Publications by authors named "Xiaobo Liu"

282 Publications

Modeling the impacts of plants and internal organic carbon on remediation performance in the integrated vertical flow constructed wetland.

Water Res 2021 Sep 7;204:117635. Epub 2021 Sep 7.

Department of Environmental Informatics, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.

The integrated vertical flow (IVF) constructed wetland consists of two or more chambers with heterogeneous flow patterns and strong aeration capability, possesses favorable remediation performance. The Constructed Wetland Model No.1 (CWM1) embedded in the OpenGeoSys # IPHREEQC was applied to investigate the wetland plant effects on treatment efficiency. Two fundamental functions of the plant roots (i) the radial oxygen loss (ROL) and (ii) exudation of internal organic carbon (IOC), are developed and implemented in the model to simulate the treating processes of planted laboratory-scale IVF wetlands fed by the synthetic wastewater. The good agreement between simulated results and measurements of the planted IVF wetland and the unplanted filters mimicking wetland demonstrates the combined effects of ROL and IOC and the model reliability. In summer the ammonia (NH-N) and total nitrogen (TN) removals are high as above 90% in both IVF wetlands, and in winter they decline significantly to around 55% and 45% in unplanted wetland, contrastively to about 85% and 78% in the planted wetland. The nitrogen removal - COD/N ratio relation curves of IVF wetlands are proposed and obtained by modeling to evaluate organic carbon loading status. Based on the curves, the COD/N ratios of unplanted and planted wetlands are about 3∼7 and 3∼10 gCOD/gN for high TN removal respectively. Planted wetlands can tolerate a wider range of COD/N ratio influents than unplanted ones. The ROL in the unplanted wetland promotes COD and NH-N removal, while may inhibit denitrification under low-temperature conditions. The single addition of IOC enhances the oxygen-consuming and restrains the nitrification under the full loaded COD condition. Summing up all organic carbon releases from substrate and roots as IOC, the quantification of IOC acts on nitrogen treatment was simulated and compared with the external organic carbon (EOC) loading from influent. IOC performs higher efficiency on TN removal than EOC at the same organic loading rates. The results provide the thoughts of the solution for low TN removal in the carbon deficient constructed wetlands.
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http://dx.doi.org/10.1016/j.watres.2021.117635DOI Listing
September 2021

Ratiometric Fluorescence Imaging of Intracellular MicroRNA with NIR-Assisted Signal Amplification by a [email protected] Nanoplatform.

ACS Appl Mater Interfaces 2021 Sep 15. Epub 2021 Sep 15.

Zhangdayu School of Chemistry, Dalian University of Technology, Dalian 116023, P. R. China.

Accurate and sensitive fluorescence imaging of intracellular miRNA is essential for understanding the mechanism underlying some physiological and pathological events, as well as the prevention and diagnosis of diseases. Herein, a highly sensitive ratiometric fluorescent nanoprobe for intracellular miRNA imaging was fabricated by integrating a [email protected] ([email protected]) nanoplatform with a near-infrared light (NIR)-assisted DNA strand displacement signal amplification strategy. The [email protected] spheres have excellent biosafety, high photothermal effect, and unique photophysical properties that can both emit a stable red fluorescence and well quench the fluorophores getting closer to them. So, when the fuel DNA and carboxyfluorescein (FAM)-labeled signal DNA are co-assembled on their outer surfaces, the FAM's green fluorescence is quenched, and a low ratiometric signal is obtained. However, in the presence of miRNA, the target displaces the signal DNA from the capture DNA, releasing the signal DNA far away from the [email protected] Then, the green fluorescence recovers and leads to an enhanced / value. Under NIR light irradiation, the [email protected] increases the local temperature around the probe and triggers the release of fuel DNA, which thus recycles the target miRNA and effectively amplifies the ratiometric signal. Using A549 cells as a model, the nanoprobe realizes the highly sensitive ratiometric fluorescence imaging of miRNA let-7a, as well as its in vivo up- and down-regulation expressions. It provides a facile tool for highly sensitive and accurate intracellular miRNA detection through one-step incubation and may pave a new avenue for single-cell analysis.
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http://dx.doi.org/10.1021/acsami.1c11324DOI Listing
September 2021

Complete Genetic Analysis of Plasmids Carried by Two Nonclonal - and -Bearing Escherichia coli Strains: Insight into Plasmid Transmission among Foodborne Bacteria.

Microbiol Spectr 2021 Sep 1:e0021721. Epub 2021 Sep 1.

Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR.

Our objective was to characterize the genetic features of plasmids harbored by two genetically related, MCR-1 and NDM-5-producing Escherichia coli strains recovered from a chicken meat sample. The genetic profiles of all plasmids harbored by the two test strains, namely, 1106 and 1107, were determined by whole-genome sequencing, S1-pulsed-field gel electrophoresis (PFGE), Southern hybridization, and bioinformatics analysis. The transferability of plasmids harbored by the two strains was assessed by filter mating assay. Strains 1106 and 1107 were resistant to almost all the antibiotics, including colistin and fosfomycin, but remained susceptible to amikacin and tigecycline. The plasmids of p1107-NDM-5 and p1106-NDM-5 both contain a class I integron which lacks the IS element. The backbone of p1106-IncFII exhibited a high degree of similarity with that of p1106-NDM-5 and p1107-NDM-5, implying that events of plasmid fusion and resolution were involved in the formation of the two plasmids. The plasmids p1106-IncHI2MCR and p1107-IncHI2MCR belong to an IncHI2 replicon type, with three copies of IS being observed in p1106-IncHI2MCR, implying that the gene was transferable among bacteria that reside in the same food matrix. In this study, p1106-IncFIB, p1107-99K, p1107-111K, and p1107-118K were all found to be phage-like plasmids, with p1106-IncFIB and p1107-118K containing several virulence genes, including , , , , and . Surprisingly, resistance genes such as , , and could also be found in p1107-118K, but resistance genes were not detected in other phage-like plasmids. In conclusion, enhanced surveillance is required to monitor and control the dissemination of various resistance determinants among foodborne pathogens. Carbapenem and colistin are last-resort antibiotics used to treat serious clinical infections caused by multidrug-resistant (MDR) bacterial pathogens. Plasmids encoding resistance to carbapenems and colistin have been reported in clinical pathogens in recent years, and yet few studies reported cocarriage of and genes in Escherichia coli strains of food origin. How plasmids encoding these two important resistance determinants are being evolved and transmitted in bacterial pathogens is not well understood. In this study, we investigated the genetic features of plasmids harbored by two nonclonal, - and -bearing E. coli strains (1106 and 1107) recovered from a fresh chicken meat sample to understand and provide evidence of the level and dynamics of MDR plasmid transmission. Our data confirmed that active plasmid fusion and resolution events were involved in the formation of plasmids that harbor multiple resistance genes, which provide insights into the further control of plasmid evolution in bacterial pathogens.
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http://dx.doi.org/10.1128/Spectrum.00217-21DOI Listing
September 2021

