Publications by authors named "Xiaofei Li"

570 Publications

Clinical Outcomes in Patients With Left Bundle Branch Area Pacing vs. Right Ventricular Pacing for Atrioventricular Block.

Front Cardiovasc Med 2021 8;8:685253. Epub 2021 Jul 8.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Left bundle branch area pacing (LBBAP) is a novel pacing modality with stable pacing parameters and a narrow-paced QRS duration. We compared heart failure (HF) hospitalization events and echocardiographic measures between LBBAP and right ventricular pacing (RVP) in patients with atrioventricular block (AVB). This multicenter observational study prospectively recruited consecutive AVB patients requiring ventricular pacing in five centers if they received LBBAP or RVP and had left ventricular ejection fraction (LVEF) >50%. Data on electrocardiogram, pacing parameters, echocardiographic measurements, device complications, and clinical outcomes were collected at baseline and during follow-up. The primary outcome was first episode hospitalization for HF or upgrade to biventricular pacing. LBBAP was successful in 235 of 246 patients (95.5%), while 120 patients received RVP. During a mean of 11.4 ± 2.7 months of follow-up, the ventricular pacing burden was comparable (83.9 ± 35.1 vs. 85.7 ± 30.0%), while the mean LVEF differed significantly (62.6 ± 4.6 vs. 57.8 ± 11.4%) between the LBBAP and RVP groups. Patients with LBBAP had significantly lower occurrences of HF hospitalization and upgrading to biventricular pacing than patients with RVP (2.6 vs. 10.8%, <0.001), and differences in primary outcome between LBBAP and RVP were mainly observed in patients with ventricular pacing >40% or with baseline LVEF <60%. The primary outcome was independently associated with LBBAP (adjusted HR 0.14, 95% CI: 0.04-0.55), previous myocardial infarction (adjusted HR 6.82, 95% CI: 1.23-37.5), and baseline LVEF (adjusted HR 0.91, 95% CI: 0.86-0.96). Permanent LBBAP might reduce the risk of HF hospitalization or upgrade to biventricular pacing compared with RVP in AVB patients requiring a high burden of ventricular pacing. URL: https://www.clinicaltrials.gov; Unique identifier: NCT03851315; URL: http://www.chictr.org.cn; Unique Identifier: ChiCTR2100043296.
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http://dx.doi.org/10.3389/fcvm.2021.685253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297826PMC
July 2021

COVID-19 negatively impacts on psychological and somatic status in frontline nurses.

J Affect Disord 2021 Jul 18;294:279-285. Epub 2021 Jul 18.

Department of Neurosurgery, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang 110001, China. Electronic address:

Background: COVID-19 has become a public health emergency based on its clinical characteristics. Previous studies demonstrated that the onset of a sudden and immediately life-threatening illness could lead to extraordinary amounts of psychological pressure on nurses who play an important role in the illness. Whether COVID-19 pandemic has greater impacts on the psychological status and somatic symptoms from nurses who stand in the frontline of this crisis remain unclear.

Methods: We evaluated post-traumatic stress disorder (PTSD), anxiety and somatic symptoms in the frontline nurses (n = 438) who served in Wuhan, China, during COVID-19 crisis. Nurses who did not worked in the frontline of COVID-19 served as controls (n = 452). The investigation was processed by online questionnaires including: impact of event scale-revised (IES-R) , self-rating anxiety scale (SAS), and somatic symptoms.

Results: Prevalence of moderate and severe PTSD was significantly increased in the frontline nurses compared to non-frontline nurses. Prevalence of mild anxiety was significantly increased in frontline nurses compared to non-frontline nurses. There were more frontline nurses suffering from severe insomnia and losing weight compared to non-frontline nurses. Severity of PTSD (IES-R score), but not severity of anxiety (SAS score) was similarly positively correlated to incidence of insomnia and weight loss in both frontline and non-frontline nurses to a similar extent.

Limitations: The results only represented psychological statues and somatic symptom on one time point thus the development of psychological stress and somatic symptom during pandemic of COVID-19 in the frontline nurses were missing.

Conclusions: COVID-19 negatively impacted on psychological and somatic status in frontline nurses. PTSD may be the most reliability and validity criteria for evaluating psychological and somatic status for frontline nurses of COVID-19.
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http://dx.doi.org/10.1016/j.jad.2021.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286238PMC
July 2021

Photobleaching reduces the contribution of dissolved organic carbon to glacier melting in the Himalayas and the Tibetan Plateau.

