Publications by authors named "Xiangping Li"

196 Publications

AQP8 participates in oestrogen-mediated buffalo follicular development by regulating apoptosis of granulosa cells.

Reprod Domest Anim 2021 Feb 27. Epub 2021 Feb 27.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, China.

Aquaporins (AQPs), a family of small membrane-spanning proteins, are involved in fluid transport, cell signalling and reproduction. Regulating AQP8 expression influences apoptosis of granulosa cells (GCs), ovarian folliculogenesis, oogenesis and early embryonic development in mice, but its role has never been investigated in other species. The aim of the present study was to characterize the AQP8 function in buffalo follicular development. The expression pattern of AQP8 in buffalo follicle was analysed by immunohistochemistry method. 17β-Estradiol (E2) or oestrogen receptor antagonist ICI182780 was used to treat GCs cultured in vitro, and the expression of AQP8 was detected using qRT-PCR. Its roles in apoptosis of buffalo GCs were investigated by shRNA technology. AQP8 was found to be expressed higher in secondary follicles (p < .05), and its mRNA level in GCs was upregulated by E2 via receptor-mediated mechanism in a dose-dependent manner. A 732-bp buffalo AQP8 coding region was obtained, which was highly conserved at the amino acid level among different species. AQP8-shRNA2 had more effective inhibition on target gene than AQP8-shRNA1 (66.49% vs. 58.31%) (p < .05). Knockdown of AQP8 induced GCs arrested at G2/M stage and occurred apoptosis. Compared with the control group, higher Caspase9 expression were observed in AQP8-shRNA2 lentivirus infected GCs (p < .05), while Bcl-2 and Bax expression levels had no obvious change (p > .05). Altogether, the above results indicate that AQP8 is involved in oestrogen-mediated regulation of buffalo follicular development by regulating cell cycle progression and apoptosis of GCs.
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http://dx.doi.org/10.1111/rda.13921DOI Listing
February 2021

Ultra-sensitive nanometric flat laser prints for binocular stereoscopic image.

Nat Commun 2021 Feb 19;12(1):1154. Epub 2021 Feb 19.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou, China.

Two-dimensional (2D) transition metal dichalcogenides (TMDs) with tantalizing layer-dependent electronic and optical properties have emerged as a paradigm for integrated flat opto-electronic devices, but their widespread applications are hampered by challenges in deterministic fabrication with demanded shapes and thicknesses, as well as light field manipulation in such atomic-thick layers with negligible thicknesses compared to the wavelength. Here we demonstrate ultra-sensitive light field manipulation in full visible ranges based on MoS laser prints exfoliated with nanometric precisions. The nontrivial interfacial phase shifts stemming from the unique dispersion of MoS layers integrated on the metallic substrate empower an ultra-sensitive resonance manipulation up to 13.95 nm per MoS layer across the entire visible bands, which is up to one-order-of-magnitude larger than their counterparts. The interlayer van der Waals interactions and the anisotropic thermal conductivity of layered MoS films endow a laser exfoliation method for on-demand patterning MoS with atomic thickness precision and subwavelength feature sizes. With this, nanometric flat color prints and further amplitude-modulated diffractive components for binocular stereoscopic images can be realized in a facile and lithography-free fashion. Our results with demonstrated practicality unlock the potentials of, and pave the way for, widespread applications of emerging 2D flat optics.
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http://dx.doi.org/10.1038/s41467-021-21499-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896083PMC
February 2021

Arbitrary polarization conversion dichroism metasurfaces for all-in-one full Poincaré sphere polarizers.

Light Sci Appl 2021 Jan 27;10(1):24. Epub 2021 Jan 27.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, 510632, Guangzhou, China.

The control of polarization, an essential property of light, is of broad scientific and technological interest. Polarizers are indispensable optical elements for direct polarization generation. However, arbitrary polarization generation, except that of common linear and circular polarization, relies heavily on bulky optical components such as cascading linear polarizers and waveplates. Here, we present an effective strategy for designing all-in-one full Poincaré sphere polarizers based on perfect arbitrary polarization conversion dichroism and implement it in a monolayer all-dielectric metasurface. This strategy allows preferential transmission and conversion of one polarization state located at an arbitrary position on the Poincaré sphere to its handedness-flipped state while completely blocking its orthogonal state. In contrast to previous methods that were limited to only linear or circular polarization, our method manifests perfect dichroism of nearly 100% in theory and greater than 90% experimentally for arbitrary polarization states. By leveraging this attractive dichroism, our demonstration of the generation of polarization beams located at an arbitrary position on a Poincaré sphere directly from unpolarized light can substantially extend the scope of meta-optics and dramatically promote state-of-the-art nanophotonic devices.
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http://dx.doi.org/10.1038/s41377-021-00468-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841175PMC
January 2021

3D high precision laser printing of a flat nanofocalizer for subwavelength light spot array.

