Publications by authors named "Xiao Cong"

95 Publications

Giant c-axis nonlinear anomalous Hall effect in T-MoTe and WTe.

Nat Commun 2021 Apr 6;12(1):2049. Epub 2021 Apr 6.

Institute for Quantum Computing, Department of Physics and Astronomy, and Department of Chemistry, University of Waterloo, Waterloo, ON, Canada.

While the anomalous Hall effect can manifest even without an external magnetic field, time reversal symmetry is nonetheless still broken by the internal magnetization of the sample. Recently, it has been shown that certain materials without an inversion center allow for a nonlinear type of anomalous Hall effect whilst retaining time reversal symmetry. The effect may arise from either Berry curvature or through various asymmetric scattering mechanisms. Here, we report the observation of an extremely large c-axis nonlinear anomalous Hall effect in the non-centrosymmetric T phase of MoTe and WTe without intrinsic magnetic order. We find that the effect is dominated by skew-scattering at higher temperatures combined with another scattering process active at low temperatures. Application of higher bias yields an extremely large Hall ratio of E/E = 2.47 and corresponding anomalous Hall conductivity of order 8 × 10 S/m.
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http://dx.doi.org/10.1038/s41467-021-22343-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024290PMC
April 2021

Transcriptome Analysis Identifies Candidate Genes and Signaling Pathways Associated With Feed Efficiency in Xiayan Chicken.

Front Genet 2021 17;12:607719. Epub 2021 Mar 17.

College of Animal Science and Technology, Guangxi University, Nanning, China.

Feed efficiency is an important economic factor in poultry production, and the rate of feed efficiency is generally evaluated using residual feed intake (RFI). The molecular regulatory mechanisms of RFI remain unknown. Therefore, the objective of this study was to identify candidate genes and signaling pathways related to RFI using RNA-sequencing for low RFI (LRFI) and high RFI (HRFI) in the Xiayan chicken, a native chicken of the Guangxi province. Chickens were divided into four groups based on FE and sex: LRFI and HRFI for males and females, respectively. We identified a total of 1,015 and 742 differentially expressed genes associated with RFI in males and females, respectively. The 32 and 7 Gene Ontology (GO) enrichment terms, respectively, identified in males and females chiefly involved carbohydrate, amino acid, and energy metabolism. Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified 11 and 5 significantly enriched signaling pathways, including those for nutrient metabolism, insulin signaling, and MAPK signaling, respectively. Protein-protein interaction (PPI) network analysis showed that the pathways involving , 1, 2, 2, 1, 1, 2, and 1 may have an effect on feed efficiency, and these genes are mainly involved in the biological processes of fat metabolism and heat stress. Gene set enrichment analysis indicated that the increased expression of genes in LRFI chickens was related to intestinal microvilli structure and function, and to the fat metabolism process in males. In females, the highly expressed set of genes in the LRFI group was primarily associated with nervous system and cell development. Our findings provide further insight into RFI regulation mechanisms in chickens.
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http://dx.doi.org/10.3389/fgene.2021.607719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010316PMC
March 2021

Prehospital Tranexamic Acid Administration in Injured Patients.

JAMA Surg 2021 Mar 31. Epub 2021 Mar 31.

Department of Orthopedics, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan Province, People's Republic of China.

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http://dx.doi.org/10.1001/jamasurg.2021.0251DOI Listing
March 2021

Backbone Engineering with Asymmetric Core to Finely Tune Phase Separation for High-Performance All-Small-Molecule Organic Solar Cells.

ACS Appl Mater Interfaces 2021 Mar 26;13(9):11108-11116. Epub 2021 Feb 26.

Key Laboratory of Optoelectronic Chemical Materials and Devices (Ministry of Education), School of Chemical and Environmental Engineering, Jianghan University, Wuhan 430056, China.

In order to obtain high-performance all-small-molecule organic solar cells (ASM-OSCs), it is crucial to exploit the available strategy for molecular design and to further understand key structure-property relationship that can rationally control the blend nanomorphology and influence the physical process. In this work, we design two small molecule donors FBD-S1 and TBD-S2 with identical electron-withdrawing units but various asymmetric central cores, which exhibit differing phase separation in Y6-based blend films. It is found that TBD-S2 with increased phase separation between donor and acceptor can lead to more favorable interpenetrating networks, effective exciton dissociation, and enhanced and more balanced charge transport. Importantly, a remarkable PCE of 13.1% is obtained for TBD-S2:Y6 based ASM-OSCs, which is an attractive photovoltaic performance for ASM-OSCs. This result demonstrates that the central core modification at the atomic level for small molecule donors can delicately control the phase separation and optimize photophysical processes, and refines device performance, which facilitate development in the ASM-OSC research field.
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http://dx.doi.org/10.1021/acsami.0c21986DOI Listing
March 2021

Association of Apolipoprotein E Polymorphisms and Risks of Ischemic Stroke in Chinese Patients with Type 2 Diabetes Mellitus.

J Diabetes Res 2021 3;2021:8816996. Epub 2021 Jan 3.

Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, China.

Background: The apolipoprotein E () gene polymorphisms have been intensively studied in patients with type 2 diabetes mellitus (T2DM) and ischemic stroke (IS) in recent years. However, it is unclear whether gene polymorphisms are correlated with increased risk for developing IS in T2DM patients. Thus, this study was designed to examine the association between gene polymorphisms and risks of IS in Chinese patients with T2DM.

