Xianming Deng

Xianming Deng

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Xianming Deng

Publications by authors named "Xianming Deng"

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A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk mutation in B-cell malignancies.

Br J Pharmacol 2019 Jul 30. Epub 2019 Jul 30.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Science, Xiamen University, Xiamen, Fujian, 361102, China.

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http://dx.doi.org/10.1111/bph.14809DOI Listing
July 2019

Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair.

Acta Biomater 2019 May 28;90:49-59. Epub 2019 Mar 28.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610065, China.

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http://dx.doi.org/10.1016/j.actbio.2019.03.047DOI Listing
May 2019

Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: stereocontrolled access to bridged [4.2.1] lactones.

Chem Sci 2019 Mar 24;10(10):3123-3129. Epub 2019 Jan 24.

State Key Laboratory of Physical Chemistry of Solid Surfaces , Key Laboratory for Chemical Biology of Fujian Province , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email:

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http://dx.doi.org/10.1039/c9sc00079hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429610PMC
March 2019

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.

J Biol Chem 2019 02 26;294(8):2880-2891. Epub 2018 Dec 26.

From the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian 361102, China

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.003822
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http://dx.doi.org/10.1074/jbc.RA118.003822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393603PMC
February 2019

Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis.

Cell 2019 Feb 31;176(5):1113-1127.e16. Epub 2019 Jan 31.

Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193003
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http://dx.doi.org/10.1016/j.cell.2019.01.002DOI Listing
February 2019

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine.

Biomaterials 2018 12 19;185:322-332. Epub 2018 Sep 19.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki 00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.09.024DOI Listing
December 2018

A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.

Cancer Res 2018 10 22;78(20):5949-5957. Epub 2018 Aug 22.

State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Collaborative Innovation Center of Hematology, Collaborative Innovation Center of System Biology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0455DOI Listing
October 2018

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.

Stem Cell Reports 2018 10 20;11(4):929-943. Epub 2018 Sep 20.

Department of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, viale G.B. Morgagni, 50, Firenze 50134, Italy; Istituto Toscano Tumori (ITT), Firenze 50134, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178886PMC
October 2018

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.

Nat Commun 2018 10 8;9(1):4139. Epub 2018 Oct 8.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian, 361102, China.

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http://www.nature.com/articles/s41467-018-06556-9
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http://dx.doi.org/10.1038/s41467-018-06556-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175864PMC
October 2018

Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.

J Med Chem 2018 09 23;61(17):7560-7572. Epub 2018 Aug 23.

The Norwegian Structural Biology Centre, Department of Chemistry , UiT The Arctic University of Norway , N-9037 Tromsø , Norway.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01847DOI Listing
September 2018

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics.

Adv Mater 2018 Jun 11;30(24):e1703393. Epub 2017 Oct 11.

Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1002/adma.201703393DOI Listing
June 2018

Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities.

J Med Chem 2018 06 19;61(12):5424-5434. Epub 2018 Jun 19.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences , Xiamen University , Xiamen , Fujian 361102 , China.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00753DOI Listing
June 2018

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.

Nat Commun 2018 06 29;9(1):2550. Epub 2018 Jun 29.

Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.

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http://dx.doi.org/10.1038/s41467-018-04947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026158PMC
June 2018

ERK5 is activated by oncogenic BRAF and promotes melanoma growth.

Oncogene 2018 05 27;37(19):2601-2614. Epub 2018 Feb 27.

Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1038/s41388-018-0164-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945581PMC
May 2018

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.

EMBO Mol Med 2018 04;10(4)

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, China

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
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http://dx.doi.org/10.15252/emmm.201708689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887903PMC
April 2018

Development of three-dimensional brain arteriovenous malformation model for patient communication and young neurosurgeon education.

Br J Neurosurg 2018 Jan 15:1-4. Epub 2018 Jan 15.

b Department of Neurosurgery , Guangdong General Hospital, Institute of Neuroscience, Guangdong Academy of Medical Sciences , Guangzhou , Guangdong Province , China.

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http://dx.doi.org/10.1080/02688697.2018.1424320DOI Listing
January 2018

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.

J Exp Med 2017 Nov 11;214(11):3219-3238. Epub 2017 Oct 11.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China

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http://www.jem.org/lookup/doi/10.1084/jem.20171419
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http://dx.doi.org/10.1084/jem.20171419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679172PMC
November 2017

New 12,8-Eudesmanolides from Eutypella sp. 1-15.

J Antibiot (Tokyo) 2017 Oct 19;70(10):1029-1032. Epub 2017 Jul 19.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.

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http://dx.doi.org/10.1038/ja.2017.89DOI Listing
October 2017

Nonomuraea ceibae sp. nov., an actinobacterium isolated from Ceiba speciosa rhizosphere.

Int J Syst Evol Microbiol 2017 May 26;67(5):1158-1162. Epub 2017 May 26.

1​State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, PR China.

