Publications by authors named "XiaoYu Gu"

44 Publications

Improving the flame retardancy and accelerating the degradation of poly (lactic acid) in soil by introducing fully bio-based additives.

Int J Biol Macromol 2021 Oct 22. Epub 2021 Oct 22.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China; Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing, China. Electronic address:

In this study, a novel bio-based flame retardant LC-PA is prepared by the Mannich reaction between phytic acid (PA) and L-citrulline (LC). LC-PA is combined with tannic acid (TA) and introduced into PLA to improve fire performance and accelerate biodegradability. Compared with control PLA, the PLA composite containing 10% LC-PA/TA increases the LOI value to 26.9%, reaches a V-0 rating in the UL-94 test, and reduces the peak heat release rate and total heat release by 24.5% and 21.1%, respectively. More importantly, the introduction of LC-PA/TA accelerates the degradation rate of PLA in soil, which is of significance for biodegradable materials. The addition of LC-PA/TA can attract water and provide a suitable energy source for microbial proliferation, accelerating the hydrolysis and microbial degradation of PLA. This work provides a practical approach for high flame retardancy and rapid biodegradability in the soil to the bio-based polymer.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.10.119DOI Listing
October 2021

Phototherapy for atopic dermatitis: Systematic review and network meta-analysis of randomized controlled trials.

Photodermatol Photoimmunol Photomed 2021 Oct 15. Epub 2021 Oct 15.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Background: Phototherapies could represent an efficient option for the treatment of atopic dermatitis (AD), but the evidences available for clinical choices were contradictory.

Objective: This study aimed to evaluate the efficacy of different phototherapies on AD.

Methods: This systematic review and network meta-analysis included randomized controlled trials (RCTs) through searching keywords from PubMed, EMBASE, and the Cochrane library. We summarized different phototherapy types and scoring systems. Scoring Atopic Dermatitis (SCORAD) absolute score changes were estimated by mean differences (MDs) and standard deviations (SDs) and then included in the network meta-analysis. The effect sizes of comparison of different phototherapies were presented as MDs and 95% confidence intervals (CIs). Egger's test was used to evaluate publication bias.

Results: Eleven RCTs were included in the systematic review and 4 studies in the network meta-analysis. Based on the pooled estimates, medium-dose ultraviolet A1 (UVA1) cold light was superior to medium-dose UVA1 (MD 8.92; 95% CI: 5.60-12.24) but no significant difference between high-dose (UVA1) and medium-dose UVA1 cold light (MD 0.66; 95% CI: -5.57 to 6.90). Publication bias was not supported by Egger's test (P = .168).

Conclusions: Due to possible long-term adverse effects of high-dose UVA1, medium-dose UVA1 cold light appears to be the superior form for AD.
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http://dx.doi.org/10.1111/phpp.12741DOI Listing
October 2021

Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury.

Brain Res 2021 Oct 9;1773:147685. Epub 2021 Oct 9.

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

The outer mitochondrial membrane protein mitochondrial Rho-GTPase 1 (Miro1) is known to be involved in the regulation of mitochondrial transport required for neuronal protection. Previous reports established that disruption of Miro1-dependent mitochondrial movement could result in nervous system diseases such as Parkinson's disease and Alzheimer's disease. This study was designed to explore the expression and mechanisms of Miro1 in secondary brain injury after traumatic brain injury (TBI). A total of 115 male Sprague Dawley rats were used in the weight-drop TBI rat model, and Miro1 in vivo knockdown was performed 24 h before TBI modeling by treatment with Miro1 short-interfering RNA. Real-time polymerase chain reaction, western blot, immunofluorescence, adenosine triphosphate (ATP) level assay, neuronal apoptosis, brain water content measurement, and neurological score analyses were carried out. Our results showed that the mRNA and protein levels of Miro1 were increased after TBI and co-localized with neurons and astrocytes in the peri-injury cortex. Moreover, Miro1 knockdown further exacerbated neuronal apoptosis, brain edema, and neurological deficits at 48 h after TBI, accompanied by impaired mitochondrial transport, reduction of mitochondria number and energy deficiency. Additionally, the apoptosis-related factors Bax upregulation and Bcl-2 downregulation as Miro1 knockdown after TBI implied that antiapoptotic effects on neuroprotection of Miro1, which were verified by the Fluoro-Jade C (FJC) staining and TUNEL staining. In conclusion, these findings suggest that Miro1 probably plays a neuroprotective role against secondary brain injury through the mitochondria trafficking pathway, suggesting that enhancing Miro1 might be a new strategy for the treatment of TBI.
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http://dx.doi.org/10.1016/j.brainres.2021.147685DOI Listing
October 2021

Association Between Inflammatory Bowel Disease and Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.

Inflamm Bowel Dis 2021 Sep 30. Epub 2021 Sep 30.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

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http://dx.doi.org/10.1093/ibd/izab240DOI Listing
September 2021

Exposure to black carbon is associated with symptoms of depression: A retrospective cohort study in college students.

Environ Int 2021 12 14;157:106870. Epub 2021 Sep 14.

Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Background: Previous studies have revealed a significant association of fine particulate matter (PM) with emotional disorders. However, as a crucial component of PM, little is known about the potential effect of exposure to black carbon (BC) on the symptoms of depression and anxiety.

Objectives: To explore the associations of long-term exposure to BC during the past six years with the current symptoms of depression and anxiety in a group of incoming college students.

