Xiao-Yan Wen

Xiao-Yan Wen

UNVERIFIED PROFILE

Are you Xiao-Yan Wen?   Register this Author

Register author
Xiao-Yan Wen

Xiao-Yan Wen

Publications by authors named "Xiao-Yan Wen"

Are you Xiao-Yan Wen?   Register this Author

67Publications

2205Reads

15Profile Views

Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish.

PLoS One 2019 15;14(11):e0221796. Epub 2019 Nov 15.

Zebrafish Centre for Advanced Drug Discovery, Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221796PLOS
November 2019

Validation of a CRISPR-Mediated CFTR Correction Strategy for Preclinical Translation in Pigs.

Hum Gene Ther 2019 09 18;30(9):1101-1116. Epub 2019 Jun 18.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/hum.2019.074
Publisher Site
http://dx.doi.org/10.1089/hum.2019.074DOI Listing
September 2019

Furanoic Lipid F-6, A Novel Anti-Cancer Compound that Kills Cancer Cells by Suppressing Proliferation and Inducing Apoptosis.

Cancers (Basel) 2019 Jul 9;11(7). Epub 2019 Jul 9.

Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11070960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678287PMC
July 2019

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in .

N Engl J Med 2019 04;380(15):1433-1441

From Amsterdam University Medical Centers, University of Amsterdam, Departments of Clinical Chemistry, Pediatrics, and Clinical Genetics, Emma Children's Hospital, Amsterdam Gastroenterology and Metabolism (A.B.P.K., R.L., J.K., J. Meijer, L.A.T., M.T., M.W., R.J.A.W., H.R.W., C.D.M.K.), and United for Metabolic Diseases (A.B.P.K., R.J.A.W., H.R.W., C.D.M.K.), Amsterdam, and the Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht (J.J.F.A.V., J.H.V.), and the Project MinE ALS Sequencing Consortium (J.J.F.A.V., J.H.V.), Utrecht - all in the Netherlands; the Departments of Biochemistry and Molecular Biology and Medical Genetics, Cumming School of Medicine, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary (M.T.-G.), Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute (P.A.R., M.J.J., M.S.K., J. MacIsaac, W.W.W., C.D.M.K.), the Faculty of Pharmaceutical Sciences (B.I.D., G.E.B.W., C.J.R.), and the Departments of Medical Genetics (C.M., I.-S.R.-B., W.W.W.) and Pediatrics (C.D.M.K.), University of British Columbia, Vancouver, the Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital and University of Toronto (K.B.-A., F.K., M.L., Y.W., X.-Y.W.), the Centre for Applied Genomics, Genetics and Genome Biology, the Hospital for Sick Children (C.N., S.W.S., B.T., R.K.C.Y.), and the Department of Molecular Genetics (C.N., S.W.S., R.K.C.Y.), the McLaughlin Centre (S.W.S.), and the Departments of Medicine, Physiology, and Laboratory Medicine and Pathobiology, Institute of Medical Science (X.-Y.W.), University of Toronto, Toronto, and the Division of Medical Genetics, Department of Pediatrics, Children's Hospital Eastern Ontario, University of Ottawa, Ottawa (J.S.W., M.T.G.) - all in Canada; the Departments of Medicine and Physiology, National University of Singapore (M.A.P.), and the Translational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research (M.A.P., B.S., X.X., J.Z.) - both in Singapore; Uppsala University, Department of Chemistry-Biomedical Center, Uppsala, Sweden (D.D.); Illumina, San Diego, CA (E.D., M.A.E.); Gene Structure and Disease Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (B.H., D.K., K.U.); and the Department of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom (S.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1806627DOI Listing
April 2019

Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury.

Respir Res 2018 Sep 29;19(1):190. Epub 2018 Sep 29.

The State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510000, Guangdong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-018-0869-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162902PMC
September 2018

Zebrafish heart failure models: opportunities and challenges.

Amino Acids 2018 Jul 3;50(7):787-798. Epub 2018 May 3.

Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00726-018-2578-7DOI Listing
July 2018

Non-steric-zipper models for pathogenic α-synuclein conformers.