Sci Total Environ 2021 Jul 21;797:149178. Epub 2021 Jul 21.

State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.

Dissolved organic carbon (DOC) makes an important contribution to glacier melting in the Himalayas and the Tibetan Plateau (HTP). Photobleaching can effectively reduce the light absorption ability of DOC, further changing its impact on glacier melting, which is not yet well researched in the HTP. Therefore, snowpit samples from the Bayi, Ganglongjiama (GLJM), Jiemayangzong (JMYZ) and Demula (DML) glaciers were collected to study the influence of photobleaching on the light absorption ability of DOC and its impact on glacier melting. The results showed that the DOC concentration of snowpit samples, which was affected by the melting state and photobleaching, decreased from the northern HTP to the southern HTP. At an early stage of melting, the mass absorption cross-section value at 365 nm (MAC) values showed a negative correlation with DOC concentrations in the snowpit at the JMYZ and DML glaciers, indicating that colored DOC tended to be concentrated in the snowpit during the melting process. With the aggravation of ablation, some snowpit samples in the GLJM and Bayi glaciers had both low concentrations and MAC values of DOC due to the reduced influence of photobleaching on the light absorption ability of DOC. Similarly, two fluorescence components (one protein-like component and one humic-like component) were identified in the extracted DOC at the JMYZ and DML glaciers, while those components were not detected in the GLJM glacier. Based on the sources of fluorescent DOC and five-day backward air mass trajectories, long-distance transport of pollutants from South Asia was an important source of snowpit DOC in the southern HTP. In this study, photobleaching can effectively remove colored and fluorescent DOC from snowpit samples in the HTP, further reducing the radiation forcing and glacier melting caused by DOC.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149178DOI Listing
July 2021

STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling.

Front Cell Dev Biol 2021 6;9:621147. Epub 2021 Jul 6.

Department of Thoracic Surgery, Tangdu Hospital, The Air Force Medical University, Xi'an, China.

Aims: Serine/threonine/tyrosine kinase 1 (STYK1) has been previously shown to have oncogenic properties, and emerging evidence suggests that STYK1 expression correlates with epithelial-mesenchymal transition (EMT). However, the mechanism of STYK1 involvement in oncogenesis remains unknown. The present study aimed to elucidate how STYK1 expression level relates to the metastasis, migration, invasion, and EMT in non-small cell lung cancer (NSCLC) and to determine the molecular mechanism of STYK1 effects.

Methods: Serine/threonine/tyrosine kinase 1 (STYK1) expression level and its relationship with the prognosis of NSCLC were determined using the ONCOMINE database and clinical cases. Non-small cell lung cancer cell lines with the overexpression or knockdown of STYK1 were established to determine whether STYK1 promotes cell migration, invasion, and EMT and . In addition, a constitutively active FoxO1 mutant (FoxO1AAA) was used to examine the role of FoxO1 in the STYK1-mediated upregulation of metastasis and EMT in NSCLC.

Results: Serine/threonine/tyrosine kinase 1 (STYK1) was upregulated in NSCLC tissues and cell lines, and its overexpression correlated with poor prognosis in patients with NSCLC after surgery. Enhanced expression of STYK1 potentiated the migration, invasion, and EMT in SW900 cells, thereby promoting metastasis, whereas knockdown of STYK1 inhibited these cellular phenomena in Calu-1 cells. Furthermore, STYK1 expression was positively related to the level of phosphorylated-FoxO1, whereas the constitutively active FoxO1 mutant protected against the positive effect of STYK1 overexpression on cell migration, invasion, and EMT.

Conclusion: Serine/threonine/tyrosine kinase 1 (STYK1) was upregulated in NSCLC and correlated with poor clinical outcomes. In addition, STYK1 suppressed FoxO1 functions, thereby promoting metastasis and EMT in NSCLC.
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http://dx.doi.org/10.3389/fcell.2021.621147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290174PMC
July 2021

Identification of Causal Genes of COVID-19 Using the SMR Method.

Authors:
Yan Zong Xiaofei Li

Front Genet 2021 5;12:690349. Epub 2021 Jul 5.

Department of Infectious Diseases, Yiwu Central Hospital, Jinhua, China.