Methods: This was a retrospective cohort study of incoming students in five universities of China. Symptoms of depression and anxiety during the past two weeks were measured by the Patient Health Questionnaire-2 (PHQ-2) and Generalized Anxiety Disorder Scale-2 (GAD-2), respectively. Levels of BC and other environmental factors during 2013 ∼ 2018 (six years prior to the recruitment) was obtained from public repositories and linked to individual data by home addresses. Averagely daily dose of BC exposure was estimated according to the respiratory rate. Demographic and behavioral variables were collected through a questionnaire. The associations of BC with symptoms of depression and anxiety were estimated by mixed linear models adjusting for socioeconomic and behavioral characteristics, and the principal components of multiple environmental exposures. Subgroup analysis was conducted to assess the effect modification by covariates. Overall effect of environmental mixture was evaluated by weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR).

Results: A total of 20,079 participants was included in the current study. After adjustment for covariates, long-term BC exposure was significantly associated with symptoms of depression (β = 0.17, P < 0.001) but not anxiety (β = 0.07, P = 0.125). Effect modification by sex and parental educational level: BC was correlated with depressive symptoms in women (β = 0.23, P < 0.001) but not in men (β = 0.04, P = 0.581), and higher educational level was associated with decreased effect sizes of BC. Sensitivity analysis showed that the acute and short-term effects of BC on depression was consistent with its long-term exposure (β varied from 0.18 to 0.20). WQS identified BC as the primary pollutant in association with symptoms of depression but not anxiety. BKMR identified no significant interaction between BC and other exposures.

Conclusion: Exposure to BC is associated with symptoms of depression but not anxiety in college students, and the relationship is modified by sex and education.
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http://dx.doi.org/10.1016/j.envint.2021.106870DOI Listing
December 2021

Laser-assisted photodynamic therapy vs. conventional photodynamic therapy in non-melanoma skin cancers: Systematic review and meta-analysis of randomized controlled trials.

Photodermatol Photoimmunol Photomed 2021 Jun 2. Epub 2021 Jun 2.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

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http://dx.doi.org/10.1111/phpp.12700DOI Listing
June 2021

Magnesium Ammonium Phosphate Composite Cell-Laden Hydrogel Promotes Osteogenesis and Angiogenesis .

ACS Omega 2021 Apr 2;6(14):9449-9459. Epub 2021 Apr 2.

Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.

Injectable hydrogels provide an effective strategy for minimally invasive treatment on irregular bony defects in the maxillofacial region. To improve the osteoinduction of gelatin methacrylate (GelMA), we fabricated a three-dimensional (3D) culture system based on the incorporation of magnesium ammonium phosphate hexahydrate (struvite) into GelMA. The optimal concentration of struvite was investigated using the struvite extracts, and 500 μg mL was found to be the most suitable concentration for the osteogenesis of dental pulp stem cells (DPSCs) and angiogenesis of human umbilical vein endothelial cells (HUVECs). We prepared the GelMA composite (MgP) with 500 μg mL struvite. Struvite did not affect the cross-linking of GelMA and released Mg during degradation. The cell delivery system using MgP improved the laden-cell viability, upregulated the expression of osteogenic and angiogenic-differentiation-related genes, and promoted cell migration. Overall, the modifications made to the GelMA in this study improved osteoinduction and demonstrated great potential for application in vascularized bone tissue regeneration.
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http://dx.doi.org/10.1021/acsomega.0c06083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047646PMC
April 2021

Differentiation between renal oncocytomas and chromophobe renal cell carcinomas using dynamic contrast-enhanced computed tomography.

Abdom Radiol (NY) 2021 07 12;46(7):3309-3316. Epub 2021 Mar 12.

Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing, 210029, Jiangsu, China.

Purpose: To evaluate the ability of inferior vena cava-lesion-attenuation-difference (ILAD) and lesion-cortex-attenuation-ratio (LCAR) to differentiate renal oncocytomas (RO) from chromophobe renal cell carcinomas (chRCC).

Methods: Retrospective study with analysis of 84 cases of chRCC and 30 cases of RO confirmed by surgical pathology. ILAD was calculated by measuring the difference in Hounsfield units (HU) between the inferior vena cava and the lesion of interest on the same image slice on preoperative CT scan. Calculating LCAR using the CT attenuation ratio of lesion to renal cortex at the same image slice. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic values of ILAD and LCAR for disease activity.

Results: There were no statistically significant differences in demographic and lesion characteristics between patients with chRCC and RO (p > 0.05). ILAD has significant statistical differences in the identification of RO and chRCC in the arterial (p = 0.031), venous (p = 0.047), and delayed phase (p = 0.002). And LCAR showed a statistically significant difference between two lesions during the arterial (p = 0.043), venous (p = 0.026), and delayed phase (p = 0.008). When all significant variables were used in combination to build a predicting model (Mix), the AUC was 0.871 (95% CI 0.759-0.984) with 67.9% sensitivity and 100% specificity.

Conclusion: ILAD and LCAR at the arterial phase, venous phase and delayed phase were shown to be useful CT attenuation parameter in discriminating RO from chRCC when histologic evaluation on biopsy is indeterminate.
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http://dx.doi.org/10.1007/s00261-021-03018-7DOI Listing
July 2021

Neuroprotective effect of hydrogen sulfide against glutamate-induced oxidative stress is mediated via the p53/glutaminase 2 pathway after traumatic brain injury.

Aging (Albany NY) 2021 02 26;13(5):7180-7189. Epub 2021 Feb 26.

Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, P.R. China.

Several reports suggest that hydrogen sulfide (HS) exerts multiple biological and physiological effects on the pathogenesis of traumatic brain injury (TBI). However, the exact molecular mechanism involved in this effect is not yet fully known. In this study, we found that HS alleviated TBI-induced motor and spatial memory deficits, brain pathology, and brain edema. Moreover, sodium hydrosulfide (NaHS), an HS donor, treatment markedly increased the expression of Bcl-2, while inhibited the expression of Bax and Cleaved caspase-3 in TBI-challenged rats. Tunnel staining also demonstrated these results. Treatment with NaHS significantly reduced the glutamate and glutaminase 2 (GLS-2) protein levels, and glutamate-mediated oxidative stress in TBI-challenged rats. Furthermore, we demonstrated that HS treatment inhibited glutamate-mediated oxidative stress through the p53/GLS-2 pathway. Therefore, our results suggested that HS protects brain injury induced by TBI through modulation of the glutamate-mediated oxidative stress in the p53/GLS-2 pathway-dependent manner.
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http://dx.doi.org/10.18632/aging.202575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993660PMC
February 2021

Gemini Surfactant with Unsaturated Long Tails for Viscoelastic Surfactant (VES) Fracturing Fluid Used in Tight Reservoirs.