Decoding DNA methylation in epigenetics of multiple myeloma.

Blood Rev 2021 Jul 31:100872. Epub 2021 Jul 31.

Laboratory of Cancer Precision Medicine, the First Hospital of Jilin University, 519 Dongminzhu Street, Changchun, Jilin 130061, China. Electronic address:

Dysregulation of DNA methylation in B cells has been observed during their neoplastic transformation and therefore closely associated with various B-cell malignancies including multiple myeloma (MM), a malignancy of terminally differentiated plasma cells. Emerging evidence has unveiled pronounced alterations in DNA methylation in MM, including both global and gene-specific changes that can affect genome stability and gene transcription. Moreover, dysregulated expression of DNA methylation-modifying enzymes has been related with myelomagenesis, disease progression, and poor prognosis. However, the functional roles of the epigenetic abnormalities involving DNA methylation in MM remain elusive. In this article, we review current understanding of the alterations in DNA methylome and DNA methylation modifiers in MM, particularly focusing on DNA methyltransferases (DNMTs) and tet methylcytosine dioxygenases (TETs). We also discuss how these DNA methylation modifiers may be regulated and function in MM cells, therefore providing a rationale for developing novel epigenetic therapies targeting DNA methylation in MM.
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http://dx.doi.org/10.1016/j.blre.2021.100872DOI Listing
July 2021

Dioscin prevents DSS-induced colitis in mice with enhancing intestinal barrier function and reducing colon inflammation.

Int Immunopharmacol 2021 Oct 31;99:108015. Epub 2021 Jul 31.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, China. Electronic address:

Dioscin is a natural steroid saponin derived from plants of the genus Dioscoreaceae. Previous studies have proved its effects of antibacterial, anti-inflammatory and hypolipidemic. In this study, our aim was to explore the protective effect and preliminary mechanism of Dioscin on dextran sulfate sodium (DSS)-induced colitis in mice. The results showed that Dioscin reduced DSS-induced disease activity index (DAI) increase, colon length shortening and colon pathological damage. In addition, Dioscin reduced excessive inflammation by reversing the cytokines levels, reducing intestinal macrophage infiltration and promoting macrophage polarization to M2 phenotype. At the same time, Dioscin maintained the intestinal barrier function by increasing the expression of zonula occludens-1 (ZO-1), occludin and mucin (Muc)-2. Moreover, Dioscin inhibited NF-κB, MAPK signaling and nucleotide oligomerization domain-like receptor family pyrin domain ontaining 3(NLRP3) inflammasome pathway in DSS-induced colitis. These results suggest that Dioscin is a competent candidate for ulcerative colitis (UC) therapy in the future.
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http://dx.doi.org/10.1016/j.intimp.2021.108015DOI Listing
October 2021

The impact of air pollution on COVID-19 pandemic varied within different cities in South America using different models.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Center for Excellence in Regional Atmospheric Environment, Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.

There is a rising concern that air pollution plays an important role in the COVID-19 pandemic. However, the results were not consistent on the association between air pollution and the spread of COVID-19. In the study, air pollution data and the confirmed cases of COVID-19 were both gathered from five severe cities across three countries in South America. Daily real-time population regeneration (R) was calculated to assess the spread of COVID-19. Two frequently used models, generalized additive models (GAM) and multiple linear regression, were both used to explore the impact of environmental pollutants on the epidemic. Wide ranges of all six air pollutants were detected across the five cities. Spearman's correlation analysis confirmed the positive correlation within six pollutants. Rt value showed a gradual decline in all the five cities. Further analysis showed that the association between air pollution and COVID-19 varied across five cities. According to our research results, even for the same region, varied models gave inconsistent results. For example, in Sao Paulo, both models show SO and O are significant independent variables, however, the GAM model shows that PM has a nonlinear negative correlation with R, while PM has no significant correlation in the multiple linear model. Moreover, in the case of multiple regions, currently used models should be selected according to local conditions. Our results indicate that there is a significant relationship between air pollution and COVID-19 infection, which will help states, health practitioners, and policy makers in combating the COVID-19 pandemic in South America.
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http://dx.doi.org/10.1007/s11356-021-15508-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325399PMC
July 2021

Comparative analyses on epidemiological characteristics of dengue fever in Guangdong and Yunnan, China, 2004-2018.

BMC Public Health 2021 07 13;21(1):1389. Epub 2021 Jul 13.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, 102206, People's Republic of China.

Background: In China, Guangdong and Yunnan are the two most dengue-affected provinces. This study aimed to compare the epidemiological characteristics of dengue fever in Guangdong and Yunnan during 2004-2018.

Methods: Descriptive analyses were used to explore the temporal, spatial, and demographic distribution of dengue fever.