Opt Lett 2021 Jan;46(2):356-359

Here, we demonstrate a flat nanofocalizer for converging light field into a uniform subwavelength light spot array based on the fractional Talbot effect by developing a direct laser writing technique with 3D fabrication precision. The fractional Talbot effect endows the device with the merits of high compression ratio and modular design capability for transforming a plane wave into arrayed light focal spots. By combining a synergistic laser printing technique, we introduce a buffer layer for improving the fabrication precision of structural height in favor of accurately manipulating the phase delay. For a given light wavelength at 750 nm, by precisely producing a nanofocalizer consisting of periodic unit elements with the dimensions of 300()×600()×585(), we have achieved 5×6 light spot array with modular design, while the full width at half-maximum of a single focused light spot can be reduced to ∼0.82. Our research may pave the way for realizing subwavelength optical devices capable of being readily integrated to existing optical systems.
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http://dx.doi.org/10.1364/OL.413302DOI Listing
January 2021

Effects of tris (2-carboxyethyl) phosphine hydrochloride treatment on porcine oocyte in vitro maturation and subsequent in vitro fertilized embryo developmental capacity.

Theriogenology 2021 Mar 3;162:32-41. Epub 2021 Jan 3.

Department of Agricultural and Environmental Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan. Electronic address:

Oocyte in vitro maturation (IVM) is a crucial process that determines subsequent in vitro embryo production. The present study investigated the effects of the antioxidant tris (2-carboxyethyl) phosphine hydrochloride (TCEP-HCL) on the in vitro maturation of porcine oocytes and in vitro developmental competence of fertilized embryos. Oocytes were matured in IVM medium based on four concentration groups of TCEP-HCL (0, 50, 100, and 200 μM) treatment. 100 μM TCEP-HCL treatment significantly increased the oocyte first polar body extrusion rate, monospermy rate and subsequent in vitro fertilized embryo developmental capacity (cleavage rate, blastocyst formation rate, and blastocyst total cell number) compared to those in the control group. Furthermore, 100 μM TCEP-HCL treatment significantly reduced the levels of reactive oxygen species, significantly increased glutathione levels and mitochondrial content compared to those in the control group. Moreover, 100 μM TCEP-HCL treatment significantly decreased the oocyte apoptosis, blastocyst apoptosis compared to that in the controls. In summary, these results indicate that 100 μM TCEP-HCL treatment improves the quality and developmental capacity of in vitro-fertilized embryos by decreasing oxidative stress in porcine oocytes.
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http://dx.doi.org/10.1016/j.theriogenology.2020.12.027DOI Listing
March 2021

Development of a sensitive UHPLC-MS/MS method for the pharmacokinetics study of a novel tyrosine kinase inhibitors, 1-[4-(4-{5-Chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-phenyl)-piperazin-1-yl]-propenone in rats.

Biomed Chromatogr 2021 May 15;35(5):e5059. Epub 2021 Jan 15.

Yantai Key Laboratory of Nanomedicine and Advanced Preparations, Yantai Institute of Materia Medica, Yantai, China.

Targeted inhibition of epidermal growth factor receptor has become an important means of chemotherapy for nonsmall cell lung cancer, breast cancer, pancreatic cancer, colon cancer and other malignant tumors. Although remarkable curative effects have been achieved in the past few decades, the emergence of drug resistance is a problem. Therefore, new inhibitors need to be developed. XHL-31 is a new candidate with significant inhibitory activity against T790M and C797S mutations in vitro. In order to study the pharmacokinetics in vivo, a sensitive and efficient UHPLC-MS/MS method was developed for the determination of XHL-31 in rat plasma in this study. The lower limit of quantitation of this method was 1 ng/ml and the linear range was 1-2,000 ng/ml. Method validation showed a high accuracy and precision, a high stability, a high recovery and repeatability. The method was successfully applied to the pharmacokinetic study of XHL-31 in rats. The results indicated that there were significant gender differences in oral absorption and the absolute bioavailability of XHL-31 in female rats were extremely low (<10%).
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http://dx.doi.org/10.1002/bmc.5059DOI Listing
May 2021

Dual-shot dynamics and ultimate frequency of all-optical magnetic recording on GdFeCo.

Light Sci Appl 2021 Jan 6;10(1). Epub 2021 Jan 6.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou, 510632, China.