ACS Omega 2021 Jan 8;6(2):1593-1602. Epub 2021 Jan 8.

School of Petroleum Engineering, China University of Petroleum (East China), Qingdao, Shandong 266555, China.

The high dosage of surfactant terribly restrains the extensive application of viscoelastic surfactant (VES) fracturing fluid. In this study, a novel gemini surfactant (GLO) with long hydrophobic tails and double bonds was prepared and a VES fracturing fluid with a low concentration of GLO was developed. Because of the long tails bending near the double bonds, there is a significant improvement of the surfactant aggregate architecture, which realized the favorable viscosity of the VES fluid at a more economical concentration than the conventional VES fracturing fluids. Fourier transform infrared spectrometry (FT-IR), nuclear magnetic resonance spectrometry (H NMR, C NMR), and high-resolution mass spectrometry (HRMS) were employed to study the formation of the product and the structure of GLO. The designed GLO was produced according to the results of the structure characterizations. The formula of the VES fracturing fluid was optimized to be 2.0 wt % GLO + 0.4 wt % sodium salicylate (NaSal) + 1.0 wt % KCl based on the measurements of the viscosity. The viscosity of the VES fluid decreased from 405.5 to 98.7 mPa·s as the temperature increased from 18 to 80 °C and reached equilibrium at about 70.2 mPa·s. The VES fluid showed a typical elastic pseudoplastic fluid with a yield stress of 0.5 Pa in the rheological tests. It realized a proppant setting velocity as low as 0.08 g/min in the dynamic proppant transport test carried by GLO-based VES fracturing fluid. Compared to the formation water, the filtrate of the VES fracturing fluid decreased the water contact angle (CA) from 56.2 to 45.4° and decreased the water/oil interfacial tension (IFT) from 19.5 to 1.6 mN/m. Finally, the VES fracturing fluid induced a low permeability loss rate of 10.4% and a low conductivity loss rate of 5.4% for the oil phase in the experiments of formation damage evaluation.
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http://dx.doi.org/10.1021/acsomega.0c05450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818589PMC
January 2021

Fully Inorganic CsSnI-Based Solar Cells with >6% Efficiency and Enhanced Stability Enabled by Mixed Electron Transport Layer.

ACS Appl Mater Interfaces 2021 Jan 31;13(1):1345-1352. Epub 2020 Dec 31.

Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania 16802, United States.

Fully inorganic black orthorhombic (B-γ) CsSnI has become a promising candidate for perovskite solar cell (PSC) thanks to its low toxicity and decently high theoretical power conversion efficiency (PCE). However, so far, the reported PCE of the B-γ CsSnI PSC is still not comparable with its lead-based or organotin-based counterparts. Herein, a mixed electron transport layer (ETL) composed of ZnO nanoparticles (NPs) and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) is incorporated into inverted B-γ CsSnI PSCs. The mixed ETL exhibits the merits of both ZnO and PCBM. The highest PCE of 6.08% was recorded for the PSC with mixed ZnO-PCBM ETL, which is 34.2% higher than that of the device with plain PCBM ETL (PCE of 4.53%) and 28.8% superior to that of plain ZnO ETL-based device (PCE of 4.72%). Meanwhile, the mixed ZnO-PCBM ETL-based PSC retained 71% of its initial PCE under inert conditions at room temperature after 60 days of storage and maintained 67% PCE after 20 days of storage under ambient air at 30% relative humidity and room temperature.
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http://dx.doi.org/10.1021/acsami.0c16634DOI Listing
January 2021

Self-intumescent polyelectrolyte for flame retardant poly (lactic acid) nonwovens.

J Clean Prod 2021 Feb 2;282:124497. Epub 2020 Oct 2.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, China.

The demand for eco-friendly poly (lactic acid) (PLA) nonwovens grows at a high rate in the past several decades, however, only a little attention has been received for flame retardant PLA nonwoven fabrics. In this work, a novel halogen-free self-intumescent polyelectrolyte tris (hydroxymethyl)-aminomethane polyphosphate (APTris) was synthesized by reacting ammonium polyphosphate with tris (hydroxymethyl) aminomethane, and was then used to improve the fire resistance of PLA nonwovens via a dip-nip process. The flammability characterization indicated the limiting oxygen index value was increased to 30.0% from 18.3%, and the damaged area in the vertical burning test was reduced by about 87.0% by the presence of APTris. The cone calorimeter test results revealed that the peak heat release rate and total heat release of the treated sample were decreased by 41.0% and 28.2% respectively compared with that of the control PLA nonwoven sample. The char residue was increased to 12.3 from 1.7 wt % at 800 °C. It is suggested that the dense char barrier formed at the presence of APTris prevents heat, smoke, and gas transfer, and hence enhance thermal dilatability and flame retardancy of PLA nonwovens. This simple sustainable halogen-free treatment has great potential to produce cleaner commercialized flame-retardant PLA nonwovens.
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http://dx.doi.org/10.1016/j.jclepro.2020.124497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529633PMC
February 2021

Combination of targeted UVB phototherapy and calcipotriene versus targeted UVB alone in psoriasis: systematic review and meta-analysis of randomized controlled trials.

