Publications by authors named "Xiangyu Liu"

226 Publications

Flexible Seaweed-Like Triboelectric Nanogenerator as a Wave Energy Harvester Powering Marine Internet of Things.

ACS Nano 2021 Sep 16. Epub 2021 Sep 16.

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0245, United States.

The marine internet of things (MIoT), an increasingly important foundation for ocean development and protection, consists of a variety of marine distributed sensors under water. These sensors of the MIoT have always been highly dependent on batteries. To realize power supply, a flexible seaweed-like triboelectric nanogenerator (S-TENG) capable of harvesting wave energy is proposed in this study. The flexible structure, designed with inspiration from the seaweed structure, processes extensive marine application scenarios. The bending and recovering of the S-TENG structure under wave excitations are converted to electricity. As the output performance increases with the number of parallel connected S-TENG units, an S-TENG system with multiple units could serve for floating buoys, coastal power stations, and even submerged devices. Through the demonstration experiments performed in this study, the flexible, low-cost S-TENG could become an effective approach to achieve a battery independent MIoT.
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http://dx.doi.org/10.1021/acsnano.1c05127DOI Listing
September 2021

Effects of Video Task With a High-Level Exercise Illustration on Knee Movements in Male Volleyball Spike Jump.

Front Psychol 2021 30;12:644188. Epub 2021 Aug 30.

Research Academy of Grand Health, Faculty of Sports Science, Ningbo University, Ningbo, China.

Hazardous knee biomechanics, such as excessive knee affordance link with injuries in volleyball spike jumps (SPJs) and can be reconfigured by the enhancement of internal focus. The study aimed to explore the effects of video tasks illustrating a high-level SPJ on knee movement in the volleyball SPJ with 15 elite male volleyball athletes. This study investigated the knee movements in sagittal, coronal, and transverse planes before and after the video task in SPJ using one-dimensional statistical parametric mapping (SPM 1D) and discrete statistics. The SPM 1D indicated a larger knee flexion angle (31.17-73.19%, = 2.611, and = 0.012), increased knee flexion moment (19.72-21.38%, = 0.029, and = 0.029), and increased knee adduction angular velocity (49.07-62.64%, = 3.148, and = 0.004) after video task; alternatively, smaller knee external rotation angular velocity (45.85-49.96%, = 5.199, and = 0.017) and vertical ground reaction (vGRF) (3.13-5.94%, = 4.096, and = 0.014; 19.83-21.97%, = 4.096, and = 0.024) were found after the task. With discrete value statistics, the video task increased the peak of knee flexion angle while decreased the peak of extension moment, flexion moment, abduction moment, external moment, the first peak vGRF, and related loading rate. Conclusions: The results indicate that knee biomechanics in volleyball SPJ positively influenced by the video task. The task has the athletes control the knee movements more actively and improves the original hazardous movement strategies. Therefore, the video task presumably can abate the occurrence of knee injuries in volleyball SPJ. Further validation especially in the exercise effect is needed in the future.
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http://dx.doi.org/10.3389/fpsyg.2021.644188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435894PMC
August 2021

Fast and Highly Efficient Adsorption Removal of Toxic Pb(II) by a Reusable Porous Semi-IPN Hydrogel Based on Alginate and Poly(Vinyl Alcohol).

Front Chem 2021 28;9:662482. Epub 2021 Jul 28.

Key Laboratory of Clay Mineral Applied Research of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China.

A porous semi-interpenetrating network (semi-IPN) hydrogel adsorbent with excellent adsorption properties and removal efficiency towards Pb(II) was prepared by a facile grafting polymerization reaction in aqueous medium using natural biopolymer sodium alginate (SA) as the main chains, sodium acrylate (NaA) as the monomers, and poly(vinyl alcohol) (PVA) as the semi-IPN component. FTIR, TGA and SEM analyses confirm that NaA monomers were grafted onto the macromolecular chains of SA, and PVA chains were interpenetrated and entangled with the crosslinked network. The incorporation of PVA facilitates to form pores on the surface of hydrogel adsorbent. The semi-IPN hydrogel containing 2 wt% of PVA exhibits high adsorption capacity and fast adsorption rate for Pb(II). The best adsorption capacity reaches 784.97 mg/g, and the optimal removal rate reaches 98.39% (adsorbent dosage, 2 g/L). In addition, the incorporation of PVA improved the gel strength of hydrogel, and the storage modulus of hydrogel increased by 19.4% after incorporating 2 wt% of PVA. The increase of gel strength facilitates to improve the reusability of hydrogel. After 5 times of regeneration, the adsorption capacity of SA--PNaA decreased by 23.2%, while the adsorption capacity of semi-IPN hydrogel only decreased by 10.8%. The adsorption kinetics of the hydrogel in the initial stage (the moment when the adsorbent contacts solution) and the second stage are fitted by segmentation. It is intriguing that the adsorption kinetics fits well with both pseudo-second-order kinetic model and pseudo-first-order model before 60 s, while only fits well with pseudo-second-order adsorption model in the whole adsorption process. The chemical complexing adsorption mainly contribute to the efficient capturing of Pb(II).
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http://dx.doi.org/10.3389/fchem.2021.662482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355593PMC
July 2021

Gelatin methacrylate hydrogel scaffold carrying resveratrol-loaded solid lipid nanoparticles for enhancement of osteogenic differentiation of BMSCs and effective bone regeneration.

Regen Biomater 2021 Oct 30;8(5):rbab044. Epub 2021 Jul 30.

Department of Orthopedics, First Affiliated Hospital, Bengbu Medical College, Bengbu 233004, China.

Critical-sized bone defects caused by traumatic fractures, tumour resection and congenital malformation are unlikely to heal spontaneously. Bone tissue engineering is a promising strategy aimed at developing replacements for bone transplantation and overcoming the limitations of natural bone grafts. In this study, we developed an innovative bone engineering scaffold based on gelatin methacrylate (GelMA) hydrogel, obtained via a two-step procedure: first, solid lipid nanoparticles (SLNs) were loaded with resveratrol (Res), a drug that can promote osteogenic differentiation and bone formation; these particles were then encapsulated at different concentrations (0.01%, 0.02%, 0.04% and 0.08%) in GelMA to obtain the final Res-SLNs/GelMA scaffolds. The effects of these scaffolds on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and bone regeneration in rat cranial defects were evaluated using various characterization assays. Our and investigations demonstrated that the different Res-SLNs/GelMA scaffolds improved the osteogenic differentiation of BMSCs, with the ideally slow and steady release of Res; the optimal scaffold was 0.02 Res-SLNs/GelMA. Therefore, the 0.02 Res-SLNs/GelMA hydrogel is an appropriate release system for Res with good biocompatibility, osteoconduction and osteoinduction, thereby showing potential for application in bone tissue engineering.
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http://dx.doi.org/10.1093/rb/rbab044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358478PMC
October 2021

Relationship of Circadian Rhythm and Psychological Health in Adolescents and Young Adults With Cancer.