Since the first report of COVID-19 in December 2019, more than 100 million people have been infected with SARS-CoV-2. Despite ongoing research, there is still limited knowledge about the genetic causes of COVID-19. To resolve this problem, we applied the SMR method to analyze the genes involved in COVID-19 pathogenesis by the integration of multiple omics data. Here, we assessed the SNPs associated with COVID-19 risk from the GWAS data of Spanish and Italian patients and lung eQTL data from the GTEx project. Then, GWAS and eQTL data were integrated by summary-data-based (SMR) methods using SNPs as instrumental variables (IVs). As a result, six protein-coding and five non-protein-coding genes regulated by nine SNPs were identified as significant risk factors for COVID-19. Functional analysis of these genes showed that UQCRH participates in cardiac muscle contraction, PPA2 is closely related to sudden cardiac failure (SCD), and OGT, as the interacting gene partner of PANO1, is associated with neurological disease. Observational studies show that myocardial damage, SCD, and neurological disease often occur in COVID-19 patients. Thus, our findings provide a potential molecular mechanism for understanding the complications of COVID-19.
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http://dx.doi.org/10.3389/fgene.2021.690349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287881PMC
July 2021

Crown-Rump Length Discordance, Increased Nuchal Translucency, and Detection of Fetal Structural Anomalies in Twin Pregnancies in the First Trimester: 5 Years of Experience in a Tertiary Hospital in China.

J Ultrasound Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate the efficacy of the first-trimester ultrasound scan in the detection of fetal structural anomalies in twin pregnancies. To examine the association between increased nuchal translucency (NT) thickness, crown-rump length (CRL) or NT discordance, and detection of structural anomalies in a large twin series in China.

Methods: We performed retrospective analysis of twin pregnancies who underwent 11-13 -week and second-trimester anomaly scan and booked at Beijing Obstetrics and Gynecology Hospital between January 2012 and December 2016. Measurement of fetal CRL/NT and assessment of fetal anatomic structures were based on standard (not detailed) protocols. Conjoined twins and twin-reversed arterial perfusion sequence (TRAPS) were excluded from structural anomalies. The diagnostic performance of first-trimester ultrasound in detection of fetal structural anomalies in twins was determined and compared with that of second trimester. The accuracy of independent variates associated with structural anomaly detection was calculated.

Results: A total of 1442 women with twin pregnancies were included. In 40 women and 45 fetuses, structural anomalies were found. Fetal structural anomalies verified at delivery were detected in 42.5% (17/40) of affected pregnancies in the first trimester and 92.5% (37/40) of affected pregnancies when added second trimester (P = .13). The survival rate of pregnancies detected in second trimester was higher than that of pregnancies detected in first trimester (11.8% vs 65.2%). The mean value of intertwin CRL/NT discordance in cases with fetal structural anomalies was larger in monochorionic twins than dichorionic twins, but monochorionicity was not associated with structural anomalies. CRL discordance ≥10% (OR 3.1, 95%CI 1.5-6.3) and NT ≥95th centile (OR 20.0, 95%CI 9.0-44.2) were associated with fetal structural anomalies. In both dichorionic (DC) and monochorionic (MC) twins, the percentages of CRL discordance ≥10% was larger in twins with structural anomalies than those without structural anomalies (37.5% vs 13.4% in DC twins and 50.0% vs 12.5% in MC twins), and this was also true for NT ≥95th centile (31.3% vs 1.7% in DC twins and 37.5% vs 2.2% in MC twins). In the setting of CRL discordance ≥10%, 40.0% (16/40) of twins with structural anomalies were found, in which the predominant fetal structural anomalies were cardiovascular defects, abdominal wall defects, and central nervous system defects. The AUC for detecting structural anomalies by CRL discordance ≥10% was 0.63. In the setting of NT ≥95th centile, 32.5% (13/40) of twins with structural anomalies were found, in which the predominant fetal structural anomalies were cardiovascular defects, cystic hygroma, and abdominal wall defects. The AUC for detecting structural anomalies by NT ≥95th centile was 0.65.

Conclusions: The detection rate of twins with fetal structural anomalies was 42.5% per pregnancy in the first trimester. CRL discordance ≥10% and NT ≥95th centile may indicate higher risk of fetal structural anomalies in twins, but their efficacy was limited.
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http://dx.doi.org/10.1002/jum.15784DOI Listing
July 2021

Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.