Methods: This case-control study enrolled 243 subjects with T2DM as controls, and 210 subjects with T2DM complicated with IS as case patients. The genotypes were determined using real-time PCR while HbA1c and lipid levels were detected using commercially available kits.

Results: The systolic blood pressure (SBP), diastolic blood pressure (DBP), and the proportion of patients with a history of hypertension were higher in the case patients than that in the controls. We confirmed that the 2/3 genotype, as well as SBP and history of hypertension, was the independent risk factor for developing IS in T2DM patients.

Conclusions: We conclude that the 2/3 genotype might contribute to the increased risk for developing IS in Chinese patients with T2DM.
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http://dx.doi.org/10.1155/2021/8816996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801050PMC
January 2021

Transcriptome landscapes of differentially expressed genes related to fat deposits in Nandan-Yao chicken.

Funct Integr Genomics 2021 Jan 6;21(1):113-124. Epub 2021 Jan 6.

College of Animal Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.

Nandan-Yao chicken is a Chinese native chicken with lower fat deposition and better meat quality. Fat deposition is a quite complex and important economic trait. However, its molecular mechanism is still unknown in chickens. In the current study, Nandan-Yao chicken was divided into two groups based on the rate of abdominal fat at 120 days old, namely the high-fat group and low-fat group. The total RNAs were isolated and sequenced by RNA sequencing (RNA-seq). After quality control, we gained 1222, 902, 784, 624, and 736 differentially expressed genes (DEGs) in abdominal fat, back skin, liver, pectoral muscle, and leg muscle, respectively. Analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) showed that significantly enriched GO term and KEGG signaling pathway mainly involved cytosolic ribosome, growth development, PPAR signaling pathway, Wnt signaling pathway, and linoleic acid metabolism in abdominal fat, back skin, and liver. While in pectoral muscle and leg muscle, it is mainly enriched in phosphatidylinositol signaling system, adrenergic signaling in cardiomyocytes, cytosolic ribosome, and cytosolic part. Sixteen genes were differentially expressed in all five tissues. Among them, PLA2G4A and RPS4Y1 might be the key regulators for fat deposition in Nandan-Yao chicken. The protein-protein interaction (PPI) network analysis of DEGs showed that PCK1 was the most notable genes. The findings in the current study will help to understand the regulation mechanism of abdominal fat and intramuscular fat in Nandan-Yao chicken and provide a theoretical basis for Chinese local chicken breeding.
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http://dx.doi.org/10.1007/s10142-020-00764-7DOI Listing
January 2021

Development of a recombinase polymerase amplification fluorescence assay to detect feline coronavirus.

Mol Cell Probes 2020 12 22;54:101669. Epub 2020 Oct 22.

Guangdong Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, 510633, China. Electronic address:

Feline coronavirus (FCoV) is classified into two pathotypes: the avirulent feline enteric coronavirus (FECV), and the virulent feline infectious peritonitis virus (FIPV). Rapid pathogen detection, which is efficient and convenient, is the best approach for early confirmatory diagnosis. In this study, we first developed and evaluated a rapid recombinase polymerase amplification (RPA) detection method for FCoV that can detect FCoV within 15 min at 39 °C. The detection limit of that assay was 233 copies/μL DNA molecules per reaction. The specificity was high: it did not cross-react with canine distemper virus (CDV), canine coronavirus (CCoV), canine adenovirus (CAV), feline calicivirus (FCV), feline herpesvirus (FHV), or feline parvovirus (FPV). This assay was evaluated using 42 clinical samples (30 diarrhea samples and 12 ascites samples). The coincidence rate between FCoV-RPA and RT-qPCR for detection in clinical samples was 95.2%. In summary, FCoV-RPA analysis provides an efficient, rapid, and sensitive detection method for FCoV.
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http://dx.doi.org/10.1016/j.mcp.2020.101669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581357PMC
December 2020

Comparison of Kinematic Alignment and Mechanical Alignment in Total Knee Arthroplasty: A Meta-analysis of Randomized Controlled Clinical Trials.

Orthop Surg 2020 Dec 25;12(6):1567-1578. Epub 2020 Oct 25.

Department of Orthopaedics, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China.

The aim of this study was to estimate whether kinematic alignment (KA) improves knee function or clinical outcomes compared with mechanical alignment (MA) in the short term after total knee arthroplasty (TKA). We searched the literature for randomized controlled trials published before January 2020 from PubMed, EMBASE, Google, Web of Science, Cochrane Library, and other databases. The observation markers included "The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index," "Knee Society Score (KSS)," "Oxford Knee Score (OKS)," "combined Knee Society Score (KSS)," "Knee injury and Osteoarthritis Outcome Score (KOOS)," "European Quality of Life Measure-5 Domain-5-Level (EQ-5D-5L)," range of motion (ROM), lower limb alignment, ligament release, and complications. A total of 11 randomized controlled trial studies were included in the study. During the follow-up of 6-24 months, the KA-TKA group was superior to the MA-TKA group in terms of WOMAC scores, combined KSS, KSS, knee function scores, and knee range of flexion, but there was no significant difference in EQ-5D-5L, KOOS, KOOS (symptoms, pain, ADL, sports, and quality of life), complications, knee range of extension, hip-knee-ankle (HKA) angle, tibial component slope angle, lateral distal femoral angle (LDFA) or medial proximal tibial angle (MPTA) angle between the MA-TKA group and the MA-TKA group (P > 0.05). Our meta-analysis revealed that the incidence of ligament release in the MA-TKA group was higher than that in the KA-TKA group. This meta-analysis shows that the KA-TKA group had better clinical outcomes and knee range of flexion than the MA-TKA group at short-term follow-up.
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http://dx.doi.org/10.1111/os.12826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767667PMC
December 2020

Quantized Circulation of Anomalous Shift in Interface Reflection.