Cancer Nurs 2021 Aug 11. Epub 2021 Aug 11.

Author Affiliations: The Third Xiangya Hospital (Ms Li and Drs He, Xie, Duan, and Zhou) and Xiangya Nursing School (Mss Li, Sun, Xiao, and Wang), Central South University; Clinical Nursing Safety Management Research Center of Central South University (Drs Duan and Xie); and Hunan Cancer Hospital (Dr Liu), Changsha; and Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong (Dr Cheng), China.

Background: Evidence shows that adolescent and young adult (AYA) cancer patients have an increasing survival rate but experience psychological distress and circadian rhythm dysregulation. Little is known about the effect of circadian rhythm on psychological distress.

Objective: To investigate the type of circadian rhythm in Chinese AYA cancer survivors and examine the associations among chronotype, demographic characteristics, psychological distress, anxiety and depression, character strengths, and medical coping in this group.

Methods: This cross-sectional study enrolled 800 AYA cancer participants, 728 of whom completed the Chinese version of the Morningness-Eveningness Questionnaire, the Distress Thermometer, the Hospital Anxiety and Depression Scale, the Three-Dimensional Inventory of Character Strengths, and the Medical Coping Modes Questionnaire.

Results: Evening- and morning-type participants accounted for 35.0% and 19.1%, respectively, among participants, which was significantly higher than those found in the general population. The prevalence of psychological distress was 84.9% among AYA cancer participants. Exercise, Distress Thermometer, and depression were important predictive factors for the circadian rhythm.

Conclusions: Circadian rhythm disorder and psychological distress were common among AYA cancer survivors. Evening-type participants performed worse on character strength, confrontation, and avoidance of medical coping.

Implications For Practice: Healthcare professionals need to understand the circadian rhythm and psychological health of AYA cancer survivors. Psychological rehabilitation guidance, especially within the 6 months after diagnosis, may benefit AYA survivors according to their chronotype. Character strengths can also be used during rehabilitation to properly guide AYA survivors.
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http://dx.doi.org/10.1097/NCC.0000000000000971DOI Listing
August 2021

Inflammatory Response to Spinal Cord Injury and Its Treatment.

World Neurosurg 2021 Aug 8;155:19-31. Epub 2021 Aug 8.

Department of Orthopedics, First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China. Electronic address:

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects thousands of human beings, and the pathologic changes after injury have been a hot spot for exploration in clinical medicine. With the development of new treatments, the survival of patients has shown an increasing trend; however, the inflammatory response after injury has not yet been effectively controlled. SCI is divided into primary injury and secondary injury according to the time of injury and pathophysiologic changes. Primary injury occurs immediately and the damage to the injury site is irreversible; however, secondary injury occurs after primary injury and involves pathologic changes at the cellular and molecular levels, which are reversible. Thus, the inflammatory response from secondary injuries has become the main direction of research. In recent years, a complex pathophysiologic mechanism has gradually been unveiled, which has been followed by an upgrade of treatment methods. This article describes the mechanisms of the inflammatory response after SCI and the mainstream treatment modalities. Also, neuroprotective agents and nerve regeneration agent agents are commonly used in the treatment of SCI; the therapeutic mechanism and classification of these agents are reviewed.
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http://dx.doi.org/10.1016/j.wneu.2021.07.148DOI Listing
August 2021

Alkali-Resistant Catalytic Reduction of NO via Naturally Coupling Active and Poisoning Sites.

Environ Sci Technol 2021 Jul 29. Epub 2021 Jul 29.

State Key Laboratory of Advanced Special Steel, School of Materials Science and Engineering, International Joint Laboratory of Catalytic Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China.

Releasing the poisoning effect of alkali metals over catalysts is still an intractable issue for selective catalytic reduction (SCR) of NO with ammonia. The presence of K in fly ash always dramatically suppressed catalytic activity by impairing acidity and redox properties, leading to severe reduction of lifetime for SCR catalysts. Herein, alkali-resistant NO reduction over TiO-supported Fe(SO) catalysts was originally demonstrated via naturally coupling active and poisoning sites. Notably, TiO-supported Fe(SO) catalysts expressed admirable NO conversion and K resistance within a quite broad temperature window of 200-500 °C. The catalysts with more conserved sulfate species revealed that sulfate groups preferred to migrate from the bulk phase to surface, thus effectively binding with K poisons to release the damage on iron active sites. Because of protection effects of migrated sulfates and closely coupling effects with Fe active sites, NH and NO adsorption amounts and rates were well maintained. In this way, Fe metal sites and sulfate species closely coupled together on a self-preserved TiO-supported Fe(SO) catalyst played essential roles as highly active sites and unique poisoning sites. This work paves a new way to design SCR catalysts with superior alkali resistance that are more reliable in practical deNO application.
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http://dx.doi.org/10.1021/acs.est.1c02061DOI Listing
July 2021

[Study on the gelatin methacryloyl composite scaffold with exogenous transforming growth factor β to promote the repair of skull defects].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):904-912

Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui, 233000, P.R.China.

Objective: To prepare a bone tissue engineering scaffold for repairing the skull defect of Sprague Dawley (SD) rats by combining exogenous transforming growth factor β (TGF-β ) with gelatin methacryloyl (GelMA) hydrogel.