Food Chem 2021 Jul 9;366:130561. Epub 2021 Jul 9.

College of Food Engineering and Nutritional Science, Shaanxi Normal University, PR China; National Research & Development Center of Apple Processing Technology, PR China. Electronic address:

In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v). It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon. The structural conversion was in consistent with the determination result of gel hardness. Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
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http://dx.doi.org/10.1016/j.foodchem.2021.130561DOI Listing
July 2021

VATS Versus Open Lobectomy in Pathological T1 SCLC: A Multi-Center Retrospective Analysis.

Clin Lung Cancer 2021 Jun 24. Epub 2021 Jun 24.

Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Background: Video-assisted thoracic surgery (VATS) has been widely used in the surgical treatment of thoracic diseases, and it suggested surgical and oncological advantages compared with open surgery. However, reports on the application of VATS in surgery of small cell lung cancer (SCLC) are scarce. This study aimed to explore the advantages and disadvantages of different surgical approaches in the treatment of pathological stage T1(pT1) SCLC in terms of safety, clinical outcomes, and lymph node dissection.

Patients And Methods: Patients who underwent lobectomy for pT1 SCLC between January 2014 and September 2017 were identified from the National Collaborative Lung Cancer Database (LinkDoc Database). The patients were stratified based on the surgery approach (VATS or open lobectomy). Perioperative outcomes and long-term survival were analyzed using SPSS software.

Results: A total of 169 patients with pT1 SCLC met the criteria and were enrolled for this study, including 110 cases of VATS lobectomies and 59 cases of open lobectomies. VATS lobectomy was associated with less blood loss than open surgery (168.1 ± 237.4 vs. 340.0 ± 509.8 mL, P = .002). Open lobectomy harvested more N2 LNs (11.8 ± 8.2 vs. 8.4 ± 5.8, P = .048) and identified more metastasis positive LNs (3.1 ± 6.0 vs. 1.4 ± 3.0, P = .050). Open lobectomy associated with longer overall survival (OS) but has no statistical difference (23.4 ± 13.2 vs. 20.2 ± 10.9, P = .070).

Conclusion: Open lobectomy had better lymph node dissection results, and comparable postoperative complications, postoperative hospital stay, and OS to VATS lobectomy. Further studies may still be needed to confirm the recommendation of thoracoscopic approach as a routine surgical procedure for operable SCLC, and until then, open surgery should still be considered.
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http://dx.doi.org/10.1016/j.cllc.2021.06.007DOI Listing
June 2021

A commentary on COVID-19 impact on surgical training and recovery planning (COVID-STAR) - A cross-sectional observational study.

Int J Surg 2021 07 7;91:106011. Epub 2021 Jul 7.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang, 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2021.106011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260487PMC
July 2021

ACTH treatment promotes murine cardiac allograft acceptance.

JCI Insight 2021 Jul 8;6(13). Epub 2021 Jul 8.

Transplantation Research Center.

Heart transplantation is the optimal therapy for patients with end-stage heart disease, but its long-term outcome remains inadequate. Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but how MCRs regulate the balance between alloreactive T cells and Tregs, and whether they impact chronic heart transplant rejection, is unknown. Here, we found that Tregs express MC2R, and MC2R expression was highest among all MCRs by Tregs. Our data indicate that adrenocorticotropic hormone (ACTH), the sole ligand for MC2R, promoted the formation of Tregs by increasing the expression of IL-2Rα (CD25) in CD4+ T cells and activation of STAT5 in CD4+CD25+ T cells. ACTH treatment also improved the survival of heart allografts and increased the formation of Tregs in CD28KO mice. ACTH treatment synergized with the tolerogenic effect of CTLA-4-Ig, resulting in long-term survival of heart allografts and an increase in intragraft Tregs. ACTH administration also demonstrated higher prolongation of heart allograft survival in transgenic mouse recipients with both complete KO and conditional KO of PI3Kγ in T cells. Finally, ACTH treatment reduced chronic rejection markedly. These data demonstrate that ACTH treatment improved heart transplant outcomes, and this effect correlated with an increase in Tregs.
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http://dx.doi.org/10.1172/jci.insight.143385DOI Listing
July 2021

LINC00174 Facilitates Proliferation and Migration of Colorectal Cancer Cells via MiR-3127-5p/ E2F7 Axis.