Results: Of the 73,761 dengue cases reported in mainland China during 2004-2018, 93.7% indigenous and 65.9% imported cases occurred in Guangdong and Yunnan, respectively. A total of 55,970 and 5938 indigenous cases occurred in 108 Guangdong and 8 Yunnan counties, respectively during 2004-2018. Whereas 1146 and 3050 imported cases occurred in 84 Guangdong and 72 Yunnan counties, respectively during 2004-2018. Guangdong had a much higher average yearly indigenous incidence rate (3.65 (1/100000) vs 0.86 (1/100000)), but a much lower average yearly imported incidence rate (0.07 (1/100000) vs 0.44(1/100000)) compared with Yunnan in 2004-2018. Furthermore, dengue fever occurred more widely in space and more frequently in time in Guangdong. Guangdong and Yunnan had similar seasonal characteristics for dengue fever, but Guangdong had a longer peak period. Most dengue cases were clustered in the south-western border of Yunnan and the Pearl River Delta region in Guangdong. Most of the imported cases (93.9%) in Guangdong and Yunnan were from 9 Southeast Asian countries. Thailand, Cambodia, and Malaysia imported mainly into Guangdong while Myanmar and Laos imported into Yunnan. There was a strong male predominance among imported cases and an almost equal gender distribution among indigenous cases. Most dengue cases occurred in individuals aged 21-50 years, accounting for 57.3% (Guangdong) vs. 62.8% (Yunnan) of indigenous and 83.2% (Guangdong) vs. 62.6% (Yunnan) of imported cases. The associated major occupations (house worker or unemployed, retiree, and businessman, for indigenous cases; and businessman, for imported cases), were similar. However, farmers accounted for a larger proportion of dengue cases in Yunnan.

Conclusions: Identifying the different epidemiological characteristics of dengue fever in Guangdong and Yunnan can be helpful to formulate targeted, strategic plans, and implement effective public health prevention measures in China.
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http://dx.doi.org/10.1186/s12889-021-11323-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278621PMC
July 2021

Transmission and stable inheritance of carbapenemase gene (bla or bla)-encoding and mcr-1-encoding plasmids in clinical Enterobacteriaceae strains.

J Glob Antimicrob Resist 2021 Sep 7;26:255-261. Epub 2021 Jul 7.

Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, P.R. China; State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR. Electronic address:

Objectives: The aim of this study was to investigate the potential for transmission and heritability of carbapenemase gene (bla or bla)-encoding or mcr-1-encoding plasmids in clinical Enterobacteriaceae strains.

Methods: Potential for transmission of carbapenemase gene (bla or bla)-encoding or mcr-1-encoding plasmids in clinical Enterobacteriaceae strains was tested in three conjugation models, namely filter-mating conjugation in laboratory conditions, a meat product model and the gastrointestinal (GI) tract of rats. Plasmid stability in Enterobacteriaceae strains was also determined.

Results: We demonstrated that plasmids carrying a carbapenemase gene (bla or bla) could be efficiently conjugated to strains carrying the mcr-1 gene and vice versa, and that these plasmids could stably co-exist in clinical Enterobacteriaceae strains. These findings suggest that Enterobacteriaceae can readily acquire phenotypic resistance to both carbapenems and colistin in natural environments such as food products and the GI tract of human and animals.

Conclusion: Gene transfer events are common among members of the Enterobacteriaceae and serve as a key mechanism facilitating adaptation to new environments. Development of innovative strategies and surveillance measures to curtail the dissemination of multidrug resistance plasmids is necessary. Transmission and stable inheritance of these two types of plasmids would lead to the emergence of multidrug-resistant pathogens that are resistant to all currently available last-line antibiotics for Gram-negative bacterial infections.
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http://dx.doi.org/10.1016/j.jgar.2021.05.022DOI Listing
September 2021

Entomological and Molecular Surveillance of Mosquitoes in Freetown, Sierra Leone, 2019.

Front Public Health 2021 17;9:649672. Epub 2021 Jun 17.

State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.

Malaria is endemic in Sierra Leone, with stable and perennial transmission in all parts of the country. At present, the main prevention and control measures for mosquito vectors here involve insecticide treated nets (ITN) and indoor residual spraying (IRS). The most recent entomological surveillance was conducted prior to the civil war, between 1990 and 1994. Therefore, a new entomological surveillance required to support targeted malaria control strategies. mosquitoes were collected between June and December 2019 using the light trap method. On these, we conducted species identification, analyzed seasonal fluctuation and infection rate, and monitored insecticide resistance. Surveillance of seasonal fluctuation showed that there were two peak of density in July (mean 13.67 mosquitoes/trap/night) and October (mean 13.00 mosquitoes/trap/night). Meanwhile, the lowest density was seen in early September. Ninety-one representatives of s.l. were selected and identified as ( = 35) and s.s. ( = 56) using PCR. and s.s. were found to be heterozygous resistant to the knockdown resistance () L1014F mutation (100%). Meanwhile, the East African mutation ( L1014S) was absent in the tested mosquitoes. Three mosquitoes that tested positive for the parasite, had an individual infection rate of 12.50, 16.67, and 14.29%. The sampling dates of positive mosquitoes were distributed in the two periods of peak mosquito density. This study identified the dominant species in Freetown as while the predominant species within the complex was . Surveillance of seasonal fluctuations and high infection rates in indicate that the alternation of drought and rainy seasons from June to July, and from October to November, are the key periods for malaria control and prevention in Freetown, Sierra Leone. The high frequency of allele mutations in calls for close monitoring of vector susceptibility to insecticides and tracing of resistance mechanisms in order to develop more effective vector control measures and strategies.
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http://dx.doi.org/10.3389/fpubh.2021.649672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247763PMC
July 2021

Ambient air pollution and low temperature associated with case fatality of COVID-19: A nationwide retrospective cohort study in China.

Innovation (N Y) 2021 Aug 18;2(3):100139. Epub 2021 Jun 18.

