Publications by authors named "Xiaodong He"

186 Publications

Entropy-Enthalpy Compensations Fold Proteins in Precise Ways.

Int J Mol Sci 2021 Sep 6;22(17). Epub 2021 Sep 6.

National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China.

Exploring the protein-folding problem has been a longstanding challenge in molecular biology and biophysics. Intramolecular hydrogen (H)-bonds play an extremely important role in stabilizing protein structures. To form these intramolecular H-bonds, nascent unfolded polypeptide chains need to escape from hydrogen bonding with surrounding polar water molecules under the solution conditions that require entropy-enthalpy compensations, according to the Gibbs free energy equation and the change in enthalpy. Here, by analyzing the spatial layout of the side-chains of amino acid residues in experimentally determined protein structures, we reveal a protein-folding mechanism based on the entropy-enthalpy compensations that initially driven by laterally hydrophobic collapse among the side-chains of adjacent residues in the sequences of unfolded protein chains. This hydrophobic collapse promotes the formation of the H-bonds within the polypeptide backbone structures through the entropy-enthalpy compensation mechanism, enabling secondary structures and tertiary structures to fold reproducibly following explicit physical folding codes and forces. The temperature dependence of protein folding is thus attributed to the environment dependence of the conformational Gibbs free energy equation. The folding codes and forces in the amino acid sequence that dictate the formation of β-strands and α-helices can be deciphered with great accuracy through evaluation of the hydrophobic interactions among neighboring side-chains of an unfolded polypeptide from a β-strand-like thermodynamic metastable state. The folding of protein quaternary structures is found to be guided by the entropy-enthalpy compensations in between the docking sites of protein subunits according to the Gibbs free energy equation that is verified by bioinformatics analyses of a dozen structures of dimers. Protein folding is therefore guided by multistage entropy-enthalpy compensations of the system of polypeptide chains and water molecules under the solution conditions.
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http://dx.doi.org/10.3390/ijms22179653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431812PMC
September 2021

Biliary Neuroendocrine Neoplasms: Analysis of Prognostic Factors and Development and Validation of a Nomogram.

Front Oncol 2021 19;11:654439. Epub 2021 Jul 19.

General Surgery Department, Peking Union Medical College Hospital, China Academy of Medical Science & Peking Union Medical College, Beijing, China.

Background: For this study, we explored the prognostic profiles of biliary neuroendocrine neoplasms (NENs) patients and identified factors related to prognosis. Further, we developed and validated an effective nomogram to predict the overall survival (OS) of individual patients with biliary NENs.

Methods: We included a total of 446 biliary NENs patients from the SEER database. We used Kaplan-Meier curves to determine survival time. We employed univariate and multivariate Cox analyses to estimate hazard ratios to identify prognostic factors. We constructed a predictive nomogram based on the results of the multivariate analyses. In addition, we included 28 biliary NENs cases from our center as an external validation cohort.

Results: The median survival time of biliary NENs from the SEER database was 31 months, and the value of gallbladder NENs (23 months) was significantly shorter than that of the bile duct (45 months) and ampulla of Vater (33.5 months, p=0.023). Multivariate Cox analyses indicated that age, tumor size, pathological classification, SEER stage, and surgery were independent variables associated with survival. The constructed prognostic nomogram demonstrated good calibration and discrimination C-index values of 0.783 and 0.795 in the training and validation dataset, respectively.

Conclusion: Age, tumor size, pathological classification, SEER stage, and surgery were predictors for the survival of biliary NENs. We developed a nomogram that could determine the 3-year and 5-year OS rates. Through validation of our central database, the novel nomogram is a useful tool for clinicians in estimating individual survival among biliary NENs patients.
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http://dx.doi.org/10.3389/fonc.2021.654439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327779PMC
July 2021

Portal Biliopathy and Cavernous Transformation of the Portal Vein Revealed by 68Ga-FAPI PET/CT.

Clin Nucl Med 2021 Jul 14. Epub 2021 Jul 14.

From the Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Departments of Thoracic Surgery General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract: A 47-year-old man presented with right upper abdominal pain for 1 month. Contrast-enhanced CT revealed hilar bile duct stenosis with dilatation of the intrahepatic bile ducts, and his serum CA19-9 and CA242 levels were significantly elevated. 18F-FDG and 68Ga-FAPI PET/CT were performed for differential diagnosis. 18F-FDG PET/CT showed only mild FDG uptake in the hepatic hilum. Astonishingly, in 68Ga-FAPI PET/CT, intense radioactivity was presented on the same region, which indicated massive fibroblasts aggregation in hepatic hilum. The patient was finally diagnosed as portal biliopathy caused by cavernous transformation of the portal vein.
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http://dx.doi.org/10.1097/RLU.0000000000003815DOI Listing
July 2021

Roto-Translation Invariant Formation of Multiple Underactuated Planar Rigid Bodies.

IEEE Trans Cybern 2021 Jul 8;PP. Epub 2021 Jul 8.

This article investigates the roto-translation invariant (RTI) formation of multiple underactuated planar rigid bodies, which are established under the framework of matrix Lie groups. The main contribution is that we define the RTI and pseudo RTI (P-RTI) formation of planar rigid bodies. Different from the common formation given in the earth-fixed frame, the RTI formation is defined in the body-fixed frame so that it possesses a rigid-body motion obtained by composing rotation and translation simultaneously. Moreover, regarding fully actuated planar rigid bodies, we propose the velocity and force requirements to maintain the RTI formation, which are derived based on the kinematic and dynamic model, respectively. Another contribution of this article is that the RTI formation feasibility is investigated for underactuated planar rigid bodies subject to nonholonomic constraints on velocities and accelerations. To be more specific, we study the occasions when wheeled mobile robots and underactuated surface vessels can maintain the RTI or P-RTI formation. Finally, the results of the simulation and experiment are presented so as to exhibit the RTI and P-RTI formation intuitively.
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http://dx.doi.org/10.1109/TCYB.2021.3089599DOI Listing
July 2021

Expression Status and Prognostic Value of mA RNA Methylation Regulators in Lung Adenocarcinoma.