J Microbiol Biotechnol 2021 Jun 28;31(8). Epub 2021 Jun 28.

Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region, Jinfeng District, Yinchuan City, Ningxia Hui Autonomous Region, 750021, China.

The literature indicates that LINC00174 inhibits the growth of colorectal cancer (CRC) cells, but its research needs to be enriched. We tried to explore the function and mechanism of LINC00174 in CRC cell proliferation and migration. Bioinformatics analysis predicted the binding relationship and expressions of lncRNA, miRNA and mRNA. Clinical study analyzes the relationship between LINC00174 and clinical data characteristics of CRC patients. The expressions of LINC00174, miR-3127-5p and E2F7 were verified by RT-qPCR, and the combination of the two was verified by dual luciferase analysis and RNA immunoprecipitation as needed. Western blot was used to detect the expression of EMT-related protein and E2F7 protein. Functional experiments were used to evaluate the function of the target gene on CRC cells. LINC00174 was up-regulated in CRC clinical samples and cells and was related to the clinical characteristics of CRC patients. High-expression of LINC00174, contrary to the effect of siLINC00174, promoted cell viability, proliferation, migration and invasion, up-regulated the expressions of N-Cadherin, Vimentin, E2F7, and inhibited the expression of E-Cadherin. MiR-3127-5p was one of the targeted miRNAs of LINC00174 and was down-regulated in CRC samples. In addition, miR-3127-5p mimic partially reversed the malignant phenotype of CRC cells induced by LINC00174. Besides, E2F7 was a target gene of miR-3127-5p, and LINC00174 repressed miR-3127-5p to regulate E2F7. Our research reveals that LINC00174 affected the biological characteristics of CRC cells through regulated miR-3127-5p/ E2F7 axis.
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http://dx.doi.org/10.4014/jmb.2103.03001DOI Listing
June 2021

Organic iron absorption and expression of related transporters in the small intestine of broilers.

Poult Sci 2021 Aug 11;100(8):101182. Epub 2021 Apr 11.

Mineral Nutrition Research Division, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R. China. Electronic address:

An experiment was conducted to investigate the effect of organic and inorganic Fe sources on Fe absorption and expression of related transporters in the small intestine of broilers. Iron-deficient intact broilers (7-day-old) were fed an Fe-unsupplemented corn-soybean meal basal diet or the basal diet supplemented with 60 mg Fe/kg as Fe sulfate (FeSO•7HO), Fe-Met with weak chelation strength (Fe-Met W), Fe-proteinate with moderate chelation strength (Fe-Prot M) or Fe-proteinate with extremely strong chelation strength (Fe-Prot ES) for 14 d. The plasma Fe contents were enhanced (P < 0.02) by Fe addition, and greater (P < 0.0002) in Fe-Prot M and Fe-Prot ES groups than in Fe-Met W and FeSO groups. Supplemental Fe decreased (P < 0.03) the divalent metal transporter 1 (DMT1) mRNA levels in the duodenum and jejunum, and ferroportin 1 (FPN1) mRNA levels in the duodenum on d 21, but no differences (P > 0.20) were detected among different Fe sources. Regardless of Fe source, the mRNA levels of DMT1 and FPN1 were higher (P < 0.02) in the duodenum than in the jejunum and ileum, and in the jejunum than in the ileum (P < 0.05). However, Fe addition did not affect (P > 0.10) the mRNA levels of amino acid transporters and protein levels of DMT1 and FPN1 in the small intestine of broilers. These results indicate that organic Fe sources with stronger chelation strength showed higher Fe absorption in broilers in vivo; the mRNA expression of Fe and amino acid transporters varied along with the extension of the small intestine; the absorption of Fe as organic Fe chelates was not mediated by the amino acid transporters in intact chicks in this study.
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http://dx.doi.org/10.1016/j.psj.2021.101182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253913PMC
August 2021

A Commentary on "Long-term oncological outcomes in robotic versus laparoscopic approach for rectal cancer: A systematic review and meta-analysis" [Int. J. Surg. 80 (2020) 225-230].

Authors:
Xiaofei Li

Int J Surg 2021 Jun 26:106006. Epub 2021 Jun 26.

Department of Infectious Diseases, YiWu Central Hospita, Zhejiang, 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2021.106006DOI Listing
June 2021

Albumin-bilirubin score as a useful predictor of energy malnutrition in patients with hepatocellular carcinoma.