Phys Rev Lett 2020 Aug;125(7):076801

Research Laboratory for Quantum Materials, Singapore University of Technology and Design, Singapore 487372, Singapore.

A particle beam may undergo an anomalous spatial shift when it is reflected at an interface. The shift forms a vector field defined in the two-dimensional interface momentum space. We show that, although the shift vector at individual momentum is typically sensitive to the system details, its integral along a close loop, i.e., its circulation, could yield a robust quantized number under certain conditions of interest. Particularly, this is the case when the beam is incident from a trivial medium, then the quantized circulation of anomalous shift (CAS) directly manifests the topological character of the other medium. We demonstrate that the topological charge of a Weyl medium as well as the unconventional pair potentials of a superconductor can be captured and distinguished by CAS. Our work unveils a hidden quantized feature in a ubiquitous physical process, which may also offer a new approach for probing topological media.
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http://dx.doi.org/10.1103/PhysRevLett.125.076801DOI Listing
August 2020

Impact process of the aquitard to regional arsenic accumulation of the underlying aquifer in Central Yangtze River Basin.

Environ Geochem Health 2021 Mar 24;43(3):1091-1107. Epub 2020 Aug 24.

School of Environmental Studies, China University of Geosciences, Lumo Road 388, Wuhan, 430074, China.

The clayey aquitard has the potential to release geogenic poisonous chemicals such as arsenic (As) to the adjacent aquifer owing to complex hydrologic or biogeochemical processes. However, it remains unclear whether the aquitard has effect on As enrichment in the underlying aquifer in regions without extensive groundwater pumping, and the related processes have been poorly known. Based on piezometer water chemistry, stable water isotopes, sediment chemistry and reactive-transport model, this study aims to reveal the impact process of the aquitard to As accumulation of underlying aquifer from central Yangtze River Basin, a As-affected area without extensive groundwater pumping. On the whole, As migrated from top to bottom of the aquitard (especially the depth over 10 m) and significantly influenced the As accumulation in the underlying aquifer. Nonetheless, the results of three topical boreholes showed two different hydrogeological conditions affected As release in the aquitard and enrichment in the underlying aquifer. Different hydrogeological conditions could result in the input of different species organic carbon and then impact As concentrations in the aquifer. When the aquitard was near surface water bodies, the reductive dissolution of iron oxides was the main driver for As release and the aquitard had a significant influence on the enrichment of arsenic in the aquifer. At areas without surface water bodies nearby, the desorption of As(V) from minerals was the main source of As and the concentrations of As in pore water were quite low; this pattern had little effect on the enrichment of arsenic in the aquifer.
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http://dx.doi.org/10.1007/s10653-020-00541-2DOI Listing
March 2021

Contribution of clay-aquitard to aquifer iron concentrations and water quality.

Sci Total Environ 2020 Nov 8;741:140061. Epub 2020 Jun 8.

Department of Earth System Science, Stanford University, Stanford 94305, USA.

The contribution of aquitards to aquifer water quality can be pronounced but is rarely considered. The aims of this study were to delineate the spatial distribution of iron in a shallow aquitard-aquifer system within Jianghan Plain (JHP) of central China and to identify the origin of high iron within aquifers. Infiltration, hydraulic gradients and sediment chemistry influence the distribution of iron in the aquitard pore water which has a significant effect on the underlying aquifer. Chemical equilibrium modeling of pore water was used to simulate chemical processes influencing aquifer chemistry and determined the possible precipitation of FeCO, FeS minerals (FeSx) and Fe-oxides (representing hydroxides, oxyhydroxides, and oxides of ferric iron). We presented a conceptual chemical-physical scenario to explain the observed Fe distributions: (1) Increasing iron concentrations with low-level sulfide in aquitard pore water. (2) Increasing iron concentrations with low-level sulfide in aquitard pore water underlying ponded water. (3) Decreasing iron concentrations with high-level sulfide in aquitard pore water. In combination, our findings illustrate the influence of aquitards on aquifer chemistry using Fe within the Jianghan Plain as an example.
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http://dx.doi.org/10.1016/j.scitotenv.2020.140061DOI Listing
November 2020

The relationship between parental involvement in childhood and depression in early adulthood.

J Affect Disord 2020 08 3;273:173-182. Epub 2020 May 3.

Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, One University Place, Rensselaer 12144-3456, NY, United States. Electronic address:

Background: Positive early life experiences may help prevent depression later in life. We examined the accumulated benefit, timing, and trajectories of positive parental involvement in childhood in association with incident depression in early adulthood.

Methods: Prospectively assessed Avon Longitudinal Study of Parents and Children (ALSPAC) data (n = 7120) were analyzed. Overall and developmental stage-specific parental involvement scores were estimated from multiple measures from birth to age 7 years. Trajectory groups of parental involvement were derived via latent class growth analysis. At 18 years, depression cases were identified with diagnostic instruments. Multiple imputation was used to handle missingness. We constructed logistic regression models with potential confounders adjusted.