Although photonics presents the fastest and most energy-efficient method of data transfer, magnetism still offers the cheapest and most natural way to store data. The ultrafast and energy-efficient optical control of magnetism is presently a missing technological link that prevents us from reaching the next evolution in information processing. The discovery of all-optical magnetization reversal in GdFeCo with the help of 100 fs laser pulses has further aroused intense interest in this compelling problem. Although the applicability of this approach to high-speed data processing depends vitally on the maximum repetition rate of the switching, the latter remains virtually unknown. Here we experimentally unveil the ultimate frequency of repetitive all-optical magnetization reversal through time-resolved studies of the dual-shot magnetization dynamics in GdFeCo. Varying the intensities of the shots and the shot-to-shot separation, we reveal the conditions for ultrafast writing and the fastest possible restoration of magnetic bits. It is shown that although magnetic writing launched by the first shot is completed after 100 ps, a reliable rewriting of the bit by the second shot requires separating the shots by at least 300 ps. Using two shots partially overlapping in space and minimally separated by 300 ps, we demonstrate an approach for GHz magnetic writing that can be scaled down to sizes below the diffraction limit.
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http://dx.doi.org/10.1038/s41377-020-00451-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788082PMC
January 2021

π-phase modulated monolayer supercritical lens.

Nat Commun 2021 Jan 4;12(1):32. Epub 2021 Jan 4.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou, 510632, China.

The emerging monolayer transition metal dichalcogenides have provided an unprecedented material platform for miniaturized opto-electronic devices with integrated functionalities. Although excitonic light-matter interactions associated with their direct bandgaps have received tremendous research efforts, wavefront engineering is less appreciated due to the suppressed phase accumulation effects resulting from the vanishingly small thicknesses. By introducing loss-assisted singular phase behaviour near the critical coupling point, we demonstrate that integration of monolayer MoS on a planar ZnO/Si substrate, approaching the physical thickness limit of the material, enables a π phase jump. Moreover, highly dispersive extinctions of MoS further empowers broadband phase regulation and enables binary phase-modulated supercritical lenses manifesting constant sub-diffraction-limited focal spots of 0.7 Airy units (AU) from the blue to yellow wavelength range. Our demonstrations downscaling optical elements to atomic thicknesses open new routes for ultra-compact opto-electronic systems harnessing two-dimensional semiconductor platforms with integrated functionalities.
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http://dx.doi.org/10.1038/s41467-020-20278-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782844PMC
January 2021

Expression patterns of ZO-1/2 and their effects on porcine oocyte in vitro maturation and early embryonic development.

Theriogenology 2021 Feb 13;161:262-270. Epub 2020 Dec 13.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, 530005, PR China. Electronic address:

Zonula occludens (ZO)-1 and ZO-2 are involved in epithelial polarity maintenance, gene transcription, cell proliferation and tumor cell metastasis. Regulating ZO-1/2 expression influences the early embryonic development of mice, but whether they are involved in oocyte maturation is still poorly understood. In the present study, the expression patterns of ZO-1 and ZO-2 in porcine cumulus cells and oocytes matured in vitro and early embryos from parthenogenetic activation were detected by qRT-PCR or Western blot, and then their roles in porcine oocyte maturation and early embryo development were investigated by shRNA technology. ZO-1 and ZO-2 were found to be expressed in cumulus cells, oocytes and early embryos, while ZO-1α was expressed only in cumulus cells, morula and blastocysts. During in vitro maturation (IVM), the abundance of ZO-1 and ZO-2 in oocytes was significantly higher than that in cumulus cells at 0 h (P < 0.01), and their mRNA and protein levels displayed relatively higher expression at 0 and 18 h, respectively. Compared with the control groups, cumulus cell expansion, oocyte nucleus maturation, and subsequent cleavage were not influenced by treatment of the cumulus-oocyte complexes (COCs) with ZO-1-shRNA1, ZO-2-shRNA2 or combined ZO-1-shRNA1 and ZO-2-shRNA2 lentivirus (P > 0.05). However, the blastocyst rate was reduced by treatment of COCs with ZO-1-shRNA1 but not ZO-2-shRNA2. The total cell number of blastocysts was decreased by downregulation of ZO-1 and ZO-2 (P < 0.05). Downregulation of ZO-1 and ZO-2 also resulted in a significant decrease (P < 0.05) in the expression of Cx43, Cx45, PTX3 and PTGS2 in cumulus cells, Cx45, BMP15, ZP3 and C-KIT in MII oocytes, and Nanog in blastocysts, with the exception of HAS2 expression in cumulus cells and Oct4 expression in blastocysts (P > 0.05). Altogether, the above results indicate that ZO-1 and ZO-2 display similar expression patterns during porcine oocyte IVM and are critical to porcine oocyte maturation and early embryonic development.
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http://dx.doi.org/10.1016/j.theriogenology.2020.12.009DOI Listing
February 2021

Ataxia and ophthalmoplegia: an atypical case of Miller Fisher syndrome (MFS) with anti-GAD antibody.