Clin Nutr 2021 Jun 2;40(6):3890. Epub 2021 Jun 2.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2021.05.021DOI Listing
June 2021

Fructose intake is not associated to the risk of hepatic fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD).

Clin Nutr 2021 Jun 2;40(6):3827. Epub 2021 Jun 2.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2021.05.020DOI Listing
June 2021

Emergent liver transplantation for patients with acute-on-chronic liver failure.

Authors:
Xiaofei Li

Dig Liver Dis 2021 Jun 6. Epub 2021 Jun 6.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2021.05.011DOI Listing
June 2021

Sarcopenia and acute severe ulcerative colitis patients.

Authors:
M M Xiaofei Li

Dig Liver Dis 2021 Jun 5. Epub 2021 Jun 5.

Department of infectious diseases, YiWu Central Hospital, Zhejiang 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2021.05.010DOI Listing
June 2021

Commentary on "Comparison of retrograde intrarenal surgery under regional versus general anaesthesia: A systematic review and meta-analysis" (Int J Surg 2020; 82:36-42).

Authors:
Xiaofei Li

Int J Surg 2021 06 8;90:105988. Epub 2021 Jun 8.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang, 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2021.105988DOI Listing
June 2021

Black carbon and dust in the Third Pole glaciers: Revaluated concentrations, mass absorption cross-sections and contributions to glacier ablation.

Sci Total Environ 2021 Oct 21;789:147746. Epub 2021 May 21.

Institute of International Rivers and Eco-security, Yunnan University, Kunming, Yunnan 650091, China; Yunnan Key Laboratory of International Rivers and Transboundary Eco-security, Yunnan University, Kunming 650091, China.

In snow and ice, light-absorbing particles (LAPs), such as black carbon (BC) and dust, accelerate the melting of Third Pole glaciers (TPGs). In this study, we revaluated LAP concentrations in the snow pits of TPGs (SP-TPGs), measured LAP mass absorption cross-sections (MACs), and simulated their effects on glacier darkening and melting based on the Spectral Albedo Model for Dirty Snow and a surface energy and mass balance model. The results indicated that because of their short distances to emission sources, the average BC concentrations measured in snow pits in the periphery of Third Pole were much higher than those measured in the inland Tibetan Plateau, and the average dust concentrations generally decreased from north to south. The average MACs of BC in the SP-TPGs varied from 3.1 to 7.7 m g at 550 nm, most of the average spectral values were comparable in the visible and near-infrared bands to those calculated by Mie theory, except those in Urumqi Glacier No. 1 (UR), Syek Zapadniy Glacier (SZ), and Laohugou Glacier No.12 (LH), while the average spectral MACs of dust in the SP-TPGs were considerably smaller in magnitude than most of the variations measured in other regions. Compared with the pure snow surfaces, BC and dust played comparable roles in reducing albedo in UR, SZ, LH, and Renlongba Glacier, whereas BC was the most prominent absorber in the other glaciers. The combined effect of BC and dust accelerated melting by 30.4-345.9 mm w.e. (19.7-45.3% of the total mass balance) through surface albedo darkening (0.06-0.17) and increased radiation absorption (25.8-65.7 W m) within one month of the ablation season. This study provides a new data set of LAP concentrations and MACs and helps to clarify the roles of these factors in the cryospheric environment of the Third Pole.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147746DOI Listing
October 2021

Nontuberculous mycobacterial pulmonary disease and associated risk factors in China: A prospective surveillance study.

J Infect 2021 Jul 25;83(1):46-53. Epub 2021 May 25.

Department of Clinical Laboratory, Henan Provincial Infectious Diseases Hospital, Zhengzhou, China.

Background: We aimed to address the knowledge gap that exists regarding the epidemiological, demographic, and clinical characteristics of nontuberculous mycobacterial pulmonary diseases (NTM-PDs) among smear-positive patients with symptoms suggestive of pulmonary tuberculosis (PTB) in China.

Methods: Prospective and national surveillance of NTM-PD was performed from 17 hospitals within the China Nontuberculous Mycobacteria Surveillance Study (CNTMS). Patients were eligible for inclusion if they had positive smears during hospitalization. Sputum specimens were collected for molecular species identification.