Results: Participants from trajectory groups with higher average parenting scores over time had 30% to 40% lower odds of developing depression in early adulthood than participants from the group with the lowest average parenting score over time. However, the relationship became non-significant when all covariates were adjusted. A one-unit increase in the overall parenting score corresponded to 12% lower odds of developing depression (adjusted OR=0.88 [0.79-0.98]). Protective effects on incident depression in early adulthood from parental involvement in school age (5-7 years), and not at other ages, were observed (OR=0.87 [0.77-0.99] for a one-unit increase in the parenting score at school age). However, the relationship became non-significant when all covariates were adjusted (OR=0.91 [0.80-1.03]).

Limitations: Measurements of parental involvement were only based on maternal report. The study has limited generalizability to other racial/ethnic groups.

Conclusion: Higher level of parental involvement during childhood lowers the risk of developing depression in early adulthood. These results suggest positive early life experiences may promote mental health across the life course.
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http://dx.doi.org/10.1016/j.jad.2020.03.108DOI Listing
August 2020

Tranexamic acid safely reduces hidden blood loss in patients undergoing intertrochanteric fracture surgery: a randomized controlled trial.

Eur J Trauma Emerg Surg 2020 May 15. Epub 2020 May 15.

Department of Orthopedics, The Third Hospital of Mianyang, Sichuan Mental Health Center, No. 190 The East Jiannan Road, Mianyang, 621000, China.

Purpose: To investigate the efficacy and safety of intravenous tranexamic acid (IV-TXA) in patients undergoing intertrochanteric fracture surgery.

Methods: A total of 122 patients were included in this double-blinded trial and equally randomized to receive 1 g of IV-TXA or normal saline 10 min before incision and 3 h later. The primary efficacy outcome was calculated hidden blood loss (HBL). The secondary efficacy outcome was allogeneic erythrocyte transfusion rate during hospitalization. Safety outcome was a composite of thromboembolic events including deep venous thrombosis (DVT) up to 90 days. A meta-analysis combining this study with previous randomized controlled trials in hip fracture surgery (total sample size: 1112 patients) was also conducted.

Results: The mean HBL in TXA group (640.96 ± 421.63 ml) was significantly lower than that in placebo group (1010.11 ± 398.96 ml, P < 0.001). The rate of erythrocyte transfusions was 29.5% in TXA group and 60.7% in placebo group (P = 0.001). The incidence of thromboembolic events at 90 days was 4.9% in TXA group and 1.6% in placebo group (P = 0.619). The updated meta-analysis showed that IV-TXA significantly reduced erythrocyte transfusion in hip fracture surgery (risk ratio 0.60, 95% confidence intervals 0.53-0.68), and IV-TXA caused no increased risk of thromboembolic events (risk difference 0.01, 95% confidence intervals - 0.02-0.04).

Conclusion: IV-TXA could effectively reduce the HBL and allogeneic erythrocyte transfusion requirements in patients undergoing intertrochanteric fracture surgery without an increase of thromboembolic events including DVT.

Trial Registration: Clinical trials: safety and efficiency of tranexamic acid in hip fracture patients. Date of registration: August 31, 2018.

Trial Registration Number: ChiCTR1800018110.
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http://dx.doi.org/10.1007/s00068-020-01387-0DOI Listing
May 2020

The relationship between inflammatory dietary pattern in childhood and depression in early adulthood.

Brain Behav Immun Health 2020 Feb;2:100017

Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, 1 University Place, Rensselaer, NY 12144, United States.

Background: Inflammation may be a hidden process in the relationship between dietary intake and depression, but no study has evaluated the role of diet and inflammation jointly in explaining depression risk in early life. The current study aims to investigate the relationship between inflammatory dietary pattern (IDP) in childhood and depression in early adulthood.

Methods: This study used data prospectively collected over 10 years from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (n ​= ​6939) free from depression at baseline (age 8.5 years). An IDP score was empirically derived via reduced rank regression and stepwise linear regression based on dietary intake data from the food frequency questionnaire at 8.5 years and levels of inflammatory biomarkers, C-reactive protein and interleukin-6, at 9.5 years. At age 18 years, depression cases were identified via the International Statistical Classification of Diseases, 10th Revision (ICD-10) diagnosis and the Clinical Interview Schedule-Revised (CIS-R) depression score. Logistic regression models were constructed to examine the relationship between the IDP score and risk of depression adjusted for potential confounders. Analyses stratified by weight status were also conducted. Multiple imputations were utilized to minimize bias due to loss-to-follow-up.

Results: Participants in the highest tertile of IDP score had 1.34 times odds to develop depression compared to those in the lowest tertile (95% CI, 1.08-1.66; -trend<0.01), after dietary misreporting status and energy intake were adjusted. After all covariates were adjusted, the relationship between IDP tertiles and depression was attenuated (highest tertile vs. lowest tertile: OR ​= ​1.21; 95% CI, 0.96-1.51); in addition, the relationship was marginally significant among participants who were not overweight or obese (p ​< ​0.10) but not significant among participants who were overweight or obese.

Conclusions: Higher IDP in childhood seems to be associated with higher depression risk in early adulthood. The study provides preliminary evidence that chronic inflammation may underlie the relationship between diet and depression even for children, especially those who are not overweight or obese.
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http://dx.doi.org/10.1016/j.bbih.2019.100017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043331PMC
February 2020

Berry Phase Effects in Dipole Density and the Mott Relation.

Phys Rev Lett 2020 Feb;124(6):066601

Department of Physics, The University of Texas at Austin, Austin, Texas 78712, USA.