Methods: Firstly, GelMA hydrogel composite scaffolds containing exogenous TGF-β at concentrations of 0, 150, 300, 600, 900, and 1 200 ng/mL (set to groups A, B, C, D, E, and F, respectively) were prepared. Cell counting kit 8 (CCK-8) method was used to detect the effect of composite scaffold on the proliferation of bone marrow mesenchymal stem cells (BMSCs) in SD rats. ALP staining, alizarin red staining, osteocalcin (OCN) immunofluorescence staining, and Western blot were used to explore the effect of scaffolds on osteogenic differentiation of BMSCs, and the optimal concentration of TGF-β /GelMA scaffold was selected. Thirty-six 8-week-old SD rats were taken to prepare a 5 mm diameter skull bone defect model and randomly divided into 3 groups, namely the control group, the GelMA group, and the GelMA+TGF-β group (using the optimal concentration of TGF-β /GelMA scaffold). The rats were sacrificed at 4 and 8 weeks after operation, and micro-CT, HE staining, and OCN immunohistochemistry staining were performed to observe the repair effect of skull defects.

Results: The CCK-8 method showed that the TGF-β /GelMA scaffolds in each group had a promoting effect on the proliferation of BMSCs. Group D had the strongest effect, and the cell activity was significantly higher than that of the other groups ( <0.05). The results of ALP staining, alizarin red staining, OCN immunofluorescence staining, and Western blot showed that the percentage of ALP positive area, the percentage of alizarin red positive area, and the relative expressions of ALP and OCN proteins in group D were significantly higher than those of the other groups ( <0.05), the osteogenesis effect in group D was the strongest. Therefore, experiments screened out the optimal concentration of TGF-β /GelMA scaffold to be 600 ng/mL. Micro-CT, HE staining, and OCN immunohistochemistry staining of rat skull defect repair experiments showed that the new bone tissue and bone volume/tissue volume ratio in the TGF-β +GelMA group were significantly higher than those in the GelMA group and control group at 4 and 8 weeks after operation ( <0.05).

Conclusion: The TGF-β /GelMA scaffold with a concentration of 600 ng/mL can significantly promote the osteogenic differentiation of BMSCs, can significantly promote bone regeneration at the skull defect, and can be used as a bioactive material for bone tissue regeneration.
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http://dx.doi.org/10.7507/1002-1892.202102008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311206PMC
July 2021

Evaluation indicators of nutritional quality.

J Food Sci Technol 2021 Aug 30;58(8):2943-2951. Epub 2020 Sep 30.

College of Food Science and Engineering, Ocean University of China, Qingdao, 266003 Shandong People's Republic of China.

To access the nutritional quality of the , a comprehensive quality evaluation procedure is always important to be established. In this study, fifteen nutritional quality evaluation indicators of from 7 months were analyzed, and the most important indicators were determined using a combination of multiple chemometric methods such as correlation analysis (CA), principal component analysis (PCA), and system cluster analysis (SCA). Significant differences in nutritional quality were observed across the 7 months, as per the ANOVA results ( < 0.05). The coefficient of variation values for the fifteen evaluation indicators for across 7 months was 1.67-43.47%. The CA results revealed that some indicators were correlated to each other within a certain range. Four principal components with eigen-values > 1 were obtained with PCA, and a cumulative contribution of 92.11% was achieved. In addition, four essential quality indicators were extracted using SCA. Using these four indicators, a simple and efficient procedure can be applied for quality control in aquaculture.
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http://dx.doi.org/10.1007/s13197-020-04796-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249540PMC
August 2021

Changes in synchronization of the motor unit in muscle fatigue condition during the dynamic and isometric contraction in the Biceps Brachii muscle.

Neurosci Lett 2021 09 6;761:136101. Epub 2021 Jul 6.

School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. Electronic address:

The fatigue-induced neuromuscular mechanism remains to be fully elucidated. So far, the macroscopic mechanism using global surface electromyogram (sEMG) has been widely investigated. However, the microscopic mechanism using high-level neural information based on motor unit (MU) spike train from the spinal cord lacks attention, especially for the conditions under dynamic contraction task. The synchronization of the MU spike train is generally assumed to be an excellent indicator to represent the activities of spinal nerves. Accordingly, this study employed synchronization of MU spike train decomposed from high-density sEMG (HD-sEMG) to investigate the fatigue condition in muscular contractions within the Biceps Brachii muscle under both isometric and dynamic contraction tasks, giving a complete picture of the microscopic fatigue mechanism. We compared the synchronization of MU in Delta (1-4 Hz), alpha (8-12 Hz), Beta (15-30 Hz), and Gamma (30-60 Hz) frequency bands during the fatigue condition induced by different contractions. Our results showed that MU synchronization increased significantly (p<0.05) in all frequency bands across the two contraction tasks. The results indicate that the microscopic fatigue mechanism of Biceps Brachii muscle does not vary due to different contraction tasks.
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http://dx.doi.org/10.1016/j.neulet.2021.136101DOI Listing
September 2021

Solvent-Free Lithium/Sodium-Based Metal-Organic Frameworks with Versatile Nitrogen-Rich Ligands: Insight for the Design of Promising Superheat-Resistant Explosives.

Inorg Chem 2021 Jul 24;60(13):9282-9286. Epub 2021 Jun 24.

School of Chemical Engineering, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi 710069, China.

Energetic metal-organic frameworks (EMOFs) are very promising as heat-resistant explosives, affording both thermal stability and energy properties. In this work, the self-assembly of high-energy nitrogen-rich linkers with nontoxic alkali-metal lithium/sodium leads to four new solvent-free EMOFs. Because of unparalleled decomposition temperature ( = 403 °C) and heats of detonation (3.475 kcal·g), a 3D Li(I)-EMOF can be considered to be a superheat-resistant explosive candidate.
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http://dx.doi.org/10.1021/acs.inorgchem.1c01658DOI Listing
July 2021

Transcutaneous Acupoint Electrical Stimulation on Chemotherapy-Induced Constipation for Non-Small Cell Lung Cancer Patients: A Randomized Controlled Trial.

Asia Pac J Oncol Nurs 2021 Jul-Aug;8(4):385-392. Epub 2021 Mar 12.

Department of Hospital Office, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Objective: Chemotherapy-induced constipation (CIC) adversely affects the quality of life of non-small cell lung cancer (NSCLC) patients. This study aimed to investigate the clinical effects of transcutaneous acupoint electrical stimulation (TAES) on CIC.