J Dermatolog Treat 2020 May 28:1-5. Epub 2020 May 28.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

: Targeted UVB and topical calcipotriene have frequently been used in the treatment of psoriasis, but the joint effect of calcipotriene and targeted UVB has been controversial.: The purpose of this study was to systematically evaluate whether the efficacy of the combined use of targeted UVB and calcipotriene is superior to the targeted UVB alone.: We performed systematic review and meta-analysis of randomized controlled trials (RCTs) in patients with plaque-type psoriasis through searching the defined key words in the PubMed, EMBase, and Cochrane Central Register databases. Pooled mean difference of the Psoriasis Area and Severity Index (PASI) relative change (%) was estimated using a random effect model. The quality of included studies and publication bias were assessed using the Jadad scale and the Egger's test, respectively.: A total of five RCTs including 182 patients were included in the systematic review. The mean difference of the PASI relative change (%) between the combined therapy versus the targeted UVB alone was -22.68 (95%CI: -37.12 to -8.24;  = .002). Publication bias was not supported by the Egger's test ( = .424).: Addition of calcipotriene ointment may improve the efficacy of the targeted UVB phototherapy in the treatment of plaque-type psoriasis.
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http://dx.doi.org/10.1080/09546634.2020.1770177DOI Listing
May 2020

Diagnostic accuracy of unenhanced CT texture analysis to differentiate mass-forming pancreatitis from pancreatic ductal adenocarcinoma.

Abdom Radiol (NY) 2020 05;45(5):1524-1533

Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Purpose: To investigate the value of texture analysis on unenhanced computed tomography (CT) to potentially differentiate mass-forming pancreatitis (MFP) from pancreatic ductal adenocarcinoma (PDAC).

Methods: A retrospective study consisting of 109 patients (30 MFP patients vs 79 PDAC patients) who underwent preoperative unenhanced CT between January 2012 and December 2017 was performed. Synthetic minority oversampling technique (SMOTE) algorithm was adopted to reconstruct and balance MFP and PDAC samples. A total of 396 radiomic features were extracted from unenhanced CT images. Mann-Whitney U test and minimum redundancy maximum relevance (MRMR) methods were used for the purpose of dimension reduction. Predictive models were constructed using random forest (RF) method, and were validated using leave group out cross-validation (LGOCV) method. Diagnostic performance of the predictive model, including sensitivity, specificity, accuracy, positive predicting value (PPV), and negative predicting value (NPV), was recorded.

Results: We applied 200% of SMOTE to MFP and PDAC patients, resulting in 90 MFP patients compared with 120 PDAC patients. Dimension reduction steps yielded 30 radiomic features using Mann-Whitney U test and MRMR methods. Ten radiomic features were retained using RF method. Four most predictive parameters, including GreyLevelNonuniformity_angle90_offset1, VoxelValueSum, HaraVariance, and ClusterProminence_AllDirection_offset1_SD, were used to generate the predictive model with preferable 92.2% sensitivity, 94.2% specificity, 93.3% accuracy, 92.2% PPV, and 94.2% NPV. Finally, in LGOCV analysis, a high pooled mean sensitivity, specificity, and accuracy (82.6%, 80.8%, and 82.1%, respectively) indicate a relatively reliable and stable predictive model.

Conclusions: Unenhanced CT texture analysis can be a promising noninvasive method in discriminating MFP from PDAC.
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http://dx.doi.org/10.1007/s00261-020-02506-6DOI Listing
May 2020

Time-resolved in situ monitoring of photocatalytic reactions by probe electrospray ionization mass spectrometry.

Analyst 2020 May 20;145(9):3313-3319. Epub 2020 Mar 20.

School of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, Liaoning, China.

Probe electrospray ionization mass spectrometry (PESI-MS) has been demonstrated to be a useful in situ and online analytical technique for monitoring of various reactions. In this work, PESI-MS with a surface-modified probe was adopted and applied to in situ monitoring of photocatalytic reactions. Typical reactions of semiconductor photocatalysts, namely TiO, SnO, WO, SiC and ZnS catalyzed methylene blue (MB) and brilliant green (BG) degradation, were selected to demonstrate the potential of PESI-MS to monitor heterogeneous photocatalytic reactions occurring in suspensions. Surface modification of the probe ensures increased wettability during the whole monitoring process. PESI-MS could provide continuous sampling and real-time MS results without time-consuming and cumbersome sample pretreatments. This method has other merits including good reproducibility and stability (time scale > 60 min), convenience of operation, low sample consumption, high time resolution and high tolerance to suspended photocatalyst particles. Time-resolved mass spectra and ion chromatograms of every chemical species e.g. the substrate and reactive intermediates could be obtained, which is helpful for a better understanding of the photocatalytic reaction process. Thus, PESI-MS could be a versatile analytical technique for in situ photocatalytic reaction analysis and could be an alternative means for the evaluation of photocatalyst performance.
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http://dx.doi.org/10.1039/d0an00305kDOI Listing
May 2020

Physicochemical characterization and bile acid-binding capacity of water-extract polysaccharides fractionated by stepwise ethanol precipitation from Caulerpa lentillifera.

Int J Biol Macromol 2020 May 18;150:654-661. Epub 2020 Feb 18.