We provide a unified semiclassical theory for thermoelectric responses of any observable represented by an operator θ[over ^] that is well defined in periodic crystals. The Einstein and Mott relations are established generally in the presence of Berry phase effects for various physical realizations of θ[over ^] in electronic systems, including the familiar case of the electric current as well as the currently controversial cases of the spin polarization and spin current. The magnetization current, which has been proven indispensable in the thermoelectric response of electric current, is generalized to the cases of various θ[over ^]. In our theory the dipole density of a physical quantity emerges and plays a vital role, which contains not only the statistical sum of the dipole moment of θ[over ^] but also a Berry phase correction.
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http://dx.doi.org/10.1103/PhysRevLett.124.066601DOI Listing
February 2020

Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration.

Cell Death Differ 2020 08 12;27(8):2344-2362. Epub 2020 Feb 12.

Department of Biochemistry and Molecular Biology and Department of Orthopaedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Rab5 is a master regulator for endosome biogenesis and transport while its in vivo physiological function remains elusive. Here, we find that Rab5a is upregulated in several in vivo and in vitro myogenesis models. By generating myogenic Rab5a-deficient mice, we uncover the essential roles of Rab5a in regulating skeletal muscle regeneration. We further reveal that Rab5a promotes myoblast differentiation and directly interacts with insulin receptor substrate 1 (IRS1), an essential scaffold protein for propagating IGF signaling. Rab5a interacts with IRS1 in a GTP-dependent manner and this interaction is enhanced upon IGF-1 activation and myogenic differentiation. We subsequently identify that the arginine 207 and 222 of IRS1 and tyrosine 82, 89, and 90 of Rab5a are the critical amino acid residues for mediating the association. Mechanistically, Rab5a modulates IRS1 activation by coordinating the association between IRS1 and the IGF receptor (IGFR) and regulating the intracellular membrane targeting of IRS1. Both myogenesis-induced and IGF-evoked AKT-mTOR signaling are dependent on Rab5a. Myogenic deletion of Rab5a also reduces the activation of AKT-mTOR signaling during skeletal muscle regeneration. Taken together, our study uncovers the physiological function of Rab5a in regulating muscle regeneration and delineates the novel role of Rab5a as a critical switch controlling AKT-mTOR signaling by activating IRS1.
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http://dx.doi.org/10.1038/s41418-020-0508-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370222PMC
August 2020

[Research progress on tranexamic acid in traumatic orthopedic surgery].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Nov;33(11):1457-1461

Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To summarize the research progress on the application of tranexamic acid (TXA) in traumatic orthopedic surgery in recent years.

Methods: The domestic and foreign literature in recent years was reviewed, and the efficacy and safety of TXA in traumatic orthopedic surgeries with different regimen, dose and route of administration were comprehensively summarized and compared.

Results: The application of TXA in traumatic orthopedic surgeries increased gradually in recent years. Intravenous or topical administration of TXA efficaciously reduced blood loss and transfusion requirements during hip fracture surgery without significantly increasing the risk of thromboembolic events. However, the efficacy was not clear in other traumatic orthopedic surgeries such as pelvic and acetabular fractures.

Conclusion: More studies are needed to confirm the efficacy and safety of TXA in traumatic orthopedic surgeries.
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http://dx.doi.org/10.7507/1002-1892.201902030DOI Listing
November 2019

Intermolecular Hetero-Diels-Alder Reactions of Photogenerated aza--Quinone Methides with Aldehydes.

Org Lett 2019 Nov 18;21(21):8783-8788. Epub 2019 Oct 18.

CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry , Central China Normal University , 152 Luoyu Road , Wuhan , Hubei 430079 , China.

A visible-light-driven, perfluoroalkyl radical-mediated strategy for in situ formation of aza--QMs from readily available precursors is reported. Combination of this method with a Brønsted base thus enables an efficient and highly diastereoselective HDA reaction between such photogenerated aza--QMs and π-electron-poor systems, aldehydes, providing high yielding and rapid access to valuable, diversely substituted dihydrobenzoxazines. DFT calculation elucidated the origins of stereochemistry of the products and disclosed the concerted property of the process.
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http://dx.doi.org/10.1021/acs.orglett.9b03399DOI Listing
November 2019

Effect of Change in the Supplemental Nutrition Assistance Program Guidelines on Vendor Participation and Availability of Fresh Produce.

Prev Chronic Dis 2019 08 22;16:E115. Epub 2019 Aug 22.

Department of Epidemiology and Biostatistics, University at Albany, Rensselaer, New York.

Introduction: In January 2018, new vendor eligibility standards for the Supplemental Nutrition Assistance Program (SNAP) were fully implemented to increase availability of healthy staple and perishable foods. We examined changes in SNAP vendor participation and availability of fresh fruits and vegetables (FFV) both short-term (2015 vs 2018) and long term (2003 vs 2018) in an urban, low-income community.

Methods: We conducted food store assessments from late June through early September of 2003, 2009, 2012, 2015, and 2018 in Albany, New York. SNAP status was assessed by using the US Department of Agriculture's list of SNAP-authorized stores and in-store verification.

Results: Numbers of SNAP vendors were 77 in 2003, 92 in 2009, 103 in 2012, 115 in 2015, and 109 in 2018. We observed a marginally significant (P = .049) short-term (2015, 85.9% vs 2018, 73.9%) decline in SNAP participation among convenience stores but no significant short-term changes in FFV availability among either SNAP or non-SNAP vendors. In long-term (2003 through 2018) trends, we found significant (P < .01) increases in SNAP participation among farmers markets and nonprofit organizations. The proportion of SNAP vendors stocking only 1 type of FFV also significantly increased, which was likely related to a consumer trend of favoring bananas as a grab-and-go snack.