Methods: Sixty NSCLC patients who received chemotherapy at Hunan Cancer Hospital, Changsha, China, were assigned to the TAES ( = 30) or control ( = 30) group using Research Randomizer. In the TAES group, four acupoints, namely Tianshu, Quchi, Zusanli, and Shangjuxu, were stimulated six times a week, lasting for 4 weeks, while the control group received the usual care. The Bristol Stool Form Scale (BSFS) and the Constipation Assessment Scale (CAS) were used.

Results: Both the BSFS and CAS scores for the experimental group were significantly higher than that for the control group ( = 0.004 and < 0.001 separately).

Conclusions: TAES was effective for alleviating constipation in NSCLC patients receiving chemotherapy and was a safe and practical nursing intervention.
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http://dx.doi.org/10.4103/2347-5625.311129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186381PMC
March 2021

Deep learning radiomics-based prediction of distant metastasis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy: A multicentre study.

EBioMedicine 2021 Jul 20;69:103442. Epub 2021 Jun 20.

Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, Beihang University, Beijing 100191, China; Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology, Beijing 100191, China. Electronic address:

Background: Accurate predictions of distant metastasis (DM) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) are helpful in developing appropriate treatment plans. This study aimed to perform DM prediction through deep learning radiomics.

Methods: We retrospectively sampled 235 patients receiving nCRT with the minimum 36 months' postoperative follow-up from three hospitals. Through transfer learning, a deep learning radiomic signature (DLRS) based on multiparametric magnetic resonance imaging (MRI) was constructed. A nomogram was established integrating deep MRI information and clinicopathologic factors for better prediction. Harrell's concordance index (C-index) and time-dependent receiver operating characteristic (ROC) were used as performance metrics. Furthermore, the risk of DM in patients with different response to nCRT was evaluated with the nomogram.

Findings: DLRS performed well in DM prediction, with a C-index of 0·747 and an area under curve (AUC) at three years of 0·894 in the validation cohort. The performance of nomogram was better, with a C-index of 0·775. In addition, the nomogram could stratify patients with different responses to nCRT into high- and low-risk groups of DM (P < 0·05).

Interpretation: MRI-based deep learning radiomics had potential in predicting the DM of LARC patients receiving nCRT and could help evaluate the risk of DM in patients who have different responses to nCRT.

Funding: The funding bodies that contributed to this study are listed in the Acknowledgements section.
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http://dx.doi.org/10.1016/j.ebiom.2021.103442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237293PMC
July 2021

Conceptualizing problems with symptoms, function, health behavior, health-seeking skills, and financial strain in breast cancer survivors using hierarchical clustering.

J Cancer Surviv 2021 Jun 9. Epub 2021 Jun 9.

Professor (Retired) Uniformed Services University, Bethesda, MD, USA.

Purpose: Determine whether a diverse set of problems experienced by breast cancer survivors (BCS) following curative treatment can be formulated into a reduced number of clusters, potentially simplifying the conceptualization of these problems.

Method: Female BCS were recruited from four cancer hospitals in China. The Chinese translation of the Cancer Survivor Profile (CSPro) was used to measure 18 common problem areas, as supported by epidemiological and phenomenological research. The Functional Assessment of Cancer Therapy-Breast (FACT-B) was used to measure quality of life, as a validation of any observed groupings. Hierarchical clustering using multiple distance criteria and aggregation methods to detect patterns of problems was used.

Results: A total of 1008 BCS (mean 46.51 years old) living in both urban and rural areas were investigated. Hierarchical cluster analysis identified two major clusters of problems. One set was classified as "functional limitations," while the other cluster was labeled "multi-problems." Those who fell into the multi-problem cluster experienced poorer quality of life.

Conclusion: Eighteen non-medical problems were broken down into two major clusters: (1) limitations in higher level functions required of daily life and (2) limitations in health care-seeking skills, problems with certain symptoms, unhealthy behaviors, and financial problems related to cancer. The breakdown of problem areas into these two clusters may help identify common mechanisms.

Implications For Cancer Survivors: In the future, the search for common clusters and the mechanisms for the many problems that breast cancer survivors and other cancer survivors can experience following primary treatment may improve how we help manage these problems in the future.
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http://dx.doi.org/10.1007/s11764-021-01068-wDOI Listing
June 2021

SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress.

Proc Natl Acad Sci U S A 2021 Jun;118(23)

Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, 518055 Shenzhen, China;

Ataxia telangiectasia and Rad3 related (ATR) activation after replication stress involves a cascade of reactions, including replication protein A (RPA) complex loading onto single-stranded DNA and ATR activator loading onto chromatin. The contribution of histone modifications to ATR activation, however, is unclear. Here, we report that H3K14 trimethylation responds to replication stress by enhancing ATR activation. First, we confirmed that H3K14 monomethylation, dimethylation, and trimethylation all exist in mammalian cells, and that both SUV39H1 and SETD2 methyltransferases can catalyze H3K14 trimethylation in vivo and in vitro. Interestingly, SETD2-mediated H3K14 trimethylation markedly increases in response to replication stress induced with hydroxyurea, a replication stress inducer. Under these conditions, SETD2-mediated H3K14me3 recruited the RPA complex to chromatin via a direct interaction with RPA70. The increase in H3K14me3 levels was abolished, and RPA loading was attenuated when SETD2 was depleted or H3K14 was mutated. Rather, the cells were sensitive to replication stress such that the replication forks failed to restart, and cell-cycle progression was delayed. These findings help us understand how H3K14 trimethylation links replication stress with ATR activation.
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http://dx.doi.org/10.1073/pnas.2011278118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201831PMC
June 2021

Evidence of the Involvement of a Plus-C Odorant-Binding Protein HparOBP14 in Host Plant Selection and Oviposition of the Scarab Beetle .

Insects 2021 May 10;12(5). Epub 2021 May 10.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

is one of the agriculturally important scarab beetle pests in China. In this study, was cloned, which is the most abundantly expressed among the OBP genes in the legs of female adults. Sequence comparison and phylogenetic analysis showed that HparOBP14 has a Plus-C structure motif. The expression profile analysis revealed that expression was the highest in the female antennae and then in the legs. The fluorescence competitive binding experiment of the recombinant HparOBP14 protein showed that HparOBP14 had an affinity with 6-methyl-5-heptene-2-one (plant volatile), 3-methylindole, -cymene, methanol, formaldehyde, α-pinene, and geraniol (organic fertilizer volatile). Knockdown expression decreased significantly the EAG response of the injected female adults to -cymene, methanol, formaldehyde, α-pinene, and geraniol. Similarly, the injected female adults were significantly less attracted to geraniol and methanol. Therefore, HparOBP14 might bind organic matter volatiles during oviposition. These results are not only helpful to analyze the olfactory recognition mechanism of female adult when choosing suitable oviposition sites, but also to provide target genes for green prevention and control of in the future.
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http://dx.doi.org/10.3390/insects12050430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151400PMC
May 2021

Open Access Dataset, Toolbox and Benchmark Processing Results of High-Density Surface Electromyogram Recordings.