Int J Neurosci 2020 Dec 21:1-5. Epub 2020 Dec 21.

Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA.

Background: Miller Fisher syndrome (MFS) is frequently encountered variant of Gillian Barre Syndrome (GBS). It has distinct clinical and serological features. Here we describe an atypical GQ1b seronegative case with significantly elevated anti-glutamic acid decarboxylase antibody (GAD-Ab).

Case Description: A 24-year-old previously healthy Caucasian male presented with rapidly progressive ascending weakness, binocular diplopia and autonomic instability for 2 days. Examination was remarkable for asymmetrical facial weakness (L > R), opthalmoplegia and truncal ataxia without areflexia. MRI brain was normal. CSF analysis showed elevated protein. Electromyography/Nerve Conduction Study (EMG/NCS) within the first week was normal. Antiganglioside antibodies were negative. Extended serological and neoplastic workup revealed negative anti-GQ1b antibody, but significant increase of GAD-Ab, Voltage Gated Calcium Channel (VGCC) Ab, and mild elevation of TPO Ab IgG and Thyroglobulin (Tg) Ab IgG. Clinical diagnosis of partial MFS was made. He received a course of IVIg (2 g/kg over 5 days) and had complete recovery in 3 months.

Conclusion: There are incomplete or atypical forms of MFS. Recognition of its various clinical presentations is essential for early diagnosis and optimal management. Further investigation is needed to elucidate the role of anti-GAD-ab and other autoimmune antibodies in the pathogenesis of GQ1b-seronegative MFS patients.
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http://dx.doi.org/10.1080/00207454.2020.1859502DOI Listing
December 2020

Adverse reactions of antidepressant drugs and their application in patients with cardiovascular diseases.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Oct;45(10):1228-1233

Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Depression has a high incidence in patients with cardiovascular diseases (CVD) and shows adverse effects on their life quality and prognosis. With the advent of new antidepressant drugs, oral antidepressant drugs are increasingly used in CVD patients with depression, and their efficacy and safety have attracted attention. Commonly used antidepressant drugs have many adverse reactions. When applying antidepressant drugs in CVD patients, we should pay special attention to their cardiovascular adverse reactions and their interaction drugs with commonly used CVD drugs. Clinicians should comprehensively evaluate and select appropriate antidepressant drugs for patients.
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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.190160DOI Listing
October 2020

Fluorescence decay route of optical transition calculation for trivalent rare earth ions and its application for Er-doped NaYF phosphor.

Phys Chem Chem Phys 2020 Nov 30;22(43):25177-25183. Epub 2020 Oct 30.

School of Science, Dalian Maritime University, Dalian, Liaoning 116026, P. R. China.

Usually, the optical transition properties of trivalent rare earth (RE) ions in transparent hosts can be quantitatively investigated in the framework of Judd-Ofelt theory. A standard and commonly accepted calculation procedure based on the absorption spectrum has already been established. However, it is hard to assess the optical transition properties of trivalent RE ions doped in powdered and film materials owing to the difficulty in the absolute absorption spectrum measurements. In this work, we proposed a new route to calculate the Judd-Ofelt parameters of trivalent RE ion-doped materials in any morphological and shaped forms. In this method, the fluorescence decay values bridging the radiative transition rates and the Judd-Ofelt parameters were used. As an application example of the proposed Judd-Ofelt calculation method, the Judd-Ofelt parameters of Er in NaYF were calculated via the proposed route, and it was found that the obtained results are in reasonable accordance with those derived from other routes. It was also proved that this proposed Judd-Ofelt calculation method is a practicable and effective route for evaluating optical transition properties of trivalent RE ions in non-transparent hosts as long as the fluorescence decay values can be measured.
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http://dx.doi.org/10.1039/d0cp04379fDOI Listing
November 2020

EBV-EBNA1 constructs an immunosuppressive microenvironment for nasopharyngeal carcinoma by promoting the chemoattraction of Treg cells.