Conclusion: Despite the decline of SNAP participation among convenience stores, which primarily came from increased program withdrawals, the new SNAP rule did not substantially alter FFV availability after 6 to 8 months of its full implementation. Long term, policy efforts increased SNAP participation among farmers markets.
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http://dx.doi.org/10.5888/pcd16.190020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716391PMC
August 2019

Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect.

Sci Adv 2019 08 2;5(8):eaax6946. Epub 2019 Aug 2.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.

Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material and as an antitumor agent. Inhibition of tumor growth, prevention of metastasis, and enhancement of the survival rate of tumor-bearing rabbits treated with n-HA were demonstrated. Activated mitochondrial-dependent apoptosis in vivo was confirmed, and we observed that a stimulated immune response was involved in the n-HA-induced antitumor effect. A porous titanium scaffold loaded with n-HA was fabricated and implanted into a critical-sized segmental bone defect in a rabbit tumor model. The n-HA-releasing scaffold not only showed a prominent effect in suppressing tumor growth and osteolytic lesion but also promoted bone regeneration. These findings provide a rationale for using n-HA in tumor-associated bone segmental defects.
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http://dx.doi.org/10.1126/sciadv.aax6946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677551PMC
August 2019

Characteristics of women infected with human papillomavirus in a tertiary hospital in Beijing China, 2014-2018.

BMC Infect Dis 2019 Jul 29;19(1):670. Epub 2019 Jul 29.

Clinical Laboratory, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Background: Human papillomavirus (HPV) infection is the main cause of precancerous lesions and cervical cancer in women. In order to determine the epidemiological characteristics as well as the relationship between the HPV genotype and cytology test results among women in Beijing, China, we retrospectively collected and analyzed the data from a tertiary hospital in Beijing, China.

Methods: A total of 21,239 women visited the China-Japan Friendship Hospital between 2014 and 2018 and their cervical exfoliations were collected. Thirteen HPV subtypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68) were examined and ThinPrep cytological test (TCT) was performed.

Results: Among all cases, 4473 (21.06%) women were infected with HPV. HPV52 (4.64%), HPV16 (4.44%) and HPV58 (4.28%) had higher prevalence. Single-type infection (77.26%) was more common than multiple-type infection (22.74%). Single-type infection was more frequently seen in women aged 50-60 years (17.17%), and multiple-type infection was more common in those aged < 30 years (7.88%). Significant differences in secular trends from 2014 to 2018 were observed for subtypes HPV39, 51, 52 and 58. HPV positive rates of women aged < 30 and 30-40 years changed significantly along with the time period, and the TCT positive rates of women aged 30-40, 40-50, 50-60 and >  60 years also showed significant differences from 2014 to 2018. In addition, 1746 (8.22%) women were TCT positive, of whom, 858 (4.04%), 561 (2.64%) and 327 (1.54%) had atypical squamous cells (ASCs), low-grade squamous intraepithelial lesions (LSILs) and high-grade squamous intraepithelial lesions (HSILs), respectively. Among four types of cytological lesions, the HPV infection rates were 16.76, 66.08, 63.99 and 85.32% in those negative for intraepithelial lesions or malignancy (NILM), ASC, LSIL and HSIL, respectively.

Conclusions: HPV52, 16 and 58 are the most common infection subtypes in this study and among four types of cytological lesions, HSILs has the highest HPV prevalence. Significant differences in secular trends are observed for different subtypes in recent 5 years. The results on HPV genotype-specific prevalence should be considered when the HPV vaccine program is implemented in Beijing area.
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http://dx.doi.org/10.1186/s12879-019-4313-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664751PMC
July 2019

Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration.

Aging Cell 2019 10 17;18(5):e13003. Epub 2019 Jul 17.

Department of Biochemistry and Molecular Biology, Department of Orthopaedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Cellular senescence plays both beneficial and detrimental roles in embryonic development and tissue regeneration, while the underlying mechanism remains elusive. Recent studies disclosed the emerging roles of heat-shock proteins in regulating muscle regeneration and homeostasis. Here, we found that Hsp90β, but not Hsp90α isoform, was significantly upregulated during muscle regeneration. RNA-seq analysis disclosed a transcriptional elevation of p21 in Hsp90β-depleted myoblasts, which is due to the upregulation of p53. Moreover, knockdown of Hsp90β in myoblasts resulted in p53-dependent cellular senescence. In contrast to the notion that Hsp90 interacts with and protects mutant p53 in cancer, Hsp90β preferentially bound to wild-type p53 and modulated its degradation via a proteasome-dependent manner. Moreover, Hsp90β interacted with MDM2, the chief E3 ligase of p53, to regulate the stability of p53. In line with these in vitro studies, the expression level of p53-p21 axis was negatively correlated with Hsp90β in aged mice muscle. Consistently, administration of 17-AAG, a Hsp90 inhibitor under clinical trial, impaired muscle regeneration by enhancing injury-induced senescence in vivo. Taken together, our finding revealed a previously unappreciated role of Hsp90β in regulating p53 stability to suppress senescence both in vitro and in vivo.
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http://dx.doi.org/10.1111/acel.13003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718578PMC
October 2019

Biochemical characterization of Helicobacter pylori α1-3-fucosyltransferase and its application in the synthesis of fucosylated human milk oligosaccharides.

Carbohydr Res 2019 Jul 16;480:1-6. Epub 2019 May 16.