Life (Basel) 2021 Jun 26;11(7). Epub 2021 Jun 26.

Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.

N-methyladenosine (mA) RNA modification is the most abundant modification method in mRNA, and it plays an important role in the occurrence and development of many cancers. This paper mainly discusses the role of mA RNA methylation regulators in lung adenocarcinoma (LUAD) to identify novel prognostic biomarkers. The gene expression data of 19 mA methylation regulators in LUAD patients and its relevant clinical parameters were extracted from The Cancer Genome Atlas (TCGA) database. We selected three significantly differentially expressed mA regulators in LUAD to construct the risk signature, and evaluated its prognostic prediction efficiency using the receiver operating characteristic (ROC) curve. Kaplan-Meier survival analysis and Cox regression analysis were used to identify the independent prognostic significance of the risk signature. The ROC curve indicated that the area under the curve (AUC) was 0.659, which means that the risk signature had a good prediction efficiency. The results of the Kaplan-Meier survival analysis and Cox regression analysis showed that the risk score can be used as an independent prognostic factor for LUAD. In addition, we explored the differential signaling pathways and cellular processes related to mA methylation regulators in LUAD.
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http://dx.doi.org/10.3390/life11070619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306618PMC
June 2021

Suppression of tumor growth and metastasis in Shkbp1 knockout mice.

Cancer Gene Ther 2021 Jun 10. Epub 2021 Jun 10.

Institute of Basic Medical Sciences, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, 510006, Guangzhou, China.

Epidermal growth factor receptor (EGFR) is widely accepted in cancer diagnosis and targeted therapy. Shkbp1 is an upstream molecule of EGFR, which prevents EGFR degradation. However, the role of Shkbp1 in tumor remains to be clarified. Herein we induced tumor in the lungs of Shkbp1 knockout mice with chemical drugs to investigate the function of Shkbp1. Compared with wild-type mice, tumors in the lungs were significantly fewer in Shkbp1 knockout mice. To further explore the biological characteristics and functions of Shkbp1 in cancer cells, we established cell lines with overexpression and low expression of Shkbp1, respectively. Results from our experiments showed that low expression of Shkbp1 in lung cancer remarkably inhibited cancer cell migration and invasion, while overexpression of Shkbp1 promoted their migration and invasion, which indicated that Shkbp1 was closely related with tumor migration and invasion. The mRNA expression analysis of 494 matched tumor and adjacent non-tumor tissues (data derived from TCGA database) revealed that Shkbp1 was associated with the clinic TNM staging. Furthermore, immunohistochemistry (IHC) analysis of tissue microarrays showed that Shkbp1 was also correlated with lymphatic metastasis. Mechanistically, we observed that Shkbp1 was associated with epithelial-mesenchymal transition (EMT) marker. More interestingly, Shkbp1 was also expressed in a variety of immune cells, and we hereby used a subcutaneous transplantation tumor model and a metastasis model created by tail vein injection to explore whether Shkbp1 could impact tumor growth. The results showed that Shkbp1 knockout reduced tumor growth in both tumor models. In general, our results suggest that knocking out Shkbp1 in either immune cells or tumor cells could suppress tumor growth and metastasis.
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http://dx.doi.org/10.1038/s41417-021-00349-xDOI Listing
June 2021

Diagnosis and Prognosis of Retroperitoneal Liposarcoma: A Single Asian Center Cohort of 57 Cases.

J Oncol 2021 1;2021:7594027. Epub 2021 Apr 1.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Beijing 100730, China.

Background: Liposarcoma is a soft tissue malignancy, commonly observed in the extremities. However, retroperitoneal liposarcoma is seldom reported and its diagnosis is frequently neglected. This study aims to present the clinical characteristics, diagnosis, and prognosis of five liposarcoma subtypes and report our experience of patient treatment.

Methods: We conducted a single-center noninterventional retrospective study of 57 retroperitoneal liposarcoma patients admitted to Peking Union Medical College Hospital (PUMCH, Beijing, China) between July 2011 and December 2019. We collected and analyzed their demographic, clinical, imaging, histological, therapeutic, and prognostic data over a mean 4.5-year follow-up period.

Results: Twenty-five (44%) patients were asymptomatic prior to diagnosis, with abdominal distension as the chief complaint in 18 (32%) patients and abdominal pain observed in 16 (28%) patients. Masses were evaluated by computed tomography ( = 48, 84%) or ultrasound ( = 25, 44%). Laparotomy ( = 52, 91%) was the dominant therapeutic modality rather than laparoscopy ( = 5, 9%). All patients were treated with R0 resection except two patients who underwent R2 resection. We conducted regular follow-ups every six months after surgery for a mean duration of 4.5 years. Recurrence was experienced by 14 (25%) patients and a further 9 (16%) died during follow-up.

Conclusions: Abdominal distension and pain are chief complaints with liposarcoma. As the extremities are the main liposarcomas locations, the diagnosis of retroperitoneal liposarcoma is usually neglected. Since half of the patients are asymptomatic, timely diagnosis and treatment are highly dependent on regular ultrasound and computed tomography imaging. R0 resection is the key to retroperitoneal liposarcoma treatment. In comparison, patients who underwent R2 resection, which is considered a palliative treatment, had bad prognoses. Large, symptomatic dedifferentiated, and pleomorphic liposarcomas are more likely to have poor prognoses, while the prognosis for well-differentiated or myxoid liposarcoma is relatively good.
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http://dx.doi.org/10.1155/2021/7594027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116140PMC
April 2021

Spatio-temporal analysis of urban air pollutants throughout China during 2014-2019.

