Xiaohan Lu

Xiaohan Lu

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Xiaohan Lu

Xiaohan Lu

Publications by authors named "Xiaohan Lu"

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Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells.

Am J Physiol Renal Physiol 2020 Mar 16;318(3):F817-F825. Epub 2019 Dec 16.

Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1152/ajprenal.00436.2019DOI Listing
March 2020

C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking.

Hypertension 2020 Mar 27;75(3):869-876. Epub 2020 Jan 27.

From the Division of Nephrology, Department of Medicine, Durham VA and Duke University Medical Center, NC (Y.W., N.P.R., J.Z., X.L., J.R., R.G., S.D.C.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035160PMC
March 2020

The transcription factor Twist1 in the distal nephron but not in macrophages propagates aristolochic acid nephropathy.

Kidney Int 2020 Jan 13;97(1):119-129. Epub 2019 Aug 13.

Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Durham VA Medical Center, Durham, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943184PMC
January 2020

TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis.

Am J Physiol Renal Physiol 2020 Jan 18;318(1):F107-F116. Epub 2019 Nov 18.

Division of Nephrology, Department of Medicine, Durham Veterans Affairs and Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1152/ajprenal.00347.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985827PMC
January 2020

Classical Dendritic Cells Mediate Hypertension by Promoting Renal Oxidative Stress and Fluid Retention.

Hypertension 2020 Jan 2;75(1):131-138. Epub 2019 Dec 2.

From the Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., N.P.R., J.R.P., J.R., Y.W., R.G., S.D.C.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004279PMC
January 2020

Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.

Kidney Int 2019 Dec 31;96(6):1308-1319. Epub 2019 Jul 31.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Durham Veterans Affairs Medical Center, Durham, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875628PMC
December 2019

A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.

Circ Res 2019 Dec 21;125(12):1055-1066. Epub 2019 Oct 21.

From the Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., N.P.R., Y.W., J.R., R.G., J.R.P., B.Y., M.A.S., S.D.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006714PMC
December 2019

Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis.

Am J Physiol Renal Physiol 2019 08 29;317(2):F221-F228. Epub 2019 May 29.

Division of Nephrology, Department of Medicine, Duke University School of Medicine , Durham, North Carolina.

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http://dx.doi.org/10.1152/ajprenal.00104.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732457PMC
August 2019

Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis.

Am J Pathol 2019 05 15;189(5):981-988. Epub 2019 Apr 15.

Division of Nephrology, Department of Medicine, Duke University, Durham, North Carolina; Department of Medicine, Durham Veterans Affairs Medical Centers, Durham, North Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183107
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http://dx.doi.org/10.1016/j.ajpath.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521889PMC
May 2019

Inflammation in Salt-Sensitive Hypertension and Renal Damage.

Curr Hypertens Rep 2018 10 30;20(12):103. Epub 2018 Oct 30.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, 27710, USA.

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http://link.springer.com/10.1007/s11906-018-0903-x
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http://dx.doi.org/10.1007/s11906-018-0903-xDOI Listing
October 2018

Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.

Am J Physiol Renal Physiol 2018 09 23;315(3):F682-F691. Epub 2018 May 23.

Department of Medicine, Duke University Medical Center , Durham, North Carolina.

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https://www.physiology.org/doi/10.1152/ajprenal.00104.2018
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http://dx.doi.org/10.1152/ajprenal.00104.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172579PMC
September 2018

NF-κB-dependent upregulation of (pro)renin receptor mediates high-NaCl-induced apoptosis in mouse inner medullary collecting duct cells.

Am J Physiol Cell Physiol 2017 12 11;313(6):C612-C620. Epub 2017 Oct 11.

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University , Guangzhou , China.

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http://dx.doi.org/10.1152/ajpcell.00068.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814589PMC
December 2017

Collecting duct (pro)renin receptor targets ENaC to mediate angiotensin II-induced hypertension.

Am J Physiol Renal Physiol 2017 Feb 27;312(2):F245-F253. Epub 2016 Apr 27.

Institute of Hypertension, Sun Yat-Sen University School of Medicine, Guangzhou, China;

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http://dx.doi.org/10.1152/ajprenal.00178.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109795PMC
February 2017

Activation of Renal (Pro)Renin Receptor Contributes to High Fructose-Induced Salt Sensitivity.

Hypertension 2017 02 19;69(2):339-348. Epub 2016 Dec 19.

From the Institute of Hypertension, Sun Yat-Sen University School of Medicine, Guangzhou, China (C.X., A.L., X.L., L.Z., H.F., L.Z., T.Y.); Internal Medicine, University of Utah, Salt Lake City (C.X., X.L., T.Y.); and Veterans Affairs Medical Center, Salt Lake City, Utah (X.L., T.Y.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556690PMC
February 2017

Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4.

J Am Soc Nephrol 2016 Oct 21;27(10):3022-3034. Epub 2016 Mar 21.

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah;

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http://dx.doi.org/10.1681/ASN.2015050592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042659PMC
October 2016

Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy.

Physiol Genomics 2016 10 26;48(10):711-718. Epub 2016 Aug 26.

Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1152/physiolgenomics.00082.2016DOI Listing
October 2016

Activation of ENaC in collecting duct cells by prorenin and its receptor PRR: involvement of Nox4-derived hydrogen peroxide.

Am J Physiol Renal Physiol 2016 06 23;310(11):F1243-50. Epub 2015 Dec 23.

Institute of Hypertension, Sun Yat-Sen University School of Medicine, Guangzhou, China; and Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1152/ajprenal.00492.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935776PMC
June 2016

Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor.

Proc Natl Acad Sci U S A 2016 Mar 16;113(13):E1898-906. Epub 2016 Mar 16.

Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112; Veterans Affairs Medical Center, Salt Lake City, UT 84108; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China;

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http://dx.doi.org/10.1073/pnas.1602397113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822598PMC
March 2016

Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system.

BMC Med 2015 Nov 10;13:278. Epub 2015 Nov 10.

Institute of Hypertension, Sun Yat-sen University School of Medicine, #74 Zhongshan 2nd Road, Science and Technology Building, 6th Floor, Guangzhou, 510080, P. R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641338PMC
http://dx.doi.org/10.1186/s12916-015-0514-1DOI Listing
November 2015

Prostaglandin E-prostanoid4 receptor mediates angiotensin II-induced (pro)renin receptor expression in the rat renal medulla.

Hypertension 2014 Aug 27;64(2):369-77. Epub 2014 May 27.

From the Institute of Hypertension, Sun Yat-sen University School of Medicine, Guangzhou, China (F.W., X.L., K.P., T.Y.); Department of Internal Medicine, University of Utah, Salt Lake City (F.W., X.L., T.Y.); Veterans Affairs Medical Center, Salt Lake City, UT (F.W., X.L., T.Y.); Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China (Y.D.); Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa (S.-F.Z.); and Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical University, Nanjing, China (A.Z.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445967PMC
August 2014

COX-2 mediates angiotensin II-induced (pro)renin receptor expression in the rat renal medulla.

Am J Physiol Renal Physiol 2014 Jul 16;307(1):F25-32. Epub 2014 Apr 16.

Institute of Hypertension, Sun Yat-sen University School of Medicine, Guangzhou, China; Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah; and

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http://dx.doi.org/10.1152/ajprenal.00548.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080156PMC
July 2014