IEEE Trans Neural Syst Rehabil Eng 2021 10;29:1035-1046. Epub 2021 Jun 10.

We provide an open access dataset of High densitY Surface Electromyogram (HD-sEMG) Recordings (named "Hyser"), a toolbox for neural interface research, and benchmark results for pattern recognition and EMG-force applications. Data from 20 subjects were acquired twice per subject on different days following the same experimental paradigm. We acquired 256-channel HD-sEMG from forearm muscles during dexterous finger manipulations. This Hyser dataset contains five sub-datasets as: (1) pattern recognition (PR) dataset acquired during 34 commonly used hand gestures, (2) maximal voluntary muscle contraction (MVC) dataset while subjects contracted each individual finger, (3) one-degree of freedom (DoF) dataset acquired during force-varying contraction of each individual finger, (4) N-DoF dataset acquired during prescribed contractions of combinations of multiple fingers, and (5) random task dataset acquired during random contraction of combinations of fingers without any prescribed force trajectory. Dataset 1 can be used for gesture recognition studies. Datasets 2-5 also recorded individual finger forces, thus can be used for studies on proportional control of neuroprostheses. Our toolbox can be used to: (1) analyze each of the five datasets using standard benchmark methods and (2) decompose HD-sEMG signals into motor unit action potentials via independent component analysis. We expect our dataset, toolbox and benchmark analyses can provide a unique platform to promote a wide range of neural interface research and collaboration among neural rehabilitation engineers.
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http://dx.doi.org/10.1109/TNSRE.2021.3082551DOI Listing
June 2021

A narrative review of changes in microvascular permeability after burn.

Ann Transl Med 2021 Apr;9(8):719

Burn Institute, The Fourth Medical Center of the PLA General Hospital, Beijing, China.

Objective: We aimed to review and discuss some of the latest research results related to post-burn pathophysiological changes and provide some clues for future study.

Background: Burns are one of the most common and serious traumas and consist of a series of pathophysiological changes of thermal injury. Accompanied by thermal damage to skin and soft tissues, inflammatory mediators are released in large quantities. Changes in histamine, bradykinin, and cytokines such as vascular endothelial growth factor (VEGF), metabolic factors such as adenosine triphosphate (ATP), and activated neutrophils all affect the body's vascular permeability.

Methods: We searched articles with subject words "microvascular permeability", "burn" "endothelium", and "endothelial barrier" in PubMed in English published from the beginning of database to Dec, 2020.

Conclusions: The essence of burn shock is the rapid and extensive fluid transfer in burn and non-burn tissue. After severe burns, the local and systemic vascular permeability increase, causing intravascular fluid extravasation, leading to a progressive decrease in effective circulation volume, an increase in systemic vascular resistance, a decrease in cardiac output, peripheral tissue edema, multiple organ failure, and even death. There are many cells, tissues, mediators and structures involved in the pathophysiological process of the damage to vascular permeability. Ulinastatin is a promising agent for this problem.
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http://dx.doi.org/10.21037/atm-21-1267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106041PMC
April 2021

Intracranial Angioplasty with Enterprise Stent for Intracranial Atherosclerotic Stenosis: A Single-Center Experience and a Systematic Review.

Biomed Res Int 2021 17;2021:6645500. Epub 2021 Apr 17.

Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

Background: The high rate of periprocedural complications for the endovascular stent procedure in the Stenting Versus Aggressive Medical Management Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial resulted in it being less recommended than medical therapy to treat intracranial atherosclerotic stenosis (ICAS). Because Enterprise stent use might reduce the incidence of complications in ICAS treatment compared to other frequently used stents, this paper evaluated the safety and effectiveness of the Enterprise stent for the treatment of ICAS.

Methods: We performed a comprehensive literature search for reports on intracranial angioplasty using the Enterprise stent for ICAS treatment from the earliest date available from each database to May 2020 for PubMed, EMBASE, Web of Science, Cochrane, and Clinical Trials databases. We also reviewed the single-center experience of the First Affiliated Hospital of Harbin Medical University. We extracted information regarding periprocedural complications, procedure-related morbidity, mortality, immediate angiographic outcome, and long-term clinical and angiographic outcomes, among others. Event rates were pooled across studies using random-effects or fixed-effects models depending on the heterogeneity.

Results: Five hundred fifty-seven patients with 588 lesions from seven studies, including the institutional series, were included in the analysis. The incidence of stroke or death within 30 days was 7.4% (95% confidence interval (CI), 5.5%-10.1%). The incidence of ischemic stroke or TIA in the territory of the qualifying artery beyond 30 days and during follow-up was 3.2% (95% CI, 1.1%-9.5%). The incidence of in-stent restenosis was 10.1% (95% CI, 4.6%-22.2%), and the incidence of symptomatic restenosis was 4.1% (95% CI, 1.7%-9.9%).

Conclusions: Intracranial angioplasty utilizing the Enterprise stent for ICAS treatment was relatively safe and effective but required further verification using additional sources for evidence.
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http://dx.doi.org/10.1155/2021/6645500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075681PMC
May 2021

Hoof Pressure Distribution Pattern of Blue Sheep During Walking on Different Slopes: A Subject-Specific Analysis.

Front Vet Sci 2021 9;8:633509. Epub 2021 Apr 9.

Key Laboratory of Bionic Engineering, Jilin University, Changchun, China.