Air Qual Atmos Health 2021 May 14:1-14. Epub 2021 May 14.

Department of Environmental Health, School of Public Health, Key Laboratory of Environmental Health Damage Research and Assessment, China Medical University, Shenyang, 110122 Liaoning Province China.

Air pollution control has become the top priority of China's "green development" concept since 2013. The Chinese government has enacted a range of policies and statutes to control contaminant emissions and improve air quality. On the basis of the national air quality ground observation database, the spatial and temporal distribution of air quality index value (AQI), fine particulate matter (PM), coarse particles (PM), sulfur dioxide (SO), nitrogen dioxide (NO), carbon monoxide (CO), and ozone (O) were explored in 336 cities throughout China from 2014 to 2019. AQI and most pollutants (except O) decreased in concentrations from 2014 to 2019. In 2019, all cities except Henan reached the level 2 of the ambient air quality index, and six cities had a lower ambient air quality index and reached the level 1. Spatially, higher pollutant concentrations were concentrated in large city clusters, whereas the areas with high O concentration were found across the country. Furthermore, central heating was shown to have a negative impact on air quality. The observed AQI value, PM, PM, SO, NO, and CO concentrations were highest in north and northwest China and Henan province in central China. The correlations among pollutants suggest that the main sources of pollutants are fossil fuel combustion, industrial production, and motor vehicle emissions. The influence of meteorological factors on air quality, long-distance transportation, and the transformations of pollutants should be explored in future research.

Supplementary Information: The online version contains supplementary material available at 10.1007/s11869-021-01043-5.
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http://dx.doi.org/10.1007/s11869-021-01043-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121134PMC
May 2021

UV-Assisted Deposition of Antibacterial Ag-Tannic Acid Nanocomposite Coating.

ACS Appl Mater Interfaces 2021 May 26;13(17):20708-20717. Epub 2021 Apr 26.

Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China.

The marked increase in bacterial colonization of medical devices and multiple drug resistance to traditional antibiotics underline the pressing need for developing novel antibacterial surface coatings. In the present investigation, natural polyphenol tannic acid (TA)-capped silver nanoparticles (TA-Ag NPs) were synthesized via an environmentally friendly and sustainable one-step redox reaction under UV irradiation with a simultaneous and uniform deposition on polydimethylsiloxane (PDMS) and other substrate surfaces. In the synthesis process, the dihydroxyphenyl and trihydroxyphenyl groups of TA actively participate in Ag reduction, forming co-ordination linkages with Ag NPs and bestowing the deposition on the PDMS surface. The physico-chemical features of TA-Ag NPs were characterized in detail. Microscopic examination, surface elemental analysis, and wettability measurements clearly reveal the decoration of TA-Ag NPs on the substrate surfaces. The modified PDMS surfaces can kill the adhered bacteria or resist the bacterial adhesion, and no live bacteria can be found on their surfaces. Most importantly, the modified PDMS surfaces exhibit predominant antibacterial effects both in vitro in the catheter bridge model and in vivo in a rat subcutaneous infection model. On the other hand, the functionalized surfaces exhibit only a negligible level of cytotoxicity against L929 mouse fibroblasts with no side effects on the major organs of Sprague-Dawley rats after implantation, indicating their biocompatibility for potential biomedical applications.
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http://dx.doi.org/10.1021/acsami.1c03566DOI Listing
May 2021

LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis.

Epigenomics 2021 May 20;13(9):699-713. Epub 2021 Apr 20.

School of Life Sciences & Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, P.R. China.

Although studies on lncRNAs in renal fibrosis have focused on target genes and functions of lncRNAs, a comprehensive interaction analysis of lncRNAs is lacking. Differentially expressed genes in renal fibrosis were screened, and the interaction between lncRNAs and miRNAs was searched. We constructed a ceRNA network associated with renal fibrosis, by which we found the transcription factor Creb5, a target gene of lncRNA Gas5 that might regulate extracellular Fn1 deposition. Our study not only provides a theoretical basis for the ceRNA regulation mechanism of Gas5 but also provides experimental evidence supporting the use of Gas5 targeting in the treatment of renal fibrosis.
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http://dx.doi.org/10.2217/epi-2020-0449DOI Listing
May 2021

Molecular dynamics simulation of phonon thermal transport in nanotwinned diamond with a new optimized Tersoff potential.

Phys Chem Chem Phys 2021 Apr 31;23(14):8336-8343. Epub 2021 Mar 31.

Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China.

The inaccuracy of the most widely used potentials in calculating the phonon transport of sp carbon materials hinders the use of molecular dynamics simulations for revealing the underlying mechanism of phonon transport in diamond and related materials. Here, we introduce an optimized Tersoff potential by optimizing the parameters to fit the experimentally determined phonon dispersion in diamond along the high-symmetry directions. Molecular dynamics simulations are performed using this new potential to investigate the phonon thermal transport in flawless and nanotwinned diamond. The simulation results show that while the phonon lifetimes of nanotwinned diamond are slightly lower than those of the flawless one, the phonon group velocities of nanotwinned diamond are obviously lower than those of diamond. The present results indicate that the twin boundaries in diamond are ineffective in scattering the phonons and the lower thermal conductivity of the nanotwinned diamond mainly originates from the lower group velocities due to its reduced structural rigidity.
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http://dx.doi.org/10.1039/d1cp00399bDOI Listing
April 2021

A Sample-In-Answer-Out Microfluidic System for the Molecular Diagnostics of 24 HPV Genotypes Using Palm-Sized Cartridge.

Micromachines (Basel) 2021 Mar 4;12(3). Epub 2021 Mar 4.

Deparment of Clinical Laboratory, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China.

