Xianjun Fang

Xianjun Fang

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Xianjun Fang

Xianjun Fang

Publications by authors named "Xianjun Fang"

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LPA receptor 4 deficiency attenuates experimental atherosclerosis.

J Lipid Res 2019 May 22;60(5):972-980. Epub 2019 Feb 22.

Division of Cardiovascular Medicine, Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY 40536

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http://dx.doi.org/10.1194/jlr.M091066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495174PMC
May 2019

Immunometabolism: A new target for improving cancer immunotherapy.

Adv Cancer Res 2019 17;143:195-253. Epub 2019 Apr 17.

Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2019.03.004DOI Listing
April 2019

Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876.

Cancers (Basel) 2018 Dec 31;11(1). Epub 2018 Dec 31.

Department of Biochemistry & Molecular Biology, Virginia Commonwealth University School of Medicine, 1101 East Marshall Street, Richmond, VA 23298, USA.

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http://dx.doi.org/10.3390/cancers11010033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356953PMC
December 2018

Fatty acid oxidation: An emerging facet of metabolic transformation in cancer.

Cancer Lett 2018 10 10;435:92-100. Epub 2018 Aug 10.

Department of Biochemistry & Molecular Biology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240910PMC
October 2018

Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-κB signaling pathway to protect against DSS-induced colitis.

Int Immunopharmacol 2018 Apr 24;57:121-131. Epub 2018 Feb 24.

Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, PR China; School of Basic Medicine & Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2018.01.049DOI Listing
April 2018

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.

J Pharmacol Exp Ther 2018 01 17;364(1):110-119. Epub 2017 Oct 17.

Departments of Pharmacology and Toxicology (S.L.K., W.T., D.B., J.A.M., L.D.S., A.H.L., M.I.D., D.A.G.), Neurology (Z.-J.C.), Internal Medicine (E.D.F.), Biochemistry and Molecular Biology (X.F.), and Anatomy and Neurobiology (J.W.B.), and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Experimental Animals Breeding and Research Center, Uludag University, Bursa, Turkey (D.B.).

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http://dx.doi.org/10.1124/jpet.117.243972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738719PMC
January 2018

CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis.

Mol Carcinog 2017 Nov 13;56(11):2434-2445. Epub 2017 Jul 13.

Department of Pharmacology, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1002/mc.22691DOI Listing
November 2017

The role of cPLA2 in Methylglyoxal-induced cell apoptosis of HUVECs.

Toxicol Appl Pharmacol 2017 05 22;323:44-52. Epub 2017 Mar 22.

Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.03.020DOI Listing
May 2017

In-depth LC-MS/MS analysis of the chicken ovarian cancer proteome reveals conserved and novel differentially regulated proteins in humans.

Anal Bioanal Chem 2015 Sep 10;407(22):6851-63. Epub 2015 Jul 10.

W.M. Keck FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, 2620 Yarbrough Dr., Box 8204, Raleigh, NC, 27695, USA.

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http://link.springer.com/10.1007/s00216-015-8862-4
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http://dx.doi.org/10.1007/s00216-015-8862-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266611PMC
September 2015

Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells.

Neoplasia 2015 Sep;17(9):723-734

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14765586150011
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http://dx.doi.org/10.1016/j.neo.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611075PMC
September 2015

The role of corticotropin-releasing hormone receptor 1 in the development of colitis-associated cancer in mouse model.

Endocr Relat Cancer 2014 Aug;21(4):639-51

Key Laboratory of Cardiovascular and Molecular InterventionDepartment of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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http://dx.doi.org/10.1530/ERC-14-0239DOI Listing
August 2014

Corticotropin-releasing hormone receptors mediate apoptosis via cytosolic calcium-dependent phospholipase A₂ and migration in prostate cancer cell RM-1.

J Mol Endocrinol 2014 Jun 28;52(3):255-67. Epub 2014 Apr 28.

Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China.

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http://dx.doi.org/10.1530/JME-13-0270DOI Listing
June 2014

Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263.

Mol Cancer Ther 2013 Dec 14;12(12):2640-50. Epub 2013 Oct 14.

Corresponding Authors: Huanjie Shao, Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, 1101 East Marshall Street, Richmond, VA 23298.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871201PMC
December 2013

The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents.

Bioorg Med Chem Lett 2012 Aug 16;22(15):5093-7. Epub 2012 Jun 16.

Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X120076
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http://dx.doi.org/10.1016/j.bmcl.2012.05.127DOI Listing
August 2012

Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.