APL Bioeng 2018 Jun 1;2(2):026105. Epub 2018 May 1.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1063/1.5023460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481714PMC
June 2018

Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?

Mol Cell Biochem 2017 Sep 8;433(1-2):97-102. Epub 2017 Apr 8.

Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Department of Medicine and Physiology, University of Toronto, 209 Victoria Street, LKSKI Rm 519, Toronto, ON, M5B 1T8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-017-3018-9DOI Listing
September 2017

Development of a zebrafish sepsis model for high-throughput drug discovery.

Mol Med 2017 07 7;23:134-148. Epub 2017 Jun 7.

Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital, 209 Victoria St, Toronto, Ontario, Canada M5B 1T8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2119/molmed.2016.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522968PMC
July 2017

A Novel Model of Traumatic Brain Injury in Adult Zebrafish Demonstrates Response to Injury and Treatment Comparable with Mammalian Models.

J Neurotrauma 2017 04 20;34(7):1382-1393. Epub 2016 Dec 20.

1 Institute of Medical Sciences, University of Toronto , Ontario, Canada .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/neu.2016.4497DOI Listing
April 2017

Disruption of alters endocardial and myocardial fusion during zebrafish cardiac assembly.

Biol Open 2017 Mar 15;6(3):348-357. Epub 2017 Mar 15.

Zebrafish Centre for Advanced Drug Discovery & Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada M5B 1T8

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.021212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374395PMC
March 2017

Simple animal models for amyotrophic lateral sclerosis drug discovery.

Expert Opin Drug Discov 2016 Aug 13;11(8):797-804. Epub 2016 Jun 13.

b Department of Neuroscience , FRQS Groupe de recherche sur le système nerveux central and CRCHUM, University of Montréal , Montréal , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17460441.2016.1196183DOI Listing
August 2016

New Exploration of Chinese Herbal Medicines in Hepatology.

Evid Based Complement Alternat Med 2016 20;2016:3056438. Epub 2016 Jul 20.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Edward Doisy Research Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2016/3056438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971296PMC
August 2016

A Model of Excitotoxic Brain Injury in Larval Zebrafish: Potential Application for High-Throughput Drug Evaluation to Treat Traumatic Brain Injury.

Zebrafish 2016 06 30;13(3):161-9. Epub 2016 Mar 30.

1 Institute of Medical Sciences, University of Toronto , Toronto, Ontario, Canada .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/zeb.2015.1188DOI Listing
June 2016

Chromosome Condensation 1-Like (Chc1L) Is a Novel Tumor Suppressor Involved in Development of Histiocyte-Rich Neoplasms.

PLoS One 2015 20;10(8):e0135755. Epub 2015 Aug 20.

Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135755PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546397PMC
May 2016

Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective.

Evid Based Complement Alternat Med 2016 28;2016:4750163. Epub 2016 Jan 28.

School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2016/4750163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749812PMC
March 2016

Fetal and infant exposure to the Chinese famine increases the risk of fatty liver disease in Chongqing, China.

J Gastroenterol Hepatol 2016 Jan;31(1):200-5

The Public Health Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.13044DOI Listing
January 2016

Zebrafish models of major depressive disorders.

J Neurosci Res 2016 Jan 9;94(1):3-14. Epub 2015 Oct 9.

Department of Psychiatry, University Health Network, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jnr.23639DOI Listing
January 2016

Remote Ischemic Conditioning Prevents Lung and Liver Injury After Hemorrhagic Shock/Resuscitation: Potential Role of a Humoral Plasma Factor.

Ann Surg 2015 Jun;261(6):1215-25

*Department of Surgery, the Keenan Research Centre for Biomedical Science and the Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital, Toronto, Ontario, Canada †Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario, Canada; and ‡Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/SLA.0000000000000877DOI Listing
June 2015

Uterine-derived stem cells reconstitute the bone marrow of irradiated mice.

Stem Cells Dev 2015 Apr 7;24(8):938-47. Epub 2015 Jan 7.