This paper proposes an automated microfluidic system for molecular diagnostics that integrates the functions of a traditional polymerase chain reaction (PCR) laboratory into a palm-sized microfluidic cartridge (CARD) made of polystyrene. The CARD integrates 4 independent microfluidic sample lanes, which can independently complete a sample test, and each sample lane integrates the 3 functional areas of the sample preparation area, PCR amplification area, and product analysis area. By using chemical cell lysis, magnetic silica bead-based DNA extraction, combined with multi-PCR-reverse dot hybridization with microarray, 24 HPV genotypes can be typing tested in CARD. With a custom-made automated CARD operating platform, the entire process can be automatically carried out, achieving sample-in-answer-out. The custom-made operation platform is developed based on a liquid handling station-type, which can automatically load off-chip reagents without placing reagents in CARD in advance. The platform can control six CARDs to work simultaneously, detect 24 samples at a time. The results show that the limit of detection of the microfluidic system is 200 copies/test, and the positive detection rate of clinical samples by this system is 100%, which is an effective method for detection of HPV.
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http://dx.doi.org/10.3390/mi12030263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000143PMC
March 2021

On Stochastic Reduction in Laser-Assisted Dielectric Breakdown for Programmable Nanopore Fabrication.

ACS Appl Mater Interfaces 2021 Mar 11;13(11):13383-13391. Epub 2021 Mar 11.

Department of Electrical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States.

The controlled dielectric breakdown emerged as a promising alternative toward accessible solid-state nanopore fabrication. Several prior studies have shown that laser-assisted dielectric breakdown could help control the nanopore position and reduce the possibility of forming multiple pores. Here, we developed a physical model to estimate the probability of forming a single nanopore under different combinations of the laser power and the electric field. This model relies on the material- and experiment-specific parameters: the Weibull statistical parameters and the laser-induced photothermal etching rate. Both the model and our experimental data suggest that a combination of a high laser power and a low electric field is statistically favorable for forming a single nanopore at a programmed location. While this model relies on experiment-specific parameters, we anticipate it could provide the experimental insights for nanopore fabrication by the laser-assisted dielectric breakdown method, enabling broader access to solid-state nanopores and their sensing applications.
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http://dx.doi.org/10.1021/acsami.0c23106DOI Listing
March 2021

The Prognostic Value of the CA19-9/TBIL Ratio in Patients with Biliary Tract Cancers (BTCs): A Retrospective Study.

J Oncol 2021 23;2021:5829893. Epub 2021 Feb 23.

Department of General Surgery, Peking Union Medical College Hospital, Beijing 100730, China.

Background: Incidence of biliary tract cancers (BTCs) in China is high, and surgery is the only curative option. Preoperative CA19-9 has been identified as a predictor for survival in patients with resectable BTCs, but more potential predictors need to be studied. This retrospective study aimed to establish the prognostic significance of CA19-9/TBIL ratio (CTR) in patients with BTCs.

Methods: A retrospective analysis was performed in patients who were diagnosed with BTCs and received surgical resection between 2013 and 2018 at PUMCH. Demographic and clinical parameters were collected. Preoperative CA19-9 and CTR were classified as elevated (>58.6 and >0.83) according to the receiver operating characteristic (ROC) analysis. Demographic and clinical parameters were compared between the groups using Student's -test, chi-square, or Fisher's exact test. Survival analysis was performed by the Kaplan-Meier methods, and the relationship between variables and survival was assessed by the log-rank test. Cox regression analysis was conducted to identify potential risk factors for overall survival.

Results: In total, 109 participants were involved in the final analysis. The overall survival rate was 18.0% at 5 years, with a median survival duration of 1.58 years. The Kaplan-Meier analysis indicated that higher CTR was associated with shorter OS (15 vs. 50, < 0.01). Univariate survival analysis identified TNM staging, CA19-9, and CTR as statistically significant prognostic factors. In a multiple Cox analysis, only CTR was proved as a significantly independent prognostic factor.

Conclusion: CTR acts as an independent prognostic predictor for patients with biliary tract cancer.
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http://dx.doi.org/10.1155/2021/5829893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925024PMC
February 2021

Impact-resistant carbon nanotube woven films: a molecular dynamics study.

Nanoscale 2021 Mar;13(9):5006-5013

National Key Laboratory of Science and Technology for National Defence on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin 150001, PR China. and Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin, 150080, PR China.

Fiber-based fabrics have great potential in impacting protection. Here, we propose a novel nanostructure, wherein single-walled CNTs (SWCNTs) were employed to weave plain 2D films. The in-plane mechanical properties and impacting properties of SWCNT woven films (SWFs) were investigated via fully atomic molecular dynamics (MD) simulation. It was found that their fracture strength and Young's modulus present obvious anisotropy, depending on the loading direction. When the loading is along the CNT axis, the mechanical performances are the best. From the impacting test, we found that this SWF synchronously possesses high impacting strength and a percentage of absorbed energy. This is mainly a result of high intrinsic strength, excellent flexibility and radial deformation capability of CNTs. In addition, it was observed that the high-speed impact of projectile can lead to the intricate entanglements of CNTs, which also could dissipate some energy by friction between the CNTs. This study provides an in-depth understanding on the mechanical properties of SWFs and broadens the applications of CNT-based nanomaterials.
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http://dx.doi.org/10.1039/d0nr07421gDOI Listing
March 2021

The Nomogram of MRI-based Radiomics with Complementary Visual Features by Machine Learning Improves Stratification of Glioblastoma Patients: A Multicenter Study.

J Magn Reson Imaging 2021 08 8;54(2):571-583. Epub 2021 Feb 8.

Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, China.

Background: Glioblastomas (GBMs) represent both the most common and the most highly malignant primary brain tumors. The subjective visual imaging features from MRI make it challenging to predict the overall survival (OS) of GBM. Radiomics can quantify image features objectively as an emerging technique. A pragmatic and objective method in the clinic to assess OS is strongly in need.