J Immunother Cancer 2020 10;8(2)

Department of Otorhinolaryngology Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

Background: Nasopharyngeal carcinoma (NPC) is primarily caused by the Epstein-Barr virus (EBV) infection in NPC endemic areas. EBNA1 is an EBV-encoded nuclear antigen, which plays a critical role in the maintenance and replication of EBV genome. However, the mechanisms of EBNA1-promoted NPC immune escape are unknown. Regulatory T (Treg) cells are among the key regulators in restraining antitumor responses. However, the mechanisms of accumulation of Treg cells in NPC have not been defined. This study attempted to identify the detailed mechanisms of EBNA1 functions as a tumor accelerator to promote NPC immune escape by enhancing chemoattraction of Treg cells.

Methods: mRNA profiles were determined by next-generation sequencing in NPC cells. In vitro and in vivo assays were performed to analyze the role of EBNA1 in regulation of recruitment of Treg cells. Colocation and coimmunoprecipitation analyzes were used to identify the SMAD3/c-JUN complex. Chromatin immunoprecipitation assay and dual luciferase reporter assays were designed to demonstrate c-JUN binding to miR-200a promoter and miR-200a targeting to CXCL12 3'Untranslated Regions. The hepatocellular carcinoma models were designed to demonstrate universality of the CXCL12-CXCR4-Treg axis in promoting immune evasion of various tumors.

Result: A novel molecular mechanism was identified that involves EBV-EBNA1-stimulated chemotactic migration of Treg cells toward NPC microenvironment by upregulation of the transforming growth factor-β1 (TGFβ1)-SMAD3-PI3K-AKT-c-JUN-CXCL12-CXCR4 axis and downregulation of miR-200a. EBV-EBNA1 promotes the chemoattraction of Treg cells by governing the protein-protein interactions of the SMAD3/c-JUN complex in a TGFβ1-dependent manner in vitro and in vivo. TGFβ1 suppresses miR-200a by enhancing the SMAD3/c-JUN complex. miR-200a negatively regulates the CXCL12 chemokine by direct targeting of the CXCL12 3'UTR region. However, CXCL12 acts as the target gene of miR-200a and as an inhibitor of miR-200a transcription, and inhibition of miR-200a by CXCL12 is mediated by c-JUN, which directly binds to the miR-200a promoter and forms a c-JUN-miR-200a-CXCL12-c-JUN feedback loop. In addition, enhanced CXCL12 efficiently attracts CXCR4-positive Treg cells to remodel an immunosuppressive microenvironment.

Conclusions: EBV-EBNA1 promotes chemotactic migration of Treg cells via the TGFβ1-SMAD3-PI3K-AKT-c-JUN-miR-200a-CXCL12-CXCR4 axis in the NPC microenvironment. These results suggest that EBV-EBNA1 may serve as a potential therapeutic target to reshape the NPC microenvironment.
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http://dx.doi.org/10.1136/jitc-2020-001588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597532PMC
October 2020

Full-visible transmissive metagratings with large angle/wavelength/polarization tolerance.

Nanoscale 2020 Oct;12(40):20604-20609

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China.

Metagratings have been shown to form an agile and efficient platform for extreme wavefront manipulation, going beyond the limitations of gradient metasurfaces. Here, we present all-dielectric transmissive metagratings with high diffraction efficiencies using simple rectangular inclusions with neither high index nor high aspect ratio requirement. We further experimentally demonstrate continuous phase encoding of a hologram based on such transmissive metagratings through displacement modulation of CMOS-compatible silicon nitride nanobars in the full visible range, manifesting broadband and wide-angle high diffraction efficiencies for both polarizations. Featured with extreme angle/wavelength/polarization tolerance and alleviated structural complexity for both design and fabrication, our demonstration unlocks the full potential of metagrating-based wavefront manipulation for a variety of practical applications.
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http://dx.doi.org/10.1039/d0nr05745bDOI Listing
October 2020

Influence of Experimental Autoimmune Prostatitis on Sexual Function and the Anti-inflammatory Efficacy of Celecoxib in a Rat Model.

Front Immunol 2020 9;11:574212. Epub 2020 Sep 9.