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http://www.microbiologyresearch.org/content/journal/ijsem/10
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http://dx.doi.org/10.1099/ijsem.0.001782DOI Listing
May 2017

Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway.

Appl Microbiol Biotechnol 2017 May 21;101(10):4201-4213. Epub 2017 Feb 21.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

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http://link.springer.com/10.1007/s00253-017-8187-7
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http://dx.doi.org/10.1007/s00253-017-8187-7DOI Listing
May 2017

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.

Cancer Cell 2017 05;31(5):669-684.e7

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863541PMC
May 2017

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins.

Antiviral Res 2017 02 9;138:61-67. Epub 2016 Dec 9.

Institute of Infection & Immunity, St George's, University of London, London, UK; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542163051
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http://dx.doi.org/10.1016/j.antiviral.2016.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244968PMC
February 2017

Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors.

Cancer Res 2017 01 10;77(1):175-186. Epub 2016 Oct 10.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1038DOI Listing
January 2017

Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis.

Mol Pharm 2016 11 17;13(11):3756-3763. Epub 2016 Oct 17.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen, Fujian 361102, China.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00564DOI Listing
November 2016

Discovery of a Series of 5,11-Dihydro-6-benzo[]pyrimido[5,4-][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors.

ACS Med Chem Lett 2016 Oct 2;7(10):908-912. Epub 2016 Aug 2.

Department of Cancer Biology, Dana-Farber Cancer Institute , Boston, Massachusetts 02215, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066161PMC
October 2016

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition.

Sci Signal 2016 10 18;9(450):e3. Epub 2016 Oct 18.

Department of Cellular and Molecular Physiology and Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/scisignal.aaj2227DOI Listing
October 2016

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.

Sci Transl Med 2016 08;8(352):352ra108

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China.

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http://stm.sciencemag.org/content/scitransmed/8/352/352ra108
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http://dx.doi.org/10.1126/scitranslmed.aaf2304DOI Listing
August 2016

Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling.

Cell Rep 2016 06 16;16(1):28-36. Epub 2016 Jun 16.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957947PMC
June 2016

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase.

PLoS One 2015 5;10(6):e0128364. Epub 2015 Jun 5.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", Naples, Italy; Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Naples, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128364PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457528PMC
March 2016

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proc Natl Acad Sci U S A 2015 Dec 14;112(52):15988-93. Epub 2015 Dec 14.

Department of Cell Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Laboratory of Epigenetics in Development and Tumorigenesis, Tianjin Research Center of Basic Medical Sciences, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China;

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http://dx.doi.org/10.1073/pnas.1521740112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702963PMC
December 2015

Cytochalasans and Sesquiterpenes from Eutypella scoparia 1-15.

Nat Prod Commun 2015 Dec;10(12):2027-30

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December 2015

Aspertetranones A-D, Putative Meroterpenoids from the Marine Algal-Associated Fungus Aspergillus sp. ZL0-1b14.

J Nat Prod 2015 Oct 17;78(10):2405-10. Epub 2015 Sep 17.

School of Pharmaceutical Sciences, Shandong University , Jinan, Shandong 250012, China.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00487DOI Listing
October 2015

Kribbella mirabilis sp. nov., isolated from rhizosphere soil of a herbaceous plant, Mirabilis jalapa L.

Int J Syst Evol Microbiol 2015 Sep 25;65(9):3143-7. Epub 2015 Jun 25.

2​State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, PR China 1​State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, PR China.

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http://www.microbiologyresearch.org/content/journal/ijsem/10
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http://dx.doi.org/10.1099/ijsem.0.000393DOI Listing
September 2015

Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis.

Cancer Biol Ther 2014 ;15(11):1479-88

a Laboratory of Microvascular Medicine; Medical Research Center; Shandong Provincial Qianfoshan Hospital ; Shandong University ; Jinan , Shandong , China.

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http://dx.doi.org/10.4161/15384047.2014.955728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623302PMC
August 2015

Kibdelosporangium lantanae sp. nov., isolated from the rhizosphere soil of an ornamental plant, Lantana camara L.

Int J Syst Evol Microbiol 2015 Aug 7;65(8):2581-5. Epub 2015 May 7.

1​ State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, PR China 2​ State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, PR China.

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http://www.microbiologyresearch.org/content/journal/ijsem/10
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http://dx.doi.org/10.1099/ijs.0.000302DOI Listing
August 2015

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.

Nat Commun 2015 Feb 19;6:6239. Epub 2015 Feb 19.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiang'An district, Xiamen, Fujian 361102, China.

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http://dx.doi.org/10.1038/ncomms7239DOI Listing
February 2015

Heat shock protein 90 inhibitor mycoepoxydiene modulates kinase signaling in cervical cancer cells and inhibits in-vivo tumor growth.

Anticancer Drugs 2015 Jan;26(1):25-34

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, People's Republic of China.

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http://dx.doi.org/10.1097/CAD.0000000000000135DOI Listing
January 2015

Three new asperentin derivatives from the algicolous fungus Aspergillus sp. F00785.