Results: 6,766 patients with valid results were included, consisting of 6,236 (92.2%) with PTB, 458 (6.8%) with NTM-PD, and 72 (1.0%) with colonization. The proportion of NTM-PD in PTB patients exhibited significant geographic diversity, ranging from 3.2% in the northwest to 9.2% in the south. The most prevalent species was Mycobacterium intracellulare, followed by Mycobacterium abscessus complex. Females, elderly people, and patients with bronchiectasis or COPD are at high risk for developing NTM-PD, while patients with diabetes have a lower risk of NTM-PD when compared with non-diabetic patients. Regarding clinical symptoms, lower rates of persistent cough and weight loss were noted in NTM-PD patients than in PTB patients.

Conclusions: Approximately one-fifteenth of PTB patients are afflicted with nontuberculous mycobacterial infections in China. The prevalence of NTM shows geographic diversity across the country, and it showed a gradual increase from north to south and from west to east. NTM-PD patients are prone to exhibit less severe clinical symptoms than PTB patients, highlighting the importance of raising awareness of NTM diseases to improve decision making on how to best screen, diagnose, and treat NTM in TB-endemic settings.
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http://dx.doi.org/10.1016/j.jinf.2021.05.019DOI Listing
July 2021

BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair.

Cell Death Dis 2021 May 26;12(6):546. Epub 2021 May 26.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, China.

PARP inhibitors have been approved for the therapy of cancers with homologous recombination (HR) deficiency based on the concept of "synthetic lethality". However, glioblastoma (GBM) patients have gained little benefit from PARP inhibitors due to a lack of BRCA mutations. Herein, we demonstrated that concurrent treatment with the PARP inhibitor rucaparib and the PI3K inhibitor BKM120 showed synergetic anticancer effects on GBM U251 and U87MG cells. Mechanistically, BKM120 decreased expression of HR molecules, including RAD51 and BRCA1/2, and reduced HR repair efficiency in GBM cells, therefore increasing levels of apoptosis induced by rucaparib. Furthermore, we discovered that the two compounds complemented each other in DNA damage response and drug accumulation. Notably, in the zebrafish U87MG-RFP orthotopic xenograft model, nude mouse U87MG subcutaneous xenograft model and U87MG-Luc orthotopic xenograft model, combination showed obviously increased antitumor efficacy compared to each monotherapy. Immunohistochemical analysis of tumor tissues indicated that the combination obviously reduced expression of HR repair molecules and increased the DNA damage biomarker γ-H2AX, consistent with the in vitro results. Collectively, our findings provide new insight into combined blockade of PI3K and PARP, which might represent a promising therapeutic approach for GBM.
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http://dx.doi.org/10.1038/s41419-021-03805-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150626PMC
May 2021

Letter to the Editor on "Crohn's Disease Is Associated With Longer In-Hospital Lengths of Stay and Higher Rates of Complications and Costs Following Primary Total Hip Arthroplasty".

Authors:
Xiaofei Li

J Arthroplasty 2021 06;36(6):e59

Department of Infectious Diseases, Yiwu Central Hospital, Zhejiang, People's Republic of China.

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http://dx.doi.org/10.1016/j.arth.2021.03.013DOI Listing
June 2021

Budesonide Oral Suspension Improves Outcomes in Patients With Eosinophilic Esophagitis.

Clin Gastroenterol Hepatol 2021 May 20. Epub 2021 May 20.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang, China.

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http://dx.doi.org/10.1016/j.cgh.2021.05.028DOI Listing
May 2021

Relations between achievement task values and academic achievement and depressive symptoms in Chinese elementary school students: Variable-centered and person-centered perspectives.

Sch Psychol 2021 May;36(3):167-180

School of Psychology, South China Normal University.

Based on expectancy-value theory, this longitudinal study was designed to test the relations between two achievement task values (i.e., attainment value and utility value) as well as their respective influences on academic achievement and depressive symptoms. This study incorporated a sample of 897 ( = 10.36 years, 55.8% male) and a cross-validation sample of 821 ( = 10.42 years, 55.2% male) Chinese elementary school students from Grade 4. The students completed measures of achievement task values and depressive symptoms (parent reports) in the middle of two consecutive semesters and their academic achievement levels were assessed at the end of each semester. The results of cross-lagged analyses showed that: (a) attainment value reciprocally and positively related to utility value; (b) baseline attainment value positively related to later academic achievement and negatively related to later depressive symptoms after controlling for baseline utility value; (c) baseline academic achievement positively related to later attainment value and utility value. Furthermore, latent profile analyses revealed: (a) four achievement task values profiles (i.e., high, medium, low achievement task values, and high attainment value and low utility value) in both samples; (b) the profiles were differentially related to subsequent academic achievement and depressive symptoms. Theoretically, the findings of reciprocal relations between achievement task values and their relations with the academic and mental health outcomes refine and extend the scope of expectancy-value theory. Practically, intervention strategies may be most effective by focusing on the synergistic development of high attainment value and utility value in promoting positive developmental outcomes in early adolescents. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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http://dx.doi.org/10.1037/spq0000384DOI Listing
May 2021