The purpose of this study was to quantitatively assess the vertical force distribution (VFD) of subject-specific healthy blue sheep while walking on different slopes using a pressure-sensing walkway. The blue sheep was trained to walk over the pressure-sensing walkway by choosing a comfortable walking speed, and the slope angle increased from 0° to 25°. The sheep's hooves were divided into four quadrants, namely, the cranio-lateral, cranio-medial, caudo-lateral, and caudo-medial quadrants, to investigate the VFD of the peak vertical force (PVF), vertical impulse (VI) and occurrence time of the PVF during the stance phase (TPVF). This study demonstrates that the main stressed quadrant of the front hoof changes from the caudo-medial quadrant to the cranio-medial quadrant with increasing slope. The main stressed quadrant of the rear hoof is the cranio-medial quadrant and does not change with the increasing slope. For all the slopes, the vertical force shifted from the lateral quadrant to the medial quadrant and from the caudal quadrant to the cranial quadrant. All the results obtained in the study suggest the feasibility of detecting gait changes in blue sheep, which has potential for the diagnosis of lower limb musculoskeletal diseases in quadrupeds.
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http://dx.doi.org/10.3389/fvets.2021.633509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062745PMC
April 2021

Effect of Two Interventions on Sleep Quality for Adolescent and Young Adult Cancer Survivors: A Pilot Randomized Controlled Trial.

Cancer Nurs 2021 Apr 21. Epub 2021 Apr 21.

Author Affiliations: The Third Xiangya Hospital (Ms Li and Drs Duan, Zhou, and Xie), Xiangya Nursing School (Mss Li, Wang, Sun, and Xiao), and Clinical Nursing Safety Management Research Center, Central South University (Drs Duan and Xie); and Hunan Cancer Hospital, Changsha (Dr Liu); and Department of Rehabilitation Sciences, The Hong Kong Polytechnic University (Dr Cheng), China.

Background: Sleep disturbance is common among adolescent and young adult (AYA) cancer survivors. Physical activity (PA) and behavioral activation (BA) therapy have been reported as enhancing sleep quality, but few studies exist on the effects of such interventions combined with technology to promote sleep quality in AYA cancer patients.

Objective: The aim of this study was to investigate the feasibility and effects of intelligent wearable device-based PA therapy and internet-based modified BA therapy to improve sleep quality among AYA cancer patients.

Methods: A randomized controlled trial with 143 AYA cancer patients was conducted. Participants were randomly assigned to a control group (n = 48), which performed routine care, a PA group (n = 47), which received 8-week PA therapy based on intelligent wearable devices, and a BA group (n = 48), which participated in internet-based modified BA therapy for 8 weeks.

Results: At 1 week and 3 months after the intervention for sleep quality, there were statistically significant differences between the PA group and the control group (P = .020), but no statistically significant difference between the BA group and the control group.

Conclusions: The intelligent wearable device-based PA therapy has more advantages than internet-based modified BA therapy in improving the overall state of AYA cancer patients, and the intervention effect was sustained for at least 3 months.

Implications For Practice: Developing and implementing PA plans for AYA cancer survivors can improve their sleep quality. Social media, intelligent wearable devices, and mobile health applications have unique advantages in promoting sleep quality for AYA cancer survivors.
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http://dx.doi.org/10.1097/NCC.0000000000000932DOI Listing
April 2021

Prevalence and Determinants of Psychological Distress in Adolescent and Young Adult Patients with Cancer: A Multicenter Survey.

Asia Pac J Oncol Nurs 2021 May-Jun;8(3):314-321. Epub 2021 Mar 9.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China.

Objective: This study aimed to investigate the current prevalence and determinants of psychological distress and the association of distress with general information, character strengths, medical coping, and social support in Chinese adolescents and young adults (AYAs) aged 15-39 years with cancer.

Methods: A multicenter survey was carried out. Eight hundred and nine patients completed the Chinese version of the National Comprehensive Cancer Network distress thermometer (DT), the three-dimensional inventory of character strengths, the medical coping modes questionnaire, and the Social Support Rating Scale.

Results: The current prevalence of psychological distress in Chinese AYAs with cancer was 83.4%. Binary logistic regression analysis showed that gender, age, educational level, marriage, monthly income, exercise intensity, cancer classifications, treatments, self-control, confrontation, avoidance, and subjective support were all associated with distress. AYA cancer patients who were female, younger, or divorced or had a lower monthly income, education level, or exercise intensity were more likely to have higher level of distress. Compared to AYAs with other cancer classifications, patients with digestive system malignancies, breast cancers, and head and neck malignancies had a higher prevalence of distress. Patients receiving chemotherapy or radiotherapy were more likely to be distressed. The higher the self-control, confrontation, avoidance, and subjective support scores were, the lower the prevalence of distress was among AYA cancer patients.

Conclusions: The prevalence of psychological distress in AYA cancer patients was relatively high. Potential interventions targeting exercise intensity, character strengths, medical coping, and social support may decrease the prevalence of psychological distress in this patient population.
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http://dx.doi.org/10.4103/2347-5625.311005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030586PMC
March 2021

Effect of Electrical Stimulation on Gastrointestinal Symptoms in Lung Cancer Patients during Chemotherapy: A Randomized Controlled Trial.

Asia Pac J Oncol Nurs 2021 May-Jun;8(3):246-254. Epub 2021 Feb 4.

Department of Hospital Office, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Objective: The objective was to evaluate the effects of transcutaneous acupoint electric stimulation (TAES) and gastric electrical stimulation (GES) on cancer patients with chemotherapy-induced gastrointestinal (GI) symptoms.

Methods: A total of 122 lung cancer patients receiving chemotherapy were assigned randomly to the following two groups: control group (usual care group, = 61) and intervention group (TAES plus GES, = 61). TAES involved two acupoints such as Neiguan (PC6) and Zusanli (ST36). GES was performed at gastric pacing sites on the body surface such as the places of projection of gastric antrum and corpus on the body surface. GES was performed on these sites for 14 days continuously (25 min every time, once daily). The effects of TAES and GES on GI symptoms were assessed using the Memorial Symptom Assessment Scale on the day prior to chemotherapy (time point 1) and days 14 (time point 2) and 28 (time point 3) after chemotherapy.

Results: No significant differences in the demographic and disease-related variables were detected between the two groups. Differences in symptom occurrence and severity at time point 1 were not statistically significant between the two groups (both > 0.05). At time points 2 and 3, GI symptoms such as loss of appetite, nausea, vomiting, diarrhea, and constipation in the stimulation group had statistically significantly improved compared with the control group (all < 0.05).