Mar Drugs 2014 Dec 15;12(12):5993-6002. Epub 2014 Dec 15.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.

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http://www.mdpi.com/1660-3397/12/12/5993
Publisher Site
http://dx.doi.org/10.3390/md12125993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278214PMC
December 2014

Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9.

Bioorg Med Chem Lett 2014 Nov 16;24(21):4995-8. Epub 2014 Sep 16.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.09.026DOI Listing
November 2014

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.

Sci Signal 2014 Oct 28;7(349):ra102. Epub 2014 Oct 28.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Göteborg, Sweden.

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http://dx.doi.org/10.1126/scisignal.2005470DOI Listing
October 2014

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.

Eur J Med Chem 2013 29;70:758-67. Epub 2013 Oct 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ejmech.2013.10.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914206PMC
September 2014

Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

Cell Rep 2014 May 17;7(3):871-82. Epub 2014 Apr 17.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.045DOI Listing
May 2014

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.

Biochem J 2014 Jan;457(1):215-25

*MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BJ20131152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969223PMC
January 2014

The measurement of corneal thickness from center to limbus in vivo in C57BL/6 and BALB/c mice using two-photon imaging.

Exp Eye Res 2013 Oct 3;115:255-62. Epub 2013 Aug 3.

Henan Eye Institute, Henan Eye Hospital, Department of Ophthalmology, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2013.07.025DOI Listing
October 2013

Two-photon imaging of the cornea visualized in the living mouse using vital dyes.

Invest Ophthalmol Vis Sci 2013 Oct 1;54(10):6526-36. Epub 2013 Oct 1.

Henan Eye Institute, Henan Eye Hospital, Department of Ophthalmology, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.

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http://dx.doi.org/10.1167/iovs.13-12214DOI Listing
October 2013

X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.

J Med Chem 2013 Jun 17;56(11):4413-21. Epub 2013 May 17.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1021/jm4000837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683888PMC
June 2013

A novel murine model of Fusarium solani keratitis utilizing fluorescent labeled fungi.

Exp Eye Res 2013 May 19;110:107-12. Epub 2013 Mar 19.

Henan Eye Institute, Henan Eye Hospital, Department of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Zhengzhou 450003, PR China.

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http://dx.doi.org/10.1016/j.exer.2013.03.002DOI Listing
May 2013

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011).

Expert Opin Ther Pat 2012 Dec 6;22(12):1415-26. Epub 2012 Nov 6.

Xiamen University, School of Life Sciences, State Key Laboratory of Cellular Stress Biology, Fujian 361005, China.

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http://dx.doi.org/10.1517/13543776.2012.729041DOI Listing
December 2012

Brain Penetrant LRRK2 Inhibitor.

ACS Med Chem Lett 2012 Aug 18;3(8):658-662. Epub 2012 Jun 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA ; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA.

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http://dx.doi.org/10.1021/ml300123aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467149PMC
August 2012

An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit.

Bioorg Med Chem Lett 2012 Jul 6;22(14):4579-84. Epub 2012 Jun 6.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.05.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547541PMC
July 2012

Pyrazolopyridines as inhibitors of the kinase LRRK2: a patent evaluation (WO2011141756).

Expert Opin Ther Pat 2012 Jun 21;22(6):709-13. Epub 2012 May 21.

Dana-Farber Cancer Institute, Harvard Medical School, Department of Biological Chemistry & Molecular Pharmacology, 250 Longwood Ave, SGM 628, Boston, MA 02115, USA.

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http://dx.doi.org/10.1517/13543776.2012.691968DOI Listing
June 2012

Hippo pathway in intestinal homeostasis and tumorigenesis.

Protein Cell 2012 Apr 10;3(4):305-10. Epub 2012 Apr 10.

State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China.

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http://link.springer.com/10.1007/s13238-012-2913-9
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http://dx.doi.org/10.1007/s13238-012-2913-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875478PMC
April 2012

Characterization of TAE684 as a potent LRRK2 kinase inhibitor.

Bioorg Med Chem Lett 2012 Mar 28;22(5):1864-9. Epub 2012 Jan 28.

MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/j.bmcl.2012.01.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433743PMC
March 2012

Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen.

ACS Chem Biol 2012 Jan 21;7(1):185-96. Epub 2011 Oct 21.

Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/cb200305u
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262907PMC
January 2012

Expanding the diversity of allosteric bcr-abl inhibitors.

J Med Chem 2010 Oct;53(19):6934-46

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/jm100555fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951064PMC
October 2010

Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.

Cancer Cell 2010 Sep;18(3):258-67

Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939729PMC
September 2010

Broad spectrum alkynyl inhibitors of T315I Bcr-Abl.

Bioorg Med Chem Lett 2010 Jul 19;20(14):4196-200. Epub 2010 May 19.

Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901992PMC
July 2010

Highly stereoselective synthesis of trisubstituted vinylcyclopropane derivatives via arsonium ylides.

J Org Chem 2005 Nov;70(24):10202-5

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China.

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November 2005