State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, WHO Collaborating Centre for Vector Surveillance and Management, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

The evidence for the effects of environmental factors on COVID-19 case fatality remains controversial, and it is crucial to understand the role of preventable environmental factors in driving COVID-19 fatality. We thus conducted a nationwide cohort study to estimate the effects of environmental factors (temperature, particulate matter [PM, PM], sulfur dioxide [SO], nitrogen dioxide [NO], and ozone [O]) on COVID-19 case fatality. A total of 71,808 confirmed COVID-19 cases were identified and followed up for their vital status through April 25, 2020. Exposures to ambient air pollution and temperature were estimated by linking the city- and county-level monitoring data to the residential community of each participant. For each participant, two windows were defined: the period from symptom onset to diagnosis (exposure window I) and the period from diagnosis date to date of death/recovery or end of the study period (exposure window II). Cox proportional hazards models were used to estimate the associations between these environmental factors and COVID-19 case fatality. COVID-19 case fatality increased in association with environmental factors for the two exposure windows. For example, each 10 μg/m increase in PM, PM, O, and NO in window I was associated with a hazard ratio of 1.11 (95% CI 1.09, 1.13), 1.10 (95% CI 1.08, 1.13), 1.09 (95 CI 1.03, 1.14), and 1.27 (95% CI 1.19, 1.35) for COVID-19 fatality, respectively. A significant effect was also observed for low temperature, with a hazard ratio of 1.03 (95% CI 1.01, 1.04) for COVID-19 case fatality per 1°C decrease. Subgroup analysis indicated that these effects were stronger in the elderly, as well as in those with mild symptoms and living in Wuhan or Hubei. Overall, the sensitivity analyses also yielded consistent estimates. Short-term exposure to ambient air pollution and low temperature during the illness would play a nonnegligible part in causing case fatality due to COVID-19. Reduced exposures to high concentrations of PM, PM, O, SO, and NO and low temperature would help improve the prognosis and reduce public health burden.
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http://dx.doi.org/10.1016/j.xinn.2021.100139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226106PMC
August 2021

Shared Medical Appointments and Prediabetes: The Power of the Group.

Ann Fam Med 2021 May-Jun;19(3):258-261

Center for Value-Based Care Research Cleveland Clinic, Cleveland, Ohio.

Shared medical appointments, which allow greater access to care and provide peer support, may be an effective treatment modality for prediabetes. We used a retrospective propensity-matched cohort analysis to compare patients attending a prediabetes shared medical appointment to usual care. Primary outcome was patient's weight change over 24 months. Secondary outcomes included change in hemoglobin A, low density lipoprotein, and systolic blood pressure. The shared medical appointments group lost more weight (2.88 kg vs 1.29 kg, = .003), and achieved greater reduction in hemoglobin A (-0.87% vs +0.87%, = .001) and systolic blood pressure (-4.35 mmHg vs +0.52 mmHg, = .044). The shared medical appointment model can be effective in treating prediabetes.
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http://dx.doi.org/10.1370/afm.2647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118487PMC
November 2019

Stabilizing Triglyceride in Methanol Emulsions via a Magnetic Pickering Interfacial Catalyst for Efficient Transesterification under Static Conditions.

ACS Omega 2021 Jun 24;6(22):14138-14147. Epub 2021 May 24.

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang Province Key Laboratory of Biofuel, Biodiesel Laboratory of China Petroleum and Chemical Industry Federation, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.

Pickering emulsion systems provide potential platforms for simultaneously intensifying and catalyzing transesterification between triglyceride and methanol under static conditions. However, realizing static transesterification with high biodiesel yield is still challenging due to low emulsion stability at the reaction temperature. Here, a series of magnetically recyclable Pickering interfacial catalysts (PICs) with similar surface affinities but different densities were constructed as stabilizers of a soybean oil/methanol emulsion. The variations in the emulsion volume fraction and droplet size were comparatively studied and analyzed from the viewpoint of droplet settling and catalyst particle shedding. It is found that, except for surface affinity, PIC density also plays a pivotal role in emulsion stability owing to the non-negligible effect of gravity on catalyst adsorption in triglyceride/methanol emulsion (especially at elevated temperature). By reducing the density, finely improving the lipophilicity, and optimizing the addition amount of PIC, the obtained soybean oil/methanol emulsion can remain stable for at least 12 h at 60 °C, enabling static transesterification with a high biodiesel yield of 95.6%. Moreover, the best performing PIC can be reused for at least 7 cycles. This efficient static transesterification system offers a green strategy for biodiesel production.
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http://dx.doi.org/10.1021/acsomega.1c00629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190790PMC
June 2021

Fluorinated Oligomer Wrapped Perovskite Crystals for Inverted MAPbI Solar Cells with 21% Efficiency and Enhanced Stability.

ACS Appl Mater Interfaces 2021 Jun 30;13(22):26093-26101. Epub 2021 May 30.

School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 611731, China.

Defects at the grain boundary provide sites for nonradiative recombination in halide perovskite solar cells (PSCs). Here, by polymerization and fluorination of a Lewis acid of 4,4-bis(4-hydroxyphenyl)pentanoic acid, a fluorinated oligomer (FO-19) is synthesized and applied to passivate these defects in methlyammonium lead iodide (MAPbI). It is demonstrated that the carboxyl bond of FO-19 was coordinated with Pb ions in the perovskite films to achieve a wrapping effect on the perovskite crystals. The defects of perovskite film are effectively passivated, and the undesirable nonradiative recombination is greatly inhibited. As a result, FO-19 gives a power conversion efficiency of 21.23% for the inverted MAPbI-based PSCs, which is among the highest reported values in the literature. Meanwhile, the corresponding device with FO-19 exhibits significantly improved humidity and thermal stability. Therefore, this work offers insights into the realization of high-efficiency and stable PSCs through fluorinated additive engineering.
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http://dx.doi.org/10.1021/acsami.1c06216DOI Listing
June 2021

Spatiotemporal Dynamics of Scrub Typhus in Jiangxi Province, China, from 2006 to 2018.

Int J Environ Res Public Health 2021 04 26;18(9). Epub 2021 Apr 26.

The Collaboration Unit for Field Epidemiology of State Key Laboratory of Infectious Disease Prevention and Control, Nanchang Center for Disease Control and Prevention, Nanchang 330038, China.