College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, 050024, China. Electronic address:

Fucosylated human milk oligosaccharides (HMOs) have important biological functions. Enzymatic synthesis of such compounds requires robust fucosyltransferases. A C-terminal 66-amino acid truncated version of Helicobacter pylori α1-3-fucosyltransferase (Hp3FT) is a good candidate. Hp3FT was biochemically characterized to identify optimal conditions for enzymatic synthesis of fucosides. While N-acetyllactosamine (LacNAc) and lactose were both suitable acceptors, the former is preferred. At a low guanosine 5'-diphospho-β-L-fucose (GDP-Fuc) to acceptor ratio, Hp3FT selectively fucosylated LacNAc. Based on these enzymatic characteristics, diverse fucosylated HMOs, including 3-fucosyllactose (3-FL), lacto-N-fucopentaose (LNFP) III, lacto-N-neofucopentaose (LNnFP) V, lacto-N-neodifucohexaose (LNnDFH) II, difuco- and trifuco-para-lacto-N-neohexaose (DF-paraLNnH and TF-para-LNnH), were synthesized enzymatically by varying the ratio of the donor and acceptor as well as controlling the order of multiple glycosyltransferase-catalyzed reactions.
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http://dx.doi.org/10.1016/j.carres.2019.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613818PMC
July 2019

Is intravenous tranexamic acid effective and safe during hip fracture surgery? An updated meta-analysis of randomized controlled trials.

Arch Orthop Trauma Surg 2019 Jul 14;139(7):893-902. Epub 2019 Jan 14.

Department of Orthopedics, The Third Hospital of Mianyang (Sichuan Mental Health Center), No. 190 The East Jiannan Road, Mianyang, 621000, China.

Introduction: The efficacy and safety of intravenous (IV) tranexamic acid (TXA) during hip fracture surgery remain controversial. This meta-analysis aimed to assess the efficacy of IV-TXA administration during hip fracture surgery for reducing the transfusion requirement and blood loss as well as its safety regarding the risk of thrombolysis.

Materials And Methods: PubMed, EMBASE, Web of Science, and the Cochrane Library Database were systematically searched for randomized controlled trials (RCTs) that focused on the efficacy and safety of IV-TXA in patients during hip fracture surgery. The primary outcome was the transfusion requirement. Secondary outcomes included total blood loss (TBL), deep vein thrombosis (DVT), and total thromboembolic events (TTEs). Risk ratio (RR), risk difference (RD), and mean difference (MD) for dichotomous and continuous data outcomes were determined from the meta-analysis. Data were analyzed using Rev Man 5.3.

Results: Altogether, 11 RCTs were included (total sample size 892 patients). IV-TXA significantly reduced the transfusion requirement [RR 0.60, 95% confidence interval (CI) 0.38-0.93, P = 0.02] and TBL (MD 326.64 ml, 95% CI - 462.23 to - 191.06, P < 0.00001) vs. cosntrol group. IV-TXA caused no increased risk of DVT (RD 0.02, 95% CI - 0.01 to 0.04, P = 0.13) or TTEs (RD 0.02, 95% CI - 0.01 to 0.05, P = 0.12).

Conclusion: Available evidence indicates that IV-TXA efficaciously reduces TBL and transfusion requirements during hip fracture surgery without significantly increasing the risk of TTEs including DVT.
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http://dx.doi.org/10.1007/s00402-019-03118-6DOI Listing
July 2019

Identification of a giant mediastinal teratoma by echocardiography: A case report.

J Clin Ultrasound 2019 Jul 11;47(6):380-383. Epub 2019 Jan 11.

Department of Echocardiography, The First Hospital of Jilin University, Changchun, Jilin, China.

The diagnosis of mediastinal space-occupying lesions largely relies on X-ray and computed tomography. However, thanks to technological progress, transthoracic echocardiography can clearly display the mediastinal structures surrounding the heart and great vessels, thereby improving the detection rate of mediastinal space-occupying lesions. Primary mediastinal teratoma is relatively rare, and removal of giant mediastinal teratoma by thoracoscopic surgery has rarely been reported. Here, we report a case of giant mediastinal teratoma diagnosed by transthoracic echocardiography, which was treated by complete thoracoscopic resection and confirmed by histology.
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http://dx.doi.org/10.1002/jcu.22686DOI Listing
July 2019

Everyday Discrimination Experience and Depressive Symptoms in Urban Black, Guyanese, Hispanic, and White Adults.

J Am Psychiatr Nurses Assoc 2019 Nov/Dec;25(6):445-452. Epub 2018 Dec 20.

Xiao Cong, MPH, University at Albany School of Public Health, Rensselaer, NY, USA.

Discrimination experience is a stressor that may disproportionately affect the mental health of minority populations. We examined the association between discrimination experience and depressive symptoms among four urban racial/ethnic groups. Cross-sectional community-based health survey data for Black ( = 434), Guyanese ( = 180), Hispanic ( = 173), and White ( = 809) adults aged ⩾18 years were collected in Schenectady, New York, in 2013. Discrimination experience was measured with the Everyday Discrimination Scale (EDS), and depressive symptoms were measured with the Center for Epidemiologic Studies-Depression (CES-D) scale. Logistic regression models for the association between EDS and major depressive symptoms (CES-D ⩾ 16) were fitted for each racial/ethnic group. The final model adjusted for age, sex, education, income, smoking, alcohol binge drinking, emotional/social support, and perceived stress. The mean EDS scores varied significantly across groups ( < .001), with 2.6 in Hispanics, 2.2 in Whites, 2.0 in Blacks, and 1.1 in the Guyanese. There was a consistent and significant independent association between EDS and major depressive symptoms in the crude model and at each step of covariate adjustment in each group. Fully adjusted odds ratios were 1.28 (95% confidence interval [CI; 1.16, 1.41]) in Blacks, 1.83 in the Guyanese [1.36, 2.47], 1.23 in Hispanics [1.07, 1.41], and 1.24 [1.16, 1.33] in Whites. The presence of covariates did not significantly modify the main effect in each group. : This study suggests that discrimination experience can be one of the fundamental social causes of depression. It may be feasible to assess discrimination experience as a risk factor of depression in individuals of all racial/ethnic backgrounds.
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http://dx.doi.org/10.1177/1078390318814620DOI Listing
October 2020

Long-term results of vascularized os pisiform transfer for advanced Kienböck disease after follow-up for at least 15 years: A case series.

