caused by a Gja8 mutation in extracellular loop 2.

PLoS One 2012 26;7(12):e52894. Epub 2012 Dec 26.

School of Optometry and Vision Science Program, University of California, Berkeley, California, United States of America.

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June 2013

Enhancement of ubiquitin conjugation activity reduces intracellular aggregation of V76D mutant γD-crystallin.

Invest Ophthalmol Vis Sci 2012 Sep 25;53(10):6655-65. Epub 2012 Sep 25.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

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September 2012

Diverse roles of Eph/ephrin signaling in the mouse lens.

PLoS One 2011 29;6(11):e28147. Epub 2011 Nov 29.

School of Optometry and Vision Science Program, University of California, Berkeley, California, United States of America.

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April 2012

The role of Vldlr in intraretinal angiogenesis in mice.

Invest Ophthalmol Vis Sci 2011 Aug 22;52(9):6572-9. Epub 2011 Aug 22.

School of Optometry and Vision Science Program, University of California, Berkeley, USA.

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August 2011

Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis.

J Biol Chem 2010 Dec 19;285(52):41187-93. Epub 2010 Oct 19.

School of Optometry and Vision Science Program, University of California, Berkeley, California 94720, USA.

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December 2010

Connexin mediated cataract prevention in mice.

PLoS One 2010 Sep 9;5(9). Epub 2010 Sep 9.

Vision Science Program and School of Optometry, University of California, Berkeley, California, United States of America.

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September 2010

LRP5 is required for vascular development in deeper layers of the retina.

PLoS One 2010 Jul 20;5(7):e11676. Epub 2010 Jul 20.

School of Optometry and Vision Science Program, University of California, Berkeley, California, USA.

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July 2010

Papillorenal syndrome-causing missense mutations in PAX2/Pax2 result in hypomorphic alleles in mouse and human.

PLoS Genet 2010 Mar 5;6(3):e1000870. Epub 2010 Mar 5.

Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America.

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March 2010

Lens gap junctions in growth, differentiation, and homeostasis.

Physiol Rev 2010 Jan;90(1):179-206

Department of Physiology and Biophysics, SUNY at Stony Brook, Stony Brook, New York 11794-8661, USA.

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January 2010

Severe retinal degeneration caused by a novel rhodopsin mutation.

Invest Ophthalmol Vis Sci 2010 Feb 9;51(2):1059-65. Epub 2009 Sep 9.

Vision Science Program and School of Optometry, University of California, Berkeley, Berkeley, California 94720-2020, USA.

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February 2010

The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium.

Exp Cell Res 2009 Apr 30;315(6):1063-75. Epub 2009 Jan 30.

Department of Physiology and Biophysics, State University of New York, T5-147, Basic Science Tower, Stony Brook, NY 11794-8661, USA.

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April 2009

Interaction between Connexin50 and mitogen-activated protein kinase signaling in lens homeostasis.

Mol Biol Cell 2009 May 25;20(10):2582-92. Epub 2009 Mar 25.

Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794-8661, USA.

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May 2009

Mechanism of cataract formation in alphaA-crystallin Y118D mutation.

Invest Ophthalmol Vis Sci 2009 Jun 17;50(6):2919-26. Epub 2009 Jan 17.

Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California 90095, USA.

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June 2009

Gap junction communication influences intercellular protein distribution in the lens.

Exp Eye Res 2008 Jun 28;86(6):966-74. Epub 2008 Mar 28.

UC Berkeley/UCSF Joint Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA.

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June 2008

A model for familial exudative vitreoretinopathy caused by LPR5 mutations.

Hum Mol Genet 2008 Jun 9;17(11):1605-12. Epub 2008 Feb 9.

School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720-2020, USA.

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June 2008

Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation.

Invest Ophthalmol Vis Sci 2008 Jan;49(1):304-9

Vision Science Program and School of Optometry, University of California-Berkeley, Berkeley, CA 94720, USA.

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January 2008

Optic nerve axon number in mouse is regulated by PAX2.

J AAPOS 2008 Apr 21;12(2):117-21. Epub 2007 Dec 21.

Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

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April 2008

The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins.

J Cell Sci 2007 Dec 14;120(Pt 23):4107-16. Epub 2007 Nov 14.

Department of Physiology and Biophysics and the Graduate Program in Genetics, State University of New York, Stony Brook, NY 11794, USA.

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December 2007

GammaD-crystallin associated protein aggregation and lens fiber cell denucleation.

Invest Ophthalmol Vis Sci 2007 Aug;48(8):3719-28

Vision Science Program and School of Optometry, University of California, Berkeley, Berkeley, California 94720-2020, USA.

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August 2007

Connexins in lens development and cataractogenesis.

J Membr Biol 2007 Aug 20;218(1-3):9-12. Epub 2007 Jun 20.

School of Optometry and Vision Science Program, University of California-Berkeley, Berkeley, CA 94720, USA.

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August 2007

Characterization of mouse mutants with abnormal RPE cells.

Adv Exp Med Biol 2006 ;572:95-100

School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, CA 94720-2020, USA.

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April 2007

Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency.

Invest Ophthalmol Vis Sci 2006 Jul;47(7):3004-10

School of Optometry and Vision Science Program, University of California, Berkeley, Berkeley, California 94720-2020, USA.

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July 2006

Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout mice.

Eur J Cell Biol 2006 Aug 5;85(8):729-52. Epub 2006 Jun 5.

Biologie Cellulaire, Institut Jacques Monod, CNRS, Universités Paris 6-Paris 7, 2, place Jussieu, F-75251 Paris Cedex 5, France.

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August 2006

Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells.

Exp Eye Res 2006 Sep 11;83(3):688-96. Epub 2006 May 11.

School of Optometry and Vision Science Program, University of California at Berkeley, 693 Minor Hall, Berkeley, CA 94720-2020, USA.

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September 2006

Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation.

J Cell Sci 2006 May;119(Pt 10):2138-44

School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA, USA.

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May 2006

Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis.

Development 2006 May 12;133(10):2033-40. Epub 2006 Apr 12.

School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA 94720, USA.

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May 2006

Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency.

J Biol Chem 2005 Jul 4;280(26):25071-8. Epub 2005 May 4.

School of Optometry and Vision Science Program, University of California, Berkeley, California 94720, USA.

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July 2005

Connections between connexins, calcium, and cataracts in the lens.

J Gen Physiol 2004 Oct;124(4):289-300

Department of Physiology and Biophysics, State University of New York at Stony Brook, NY 11794, USA.

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October 2004

Special fasciculiform cataract caused by a mutation in the gammaD-crystallin gene.

Mol Vis 2004 Mar 29;10:233-9. Epub 2004 Mar 29.

Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

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March 2004

Dominant cataracts result from incongruous mixing of wild-type lens connexins.

J Cell Biol 2003 Jun 2;161(5):969-78. Epub 2003 Jun 2.

Department of Physiology and Biophysics, State University of New York, Stony Brook 11794, USA.

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June 2003

Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation.

Development 2002 Jan;129(1):167-74

Department of Cell Biology, The Scripps Research Institute, La Jolla, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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January 2002