: Scrub typhus (ST) has become a significant potential threat to public health in Jiangxi. Further investigation is essential for the control and management of the spatiotemporal patterns of the disease. : Time-series analyses, spatial distribution analyses, spatial autocorrelation analysis, and space-time scan statistics were performed to detect spatiotemporal dynamics distribution of the incidence of ST. : From 2006 to 2018, a total of 5508 ST cases occurred in Jiangxi, covering 79 counties. The number of ST cases increased continuously from 2006 to 2018, and there was obvious seasonality during the variation process in each year, with a primary peak in autumn (September to October) and a smaller peak in summer (June to August). From 2007 to 2018, the spatial distribution of the ST epidemic was significant heterogeneity, and Nanfeng, Huichang, Xunwu, Anyuan, Longnan, and Xinfeng were hotspots. Seven spatiotemporal clusters were observed using Kulldorff's space-time scan statistic, and the most likely cluster only included one county, Nanfeng county. The high-risk areas of the disease were in the mountainous, hilly region of Wuyi and the southern mountainous region of Jiangxi. : Targeted interventions should be executed in high-risk regions for the precise prevention and control of ST.
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http://dx.doi.org/10.3390/ijerph18094599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123664PMC
April 2021

How to Identify Future Priority Areas for Urban Development: An Approach of Urban Construction Land Suitability in Ecological Sensitive Areas.

Int J Environ Res Public Health 2021 04 16;18(8). Epub 2021 Apr 16.

Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610041, China.

The suitability of urban construction land (SUCL) is key to the appropriate utilization of land resources and represents an important foundation for regional exploration and land management. This study explores the SUCL conceptual framework by considering the theory of human-land relationships. The upper reaches of the Yangtze River were studied, a typical ecologically-sensitive area of China. The spatial pattern and control of the SUCL were determined using the improved entropy method. The results show that an area of 91 × 10 km was categorized as prohibited or restricted, and these categories account for 28.61% and 50.66% of the total area, respectively. Priority areas and suitable areas are mainly located in the Chengdu Plain, the urban agglomeration of southern Sichuan Province, Chongqing, and the economic corridor in the west, and the surrounding cities of Guiyang and Kunming. SUCL hotspots feature obvious spatial heterogeneity and are concentrated in Sichuan Basin and Guizhou Plateau. The SUCL is obviously constrained by the physical geography of this region. In addition, towns affected by the pole-axis effect have stronger suitability for development and construction. These findings will be very useful for land managers as they provide relevant information about urban development in mountainous areas.
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http://dx.doi.org/10.3390/ijerph18084252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073476PMC
April 2021

Gut Structure and Microbial Communities in (Hymenoptera: Siricidae) and Their Predicted Contribution to Larval Nutrition.

Front Microbiol 2021 8;12:641141. Epub 2021 Apr 8.

Beijing Key Laboratory for Forest Pest Control, Beijing Forestry University, Beijing, China.

The European woodwasp, Fabricius, is a major invasive quarantine pest that attacks and kills pine trees outside of its native range. Insect gut structure and gut microbiota play crucial roles in various life activities. Despite a few reports in nutrition and survival, an extensive study on the larval gut microbiome is lacking. We studied the gut structure using a stereo microscope and used high throughput sequencing of the bacterial 16S rRNA genes and fungal internal transcribed spacer 2 (ITS2) regions to investigate gut microbiota in different developmental stages of , including larvae, adults, and larval frass. We used PICRUSt2 to predict the functional profiles. The larval gut was thin and thread-like from the oral cavity to the anus, carrying few xylem particles in the crop. , , and s.l were the dominant bacteria in the guts of larvae, adults, and frass, respectively. Even though was the most abundant among all bacteria, , , and , which might be involved in degrading organic matter and fixing nitrogen occurred exclusively in the larval gut indicating their possible role in the growth and development of larvae in pine tree xylem. Fungal communities did not change significantly across different developmental stages or the frass. was dominant in the woodwasp's larval gut. Functional prediction of bacterial and fungal communities revealed that they may encod enzymes involved in degrading lignocellulose and fixing nitrogen. Ours is the first study that compares gut microbial communities present in larvae, adults, and frass. This study could provide an understanding of larval nutrient acquisition in nutrient-deficient host xylem to some extent. Our study may unlock novel strategies for the development of pest management approaches based on interfering with the gut microbiota and restricting their role in larval survival and development.
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http://dx.doi.org/10.3389/fmicb.2021.641141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060704PMC
April 2021

Spatial Dynamics of Dengue Fever in Mainland China, 2019.

Int J Environ Res Public Health 2021 03 11;18(6). Epub 2021 Mar 11.

Chinese Center for Disease Control and Prevention, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable, Disease Control and Prevention, Beijing 102206, China.

New spatial characteristics of dengue fever in mainland China during 2019 were analyzed. There was a dengue fever outbreak in mainland China in 2019, with 15,187 indigenous cases in 13 provinces, 1281 domestic imported cases from 12 provinces and 5778 overseas imported cases from 47 countries, more than the previous cases during the period 2005-2018, except for in 2014. Indigenous cases occurred in Sichuan, Hubei and Chongqing in 2019. There have been big changes in the spatial distribution and proportion of dengue cases. Indigenous cases were not only located in the southwestern border and southeastern coastal provinces of Yunnan, Guangdong, Guangxi and Fujian but also in the central provinces of Jiangxi and Chongqing. Domestic imported cases were not only from Guangdong, but also from Yunnan. There were five new sources of importation of cases. Overseas imported cases were mainly from Cambodia and Myanmar in 2019. Understanding the new spatial characteristics of dengue fever in China helps to formulate targeted, strategic plans and implement effective public health prevention and control measures.
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http://dx.doi.org/10.3390/ijerph18062855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999437PMC
March 2021

Assessing the suitability for Aedes albopictus and dengue transmission risk in China with a delay differential equation model.

PLoS Negl Trop Dis 2021 03 26;15(3):e0009153. Epub 2021 Mar 26.