Liver fibrosis assessed by transient elastography and albuminuria.

Dig Liver Dis 2021 Aug 11;53(8):1057. Epub 2021 May 11.

Department of infectious diseases, YiWu Central Hospital, Zhejiang 322000, China. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2021.04.012DOI Listing
August 2021

Bisphosphonates on mortality and cardiovascular risk.

J Formos Med Assoc 2021 May 12. Epub 2021 May 12.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang, China. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2021.04.027DOI Listing
May 2021

Infliximab vs Ustekinumab in Biologic Naive Crohn's Disease.

Clin Gastroenterol Hepatol 2021 May 13. Epub 2021 May 13.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang, China.

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http://dx.doi.org/10.1016/j.cgh.2021.05.013DOI Listing
May 2021

Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats.

Biomed Chromatogr 2021 May 12:e5172. Epub 2021 May 12.

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.

A sensitive gas chromatography-mass spectroscopy method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates. During the experiment, rats were randomly divided into two groups (low, high) and were administered aqueous extract of Mylabris compound for 7 days. Then, plasma and tissue samples were taken at different time points to study the pharmacokinetics and tissue distribution of CTD in rats. The selected reaction monitoring transitions for CTD and clofibrate (internal standard) were m/z 128 → 85 and m/z 169 → 141, respectively. The calibration curve ranged from 10.26 to 3,078 ng/ml for plasma and from 10.26 to 246.24 ng/ml for liver homogenates. The lower limits of quantification were 10.26 ng/ml for both plasma and liver. The intra- and inter-day precision and accuracy were <20% for both plasma and liver homogenates. Extraction recovery ranged from 89.21 to 103.61% for CTD in rat plasma and liver and from 83.79 to 102.74% for IS in rat plasma and liver. Matrix effects ranged from 93.06 to 110.44% for CTD and from 91.65 to 110.80% for IS.
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http://dx.doi.org/10.1002/bmc.5172DOI Listing
May 2021

Metabolomics and Proteomics Reveal the Variation of Substances in Apheresis Platelets during Storage and Their Effects on Cancer Cell Proliferation.

Transfus Med Hemother 2021 Mar 25;48(2):79-90. Epub 2020 Sep 25.

Department of Blood Transfusion, Chinese PLA General Hospital, Beijing, China.

Introduction: Apheresis platelets (APs) are clinically and crucially important in the prevention and treatment of bleeding in patients with thrombocytopenia or cancer. However, few researchers have addressed the variation of supernatant metabolites and exosome proteins in APs during storage and their effects on cancer cell proliferation.

Objective: This study was designed to explore the change rules of the metabolites and exosomal proteins of APs during storage and their effects on cancer cell proliferation.

Methods: Metabolomics and proteomics were separately applied to analyze the variation of AP supernatant metabolites and exosomal proteins between freshly prepared day-0 and day-5 terminal-stored APs. Cell counting kit (CCK)-8 assay was performed to detect the effects of AP supernatants and exosomes on the proliferation of cancer cells.

Results: We found that the supernatant metabolites and exosomal proteins in APs were significantly different on day 0 and day 5, and that many differential metabolites and exosomal proteins were associated with cancer characteristics. Furthermore, the day-5 AP supernatants had a greater inhibition of the proliferation of K562, HepG2, and HCT116 cancer cells, but the day-5 AP exosomes had no significant effect on the proliferation of these cancer cells.

Conclusion: The variant terminal-stored AP supernatants may inhibit the proliferation of cancer cells but the variant terminal AP exosomes have no effect on cancer cell proliferation.
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http://dx.doi.org/10.1159/000509944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077496PMC
March 2021
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