College of Light Industry and Food Engineering, Guangxi University, No. 100, Daxue Road, Nanning, Guangxi 530004, China; Department of Food Science and Technology, South China University of Technology, No. 381 Wushan Road, Guangzhou, Guangdong 510640, China. Electronic address:

Herein, water-extracted Caulerpa lentillifera polysaccharides were structurally characterized and their bile acid-binding capacities were investigated. WCLP-25, WCLP-40, WCLP-55, WCLP-70, and WCLP-85 were obtained by graded ethanol precipitation with ethanol concentrations of 25%, 40%, 55%, 70%, and 85%. The total carbohydrate, protein, uronic acid and sulfate contents as well as the monosaccharide composition, molecular weight, and rheological properties were determined. Their infrared spectra, thermogravimetric curves, and scanning electron microscopy (SEM) images were acquired. The hypolipidaemic effects of the WCLPs were assessed with in vitro simulated bile acid-binding capacity experiments. The WCLPs are high-molecular-weight sulfated heteropolysaccharides, and the ethanol concentration significantly influenced the physicochemical properties of the extract. The bile acid-binding capacities of WCLP-55 and WCLP-70 were significantly higher than those of the other tested WCLP samples, which may be due to their higher neutral sugar, uronic acid and sulfate contents or due to their higher viscosities and a larger sheet structure based on SEM. This study will broaden the sources of raw materials for functional foods and provide a reference for the scientific use of C. lentillifera.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.02.121DOI Listing
May 2020

The preparation of starch derivatives reacted with urea-phosphoric acid and effects on fire performance of expandable polystyrene foams.

Carbohydr Polym 2020 Apr 8;233:115841. Epub 2020 Jan 8.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China; Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing, China. Electronic address:

A novel bio-based flame retardant, ammonium phosphate starch carbamates (APSC) was synthesized from starch, phosphoric acid and urea to achieve better thermal stability and char formation. Flame retardant expandable polystyrene foams (EPS) were prepared by coating method with APSC. The fire resistance evaluation of EPS composites by limiting oxygen index (LOI), vertical burning (UL-94) and cone calorimeter tests indicated that the addition of 47 wt.% of APSC enhanced the LOI from 17.6%-35.2%, with V-0 rating in UL-94, and decreased the peak heat release rate from 666 kW/m to 316 kW/m. Moreover, the total smoke production was also sharply decreased from 70 m of pure EPS to 17 m. By the presence of APSC, the substantial char formation prevented the heat and oxygen transfer, and interrupted the releasing of flammable products, thus protecting the EPS foam from burning.
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http://dx.doi.org/10.1016/j.carbpol.2020.115841DOI Listing
April 2020

Copy number variations primed lncRNAs deregulation contribute to poor prognosis in colorectal cancer.

Aging (Albany NY) 2019 08 22;11(16):6089-6108. Epub 2019 Aug 22.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Copy number variations (CNVs) are crucial genetic change elements in malignancies, and lncRNAs deregulation induced by genomic and epigenomic aberrations plays key driving role in tumorigenesis, including colorectal cancer (CRC). However, effects of CNVs associated with lncRNAs in CRC is largely unknown. Here, we perform integrative analysis considering messenger RNA expression levels, DNA methylation and DNA copy numbers from 289 cases of CRC specimens. There are five prognostic subtypes of CRC determined by multi-omics integration, and differentially expressed lncRNAs (DE-lncRNAs) are acquired among five subtypes and normal cases. Finally, CNVs pattern matched with DE-lncRNAs reveals a signature including 10 lncRNAs (LOC101927604, LOC105377267, CASC15, LINC-PINT, CLDN10-AS1, C14orf132, LMF1, LINC00675, CCDC144NL-AS1, LOC284454), conspicuously contributing to poor prognosis in CRC, which can be validated in another independent dataset. Together, our research is interested in copy number changes relevant with lncRNAs, not only expending the spectrum of CNVs, but also perfecting the regulation network of lncRNAs in CRC. The main purpose is to provide novel biomarkers for prognostic managements of CRC patients.
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http://dx.doi.org/10.18632/aging.102168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738420PMC
August 2019

The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):3329-3337

a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.

The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation of TLR2 signaling pathway is involved in enhancing tissue vascularization and wound healing. However, the mechanisms underlying the therapeutic effects of TLR2 on regulating bone marrow stromal cells (BMSCs) mediated periodontal bone tissue regeneration still need to be further investigated. In this study, we tested the effect of TLR2 on regulating BMSCs mediated alveolar bone regeneration by establishing a TLR2 gene-modified canine BMSCs using a lentivirus. Activation of TLR2 significantly enhanced the expression of hypoxia-inducible factor-1α (HIF-1α) and bone morphogenetic protein 2 (BMP-2) and then upregulated the expression of their downstream osteogenic and angiogenic related gene in BMSCs. TLR2-BMSCs mediated bone regeneration in canine tooth extraction sockets under an inflammatory environment demonstrated that activation of the TLR2 signaling pathway significantly stimulated BMSCs meditated angiogenesis and osteogenesis.
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http://dx.doi.org/10.1080/21691401.2019.1626867DOI Listing
December 2019

Experimental and mechanism study: Partially hydrolyzed polyacrylamide gel degradation and deplugging via ultrasonic waves and chemical agents.

Ultrason Sonochem 2019 Sep 9;56:350-360. Epub 2019 Apr 9.

Department of Chemistry, University of Turbat (KECH), 92600 Balochistan, Pakistan.