1 Division of Cardiovascular Surgery, Toronto General Research Institute, University Health Network , Toronto, Canada .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2014.0478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390114PMC
April 2015

Could pharmacological curtailment of the RhoA/Rho-kinase pathway reverse the endothelial barrier dysfunction associated with Ebola virus infection?

Antiviral Res 2015 Feb 13;114:53-6. Epub 2014 Dec 13.

Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2014.12.005DOI Listing
February 2015

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

J Am Heart Assoc 2014 Oct 20;3(5):e001018. Epub 2014 Oct 20.

Department of Physiology, University of Toronto, Ontario, Canada (D.Y.W., C.A., J.Y.L., P.S., N.B., S.S., P.H.B., B.C., X.Y.W., P.P.L., A.O.G.) Faculty of Medicine and Institute of Medical Science, University of Toronto, Ontario, Canada (S.E.R., F.D., K.N., P.H.B., X.Y.W., P.P.L., A.O.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.114.001018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323785PMC
October 2014

Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio).

J Cereb Blood Flow Metab 2014 Sep 16;34(9):1430-3. Epub 2014 Jul 16.

1] Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada [2] Institute of Medical Science, Departments of Medicine and Surgery, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jcbfm.2014.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158677PMC
September 2014

Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: highlights from animal studies.

Reprod Toxicol 2014 Jul 13;46:115-20. Epub 2014 Apr 13.

Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Science & Department of Medicine, University of Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reprotox.2014.04.001DOI Listing
July 2014

A call for rigorous study of statins in resolution of cerebral cavernous malformation pathology.

Stroke 2014 Jun 6;45(6):1859-61. Epub 2014 May 6.

From the Zebrafish Centre for Advanced Drug Discovery (S.E.-B., X.-Y.W., R.L.M.) and Keenan Research Centre for Biomedical Science (S.E.-B., X.-Y.W., R.L.M.), St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Medicine and Surgery, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada (S.E.-B., X.-Y.W., R.L.M.); and Division of Neurosurgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Toronto, Ontario, Canada (R.L.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.114.005132DOI Listing
June 2014

rbm47, a novel RNA binding protein, regulates zebrafish head development.

Dev Dyn 2013 Dec 30;242(12):1395-404. Epub 2013 Sep 30.

Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Medicine, Physiology and Institute of Medical Science, University of Toronto, Canada; Department of Laboratory Medicine and Pathology, University of Toronto & Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Canada; Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital and Cancer Research Institute, Central South, Hunan Province, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dvdy.24039DOI Listing
December 2013

Digital image correlation-based optical coherence elastography.

J Biomed Opt 2013 Dec;18(12):121515

Ryerson University, Biophotonics and Bioengineering Laboratory, Toronto, Ontario, Canada M5B 2K3bRyerson University, Department of Electrical and Computer Engineering, Toronto, Ontario, Canada M5B 2K3eUniversity of Toronto, Department of Electrical and Computer Engineering, Toronto, Ontario, Canada M5S1A1fSunnybrook Health Sciences Centre, Division of Neurosurgery, Toronto, Ontario, Canada M4N 3M5gUniversity of Toronto, Faculty of Medicine, Division of Neurosurgery, Toronto, Ontario, Canada M5S1A1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1117/1.JBO.18.12.121515DOI Listing
December 2013

The anti-oxidant effects are not the main mechanism for glutamine's protective effects on acute kidney injury in mice.

Eur J Pharmacol 2013 Apr 27;705(1-3):11-9. Epub 2013 Feb 27.

The CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2013.02.028DOI Listing
April 2013

Advances in zebrafish high content and high throughput technologies.

Comb Chem High Throughput Screen 2012 Aug;15(7):515-21

Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138620712801619140DOI Listing
August 2012

Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.

Mol Cell Biochem 2012 Jun 19;365(1-2):211-22. Epub 2012 Feb 19.

Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital and Cancer Research Institute, Central South University, Changsha 410008, Hunan Province, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-012-1262-6DOI Listing
June 2012

Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis.

Kidney Int 2012 Feb 14;81(4):363-9. Epub 2011 Sep 14.

The CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ki.2011.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269547PMC
February 2012

N-acetylcysteine is effective for prevention but not for treatment of folic acid-induced acute kidney injury in mice.

Crit Care Med 2011 Nov;39(11):2487-94

Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0b013e31822575fcDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196819PMC
November 2011

Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer.

Eur Urol 2010 Sep 22;58(3):418-26. Epub 2010 May 22.

Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital and Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2010.05.024DOI Listing
September 2010

Effect of surfactant concentration on transdermal lidocaine delivery with linker microemulsions.

Int J Pharm 2010 Jun 2;392(1-2):274-84. Epub 2010 Apr 2.

University of Toronto, Department of Chemical Engineering and Applied Chemistry, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2010.03.051DOI Listing
June 2010

Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.

FASEB J 2010 Mar 18;24(3):947-56. Epub 2009 Nov 18.

St. Michael's Hospital, 30 Bond St., Queen Wing, Rm 8-019, Toronto, ON, Canada M5B 1W8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.09-140806DOI Listing
March 2010

SRD5A2 V89L polymorphism and prostate cancer risk: a meta-analysis.

Prostate 2010 Feb;70(2):170-8

Tianjin Institute of Urological Surgery, Tianjin Key Laboratory of Urology, Tianjin Medical University, Tianjin, China.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pros.21050
Publisher Site
http://dx.doi.org/10.1002/pros.21050DOI Listing
February 2010

The Blimp-1 gene regulatory region directs EGFP expression in multiple hematopoietic lineages and testis in mice.

Transgenic Res 2008 Apr 19;17(2):193-203. Epub 2007 Sep 19.

Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 620 University Avenue, Room 8-205, Toronto, ON, Canada, M5G 2C1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11248-007-9140-9DOI Listing
April 2008

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma.

Blood 2007 Jun 1;109(12):5430-8. Epub 2007 Mar 1.

Hematology-Oncology, Princess Margaret Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-10-047951DOI Listing
June 2007

[Association mapping of schizophrenia loci on chromosome 1 by use of pooled DNA genomic screening in eastern Shandong peninsula].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Jun;24(3):288-92

Laboratory of Medical Genetics, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062 PR China.

View Article

Download full-text PDF

Source
June 2007

The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

Clin Cancer Res 2007 Jan;13(2 Pt 1):621-9

Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, 620 University Avenue, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-06-1526DOI Listing
January 2007

A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice.

Genetics 2006 May 19;173(1):297-307. Epub 2006 Feb 19.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/genetics.105.054833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461454PMC
May 2006

[Genetic effects on physical growth items of child twins in Han nationality].

Zhonghua Yu Fang Yi Xue Za Zhi 2005 Sep;39(5):345-7

Institute of Child and Adolescent Health, Peking University, Beijng 100083, China.

View Article

Download full-text PDF

Source
September 2005

Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo.

Cancer Res 2004 May;64(9):3271-5

Division of Experimental Therapeutics, Toronto General Research Institute, McLaughlin Centre for Molecular Medicine, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.can-03-3764DOI Listing
May 2004

Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma.

Br J Haematol 2004 Mar;124(5):595-603

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2141.2004.04814.xDOI Listing
March 2004

RU486-inducible retrovirus-mediated caspase-3 overexpression is cytotoxic to bcl-xL-expressing myeloma cells in vitro and in vivo.

Mol Ther 2003 Aug;8(2):230-7

Division of Experimental Therapeutics, Toronto General Research Institute, and Department of Medical Oncology, Princess Margaret Hospital, M5G 2M9, Toronto, Ontario, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1525-0016(03)00146-1DOI Listing
August 2003

Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans.

Hum Mol Genet 2003 May;12(10):1131-43

Department of Experimental Therapeutics, Toronto General Research Institute, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddg124DOI Listing
May 2003

Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 ( PSPLA1).

J Hum Genet 2002 ;47(11):611-3

Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406-100 Perth Drive, London, ON N6A 5K8, Canada.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1007/s100380200093
Publisher Site
http://dx.doi.org/10.1007/s100380200093DOI Listing
January 2003