Publications by authors named "Xiao-Fei Chang"

2 Publications

  • Page 1 of 1

Evaluation of efficacy and safety of PARP inhibitors in breast cancer: A systematic review and meta-analysis.

Breast 2021 May 27;59:44-50. Epub 2021 May 27.

Department of Breast, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China. Electronic address:

Background: Many breast cancer clinical trials with PARPi have been completed or are currently carried out, either by monotherapy or combined with chemotherapy. We aim to assess the efficacy and safety of PARPi in breast cancer patients as compared to chemotherapy.

Methods: A comprehensive literature search of PubMed, EMBASE, CENTRAL, conference meetings and clinical trial registry was performed. The primary outcomes were progression-free survival (PFS), overall survival (OS), overall response rate (ORR). The secondary outcome was safety profile. The comparative effects were measured using hazard ratio (HR) or relative risk (RR) with 95% confidence interval. Subgroup analyses were conducted based on types of intervention and baseline characteristics of patients.

Results: Six RCTs (n = 1953) were included. Two RCTs were recognized as high risk. PARPi was associated with an improved PFS (HR, 0.65; 95% CI, 0.56-0.74), OS (HR, 0.86; 95% CI, 0.73-1.01), and a higher ORR (RR, 1.38; 95% CI, 1.05-1.82). PARPi, however, significantly increased risk of grade 3-4 thrombocytopenia (RR, 1.63; 95% CI, 1.06-2.52). Monotherapy was observed with lower risk of disease progression and higher ORR rate than combination therapy, 0.56 to 0.65 and 2.21 to 1.05, respectively. For patients without prior platinum treatment, PARPi significantly improved PFS (HR, 0.64; 95% CI, 0.52-0.79).

Conclusions: PARPi was observed with a significantly improved efficacy in aspects of PFS and ORR, but also higher risk of grade 3-4 thrombocytopenia as compared to chemotherapy. PARPi was a better choice for patients who had not received previous platinum treatment.
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http://dx.doi.org/10.1016/j.breast.2021.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215282PMC
May 2021

Mechanosensitive Channel Currents Recorded in Rat Brain Microvascular Endothelial Cells with Whole-cell Mode.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2000 ;32(5):529-532

Biomedical Engineering Center, Beijing Polytechnic University, Beijing 100022, China.

Using the whole-cell patch-clamp technique, delayed outward currents were recorded in rat brain microvascular endothelial cells(RBMECs), which were nearly completely inhibited by extracellular TEA-Cl at a concentration of 20 mmol/L. Whole-cell currents were elicited by 2 100 ms depolarizing voltage pulses applied every 7 s between -100 mV to +90 mV, with 10 mV increment, from a holding potential of -100 mV. The currents were similar with delayed rectified K(+) currents (IKv)which were inhibited in a concentration-dependent manner by both application of TEA-Cl, with an IC(50) approximately 2.0 mmol/L. In the presence of mechanical force, outward currents were increased in amplitude as compared with controls. These mechanical force-induced currents were also defined as IKv, which were different from previous described mechanosensitive currents induced by mechanical force with characteristic of inward rectifier.
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January 2000
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