Department of Urology and Andrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Experimental autoimmune prostatitis (EAP) is a well-established model induced by an autoimmune response to prostate antigen. The symptomatic, pathological, and immunological characteristics of EAP animals are highly consistent with human chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), which makes EAP an ideal model for this disease. Here, we investigate the influence of EAP on male rat sexual function and the efficacy of anti-inflammatory therapy with celecoxib. EAP rat models were established using male Wistar rats. Rats were randomly assigned to a normal control group, an EAP model group, or an EAP model with celecoxib treatment group (celecoxib group). Behavioral changes, sexual behavioral changes, and erectile function were estimated using an open-field test, a sucrose consumption test, mating experiments, and by intracavernous pressure/mean arterial pressure ratio (ICP/MAP). Histological changes in the prostate were observed by HE staining, and the serum inflammatory factors IL-1β and TNF-α levels were measured by enzyme-linked immunosorbent assay. In addition, serotonin (5-hydroxytryptamine, 5-HT), 5-HT receptor, 5-HT receptor, and serotonin transporter (SERT) expression levels in the hippocampus and spinal cord (T13-L1, L5-S2) were examined by immunohistochemistry and western blot analysis. Results showed that EAP rats exhibited characteristics of depression, decreased sexual drive, premature ejaculation, and increased threshold of penile erection. Moreover, all these changes were effectively alleviated by celecoxib. Significant increases in prostatic interstitial infiltration by inflammatory cells and in serum IL-1β and TNF-α levels were observed in EAP rats, and these were partially reduced by celecoxib. Additionally, the expression pattern of serotonin system regulators in the hippocampus and spinal cord were altered in EAP model rats, including a decrease in 5-HT levels and an increase in 5-HT receptor levels. In conclusion, autoimmune prostatitis impaired rat sexual function, and this was effectively prevented by anti-inflammatory therapy with celecoxib. Moreover, a serotonin system disorder in the central nervous system was likely mediated via inflammation in EAP rats.
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http://dx.doi.org/10.3389/fimmu.2020.574212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509491PMC
September 2020

Tracking annual changes of coastal tidal flats in China during 1986-2016 through analyses of Landsat images with Google Earth Engine.

Remote Sens Environ 2020 Mar 5;238. Epub 2018 Dec 5.

Ministry of Education Key Laboratory of Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, Fudan University, Shanghai 200433, China.

Tidal flats (non-vegetated area), along with coastal vegetation area, constitute the coastal wetlands (intertidal zone) between high and low water lines, and play an important role in wildlife, biodiversity and biogeochemical cycles. However, accurate annual maps of coastal tidal flats over the last few decades are unavailable and their spatio-temporal changes in China are unknown. In this study, we analyzed all the available Landsat TM/ETM+/OLI imagery (~ 44,528 images) using the Google Earth Engine (GEE) cloud computing platform and a robust decision tree algorithm to generate annual frequency maps of open surface water body and vegetation to produce annual maps of coastal tidal flats in eastern China from 1986 to 2016 at 30-m spatial resolution. The resulting map of coastal tidal flats in 2016 was evaluated using very high-resolution images available in Google Earth. The total area of coastal tidal flats in China in 2016 was about 731,170 ha, mostly distributed in the provinces around Yellow River Delta and Pearl River Delta. The interannual dynamics of coastal tidal flats area in China over the last three decades can be divided into three periods: a stable period during 1986-1992, an increasing period during 1993-2001 and a decreasing period during 2002-2016. The resulting annual coastal tidal flats maps could be used to support sustainable coastal zone management policies that preserve coastal ecosystem services and biodiversity in China.
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http://dx.doi.org/10.1016/j.rse.2018.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449126PMC
March 2020

Temperature dependence of up-conversion luminescence and sensing properties of LaNbO: Nd/Yb/Ho phosphor under 808 nm excitation.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jan 17;244:118846. Epub 2020 Aug 17.

School of Science, Dalian Maritime University, Dalian, Liaoning 116026, PR China.

LaNbO: Nd/Yb/Ho phosphor was prepared by a conventional high temperature solid-state reaction method. The temperature dependence of up-conversion (UC) luminescence property of LaNbO: Nd/Yb/Ho phosphor under 808 nm excitation and the potential application of exploiting the red-to-green UC emission intensity ratio (I/I) of Ho in temperature sensing were studied. Two-photon processes were confirmed to be responsible for both the green and the red UC emissions at different temperatures by analyzing the excitation power density dependent UC luminescence spectra measured at different temperatures. The energy level diagram was drawn to analyze the UC luminescence mechanism of Ho. In addition, it was found that the ratio I/I of Ho was independent of the excitation power density of 808 nm laser under the current experimental condition, but it was sensitive to the temperature. And the temperature dependent UC luminescence spectra displayed that the ratio I/I exhibited a good linear increasing tendency with temperature rising. The obtained temperature sensing sensitivity was 2.04 × 10 K in the temperature range of 303-693 K. The results suggest that LaNbO: Nd/Yb/Ho phosphor may be a good candidate for application in optical temperature sensors.
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http://dx.doi.org/10.1016/j.saa.2020.118846DOI Listing
January 2021

Atomically Thin Noble Metal Dichalcogenides for Phase-Regulated Meta-optics.

Nano Lett 2020 Nov 1;20(11):7811-7818. Epub 2020 Sep 1.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, People's Republic of China.