Conclusions: TAES and GES were efficacious in relieving GI discomfort in lung cancer patients after chemotherapy. TAES combined with GES is a safe and easy-to-use tool to manage GI symptoms in practice.
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http://dx.doi.org/10.4103/apjon.apjon_61_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030592PMC
February 2021

Preparation and evaluation of chitosan-polyvinyl alcohol/polyhexamethylene guanidine hydrochloride antibacterial dressing to accelerate wound healing for infectious skin repair.

Ann Transl Med 2021 Mar;9(6):482

Department of Burn Surgery, the Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital), Baotou, China.

Background: Wound infections, especially multidrug-resistant (MDR) bacterial infections, are a major challenge in clinical medicine.

Methods: In this study, a new type of antibacterial sponge was prepared from a solution containing a chitosan-polyvinyl alcohol (CTS-PVA) emulsion with added polyhexamethylene guanidine hydrochloride (PHMG) in a homogeneous medium using lyophilization technology. The antibacterial ability of and CTS-PVA/PHMG sponge against , , , , Methicillin-resistant , multidrug-resistant , and multidrug-resistant in vitro. The structure and physical properties were characterized. The sponge dressing was tested in a -infected full-thickness mouse skin wound defect model. The effects were evaluated by wound area measurement and histological analysis.

Results: The CTS-PVA/PHMG sponge showed broad-spectrum antibacterial ability, including for MDR bacterial stains from clinical sources, while maintaining excellent physicochemical properties, including a high swelling degree and good moisture retention capability. Scanning electron microscopy images displayed the surface morphology of the CTS-PVA/PHMG sponge dressing. The detection of the wound healing rate and histological analysis supported that the new dressing can alleviate the inflammation and accelerate the healing speed of infected wounds and .

Conclusions: CTS-PVA/PHMG sponge shows broad-spectrum antibacterial activity, which can provide a new pathway for clinical prevention and treatment of superbug-infected wounds.
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http://dx.doi.org/10.21037/atm-21-509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039659PMC
March 2021

Phylogenetic and Haplotype Network Analyses of Species in China Based on Sequences of Multiple Loci.

Biology (Basel) 2021 Mar 1;10(3). Epub 2021 Mar 1.

Key Lab of Horticultural Plant Biology, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.

is considered one of the most important causal agents of many plant diseases, with a broad host range worldwide. In this study, multiple sequences of ribosomal internal transcribed spacer region (ITS), translation elongation factor 1-α gene (), beta-tubulin gene (), calmodulin gene (), and histone-3 gene () were used for multi-locus phylogenetic analysis. For phylogenetic analysis, maximum likelihood (ML), maximum parsimony (MP), and Bayesian inferred (BI) approaches were performed to investigate relationships of with closely related species. The results strongly support that the species falls into a monophyletic lineage, with the characteristics of a species complex. Phylogenetic informativeness (PI) analysis showed that clear boundaries could be proposed by using , whereas ITS showed an ineffective reconstruction and, thus, was unsuitable for speciating boundaries for species. A combined dataset of , , , and showed strong resolution for species, providing insights for the complex. Accordingly, besides , , , , , , , , , and , which have already been previously considered the synonymous species of , another three species, , and , were further revealed to be synonyms of in this study. In order to demonstrate the genetic diversity of species in China, 138 isolates were randomly selected from previous studies in 16 provinces. These isolates were obtained from different major plant species from 2006 to 2020. The genetic distance was estimated with phylogenetic analysis and haplotype networks, and it was revealed that two major haplotypes existed in the Chinese populations of . The haplotype networks were widely dispersed and not uniquely correlated to specific populations. Overall, our analyses evaluated the phylogenetic identification for species and demonstrated the population diversity of in China.
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http://dx.doi.org/10.3390/biology10030179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000818PMC
March 2021

Initial exploration of training for palliative care specialist nurses in mainland China.

Nurse Educ Today 2021 Jun 17;101:104869. Epub 2021 Mar 17.

Hunan Cancer Hospital, Changsha, PR China. Electronic address:

This paper describes the initial exploration of training program for palliative care specialist nurses in mainland China. The training program included one month of theoretical learning and one month of clinical practice. The theoretical training contents were mainly set up around four modules such as clinical practice, teaching, scientific research and management. After the theoretical training, the trainees needed to practice in specific clinical practice hospitals. In total, 192 trainees from 27 provinces (municipalities) in mainland China participated in the training program. All trainees passed theoretical and clinical practice examinations. Their knowledge, attitude and behavior concerning palliative care were significantly improved after training (p < 0.001). The overall satisfaction rate of the trainees towards the theoretical courses was 95.6%, and the overall satisfaction rate of the trainees towards the clinical teaching base was 94.2%. The training program for palliative care specialist nurses can ensure the trainees to acquire basic professional knowledge and skills and improve their knowledge, attitudes and behaviors concerning palliative care. However, it is needed to explore training programs that are in part-time model, delivered online or suitable for different levels of nursing staff to improve the accessibility.
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http://dx.doi.org/10.1016/j.nedt.2021.104869DOI Listing
June 2021

Serum Levels of S100A11 and MMP-9 in Patients with Epithelial Ovarian Cancer and Their Clinical Significance.

Biomed Res Int 2021 3;2021:7341247. Epub 2021 Mar 3.

Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

Objective: To investigate the serum levels of calgizzarin (S100A11) and matrix metalloproteinase-9 (MMP9) in patients with epithelial ovarian cancer (EOC) and determine their clinical significance.

Methods: Serum levels of S100A11 and MMP9 were detected in patients with EOC, patients with benign ovarian tumor, and healthy women. The correlation between the two markers and clinicopathological characteristics of ovarian cancer was analysed.

Results: The serum levels of S100A11 and MMP-9 in patients with EOC were higher than those in patients with benign ovarian tumor and in healthy women, and the expression levels of S100A11 and MMP-9 were positively correlated. S100A11 and MMP-9 were correlated with tumor staging, postoperative residual foci, ascites volume, serum CA125 level, chemotherapy response, and lymph node metastasis, while S100A11 and MMP-9 were not associated with the bilevel classification, histological type, age, and degree of differentiation.

Conclusion: S100A11 and MMP-9 were both highly expressed in the serum of patients with EOC and were associated with cancer development, invasion, and metastasis. Therefore, they can be used as an important reference maker in the diagnosis and treatment of ovarian cancer.
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http://dx.doi.org/10.1155/2021/7341247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952149PMC
May 2021

Discrepancies among knowledge, practice, and attitudes towards advance care planning among Chinese clinical nurses: A national cross-sectional study.