State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, WHO Collaborating Centre for Vector Surveillance and Management, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Dengue is considered non-endemic to mainland China. However, travellers frequently import the virus from overseas and local mosquito species can then spread the disease in the population. As a consequence, mainland China still experiences large dengue outbreaks. Temperature plays a key role in these outbreaks: it affects the development and survival of the vector and the replication rate of the virus. To better understand its implication in the transmission risk of dengue, we developed a delay differential equation model that explicitly simulates temperature-dependent development periods and tested it with collected field data for the Asian tiger mosquito, Aedes albopictus. The model predicts mosquito occurrence locations with a high accuracy (Cohen's κ of 0.78) and realistically replicates mosquito population dynamics. Analysing the infection dynamics during the 2014 dengue outbreak that occurred in Guangzhou showed that the outbreak could have lasted for another four weeks if mosquito control interventions had not been undertaken. Finally, we analyse the dengue transmission risk in mainland China. We find that southern China, including Guangzhou, can have more than seven months of dengue transmission per year while even Beijing, in the temperate north, can have dengue transmission during hot summer months. The results demonstrate the importance of using detailed vector and infection ecology, especially when vector-borne disease transmission risk is modelled over a broad range of climatic zones.
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http://dx.doi.org/10.1371/journal.pntd.0009153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996998PMC
March 2021

Effects and interaction of meteorological factors on hemorrhagic fever with renal syndrome incidence in Huludao City, northeastern China, 2007-2018.

PLoS Negl Trop Dis 2021 03 25;15(3):e0009217. Epub 2021 Mar 25.

State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Hemorrhagic fever with renal syndrome (HFRS), a rodent-borne disease, is a severe public health threat. Previous studies have discovered the influence of meteorological factors on HFRS incidence, while few studies have concentrated on the stratified analysis of delayed effects and interaction effects of meteorological factors on HFRS.

Objective: Huludao City is a representative area in north China that suffers from HFRS with primary transmission by Rattus norvegicus. This study aimed to evaluate the climate factors of lag, interaction, and stratified effects of meteorological factors on HFRS incidence in Huludao City.

Methods: Our researchers collected meteorological data and epidemiological data of HFRS cases in Huludao City during 2007-2018. First, a distributed lag nonlinear model (DLNM) for a maximum lag of 16 weeks was developed to assess the respective lag effect of temperature, precipitation, and humidity on HFRS incidence. We then constructed a generalized additive model (GAM) to explore the interaction effect between temperature and the other two meteorological factors on HFRS incidence and the stratified effect of meteorological factors.

Results: During the study period, 2751 cases of HFRS were reported in Huludao City. The incidence of HFRS showed a seasonal trend and peak times from February to May. Using the median WAT, median WTP, and median WARH as the reference, the results of DLNM showed that extremely high temperature (97.5th percentile of WAT) had significant associations with HFRS at lag week 15 (RR = 1.68, 95% CI: 1.04-2.74) and lag week 16 (RR = 2.80, 95% CI: 1.31-5.95). Under the extremely low temperature (2.5th percentile of WAT), the RRs of HFRS infection were significant at lag week 5 (RR = 1.28, 95% CI: 1.01-1.67) and lag 6 weeks (RR = 1.24, 95% CI: 1.01-1.57). The RRs of relative humidity were statistically significant at lag week 10 (RR = 1.19, 95% CI: 1.00-1.43) and lag week 11 (RR = 1.24, 95% CI: 1.02-1.50) under extremely high relative humidity (97.5th percentile of WARH); however, no statistically significance was observed under extremely low relative humidity (2.5th percentile of WARH). The RRs were significantly high when WAT was -10 degrees Celsius (RR = 1.34, 95% CI: 1.02-1.76), -9 degrees Celsius (1.37, 95% CI: 1.04-1.79), and -8 degrees Celsius (RR = 1.34, 95% CI: 1.03-1.75) at lag week 5 and more than 23 degrees Celsius after 15 weeks. Interaction and stratified analyses showed that the risk of HFRS infection reached its highest when both temperature and precipitation were at a high level.

Conclusions: Our study indicates that meteorological factors, including temperature and humidity, have delayed effects on the occurrence of HFRS in the study area, and the effect of temperature can be modified by humidity and precipitation. Public health professionals should pay more attention to HFRS control when the weather conditions of high temperature with more substantial precipitation and 15 weeks after the temperature is higher than 23 degrees Celsius.
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http://dx.doi.org/10.1371/journal.pntd.0009217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993601PMC
March 2021

Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen.

Sci China Life Sci 2021 Mar 16. Epub 2021 Mar 16.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

A stable, rapid and effective neural differentiation method is essential for the clinical applications of human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) in treating neurological disorders and diseases. Herein, we established a novel and robust monolayer differentiation method to produce functional neural progenitor cells (NPCs) from human ESC/iPSCs on Type I Collagen. The derived cells not only displayed the requisite markers, but also behaved similarly to classic NPCs both in vitro and in vivo. Upon transplantation into traumatic brain injury model, the derived NPCs facilitated recovery from injury. We also found that SMAD signaling stayed down throughout the differentiation process on Type I Collagen, and the pluripotent signals were rapidly downregulated along with raising up of neural early markers on the third day. Meanwhile, ATAC-seq data showed the related mediation of distinct transcriptome and global chromatin dynamics during NPC induction. Totally, our results thus provide a convenient way to generate NPCs from human ESC/iPSCs for neural diseases' treatment.
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http://dx.doi.org/10.1007/s11427-020-1897-0DOI Listing
March 2021

Ecological distribution and potential roles of Woesearchaeota in anaerobic biogeochemical cycling unveiled by genomic analysis.

Comput Struct Biotechnol J 2021 16;19:794-800. Epub 2021 Jan 16.

Environmental Engineering Program, Guangdong Technion-Israel Institute of Technology (GTIIT), 241 Daxue Road, Shantou 515063, Guangdong, China.

