Publications by authors named "Xiangxi Wang"

52Publications

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.

Cell Host Microbe 2020 Dec 26. Epub 2020 Dec 26.

Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China. Electronic address:

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December 2020

Structure-based development of human antibody cocktails against SARS-CoV-2.

Cell Res 2021 01 1;31(1):101-103. Epub 2020 Dec 1.

CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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January 2021

Cryo-electron microscopy structure of human ABCB6 transporter.

Protein Sci 2020 12 15;29(12):2363-2374. Epub 2020 Oct 15.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

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December 2020

Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B.

Nat Commun 2020 09 4;11(1):4419. Epub 2020 Sep 4.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy and Drug Discovery Center for Infectious Diseases, Nankai University, 300353, Tianjin, China.

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September 2020

Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage.

Nat Commun 2020 09 4;11(1):4421. Epub 2020 Sep 4.

CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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September 2020

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.

Science 2020 09 23;369(6510):1505-1509. Epub 2020 Jul 23.

CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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September 2020

Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection.

Cell Rep 2020 07 3;32(3):107918. Epub 2020 Jul 3.

Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

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July 2020

Development of an inactivated vaccine candidate for SARS-CoV-2.

Science 2020 07 6;369(6499):77-81. Epub 2020 May 6.

Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.

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July 2020

Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation.

Protein Cell 2020 05 23;11(5):339-351. Epub 2020 Apr 23.

CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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May 2020

Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.

Protein Cell 2020 05;11(5):366-373

CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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May 2020

Design, Synthesis, and Evaluation of Novel Enterovirus 71 Inhibitors as Therapeutic Drug Leads for the Treatment of Human Hand, Foot, and Mouth Disease.

J Med Chem 2020 02 29;63(3):1233-1244. Epub 2020 Jan 29.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy , Nankai University , Tianjin 300353 , China.

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February 2020

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.

Nat Commun 2020 01 7;11(1):38. Epub 2020 Jan 7.

Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK.

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January 2020

Architecture of African swine fever virus and implications for viral assembly.

Science 2019 Nov 17;366(6465):640-644. Epub 2019 Oct 17.

CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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November 2019

AgBiS-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation.

Biomater Sci 2019 Nov 11;7(11):4769-4781. Epub 2019 Sep 11.

Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. and College of Sciences, Heihe University, 164300, P. R. China.

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November 2019

China's dams threaten green peafowl.

Science 2019 06;364(6444):943

College of Environmental Science and Engineering, Hunan University, Changsha 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China.

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June 2019

Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors.

PLoS Biol 2019 04 30;17(4):e3000229. Epub 2019 Apr 30.

CAS Key Laboratory of Infection and Immunity, CAS Centre for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

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April 2019

Assembly of complex viruses exemplified by a halophilic euryarchaeal virus.

Nat Commun 2019 03 29;10(1):1456. Epub 2019 Mar 29.

Division of Structural Biology, University of Oxford, Wellcome Centre for Human Genetics, Oxford, OX3 7BN, UK.

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March 2019

[Correlation of glutamate dehydrogenase with several tumors].

Sheng Wu Gong Cheng Xue Bao 2019 Mar;35(3):389-395

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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March 2019

Electro-assisted Adsorption of Zn(II) on Activated Carbon Cloth in Batch-Flow Mode: Experimental and Theoretical Investigations.

Environ Sci Technol 2019 03 19;53(5):2670-2678. Epub 2019 Feb 19.

College of Environmental Science and Engineering , Hunan University , Changsha 410082 , P. R. China.

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March 2019

Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.

Cell Rep 2019 01;26(2):438-446.e5

Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address:

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January 2019

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Nat Microbiol 2019 03 10;4(3):414-419. Epub 2018 Dec 10.

Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

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March 2019

Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating.

Nat Commun 2018 11 26;9(1):4985. Epub 2018 Nov 26.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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November 2018

Cryo-EM structure of Type III-A CRISPR effector complex.

Cell Res 2018 12 21;28(12):1195-1197. Epub 2018 Nov 21.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

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December 2018

Honeycomb-Satellite Structured pH/HO-Responsive Degradable Nanoplatform for Efficient Photodynamic Therapy and Multimodal Imaging.

ACS Appl Mater Interfaces 2018 Oct 25;10(40):33901-33912. Epub 2018 Sep 25.

Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering , Harbin Engineering University , Harbin 150001 , P. R. China.

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October 2018

Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component.

Nat Commun 2018 09 10;9(1):3668. Epub 2018 Sep 10.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, 100101, China.

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September 2018

Hepatitis A Virus Capsid Structure.

Cold Spring Harb Perspect Med 2019 05 1;9(5). Epub 2019 May 1.

Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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May 2019

Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71.

mBio 2018 07 3;9(4). Epub 2018 Jul 3.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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July 2018

Pushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions.

Nat Commun 2018 04 19;9(1):1552. Epub 2018 Apr 19.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

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April 2018

Cryo-EM structure of a herpesvirus capsid at 3.1 Å.

Science 2018 04;360(6384)

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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April 2018

A single residue in the αB helix of the E protein is critical for Zika virus thermostability.

Emerg Microbes Infect 2018 01 24;7(1). Epub 2018 Jan 24.

Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.

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January 2018

Two Cases of Dermatophytic Granuloma Successfully Treated with Terbinafine.

Mycopathologia 2018 Jun 17;183(3):611-614. Epub 2018 Jan 17.

Department of Dermatology, Peking University First Hospital, 1st Xi'an men Street, Xicheng District, Beijing, China.

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June 2018

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly.

Science 2017 11 28;358(6365):933-936. Epub 2017 Sep 28.

Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

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November 2017

Uncovering Drug Mechanism of Action by Proteome Wide- Identification of Drug-Binding Proteins.

Med Chem 2017 ;13(6):526-535

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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September 2017

The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection.

Protein Cell 2017 Aug 26;8(8):590-600. Epub 2017 Apr 26.

Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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August 2017

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

Proc Natl Acad Sci U S A 2017 01 10;114(4):770-775. Epub 2017 Jan 10.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China;

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January 2017

Structure of human Aichi virus and implications for receptor binding.

Nat Microbiol 2016 Sep 5;1(11):16150. Epub 2016 Sep 5.

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK.

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September 2016

Structure of Ljungan virus provides insight into genome packaging of this picornavirus.

Nat Commun 2015 Oct 8;6:8316. Epub 2015 Oct 8.

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK.

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October 2015

Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity.

J Virol 2015 Oct 12;89(20):10500-11. Epub 2015 Aug 12.

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, United Kingdom Diamond Light Sources, Harwell Science and Innovation Campus, Didcot, United Kingdom

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October 2015

Hepatitis A virus and the origins of picornaviruses.

Nature 2015 Jan 19;517(7532):85-88. Epub 2014 Oct 19.

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, UK.

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January 2015

Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71.

Protein Cell 2014 Sep 2;5(9):692-703. Epub 2014 Jul 2.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, 100101, China.

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September 2014

An open conformation determined by a structural switch for 2A protease from coxsackievirus A16.

Protein Cell 2013 Oct 11;4(10):782-92. Epub 2013 Sep 11.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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October 2013

Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c.

Protein Cell 2013 Aug 5;4(8):628-40. Epub 2013 Jul 5.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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August 2013

Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase.

Nucleic Acids Res 2012 Aug 4;40(14):6957-65. Epub 2012 May 4.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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August 2012