Appl Nurs Res 2021 04 15;58:151409. Epub 2021 Feb 15.

Administrative Office, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China. Electronic address:

Aims And Objectives: To explore the Chinese nurses' knowledge and attitudes concerning advance care planning (ACP) and their engagement in ACP practice.

Background: Nurses' knowledge, attitude, and practice of ACP are important in promoting ACP in patients, but little is known about knowledge, attitudes, and practice of ACP among nurses in countries where there are no national policies or regulations on ACP.

Design: A descriptive study with a cross-sectional design.

Methods: An online questionnaire survey was distributed to Chinese nurses who attended a national conference.

Results: A total of 531 nurses completed the survey and were included in the final analysis. No nurses answered all questions correctly, while 31 (5.8%) answered all the survey questions wrong. The participants were most knowledgeable about the item "Once ACP is made, the content of advance directives cannot be revoked" and were least knowledgeable about the item "ACP is valid only when the patients are well informed of the medical condition". The implementation of ACP was favored by 92.5% of participants, but only 3.4% of them had actually engaged in all 5 ACP practices listed in the survey. Experience of dealing with death was positively associated with nurses' knowledge concerning ACP. The number of dying patients cared for in the past 6 months, school education of palliative care, knowledge of ACP, and age were related to engagement in the practice of ACP.

Conclusion: Chinese nurses have supportive attitudes towards ACP, but they have limited knowledge and little practice in ACP.
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http://dx.doi.org/10.1016/j.apnr.2021.151409DOI Listing
April 2021

Hypoxia-induced CNPY2 upregulation promotes glycolysis in cervical cancer through activation of AKT pathway.

Biochem Biophys Res Commun 2021 04 12;551:63-70. Epub 2021 Mar 12.

Department of Gynecology, Dongguan Southeast Central Hospital, No.113 Jiaoping Avenue, Tangxia Town, Dongguan, 523000, Guangdong, China. Electronic address:

This study aimed to investigate the function and mechanism of the protein-coding gene CNPY2 in the glycolysis of cervical cancer cells. Cells were exposed to normoxia and hypoxia conditions. Knockdown and ectopic overexpression of CNPY2 were achieved by transfection of small interfering RNA (siRNA) specific to CNPY2 or CNPY2 overexpression vectors, respectively. Quantitative real-time PCR and Western blot were used to evaluate CNPY2 expression in patient specimens and different cervical cancer cell lines under normoxia or hypoxia conditions. Cell viability was assessed by MTT and colony formation assays. Glucose consumption, lactate production, oxygen consumption and ATP production were analyzed by enzyme-linked immunosorbent assays. Dual-luciferase reporter assay and chromatin immunoprecipitation assay were performed to detect interaction between hypoxia-induced factor 1α (HIF-1α) on CNPY2 promoter. CNPY2 upregulation was a characteristic of cervical cancer and correlated with poor prognosis. Knockdown and overexpression of CNPY2 inhibited and promoted proliferation glucose consumption, lactate production, oxygen consumption and ATP production in cervical cancer cells, respectively. CNPY2 was transcriptionally regulated by HIF-1α. The hypoxia-induced "Warburg effect" in cervical cancer cells was at least partially dependent on the CNPY2/AKT signaling pathway. Hypoxia-induced CNPY2 promoted glycolysis in cervical cancer cells by activating the AKT pathway. CNPY2 may serve as a potential diagnostic marker and therapeutic target for cervical cancer patients.
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http://dx.doi.org/10.1016/j.bbrc.2021.02.116DOI Listing
April 2021

Dietary shifts and diversities of individual life histories reveal cultural dynamics and interplay of millets and rice in the Chengdu Plain, China during the Late Neolithic (2500-2000 cal. BC).

Am J Phys Anthropol 2021 08 27;175(4):762-776. Epub 2021 Feb 27.

Department of Archaeology and Anthropology, University of Chinese Academy of Sciences, Beijing, China.

Objectives: We undertook a more comprehensive analyses than our previous study (Yi et al., International Journal of Osteoarchaeology, 2018, 28, 636-644) at the Gaoshan site (~2500-2000 cal. BC) to expand our understanding of the different roles of rice and millets to human subsistence strategies, diachronic shift of human diets, diversity of human life histories and cultural influence (dental ablation) to human population.

Materials And Methods: Carbon and nitrogen isotopic analyses of human (ribs and long bones, n = 68) and animal (n = 15) bones as well as carbonized seeds from rice and millets (n = 8) were undertaken. Human bones were directly AMS- C dated. In addition, sequential sampling of 16 individuals with varied age and sex and cultural contexts for isotopic analysis was also conducted.

Results: The calibrated dating results (n = 27) indicate that there existed two periods of occupation at the site, ~2500-2200 BC and ~2200-1900 BC. Moderate high δ N values were found in the crops. Isotopic data from bone collagen suggest that the humans mainly relied on C -based animal protein and were supplemented by C -based foods. This isotopic pattern is also seen in pigs. Significant difference of human δ C values (Mann-Whitney U test, p < 0.05) between the two periods was observed. Compared to the bones, the isotopic data of human dentine serial sections show a much wider variability and higher δ C values.

Discussion: The crops (millets and rice) were probably manured. Human individuals subsisted on rice/millet agriculture and pigs in general. In combination with the radiocarbon dates, the increase of C (rice) consumption by the humans was found from the early (2500-2200 cal. BC) to late (2200-2000 cal. BC) periods, indicating the intensification of rice agriculture through time. However, four categories of human life histories during childhood are identified given different isotopic profiles of dentine sections, demonstrating that C (rice) and C (millets)-based foods played different roles in human lives. Even though, there were similar weaning practices among the human populations. It is surprising that human individuals with dental ablation, cultural characteristic in the Middle and Lower Yangtze River Valley, consumed more millets during childhood in the early period than those without dental ablation in the late period. Our study here provides novel insights into cultural dynamics and the interplay between rice and millets in rice-millet agricultural system during the Late Neolithic in Southwest China.
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http://dx.doi.org/10.1002/ajpa.24259DOI Listing
August 2021
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