Purpose: To construct a radiomics nomogram to stratify GBM patients into long- vs. short-term survival.

Study Type: Retrospective.

Population: One-hundred and fifty-eight GBM patients from Brain Tumor Segmentation Challenge 2018 (BRATS2018) were for model construction and 32 GBM patients from the local hospital for external validation.

Field Strength/sequence: 1.5 T and 3.0 T MRI Scanners, T WI, T WI, T FLAIR, and contrast-enhanced T WI sequences ASSESSMENT: All patients were divided into long-term or short-term based on a survival of greater or fewer than 12 months. All BRATS2018 subjects were divided into training and test sets, and images were assessed for ependymal and pia mater involvement (EPI) and multifocality by three experienced neuroradiologists. All tumor tissues from multiparametric MRI were fully automatically segmented into three subregions to calculate the radiomic features. Based on the training set, the most powerful radiomic features were selected to constitute radiomic signature.

Statistical Tests: Receiver operating characteristic (ROC) curve, sensitivity, specificity, and the Hosmer-Lemeshow test.

Results: The nomogram had a survival prediction accuracy of 0.878 and 0.875, a specificity of 0.875 and 0.583, and a sensitivity of 0.704 and 0.833, respectively, in the training and test set. The ROC curve showed the accuracy of the nomogram, radiomic signature, age, and EPI for external validation set were 0.858, 0.826, 0.664, and 0.66 in the validate set, respectively.

Data Conclusion: Radiomics nomogram integrated with radiomic signature, EPI, and age was found to be robust for the stratification of GBM patients into long- vs. short-term survival.

Level Of Evidence: 3 TECHNICAL EFFICACY STAGE: 2.
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http://dx.doi.org/10.1002/jmri.27536DOI Listing
August 2021

Folding photopolymerized origami sheets by post-curing.

SN Appl Sci 2021 13;3(1):133. Epub 2021 Jan 13.

Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, Canada.

The paper presents a novel manufacturing approach to fabricate origami based on 3D printing utilizing digital light processing. Specifically, we propose to leave part of the model uncured during the printing step, and then cure it in the post-processing step to set the shape in a folded configuration. While the cured regions in the first step try to regain their unfolded shape, the regions cured in the second step attempt to keep their folded shape. As a result, the final shape is obtained when both regions' stresses reach equilibrium. Finite element analysis is performed in ANSYS to obtain the stress distribution on common hinge designs, demonstrating that the square-hinge has a lower maximum principal stress than elliptical and triangle hinges. Based on the square-hinge and rectangular cavity, two variables-the hinge width and the cavity height-are selected as principal variables to construct an empirical model with the final folding angle. In the end, experimental verification shows that the developed method is valid and reliable to realize the proposed deformation and 3D development of 2D hinges.
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http://dx.doi.org/10.1007/s42452-020-04018-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806536PMC
January 2021

Biliary diversion increases resting energy expenditure leading to decreased blood glucose level in mice with type 2 diabetes.

J Diabetes Investig 2021 Jun 9;12(6):931-939. Epub 2021 Feb 9.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Aims/introduction: Type 2 diabetes mellitus is a group of metabolism abnormalities in carbohydrates and energy. Our aim was to investigate resting energy expenditure (REE) and blood glucose changes after biliary diversion in mice with diabetes.

Materials And Methods: Male mice with diabetes were randomly divided into biliary diversion and sham groups. REE was detected by indirect calorimetry, the levels of fasting blood glucose, total bile acids and triiodothyronine were analyzed. After mice were killed, the weight amount of brown adipose tissue (BAT) and gastrocnemius was measured, and the expression level of G protein-coupled bile acid receptor and type 2 iodothyronine deiodinase in BAT and gastrocnemius were examined.

Results: The two groups of mice were pair-fed, the bodyweights (P < 0.001) and the fasting blood glucose level (P < 0.001) in the biliary diversion group significantly decreased 24 weeks after surgery. The intraperitoneal glucose tolerance test (P = 0.035) and oral glucose tolerance test (P = 0.027) showed improvement in glucose tolerance after surgery. The REE level significantly increased 24 weeks after surgery (P = 0.005), the levels of total bile acids (P = 0.014) and triiodothyronine (P < 0.001) increased at the 24th postoperative week. The weight ratio of BAT (P = 0.038) and gastrocnemius (P = 0.026) in the biliary diversion group were higher than that in the sham group. The expression of G protein-coupled bile acid receptor in BAT (P < 0.001) and gastrocnemius (P = 0.003) were upregulated after surgery, and the type 2 iodothyronine deiodinase expression also increased in BAT (P = 0.015) and gastrocnemius (P = 0.015).

Conclusions: The REE level increased and the glucose metabolism improved in mice with diabetes after biliary diversion.
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http://dx.doi.org/10.1111/jdi.13499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169353PMC
June 2021

Improvement of Postprandial Lipid Metabolism After Ileal Transposition in Non-obese Diabetic Rats.

Obes Surg 2021 04 6;31(4):1572-1578. Epub 2021 Jan 6.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic of China.

Background: Ileal transposition (IT) could reduce obesity and improve type 2 diabetes mellitus (T2DM). The main aim of our study was to investigate lipid metabolism changes in T2DM rats after IT without a weight reduction effect.

Methods: Thirty male diabetic rats were randomly divided into IT, sham IT (SI), and control groups. The levels of plasma cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TGs), and bile acid were measured. After sacrifice, the white adipose tissue, brown adipose tissue and liver were weighed.