Medicine (Baltimore) 2018 Nov;97(48):e13229

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

No surgical procedure perfectly treats advanced Kienböck disease. Although vascularized os pisiform transferring (VOPT) is one of the main therapeutic approaches, reports on long-term follow-up and case series for this technique are scarce.We collected postoperative results in 11 patients with advanced Kienböck disease who underwent VOPT between 1986 and 2001 in our Hospital. Follow-up durations ranged from 15 to 26 years.At the last follow-up, excellent and good results were found in 81.8% according to the Modified Green and O'Brien score. Postoperative imaging revealed significantly reduced pisiform bone; carpal height ratio and Nattrass index were decreased, while the radioscaphoid angle was increscent, compared with preoperative and mid-term follow-up results.The favorable long-term results demonstrated that VOPT is a dependable and durable procedure for the treatment of advanced Kienböck disease, with pain relief and functional improvement despite some radiographic findings such as wrist osteoarthritis occurrence.
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http://dx.doi.org/10.1097/MD.0000000000013229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283118PMC
November 2018

Characterization and Genomic Analyses of Podovirus TC6: Establishment of Genus .

Front Microbiol 2018 25;9:2561. Epub 2018 Oct 25.

Department of Microbiology, Army Medical University, Chongqing, China.

Phages have attracted a renewed interest as alternative to chemical antibiotics. Although the number of phages is 10-fold higher than that of bacteria, the number of genomically characterized phages is far less than that of bacteria. In this study, phage TC6, a novel lytic virus of , was isolated and characterized. TC6 consists of an icosahedral head with a diameter of approximately 54 nm and a short tail with a length of about 17 nm, which are characteristics of the family . TC6 can lyse 86 out of 233 clinically isolated . strains, thus showing application potentials for phage therapy. The linear double-stranded genomic DNA of TC6 consisted of 49796 base pairs and was predicted to contain 71 protein-coding genes. A total of 11 TC6 structural proteins were identified by mass spectrometry. Comparative analysis revealed that the phages TC6, O4, PA11, and IME180 shared high similarity at DNA sequence and proteome levels, among which PA11 was the first phage discovered and published. Meanwhile, these phages contain 54 core genes and have very close phylogenetic relationships, which distinguish them from other known phage genera. We therefore proposed that these four phages can be classified as , comprising a new phage genus of that infects spp. The results of this work promoted our understanding of phage biology, classification, and diversity.
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http://dx.doi.org/10.3389/fmicb.2018.02561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209634PMC
October 2018

Synthesis of Phenolic Glycosides: Glycosylation of Sugar Lactols with Aryl Bromides via Dual Photoredox/Ni Catalysis.

J Org Chem 2018 11 22;83(21):13325-13334. Epub 2018 Oct 22.

CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry , Central China Normal University , 152 Luoyu Road , Wuhan 430079 , China.

Multifarious sugar lactols were efficiently transformed into the corresponding phenolic glycosides by treating with aryl bromides in acetonitrile with Ir[dF(CF)ppy](dtbbpy)(PF) as a photocatalyst under visible light irradiation. Both pyranoses and furanoses or even disaccharide could all suffer this glycosylation protocol under mild reaction conditions. A variety of phenyl glycosides can be produced in moderate to good yields (up to 93% yield), and a gram scale process of this protocol was also well-established.
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http://dx.doi.org/10.1021/acs.joc.8b02129DOI Listing
November 2018

Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration.

Mol Cell Biol 2018 12 28;38(24). Epub 2018 Nov 28.

Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou, China

The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblasts derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis and regeneration, but the precise cellular mechanism remains elusive. In this study, we found that Hsp70 was upregulated during myoblast differentiation. Depletion or inhibition of Hsp70/Hsc70 impaired myoblast differentiation. Importantly, overexpression of p38 mitogen-activated protein kinase α (p38MAPKα) but not AKT1 rescued the impairment of myogenic differentiation in Hsp70- or Hsc70-depleted myoblasts. Moreover, Hsp70 interacted with MK2, a substrate of p38MAPK, to regulate the stability of p38MAPK. Knockdown of Hsp70 also led to downregulation of both MK2 and p38MAPK in intact muscles and during cardiotoxin-induced muscle regeneration. Hsp70 bound MK2 to regulate MK2-p38MAPK interaction in myoblasts. We subsequently identified the essential regions required for Hsp70-MK2 interaction. Functional analyses showed that MK2 is essential for both myoblast differentiation and skeletal muscle regeneration. Taken together, our findings reveal a novel role of Hsp70 in regulating myoblast differentiation by interacting with MK2 to stabilize p38MAPK.
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http://dx.doi.org/10.1128/MCB.00211-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275188PMC
December 2018