Partially hydrolyzed Polyacrylamide (PHPAM) crosslinked by Cr is frequently applied to plug thief zone for the better water management in matured oil reservoir. However, PHPAM gel may certainly cause inevitable formation damage nearby the wellbore. Although various kinds of chemical agents, such as hydrogen peroxide (HO), sodium hypochlorite (NaOCl), and chlorine dioxide (ClO) were employed to mitigate the nearby wellbore damage. But, huge financial investment, poor degelation efficiency, environmentally insecure, corrosion problem, and long time span requirement persuade researchers to look for other effective technique. In this connection, ultrasonic waves is characterized by reliable, environment friendly, and cost effective technology. Current work involves comparative study of PHPAM gel degradation by the individual means of chemical agent and ultrasonic waves. Subsequently, the best-performed ultrasonic parameters and well-performed chemical agent were used independently and then simultaneously to deplug (PHPAM gel) the core sample. Results showed that 20 KHz frequency (1000 W) effectively reduced gel viscosity from original (2495 mPa.s) to 1.37 mPa.s after 10 min irradiation. This degradation is attributed to cavitation, heat energy, and hydroxyl radical (HO∙). However, after 2 min further exposure, the viscosity grew back to 3.29 mPa.s (18 KHz), 1.42 mPa.s (20 KHz), and 3.74 mPa.s (25 KHz). This adverse behavior is owing to hydroxyl radical (HO∙) annihilation. In chemical treatment, HO among other chemicals efficiently degelled the PHPAM gel's original viscosity to 2.64 mPa.s after 24 h reaction. Similarly, NaOCl and ClO brought down original viscosity to 6.5 mPa.s and 159 mPa.s respectively. SEM of the samples before and after treatment was performed for the better understanding of PHPAM gel morphology. Considering dynamic experiment, maximum 23.5% and 19.80% damaged permeability recovery (30 × 10 μm gas permeability) were obtained by applying ultrasonic waves (20 KHz, 1000 W, and 100 min irradiation) and chemical agent (HO) respectively. Permeability recovery was further increased to 40.90% by the simultaneous application of ultrasonic waves and chemical agent.
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http://dx.doi.org/10.1016/j.ultsonch.2019.04.018DOI Listing
September 2019

Factors that Influence Direction Deviation in Freehand Implant Placement.

J Prosthodont 2019 Jun 8;28(5):511-518. Epub 2019 May 8.

Department of Prosthodontics, 9th People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, P.R. China.

Purpose: This retrospective study investigates the accuracy of freehand implant placement and whether the factors of presence of an adjacent tooth, implant quadrant, number of missing teeth, and location of the implant site influence direction and angulation deviations.

Materials And Methods: According to specific inclusion and exclusion criteria, a total of 112 implants from 75 partially edentulous patients were recruited for this retrospective study. The implants were inserted using a freehand approach by one experienced clinician (right-handed). The full thickness flap was elevated to expose the alveolar bone in the implant surgery, and the implant crown consisted of an all-ceramic restoration retained by cement. The planned implant position was preoperatively determined using implant planning software. The postoperative implant position was determined by analyzing the alignment after optically scanning the dentition using a specifically designed registration model in Geomagic Studio software. The deviations between the planned and postoperative implant positions were then calculated. The outcomes included direction and angulation deviations between the planned and postoperative implant positions. All data were analyzed by ANOVA, Bonferroni correction, regression analysis, and one-sample t-tests conducted using SPSS.

Results: The 3D deviations between planned and postoperative implant positions were 1.22 ± 0.63 mm at the entrance point, 1.91 ± 1.17 mm at the apical point, and 7.93 ± 5.56° in angulation. The presence of adjacent teeth influenced deviations in the mesiodistal (F = 4.338, p = 0.006) and buccolingual directions (F = 3.017, p = 0.033) at the entrance point and mesiodistal angulation (F = 7.979, p < 0.001). The quadrant influenced deviation in the buccolingual direction at the apical point (F = 6.093, p = 0.001) and buccolingual angulation (F = 6.457, p < 0.001). The number of missing teeth had no effect on deviations of direction and angulation of implants. The location of the implant site affected the deviation in the buccolingual direction at the entrance point (F = 3.096, p = 0.049) and the mesiodistal direction at the apical point (F = 3.724, p = 0.027).

Conclusion: The 3D accuracy of freehand-placed implants could be acceptable in clinical situations. The results showed that the presence of an adjacent tooth and the quadrant and the location of the implant site influenced the direction and angulation deviations of the implant position; however, the factor of number of missing teeth did not.
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http://dx.doi.org/10.1111/jopr.13065DOI Listing
June 2019

Accuracy of the evaluation of implant position using a completely digital registration method compared with a radiographic method.

J Prosthet Dent 2019 Dec 9;122(6):537-542. Epub 2019 Apr 9.

Professor, Department of Prosthodontics, 9th People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, PR China. Electronic address:

Statement Of Problem: Conventional radiographic methods are widely used to evaluate the clinical accuracy of implant position. However, such methods require a second computerized tomography (CT) scan and manual registration between presurgical and postsurgical CT data. The alignment errors cannot be calculated.

Purpose: The purpose of this clinical study was to introduce a completely digital registration method to evaluate the clinical accuracy of implant position. The digital registration method was then compared with the radiographic method in evaluating accuracy. Some of the alignment errors produced in the digital registration procedures were recorded.

Material And Methods: A total of 32 implants from 19 patients with sufficient bone volume were enrolled in the study, and all implant surgeries were conducted by one experienced practitioner. Before the surgery, a cone beam computerized tomography (CBCT) scan was made for each patient along with a diagnostic impression to design the ideal implant position using the Simplant software. After the surgery, the postsurgical implant position was determined using an optical scan of the dentition cast and a series of custom registration models (the digital registration method). A simulated cylinder was designed using the Geomagic Studio software to represent the implant, and the deviation of the ideal and postsurgical implant position was calculated. The accuracy evaluated by the 2 methods was also compared. The parameters of the entrance point, apical point, and axis were recorded for each implant. A part of the alignment errors in the digital registration was calculated automatically and recorded. One sample t test and paired t test were conducted by using a statistical software program.

Results: The mean deviation between the ideal and postsurgical implant positions evaluated using the digital registration method was 0.84 ±0.57 mm for the entrance point, 1.03 ±0.78 mm for the apical point, and 4.52 ±2.37 degrees for the angulation. No significant difference was found between the accuracy evaluated by the digital registration method and the radiographic method (P>.05). In the digital registration procedure, the alignment error was 0.03 mm for the registration model and 0.29 mm for the dentition. Significant differences were found in the alignment procedure of the impression cylinder (P<.001) and dentition (P<.001). The average positive and negative errors were +0.09 and -0.19 mm for the simulated cylinder of the ideal implant and +0.08 and -0.15 mm for the simulated cylinder of the postsurgical implant.