Results: IT induced significant improvement in glucose and lipid metabolism. There were no significant differences in the levels of cholesterol (P = 0.87), HDL (P = 0.70), LDL (P = 0.96), or TGs (P = 0.97) among the groups before surgery. After IT, the levels of cholesterol (P = 0.019), LDL (P = 0.004), and TGs (P < 0.001) were lower than those in the SI and control groups, while the level of HDL was not significantly different compared to those of the other groups (P = 0.437). Higher bile acid level (P = 0.001), lower white adipose tissue/total body weight ratio (P < 0.001), and lower liver/total body weight ratio (P = 0.003) were found in the IT group. The BAT/total body weight ratio in the IT group was higher than that in the SI or control groups (P = 0.002).

Conclusions: IT could improve lipid metabolism in diabetic rats.
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http://dx.doi.org/10.1007/s11695-020-05158-zDOI Listing
April 2021

DR-GAN: Conditional Generative Adversarial Network for Fine-Grained Lesion Synthesis on Diabetic Retinopathy Images.

IEEE J Biomed Health Inform 2020 Dec 17;PP. Epub 2020 Dec 17.

Diabetic retinopathy (DR) is a complication of diabetes that severely affects eyes. It can be graded into five levels of severity according to international protocol. However, optimizing a grading model to have strong generalizability requires a large amount of balanced training data, which is difficult to collect, particularly for the high severity levels. Typical data augmentation methods, including random flipping and rotation, cannot generate data with high diversity. In this paper, we propose a diabetic retinopathy generative adversarial network (DR-GAN) to synthesize high-resolution fundus images which can be manipulated with arbitrary grading and lesion information. Thus, large-scale generated data can be used for more meaningful augmentation to train a DR grading and lesion segmentation model. The proposed retina generator is conditioned on the structural and lesion masks, as well as adaptive grading vectors sampled from the latent grading space, which can be adopted to control the synthesized grading severity. Moreover, a multi-scale spatial and channel attention module is devised to improve the generation ability to synthesize small details. Multi-scale discriminators are designed to operate from large to small receptive fields, and joint adversarial losses are adopted to optimize the whole network in an end-to-end manner. With extensive experiments evaluated on the EyePACS dataset connected to Kaggle, as well as the FGADR dataset, we validate the effectiveness of our method, which can both synthesize highly realistic (1280 × 1280) controllable fundus images and contribute to the DR grading task.
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http://dx.doi.org/10.1109/JBHI.2020.3045475DOI Listing
December 2020

The Prognostic Impact of Pathology on Patients With Pseudomyxoma Peritonei Undergoing Debulking Surgery: A Systematic Review and Meta-Analysis of Retrospective Studies.

Front Surg 2020 16;7:554910. Epub 2020 Nov 16.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Pseudomyxoma peritonei (PMP) is a rare clinical condition with fatal outcomes, which is characterized by the progressive accumulation of mucinous ascites and peritoneal implants. Some studies have reported the effect of PMP biology on patient outcome. The objective of this study was to analyze published articles focusing on the impact of pathology on the prognosis of PMP patients undergoing debulking. Data from all studies regarding the prognosis of patients, with different pathologies, who underwent debulking surgery were analyzed. We searched PubMed, the Wiley Online Library, Ovid, and the Cochrane Library (through January 2020). Studies were confined to those articles written in English. Five studies were identified, and the differences in 5-year survival rates were analyzed according to the Kaplan-Meier survival curves. The hazard ratios (HRs) of the 5-year survival rates were calculated. The mean and median 5-year survival rates of all patients were 39 and 40%, respectively. The median overall survival was 49.3 months. The mean 5-year survival rates of low-grade PMP was 45.2%. The five studies had sufficient data to calculate HRs from the 5-year survival rates data, and three had HRs lower than 1. The total HRs was 0.54, with a 95% CI between 0.33 and 0.89 ( = 0.01). Among PMP patients receiving debulking surgery who are not able to undergo complete cytoreductive surgery, low-grade biological PMP had a better prognosis than high-grade PMP.
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http://dx.doi.org/10.3389/fsurg.2020.554910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701122PMC
November 2020

Developing a toolbox for identifying when to engage senior surgeons in emergency general surgery: A multicenter cohort study.

Int J Surg 2021 Jan 2;85:30-39. Epub 2020 Dec 2.

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Background: Having a senior surgeon present for high-risk patients is an important safety measure in emergency surgery, but 24-h consultant cover is not efficient. We aimed to develop a user-friendly toolbox (risk identification, outcome prediction and patient stratification) to support when to involve a senior surgeon.

Materials And Methods: We included 11,901 general surgery patients (10.0% emergencies) in a multicenter prospective cohort in China (2015-2016). Patient information and surgeons' seniority were compared between emergency and elective surgery with the same procedure codes. Risk indicators common in these two surgical timings and specific to emergency surgery were identified, and their clinical importance was evaluated by a working group of 48 experienced surgeons. Predictive models for mortality and morbidity were built using logistic regression models. Stratification rules were created to balance patients' risk and surgeons' caseload with an Acute Call Team (ACT) model.

Results: Emergency patients had significantly higher risks of mortality (3.6% vs 0.6%) and morbidity (7.8% vs 4.3%) than elective patients, but disproportionally fewer senior surgeons (59.9% vs 91.4%) were present. Using three risk indicators (American Society of Anesthesiologists score, age, blood urea nitrogen), C-statistic (95% CI) for prediction of emergency mortality was high [0.90 (0.84-0.96)]. It was less complex but equally accurate as two existing and validated models (0.86 [0.79-0.93] and 0.86 [0.77-0.95]). Using five indicators, C-statistic (95% CI) was moderate for prediction of overall morbidity [0.77 (0.72-0.83)], but high for severe morbidity [0.92 (0.88-0.97)]. Based on stratification rules of the ACT model, patient mortality and morbidity were 0.5% and 5.3% in the low-risk stratum (composing 64.6% of emergency caseload), and 15.9% and 29.0% in the very high-risk stratum (6.9% of caseload).