J Biol Chem 2012 Jul 3;287(30):24990-5000. Epub 2012 Jun 3.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1074/jbc.M112.340083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408203PMC
July 2012

Lysophosphatidic acid-induced p21Waf1 expression mediates the cytostatic response of breast and ovarian cancer cells to TGFβ.

Mol Cancer Res 2011 Nov 2;9(11):1562-70. Epub 2011 Sep 2.

Virginia Commonwealth University School of Medicine, Department of Biochemistry and Molecular Biology, Richmond, VA 23298, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-11
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http://dx.doi.org/10.1158/1541-7786.MCR-11-0340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388908PMC
November 2011

Characterization of lysophosphatidic acid subspecies produced by autotaxin using a modified HPLC ESI-MS/MS method.

Anal Methods 2011 Nov;3(12):2822-2828

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 1101 East Marshall Street, P.O. Box 980614, Richmond, Virginia, 23298-0614 ; Research and Development, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, Virginia, 23249 ; The Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, 23298.

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http://dx.doi.org/10.1039/C1AY05459GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956132PMC
November 2011

Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.

FEBS Lett 2010 Sep 7;584(18):4077-82. Epub 2010 Sep 7.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1016/j.febslet.2010.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947956PMC
September 2010

Large scale purification and characterization of recombinant human autotaxin/lysophospholipase D from mammalian cells.

BMB Rep 2010 Aug;43(8):541-6

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872511PMC
http://dx.doi.org/10.5483/bmbrep.2010.43.8.541DOI Listing
August 2010

Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study.

J Mol Graph Model 2009 Aug 19;28(1):70-9. Epub 2009 Apr 19.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.

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http://dx.doi.org/10.1016/j.jmgm.2009.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373609PMC
August 2009

Sp-1 and c-Myc mediate lysophosphatidic acid-induced expression of vascular endothelial growth factor in ovarian cancer cells via a hypoxia-inducible factor-1-independent mechanism.

Clin Cancer Res 2009 Jan;15(2):492-501

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872515PMC
January 2009

Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.

Mol Biol Cell 2008 Dec 8;19(12):5435-45. Epub 2008 Oct 8.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1091/mbc.e08-03-0316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592656PMC
December 2008

Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.

J Natl Cancer Inst 2008 Nov 11;100(22):1630-42. Epub 2008 Nov 11.

Department of Systems Biology, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/jnci/djn378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720766PMC
November 2008

Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells.

FASEB J 2008 Aug 24;22(8):2639-51. Epub 2008 Mar 24.

Virginia Commonwealth University, Department of Biochemistry and Molecular Biology, 1101 East Marshall St., Richmond, VA 23298, USA.

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http://dx.doi.org/10.1096/fj.07-101428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493458PMC
August 2008

Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.

Cancer Res 2008 Aug;68(16):6569-77

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0614, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763580PMC
August 2008

Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.

Cancer Res 2006 Mar;66(5):2740-8

Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2947DOI Listing
March 2006

Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.

J Biol Chem 2004 Dec 1;279(49):51075-81. Epub 2004 Oct 1.

Department of Molecular Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M408607200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328675PMC
December 2004

Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.

J Biol Chem 2004 Sep 13;279(38):39541-54. Epub 2004 Jul 13.

Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M403449200DOI Listing
September 2004

Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.

J Biol Chem 2004 Mar 11;279(10):9653-61. Epub 2003 Dec 11.

Department of Molecular Therapeutics, M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M306662200DOI Listing
March 2004

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

J Biol Chem 2003 Oct 17;278(41):40057-66. Epub 2003 Jul 17.

Department of Molecular Therapeutics, Division of Cancer Medicine, M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M303621200DOI Listing
October 2003

Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer.

Semin Oncol 2003 Oct;30(5 Suppl 16):93-104

Department of Molecular Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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October 2003

ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.

Oncogene 2003 May;22(19):2897-909

Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/sj.onc.1206380DOI Listing
May 2003

Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells.

J Biol Chem 2003 Jan 5;278(2):1380-7. Epub 2002 Nov 5.

Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network, Ontario M5G 2M1, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M206006200
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http://dx.doi.org/10.1074/jbc.M206006200DOI Listing
January 2003

Lysophosphatidic acid is a bioactive mediator in ovarian cancer.

Biochim Biophys Acta 2002 May;1582(1-3):257-64

Department of Molecular Therapeutics, University of Texas M.D. Anderson Cancer Center, Box 317, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s1388-1981(02)00179-8DOI Listing
May 2002