Owing to its good air stability and high refractive index, two-dimensional (2D) noble metal dichalcogenide shows intriguing potential for versatile flat optics applications. However, light field manipulation at the atomic scale is conventionally considered unattainable because the small thickness and intrinsic losses of 2D materials completely suppress both resonances and phase accumulation effects. Here, we demonstrate that losses of structured atomically thick PtSe films integrated on top of a uniform substrate can be utilized to create the spots of critical coupling, enabling singular phase behaviors with a remarkable π phase jump. This finding enables the experimental demonstration of atomically thick binary meta-optics that allows an angle-robust and high unit thickness diffraction efficiency of 0.96%/nm in visible frequencies (given its thickness of merely 4.3 nm). Our results unlock the potential of a new class of 2D flat optics for light field manipulation at an atomic thickness.
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http://dx.doi.org/10.1021/acs.nanolett.0c01805DOI Listing
November 2020

Subwavelength Silicon Nanoblocks for Directional Emission Manipulation.

Nanomaterials (Basel) 2020 Jun 26;10(6). Epub 2020 Jun 26.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China.

Manipulating the light emission direction and boosting its directivity have essential importance in integrated nanophotonic devices. Here, we theoretically propose a single dielectric silicon nanoblock as an efficient, multifunctional and ultracompact all-dielectric nanoantenna to direct light into a preferential direction. Unidirectional scattering of a plane wave as well as switchable directive emission fed by a localized emitter are demonstrated within the nanoantenna. The high directionalities are revealed to originate from a variety of mechanisms that can coexist within a single nanoblock, which contribute to the far-field radiation patterns of the outcoming light, thanks to the wealth of multipolar electric and magnetic resonances. The efficient beam redirections are also observed, which are sensitive to the local configurations of the emitter antenna coupled system. The designed antenna, with extreme geometry simplicity, ultracompact and low-loss features, could be favorable for highly sensitive sensing as well as applications in optical nanocircuits.
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http://dx.doi.org/10.3390/nano10061242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353081PMC
June 2020

Metformin attenuates antipsychotic-induced metabolic dysfunctions in MK801-induced schizophrenia-like rats.

Psychopharmacology (Berl) 2020 Aug 25;237(8):2257-2277. Epub 2020 Jun 25.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China.

Rationale: Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced metabolic dysfunctions (AIMD) in clinical practice. Whether metformin can reverse AIMD and whether metformin affects the therapeutic effects of antipsychotics in animal models of schizophrenia are questions that still need to be investigated.

Methods: In this study, an animal model of schizophrenia was established by consecutive injections of MK801 during the neurodevelopmental period. In adulthood, different dosages of olanzapine or risperidone treatment were administered to the schizophrenia model animals for 14 days. Both therapeutic effects and metabolic adverse effects were measured by behavioral tests, histopathological tests, and biochemical tests. The coadministration of different doses of metformin with olanzapine or risperidone was used to evaluate the effects of metformin on both AIMD and the therapeutic effect of those antipsychotics.

Results: The MK801-treated rats showed schizophrenia-like behavior and variations in the shape and volume of the hippocampus. Both olanzapine and risperidone reversed the MK801-induced behavioral abnormalities as the dosage increased; however, they degenerated the hepatocytes in the liver and influenced the blood lipid levels and blood glucose levels. The coadministration of metformin did not affect the therapeutic effects of olanzapine or risperidone on behavioral abnormalities but attenuated the metabolic dysfunctions induced by those antipsychotics.

Conclusion: Metformin attenuated the olanzapine- and risperidone-induced metabolic dysfunctions in MK801-induced schizophrenia-like rats without reducing the therapeutic effects of the antipsychotics.
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http://dx.doi.org/10.1007/s00213-020-05524-wDOI Listing
August 2020

Mechanisms of Epstein-Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma.

Cancer Med 2020 08 22;9(15):5598-5608. Epub 2020 Jun 22.

Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Documented reports proved that Epstein-Barr virus (EBV) infection increased infiltration of Tregs in malignancy. However, the mechanism of EBV recruitment Tregs into nasopharyngeal carcinoma (NPC) tissues has not been detailed discussion.

Methods: Expression of EBV nuclear antigen 1 (EBNA1) and Foxp3 in NPC tissue samples was detected by immunohistochemistry. EBNA1+ NPC cell lines were used to coculture with PBMC, naïve T cells, Tregs, and monocytes. Percent of Treg was detected by flow cytometry.