Conclusion: These findings show the practical feasibility of using a risk assessment tool to direct senior surgeons' involvement in emergency general surgery.
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http://dx.doi.org/10.1016/j.ijsu.2020.11.004DOI Listing
January 2021

A Hydrophobic-Interaction-Based Mechanism Triggers Docking between the SARS-CoV-2 Spike and Angiotensin-Converting Enzyme 2.

Glob Chall 2020 Oct 15:2000067. Epub 2020 Oct 15.

National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Center for Composite Materials and Structures Harbin Institute of Technology Harbin 150080 P. R. China.

A recent experimental study found that the binding affinity between the cellular receptor human angiotensin-converting enzyme 2 (ACE2) and receptor-binding domain (RBD) in the spike (S) protein of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is more than tenfold higher than that of the original severe acute respiratory syndrome coronavirus (SARS-CoV). However, main chain structures of the SARS-CoV-2 RBD are almost the same with that of the SARS-CoV RBD. Understanding the physical mechanism responsible for the outstanding affinity between the SARS-CoV-2 S and ACE2 is an "urgent challenge" for developing blockers, vaccines, and therapeutic antibodies against the coronavirus disease 2019 (COVID-19) pandemic. Taking into account the mechanisms of hydrophobic interaction, hydration shell, surface tension, and the shielding effect of water molecules, this study reveals a hydrophobic-interaction-based mechanism by means of which SARS-CoV-2 S and ACE2 bind together in an aqueous environment. The hydrophobic interaction between the SARS-CoV-2 S and ACE2 protein is found to be significantly greater than that between SARS-CoV S and ACE2. At the docking site, the hydrophobic portions of the hydrophilic side chains of SARS-CoV-2 S are found to be involved in the hydrophobic interaction between SARS-CoV-2 S and ACE2.
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http://dx.doi.org/10.1002/gch2.202000067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646041PMC
October 2020

Hydrogeochemical Processes Affecting Groundwater Chemistry in the Central Part of the Guanzhong Basin, China.

Arch Environ Contam Toxicol 2021 Jan 4;80(1):74-91. Epub 2020 Nov 4.

Department of Hydrology, University of Zululand, Kwa Dlangezwa, Durban, 3886, South Africa.

Groundwater is essential for the sustainable development of the Guanzhong Basin, China, and its quality is mainly controlled by hydrogeochemical processes and anthropogenic pollution. This study used statistical and multivariate statistical analysis approaches to recognize the hydrogeochemical processes and affecting factors of groundwater in the central part of the Guanzhong Basin. Correlations among 14 hydrochemical parameters were statistically examined. Principal component analysis (PCA), factor analysis (FA), and hierarchical cluster analysis (HCA) techniques were applied to analyze the physicochemical variables to understand the affecting factors of groundwater quality in the study area. The correlation analysis results indicate that cation exchange is the dominant process affecting the concentration of Na and Ca in the groundwater. Both the PCA and FA indicate that minerals dissolution/precipitation and human activities are the key factors that affect groundwater quality. All parameters except CO and pH increase from C1 to C4 obtained through the Q mode HCA. C4 has a hydrochemical type of SO-Na·K, indicating that the sample of this cluster is primarily influenced by anthropogenic processes.
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http://dx.doi.org/10.1007/s00244-020-00772-5DOI Listing
January 2021

Thermal transport properties of graphite carbon nitride.

Phys Chem Chem Phys 2020 Oct;22(39):22785-22795

National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin 150080, P. R. China.

Graphite carbon nitride (GCN), which can be regarded as a nitrogen heteroatom-substituted graphite framework, has attracted great attention as a new 2D layered structure material with semiconductor electronic characteristics. Using molecular dynamics simulations, the in-plane thermal conductivity and cross-plane thermal resistance of two GCN structures (i.e., triazine-based and heptazine-based) are investigated. Our results show that the in-plane thermal conductivities of the triazine-based and heptazine-based GCN monolayers along the armchair direction are 55.39 and 17.81 W m-1 K-1, respectively. The cross-plane thermal resistance decreases with increasing layer number and reaches asymptotic values of 3.6 × 10-10 and 9.3 × 10-10 m2 K W-1 at 40 layers for triazine-based and heptazine-based GCN, respectively. The in-plane thermal conductivity can be effectively manipulated by changing the temperature and applying strain, while it is insensitive to the number of layers, which is in sharp contrast to that of graphene. Moreover, the cross-plane thermal resistance decreases monotonically with temperature and coupling strength, and can be modulated by external strain. Surprisingly, the cross-plane tensile strain can reduce the thermal resistance of the heptazine-based GCN. Our study serves as a guide to groups interested in the physical properties of GCN.
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http://dx.doi.org/10.1039/d0cp03513kDOI Listing
October 2020

Coherently forming a single molecule in an optical trap.

Science 2020 10 24;370(6514):331-335. Epub 2020 Sep 24.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, APM, Chinese Academy of Sciences, Wuhan 430071, China.

Ultracold single molecules have wide-ranging potential applications, such as ultracold chemistry, precision measurements, quantum simulation, and quantum computation. However, given the difficulty of achieving full control of a complex atom-molecule system, the coherent formation of single molecules remains a challenge. Here, we report an alternative route to coherently bind two atoms into a weakly bound molecule at megahertz levels by coupling atomic spins to their two-body relative motion in a strongly focused laser with inherent polarization gradients. The coherent nature is demonstrated by long-lived atom-molecule Rabi oscillations. We further manipulate the motional levels of the molecules and measure the binding energy precisely. This work opens the door to full control of all degrees of freedom in atom-molecule systems.
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http://dx.doi.org/10.1126/science.aba7468DOI Listing
October 2020

Risk Factors for Lateral Lymph Node Metastases in Patients With Sporadic Medullary Thyroid Carcinoma.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962089

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: Medullary thyroid carcinoma is a rare endocrine malignancy; 75% of patients with this disease have sporadic medullary thyroid carcinoma. While surgery is the only curative treatment, the benefit of prophylactic lateral neck dissection is unclear. This study aimed to analyze the clinicopathological risk factors associated with lateral lymph node metastases and determine the indication for prophylactic lateral neck dissection in patients with sporadic medullary thyroid carcinoma.