Conclusions: The precision of the digital registration method could be accepted in clinical applications. No significant difference was found between the digital registration method and the radiographic method in evaluating the clinical accuracy of the implant position. The digital registration method was able to control and minimize the alignment errors produced during data processing.
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http://dx.doi.org/10.1016/j.prosdent.2018.11.020DOI Listing
December 2019

A comparative study on influences of static electric field and power frequency electric field on cognition in mice.

Environ Toxicol Pharmacol 2019 Feb 4;66:91-95. Epub 2019 Jan 4.

Institute of Environmental Process, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, PR China.

Recently, electromagnetic fields around ultra-high voltage transmission lines have received considerable attentions for their potential biological effects. This study aimed to investigate the effects of static electric field (SEF) and power frequency electric field (PFEF) on cognition. Mice were exposed to SEF and PFEF with the same strength (35 kV/m) for 49 days, respectively. Behaviors in Morris water maze test and amino acid neurotransmitter levels in hippocampus were examined during exposure. Results indicated that the exposure of 35 kV/m SEF would not cause significant influences on learning and memory ability in mice, while the exposure of 35 kV/m PFEF would cause significant positive effects on learning and memory ability in mice on day 33. This difference in effects from SEF and PFEF on cognition was possibly induced by the difference in the degree of molecular polarization and ion migration in organisms under exposure of two kinds of electric fields with different frequency.
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http://dx.doi.org/10.1016/j.etap.2019.01.001DOI Listing
February 2019

A comparative study on effects of static electric field and power frequency electric field on hematology in mice.

Ecotoxicol Environ Saf 2018 Dec 22;166:109-115. Epub 2018 Sep 22.

Institute of Environmental Process, College of Environmental and Resource Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, PR China.

With the development of the ultra high voltage transmission technology, the voltage level of transmission line rised. Accordingly, the strength of electric field in the vicinity of transmission line increased, thus possible health effects from electric field have caused many public attentions. In this study, in order to compare effects induced by static electric field (SEF) and power frequency electric field (PFEF) on immune function, Institute of Cancer Research (ICR) mice were exposed to 35 kV/m SEF (0 Hz) and PFEF (50 Hz),respectively. Several indicators of white blood cell, red blood cell as well as hemoglobin in peripheral blood were tested after exposure of 7, 14 and 21 days, respectively. There was no significant difference in any indicators under SEF exposure of 35 kV/m for 7d, 14d and 21d between experimental group and control group. Under the PFEF exposure of 35 kV/m, white blood cell count significantly reduced after exposure of 7d, 14d and 21d. Meanwhile, red blood cell count significantly reduced after exposure of 7d, and returned to normal level through the compensatory response of organism after exposure of 14d and 21d. Hemoglobin concentration significantly decreased only after exposure of 21d. Based on tested results of hematological indicators, SEF exposure of 35 kV/m did not affect immune functions in mice but PFEF exposure of 35 kV/m could cause a decline of immune function. This difference of effects from SEF and PFEF on immune function was possibly caused by the difference of the degree of molecular polarization and ion migration in organism under exposure of two kinds of electric fields.
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http://dx.doi.org/10.1016/j.ecoenv.2018.09.071DOI Listing
December 2018

Rapid Evaluation of Chemical Consistency of Artificially Induced and Natural Resina Draconis Using Ultra-Performance Liquid Chromatography Quadrupole-Time-of-Flight Mass Spectrometry-Based Chemical Profiling.

Molecules 2018 Jul 25;23(8). Epub 2018 Jul 25.

National Engineering Institute for the Research and Development of Endangered Medicinal Resources in Southwest China, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.

Resina Draconis is a highly valued traditional medicine widely used in Arabia since ancient times, and it has been commonly used as an antidiarrheic, antimicrobial, antiulcer, blood circulation promoter as well as an anti-inflammatory agent. The tree source from which this medicine orignates grows extremely slowly, producing a very low yield of Resina Draconis. To meet the increasing market demand, artificial methods for stimulating Resina Draconis formation have been developed and applied. However, the chemical differences between artificially induced Resina Draconis () and natural Resina Draconis () have been rarely studied. The aim of this research was to explore and identify the chemical constituents of and using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS) based chemical profiling. A total of 56 chromatographic peaks were detected in , of these, 44 peaks have had their structures tentatively characterized based on high-resolution mass spectra (HRMS) data, fragmentation ions information, reference standards data and literature review. In total, 40 peaks were found both in and The potential chemical transformation mechanisms active in Resina Draconis during formation were explored. To the best of our knowledge, this is the first evaluation of the chemical profiles of both and . Furthermore, these findings are expected to provide a rational basis for the quality assessment of and the use of as a substitute for .
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http://dx.doi.org/10.3390/molecules23081850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222434PMC
July 2018

Duration-dependent effect of exposure to static electric field on learning and memory ability in mice.

Environ Sci Pollut Res Int 2018 Aug 7;25(24):23864-23874. Epub 2018 Jun 7.

Department of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, People's Republic of China.

