Publications

GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory.
Sci Rep 2017 Jul 18;7(1):5781. Epub 2017 Jul 18.
Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China.

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.
Sci Rep 2017 Jun 20;7(1):3914. Epub 2017 Jun 20.
Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Asperterpenes A and B, two unprecedented meroterpenoids from Aspergillus terreus with BACE1 inhibitory activities.
Chem Sci 2016 Oct 27;7(10):6563-6572. Epub 2016 Jun 27.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation , School of Pharmacy , Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , China . Email:

Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K.
J Exp Med 2014 Dec 8;211(13):2537-47. Epub 2014 Dec 8.
Molecular Development of the Immune System Section, Laboratory of Immunology; NIAID Clinical Genomics Program; Human Immunological Diseases Unit, Laboratory of Host Defenses; and Intramural Clinical Management and Operations Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Molecular Development of the Immune System Section, Laboratory of Immunology; NIAID Clinical Genomics Program; Human Immunological Diseases Unit, Laboratory of Host Defenses; and Intramural Clinical Management and Operations Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H₂O₂.
J Neurochem 2013 Jul 30;126(2):234-42. Epub 2013 May 30.
Department of Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.


An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide.
Acta Neuropathol 2012 Jan 15;123(1):133-51. Epub 2011 Nov 15.
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.

Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries.
Medicine (Baltimore) 2010 Nov;89(6):381-402
Laboratory of Human Genetics of Infectious Diseases U980, Institut National de la Santé et de la Recherche Médicale, Paris, France.

Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay.
Am J Pathol 2002 Apr;160(4):1269-78
Pathophysiology Department, Institute forNeuroscience, Tongji Medical School, Huazhong University of Science andTechnology, Wuhan, People's Republic of China.


Ginkgo biloba extract EGb761 attenuates Hyperhomocysteinemia-induced AD like tau hyperphosphorylation and cognitive impairment in rats.
Curr Alzheimer Res 2017 08 28. Epub 2017 Aug 28.
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030. China.


AKT2 deficiency induces retardation of myocyte development through EndoG-MEF2A signaling in mouse heart.
Biochem Biophys Res Commun 2017 12 28;493(4):1410-1417. Epub 2017 Sep 28.
State Key Laboratory of Natural Medicines, Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210006, China. Electronic address:

Interleukin-6 deficiency attenuates angiotensin II-induced cardiac pathogenesis with increased myocyte hypertrophy.
Biochem Biophys Res Commun 2017 12 25;494(3-4):534-541. Epub 2017 Oct 25.
State Key Laboratory of Natural Medicines, Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210006, China. Electronic address:

Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD.
Front Aging Neurosci 2017 31;9:347. Epub 2017 Oct 31.
Key Laboratory of Ministry of Education of China for Neurological Disorders, Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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