Methods: The medical records of patients with medullary thyroid carcinoma who were treated at our hospital between January 2002 and January 2020 were retrospectively reviewed; a database of their demographic characteristics, test results, and pathological information was constructed. The relationship between lateral lymph node metastases and clinicopathologic sporadic medullary thyroid carcinoma features were analyzed using univariate and multivariate analyses.

Results: Overall, 125 patients with sporadic medullary thyroid carcinoma were included; 47.2% and 39.2% had confirmed central and lateral lymph node metastases, respectively. Univariate and multivariate analyses identified 2 independent factors associated with lateral lymph node metastases: positive central lymph node metastases (odds ratio = 9.764, 95% confidence interval: 2.610-36.523; p = 0.001) and positive lateral lymph nodes on ultrasonography (odds ratio = 101.747, 95% confidence interval: 14.666-705.869; p < 0.001).

Conclusion: Medullary thyroid carcinoma is a rare endocrine malignancy. Lymph node metastases are common in patients with sporadic medullary thyroid carcinoma. Prophylactic lateral neck dissection is recommended for patients who exhibit positive central lymph node metastases and/or positive lateral lymph nodes on ultrasonography.
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http://dx.doi.org/10.1177/1533033820962089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517989PMC
September 2020

is a novel prognostic marker in human hepatocellular carcinoma.

Oncol Lett 2020 Oct 29;20(4):70. Epub 2020 Jul 29.

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.

Reliable biomarkers for the prognosis of hepatocellular carcinoma (HCC) are rare, and novel biomarkers are required for the appropriate management of HCC. 5'-Nucleotidase domain containing 2 () acts as an oncogene in various tumors, but its functions as a biomarker have not been confirmed. Therefore, the present study aimed to resolve these functions by analyzing the prognostic value of in patients with HCC. A tissue microarray (TMA) was prepared and expression was measured via IHC staining in TMA dots. The liver cancer (LIHC) cohort in The Cancer Genome Atlas (TCGA) was enrolled as a secondary cohort. Kaplan-Meier survival analyses and Cox regression models were used for assessment of the prognostic value of . Gene set enrichment analysis (GSEA) was performed in TCGA LIHC cohort. A total of 134 patients with HCC were retrospectively enrolled in the Peking Union Medical College Hospital cohort and clinical data were collected. A total of 359 patients with HCC in TCGA were enrolled as TCGA cohort. was used as an indicator of overall survival (OS) and relapse-free survival (RFS) in multiple cohorts. In the multivariate Cox regression model, upregulation was an independent prognostic factor of OS in both cohorts. GSEA indicated the enrichment of a series of survival- and metastasis-related gene-sets, such as LEE_LIVER_CANCER_SURVIVAL_UP and LIAO_METASTASIS. Collectively, it was suggested that upregulation was associated with poor OS and RFS in HCC, and was a potential predictive marker for HCC stratification.
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http://dx.doi.org/10.3892/ol.2020.11931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436888PMC
October 2020

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats.

Nutr Metab (Lond) 2020 12;17:66. Epub 2020 Aug 12.

Department of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong China.

Background: Early diagnosis of type 2 diabetes mellitus (T2DM) is still difficult. Screening of plasma biomarkers has great significance of optimizing diagnosis and predicting the complications of T2DM.

Methods: We used a special diet, Purina #5008, to induce diabetes in Zucker leptin receptor gene-deficient rats (fa/fa) to establish Zucker diabetic fatty (ZDF) rats, simulating the early stage of T2DM. The differentially expressed proteins (DEP) and lipids (DEL), as potential biomarkers, were screened to compare the plasma expression levels in ZDF rats and their basic diet-fed wild-type controls (fa/+) by Tandem Mass Tags (TMT) and liquid chromatography-tandem mass spectrometry.

Results: These two groups had different plasma proteins and lipids profiles consisting of 84 DEPs and, 179 DELs identified in the positive ion mode and 178 DELs in the negative ion mode, respectively. Enrichment analysis of these different indicators showed that oxidative stress, insulin resistance and metabolic disorders of glycan and lipid played an important role in generating the difference. Some markers can be used as candidate biomarkers in prediction and treatments of T2DM, such as ceruloplasmin, apolipoprotein C-I, apolipoprotein C-II and apolipoprotein C-IV.

Conclusion: These plasma differences help to optimize the diagnosis and predict the complications of T2DM, although this remains to be verified in the crowd. Trace elements related-metalloproteins, such as ceruloplasmin, and lipid metabolism and transport-related apolipoprotein C are expected to be candidate biomarkers of T2DM and should be given more attention.
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http://dx.doi.org/10.1186/s12986-020-00488-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425165PMC
August 2020

Introducing a cell moisturizer: organogel nano-beads with rapid response to electrolytes for Prussian white analogue based non-aqueous potassium ion battery.

Chem Commun (Camb) 2020 Aug;56(67):9719-9722

CAS Key Laboratory of Materials for Energy Conversions, Department of Materials Science and Engineering, Collaborative Innovation Center of Suzhou Nano Scienceand Technology, University of Science and Technology of China, Hefei 230026, Anhui, China.

Prussian white analogue nanoparticles were connected internally by a composite consisting of poly(butyl methacrylate) (PBMA) nano-gel and a conducting polymer layer via a one-step route. The powder falling problems have been mitigated by the intrinsic good binding strength of PBMA organogel; meanwhile, the conducting polymer provides extra transfer paths for electrons.
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http://dx.doi.org/10.1039/d0cc03646cDOI Listing
August 2020
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