With the rapid development of ultra-high-voltage direct-current (UHVDC) transmission, the strength of environmental static electric field (SEF) around UHVDC transmission lines increased substantially, which has aroused widely public attention on the potential health effects of SEF. In this study, the effect of SEF exposure on learning and memory ability was investigated. Institute of Cancer Research mice were exposed to 56.3 kV/m SEF for a short term (7 days) or long term (49 days). Behaviors in the Morris water maze (MWM) test, hippocampal neurotransmitter contents, and oxidative stress indicators were examined. Results showed that short-term SEF exposure significantly prolonged escape latency and decreased the number of platform-site crossovers, as well as decreased the time spent in the target quadrant in the MWM test. Meanwhile, serotonin level and the ratio of glutamate level to γ-aminobutyric acid level changed significantly. Besides, malondialdehyde content and glutathione peroxidase activity increased significantly, while superoxide dismutase activity decreased significantly. After long-term SEF exposure, all indices above showed no significant differences between the SEF and sham exposure groups. These data indicated that short-term exposure to 56.3 kV/m SEF could cause abnormal neurotransmitter levels and oxidative stress in the hippocampus, which led to the decline in learning and memory ability. Under the condition of long-term exposure, the SEF-induced disturbances in neurotransmitter contents and redox balance were offset by the compensatory responses of mice, and thus, the learning and memory ability returned to normal level. The temporary and reversible decline in learning and memory ability was only a common biological effect of SEF rather than a health hazard.
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http://dx.doi.org/10.1007/s11356-018-2458-4DOI Listing
August 2018

Microstructures, mechanical, and biological properties of a novel Ti-6V-4V/zinc surface nanocomposite prepared by friction stir processing.

Int J Nanomedicine 2018 28;13:1881-1898. Epub 2018 Mar 28.

Department of Prosthodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.

Background: The interaction between the material and the organism affects the survival rate of the orthopedic or dental implant in vivo. Friction stir processing (FSP) is considered a new solid-state processing technology for surface modification.

Purpose: This study aims to strengthen the surface mechanical properties and promote the osteogenic capacity of the biomaterial by constructing a Ti-6Al-4V (TC4)/zinc (Zn) surface nanocomposites through FSP.

Methods: FSP was used to modify the surface of TC4. The microstructures and mechanical properties were analyzed by scanning electron microscopy, transmission electron microscopy, nanoindentation and Vickers hardness. The biological properties of the modified surface were evaluated by the in vitro and in vivo study.

Results: The results showed that nanocrystalline and numerous β regions, grain boundary α phase, coarser acicular α phase and finer acicular martensite α' appeared because of the severe plastic deformation caused by FSP, resulting in a decreased elastic modulus and an increased surface hardness. With the addition of Zn particles and the enhancement of hydrophilicity, the biocompatibility was greatly improved in terms of cell adhesion and proliferation. The in vitro osteogenic differentiation of rat bone marrow stromal cells and rapid in vivo osseointegration were enhanced on the novel TC4/Zn metal matrix nanocomposite surface.

Conclusion: These findings suggest that this novel TC4/Zn surface nanocomposite achieved by FSP has significantly improved mechanical properties and biocompatibility, in addition to promoting osseointegration and thus has potential for dental and orthopedic applications.
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http://dx.doi.org/10.2147/IJN.S154260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880573PMC
June 2018

The novel application of chitosan: Effects of cross-linked chitosan on the fire performance of thermoplastic polyurethane.

Carbohydr Polym 2018 Jun 12;189:313-321. Epub 2018 Feb 12.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, PR China; Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing, 100029, PR China. Electronic address:

In this paper, a novel flame retardant (ACS) was prepared by crosslinking chitosan with bis-(4-formylphenyl)-phenyl-phosphonate (ABPO). ACS in association with ammonium polyphosphate (APP) and organic modified montmorillonite (OMMT) were used to prepare flame retardant thermoplastic polyurethane (TPU) composite through melt blending. For the TPU sample containing 10% flame retardants, the limiting oxygen index was increased from 20.8 to 29.0%, the vertical burning (UL-94) rating was upgraded from no rating to V-0, and the peak heat release rate was decreased from 1090 to 284 kW/m. The thermal gravity analysis (TGA) indicated that ACS had excellent char formation ability and could greatly enhance the thermal stability of TPU. The tensile strength and elongation at break for flame retardant sample could reach 16.5 MPa and 1443% respectively.
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http://dx.doi.org/10.1016/j.carbpol.2018.02.034DOI Listing
June 2018

Reconstruction of a digital core containing clay minerals based on a clustering algorithm.

Phys Rev E 2017 Oct 9;96(4-1):043304. Epub 2017 Oct 9.

Daqing Oilfield Company Ltd., CNPC, Daqing, Heilongjiang, 163712, China.

It is difficult to obtain a core sample and information for digital core reconstruction of mature sandstone reservoirs around the world, especially for an unconsolidated sandstone reservoir. Meanwhile, reconstruction and division of clay minerals play a vital role in the reconstruction of the digital cores, although the two-dimensional data-based reconstruction methods are specifically applicable as the microstructure reservoir simulation methods for the sandstone reservoir. However, reconstruction of clay minerals is still challenging from a research viewpoint for the better reconstruction of various clay minerals in the digital cores. In the present work, the content of clay minerals was considered on the basis of two-dimensional information about the reservoir. After application of the hybrid method, and compared with the model reconstructed by the process-based method, the digital core containing clay clusters without the labels of the clusters' number, size, and texture were the output. The statistics and geometry of the reconstruction model were similar to the reference model. In addition, the Hoshen-Kopelman algorithm was used to label various connected unclassified clay clusters in the initial model and then the number and size of clay clusters were recorded. At the same time, the K-means clustering algorithm was applied to divide the labeled, large connecting clusters into smaller clusters on the basis of difference in the clusters' characteristics. According to the clay minerals' characteristics, such as types, textures, and distributions, the digital core containing clay minerals was reconstructed by means of the clustering algorithm and the clay clusters' structure judgment. The distributions and textures of the clay minerals of the digital core were reasonable. The clustering algorithm improved the digital core reconstruction and provided an alternative method for the simulation of different clay minerals in the digital cores.
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http://dx.doi.org/10.1103/PhysRevE.96.043304DOI Listing
October 2017
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