Woesearchaeota as a newly established member of the superphylum DPANN (Diapherotrites, Parvarchaeota, Aenigmarchaeota, Nanoarchaeota and Nanohaloarchaea) are surprisingly abundant and diverse in a wide variety of environments, including deep oil reservoir, sulfuric springs and anoxic aquifers, indicating a high diversity of their roles in global biogeochemical cycles. However, ecological functions of them remain elusive. To fill up this gap, we analyzed and compared the global distribution patterns of Woesearchaeota using the genomes available publicly. As a result, both ecological distribution patterns and metabolic predictions support a key role of woesearchaeotal lineages in cycling of carbon, nitrogen, and sulfur. Multivariate regression analysis reveals that Woesearchaeota might function in consortium with methanogens in the cycling of carbon in anaerobic environments, particularly in soils or sediments. Moreover, comparative genomic analysis and ecological distribution suggest the potential roles of Woesearchaeota in the processes of denitrification, nitrogen fixation, and dissimilatory nitrite reduction, especially in the wastewater treatment systems; and also uncovered the potential capability of sulfate reduction, sulfide oxidation and thiosulfate oxidation in sulfuric or sulfidic-rich environments. Our findings add more information into the ecological roles of archaea in the anoxic environment.
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http://dx.doi.org/10.1016/j.csbj.2021.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844129PMC
January 2021

Determination of Factors Affecting Dengue Occurrence in Representative Areas of China: A Principal Component Regression Analysis.

Front Public Health 2020 18;8:603872. Epub 2021 Jan 18.

State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, WHO Collaborating Centre for Vector Surveillance and Management, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Determination of the key factors affecting dengue occurrence is of significant importance for the successful response to its outbreak. Yunnan and Guangdong Provinces in China are hotspots of dengue outbreak during recent years. However, few studies focused on the drive of multi-dimensional factors on dengue occurrence failing to consider the possible multicollinearity of the studied factors, which may bias the results. In this study, multiple linear regression analysis was utilized to explore the effect of multicollinearity among dengue occurrences and related natural and social factors. A principal component regression (PCR) analysis was utilized to determine the key dengue-driven factors in Guangzhou city of Guangdong Province and Xishuangbanna prefecture of Yunnan Province, respectively. The effect of multicollinearity existed in both Guangzhou city and Xishuangbanna prefecture, respectively. PCR model revealed that the top three contributing factors to dengue occurrence in Guangzhou were Breteau Index (BI) (positive correlation), the number of imported dengue cases lagged by 1 month (positive correlation), and monthly average of maximum temperature lagged by 1 month (negative correlation). In contrast, the top three factors contributing to dengue occurrence in Xishuangbanna included monthly average of minimum temperature lagged by 1 month (positive correlation), monthly average of maximum temperature (positive correlation), monthly average of relative humidity (positive correlation), respectively. Meteorological factors presented stronger impacts on dengue occurrence in Xishuangbanna, Yunnan, while BI and the number of imported cases lagged by 1 month played important roles on dengue transmission in Guangzhou, Guangdong. Our findings could help to facilitate the formulation of tailored dengue response mechanism in representative areas of China in the future.
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http://dx.doi.org/10.3389/fpubh.2020.603872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848178PMC
May 2021

Quantum dots encoded white-emitting polymeric superparticles for simultaneous detection of multiple heavy metal ions.

J Hazard Mater 2021 03 13;405:124263. Epub 2020 Oct 13.

School of Materials and Energy, University of Electronic Science and Technology of China, 611731 Chengdu, PR China.

Simultaneous detection of multiple heavy metal ions (HMI) is of great importance for the environmental monitoring, and the analytical tools based on multiband emissive fluorescent probes have been regarded as one of the most promising candidate for multiple HMI detection. Herein, the rod-coil amphiphilic block copolymer (BCP) with intrinsic blue fluorescence emission has been synthesized and subsequently employed to encapsulate two types of hydrophobic quantum dots (QD) with green and red fluorescence emission via the three dimensionally confined emulsion self-assembly, leading to the generation of white-emitting superparticles showing good colloidal stability and stable aqueous phase fluorescence. Furthermore, it was found that the fluorescence emission intensity of obtained superparticles can be selectively quenched by Ag, Hg, Cu and Fe ions via different mechanisms, and the four metal ions can be further discriminated according to their distinct combinational quenching effects onto three fluorescent bands of white-emitting superparticles. In addition, an analytical model was built to enable the simultaneous detection of Cu, Hg and Fe in the real sample. Basically, the current work opens the new way to fabricate fluorescent probes with multiple emission bands, which can be easily adapted to prepare more complicated QD encoded fluorescent probes for high throughput detection.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124263DOI Listing
March 2021

Overwintering Larval Cold Tolerance of (Hymenoptera: Siricidae): Geographic Variation in Northeast China.

Insects 2021 Jan 28;12(2). Epub 2021 Jan 28.

Beijing Key Laboratory for Forest Pest Control, School of Forestry, Beijing Forestry University, Beijing 100083, China.

(Hymenoptera: Siricidae) is an invasive pest that has spread and established in many regions worldwide. However, its cold tolerance strategy is still unclear. We measured the supercooling point (SCP) and the lower lethal temperature (LLT) of overwintering larvae during three overwintering periods in four geographically separated populations in China. In addition, using the statistical analysis of the local historical temperature data, we also conducted comprehensive studies of cold tolerance variations and strategies. We measured the SCP of all samples as could survive at its SCP during a short period of exposure (<48 h) and its cold tolerance strategy was freeze-avoidance. The average SCPs of the groups in different spatiotemporal scales were significantly related to average temperature variation with most individuals exhibiting stronger cold hardiness at low ambient temperatures. exhibited a strong cold tolerance and it has the ability to withstand lower temperatures in cold environments. The geographic population showed a positive tendency as the ambient temperature decreased, which would increase its chance of developing in cold regions.
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http://dx.doi.org/10.3390/insects12020116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911264PMC
January 2021

Occurrence and toxicity of perfluoroalkyl acids along the estuarine and coastal regions under varied environmental factors.

Sci Total Environ 2021 May 9;769:144584. Epub 2021 Jan 9.

Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China. Electronic address:

Due to the significant economic and ecological value, the increasing pollution threat to estuarine and coastal regions is of great concern. Perfluoroalkyl acids (PFAAs) are emerging pollutants which possess adverse ecological risk. In this review, we have compiled the data on the levels of PFAAs in environmental samples, mainly in estuarine and coastal zones. A worldwide map was generated to show the distribution of PFAAs. The experimental results have also been considered, which, together with those of environmental samples, has allowed us to infer about the factors that intervene in the behavior of PFAAs. The presence of PFAAs is determined primarily by the source of pollution. Salinity is as well shown as a significant condition, dependent too on the sampling environment. The analysis of PFAAs from environmental samples constitutes a fundamental tool for the surveillance of these pollutants, but the lack of homogeneity of protocols for sampling, as well as for the results presentation, limits the comparative capacity. Laboratory studies are also an essential tool in the analysis of particular aspects related to PFAAs, but many times the conditions tested are not environmentally significant. In this way, it would not be prudent to establish "paradigms" about the behavior of the PFAAs in certain areas or organisms, instead to suggest the points that can be considered fundamental for each issue addressed. The main variables that appear to intervene in estuarine and coastal regions are mainly the proximity to the source of pollution, salinity, pH, precipitation (rain) as well as types of PFAAs. All these can synergistically lead to different impacts on the ecosystem. Therefore, the particular risks of PFAAs in estuarine and coastal regions is a set of multiple variables, dependent on each sampling condition and according to the previously named parameters.
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http://dx.doi.org/10.1016/j.scitotenv.2020.144584DOI Listing
May 2021

Enhancing the Stability of Medium Range and Misalignment Wireless Power Transfer System by Negative Magnetic Metamaterials.

Materials (Basel) 2020 Dec 14;13(24). Epub 2020 Dec 14.

State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

The misalignment of the resonant coils in wireless power transfer (WPT) systems causes a sharp decrease in transfer efficiency. This paper presents a method which improves the misalignment tolerance of WPT systems. Based on electromagnetic simulations, the structural unit parameters of the electromagnetic material were extracted, and an experimental prototype of a four-coil WPT system was built. The influence of electromagnetic metamaterials on the WPT system under the conditions of lateral misalignment and angular offset was investigated. Experiments showed that the transfer efficiency of the system could be maintained above 45% when the transfer distance of the WPT system with electromagnetic metamaterials was 1 m and the resonant coils were shifted laterally within one coil diameter. Furthermore, the system transfer efficiency could be stabilized by more than 40% within an angle variation range of 70 degrees. Under the same conditions, the transfer efficiency of a system without electromagnetic metamaterials was as low as 30% when lateral migration occurred, and less than 25% when the angle changed. This comparison shows that the stability of the WPT system loaded with electromagnetic metamaterials was significantly enhanced.
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http://dx.doi.org/10.3390/ma13245695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764840PMC
December 2020

Xiaoyao Pills Attenuate Inflammation and Nerve Injury Induced by Lipopolysaccharide in Hippocampal Neurons In Vitro.

Neural Plast 2020 21;2020:8841332. Epub 2020 Sep 21.

Department of Pharmacology, College of Pharmacy, Chengdu University of TCM, Chengdu City, Sichuan Province 611137, China.

Lipopolysaccharides (LPS) are proinflammation mediators that can induce the inflammatory model of the hippocampal neuron, and neuroinflammation participates in the pathophysiology of depression. Xiaoyao Pill is a classical Chinese medicine formula that has been used for the treatment of mental disorders such as depression in China since the Song dynasty. We established a hippocampal neuronal cell inflammation model by LPS and investigate the intervention effect and mechanism of Xiaoyao Pills. The expression levels of IL-6, TNF-, IDO, 5-HT, brain-derived neurotrophic factor, and -nerve growth factor were detected by enzyme-linked immunosorbent assay. mRNA levels of IL-6, TNF-, 5-HT1A, IDO-1, brain-derived neurotrophic factor, nerve growth factor, tropomyosin receptor kinase B, tropomyosin receptor kinase A, and cAMP response element-binding protein were detected by reverse transcription-polymerase chain reaction. To further validate, protein expression was determined by western blot and immunofluorescence. Lipopolysaccharide-induced neuroinflammatory state resulted in the release of IL-6, TNF-, and IDO and a decrease of BDNF, NGF, TrkB, TrkA, CREB, p-CREB, p-CREB/CREB, and SYP and inhibited hippocampal neurogenesis in the hippocampal neuron. Xiaoyao Pills significantly decreased the levels of IL-6, TNF-, and IDO in cell supernatant and increased the expression of BDNF, NGF, TrkB, TrkA, CREB, p-CREB, p-CREB/CREB, and SYP as well as the average optical density of BrdU/NeuN double-labelled positive cells. Our study shows that lipopolysaccharides induce inflammation and nerve damage in hippocampal neurons, which are closely related to the pathological mechanism of depression. Xiaoyao Pills (XYW) play an important neuroprotective effect, which is related to its inhibition of neuronal inflammation and promoting the recovery of nerve injury. These results provide a pharmacologic basis for the treatment of depression of XYW in clinical application.
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http://dx.doi.org/10.1155/2020/8841332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525321PMC
September 2021

Spatiotemporal dynamics of hemorrhagic fever with renal syndrome in Jiangxi province, China.

Sci Rep 2020 08 31;10(1):14291. Epub 2020 Aug 31.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

Historically, Jiangxi province has had the largest HFRS burden in China. However, thus far, the comprehensive understanding of the spatiotemporal distributions of HFRS is limited in Jiangxi. In this study, seasonal decomposition analysis, spatial autocorrelation analysis, and space-time scan statistic analyses were performed to detect the spatiotemporal dynamics distribution of HFRS cases from 2005 to 2018 in Jiangxi at the county scale. The epidemic of HFRS showed the characteristic of bi-peak seasonality, the primary peak in winter (November to January) and the second peak in early summer (May to June), and the amplitude and the magnitude of HFRS outbreaks have been increasing. The results of global and local spatial autocorrelation analysis showed that the HFRS epidemic exhibited the characteristic of highly spatially heterogeneous, and Anyi, Fengxin, Yifeng, Shanggao, Jing'an and Gao'an county were hot spots areas. A most likely cluster, and two secondary likely clusters were detected in 14-years duration. The higher risk areas of the HFRS outbreak were mainly located in Jiangxi northern hilly state, spreading to Wuyi mountain hilly state as time advanced. This study provided valuable information for local public health authorities to design and implement effective measures for the control and prevention of HFRS.
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http://dx.doi.org/10.1038/s41598-020-70761-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458912PMC
August 2020
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