Results: EBNA1 protein was overexpressed in NPC tissues, and was associated with a number of infiltrated Tregs. EBNA1+ NPC cells converted naïve T cells into Tregs by up-regulated TGF-β1. Enhanced CCL20 production in EBNA1-expressed tumor cells increased Tregs migration. Polarized-M2 macrophages by EBNA1 expression cells converted naïve T cells into Tregs.

Conclusions: EBNA1 favors accumulation of Tregs in NPC through: (a) upregulated TGF-β1 converted naïve T cell into Treg; (b) upregulated CCL20 increased Treg migration; and (c) polarized-M2 macrophage converted naïve T cell into Treg.
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http://dx.doi.org/10.1002/cam4.3213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402843PMC
August 2020

ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death.

Metabolism 2020 08 17;109:154296. Epub 2020 Jun 17.

Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, China. Electronic address:

Rationale: ApoC2 is an important activator for lipoprotein lipase-mediated hydrolysis of triglyceride-rich plasma lipoproteins. ApoC2-deficient patients display severe hypertriglyceridemia (sHTG) and recurrent acute pancreatitis. However, due to embryonic lethality in ApoC2 deleted mouse extensive understanding of ApoC2 function is limited in mammalian species.

Objective: We sought to generate an animal model with ApoC2 deficiency in a rodent with some human-like features and then study the precise effects of ApoC2 on lipid and glucose homeostasis.

Methods And Results: Using CRISPR/Cas9, we deleted Apoc2 gene from golden Syrian hamster and the homozygous (-/-) pups can be born in matured term but exhibited neonatal lethality. By continuous iv administration of normal hamster serum the ApoC2 pups could survive till weaning and displayed severe HTG in adulthood on chow diet. A single iv injection of AAV-hApoC2 at birth can also rescue the neonatal death of ApoC2 pups. Adult ApoC2hamsters exhibited a unique phenotype of sHTG with hypoglycemia, hypoinsulinemia and spontaneous atherosclerosis. The sHTG in ApoC2 adult hamsters could not be corrected by various lipid-lowering medications, but partially ameliorated by medium chain triglyceride diet and completely corrected by AAV-hApoC2.

Conclusions: Our study provides a novel ApoC2-deleted mammalian model with severe hypertriglyceridemia that was fully characterized and highlights a potential therapeutic approach for the treatment of ApoC2 deficient patients.
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http://dx.doi.org/10.1016/j.metabol.2020.154296DOI Listing
August 2020

Anapole mediated giant photothermal nonlinearity in nanostructured silicon.

Nat Commun 2020 Jun 15;11(1):3027. Epub 2020 Jun 15.

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, 510632, Guangzhou, China.

Featured with a plethora of electric and magnetic Mie resonances, high index dielectric nanostructures offer a versatile platform to concentrate light-matter interactions at the nanoscale. By integrating unique features of far-field scattering control and near-field concentration from radiationless anapole states, here, we demonstrate a giant photothermal nonlinearity in single subwavelength-sized silicon nanodisks. The nanoscale energy concentration and consequent near-field enhancements mediated by the anapole mode yield a reversible nonlinear scattering with a large modulation depth and a broad dynamic range, unveiling a record-high nonlinear index change up to 0.5 at mild incident light intensities on the order of MW/cm. The observed photothermal nonlinearity showcases three orders of magnitude enhancement compared with that of unstructured bulk silicon, as well as nearly one order of magnitude higher than that through the radiative electric dipolar mode. Such nonlinear scattering can empower distinctive point spread functions in confocal reflectance imaging, offering the potential for far-field localization of nanostructured Si with an accuracy approaching 40 nm. Our findings shed new light on active silicon photonics based on optical anapoles.
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http://dx.doi.org/10.1038/s41467-020-16845-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296001PMC
June 2020

Chemical switching of low-loss phonon polaritons in α-MoO by hydrogen intercalation.

Nat Commun 2020 May 27;11(1):2646. Epub 2020 May 27.

Department of Materials Science and Engineering, and ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET), Monash University, Clayton, Australia.

Phonon polaritons (PhPs) have attracted significant interest in the nano-optics communities because of their nanoscale confinement and long lifetimes. Although PhP modification by changing the local dielectric environment has been reported, controlled manipulation of PhPs by direct modification of the polaritonic material itself has remained elusive. Here, chemical switching of PhPs in α-MoO is achieved by engineering the α-MoO crystal through hydrogen intercalation. The intercalation process is non-volatile and recoverable, allowing reversible switching of PhPs while maintaining the long lifetimes. Precise control of the intercalation parameters enables analysis of the intermediate states, in which the needle-like hydrogenated nanostructures functioning as in-plane antennas effectively reflect and launch PhPs and form well-aligned cavities. We further achieve spatially controlled switching of PhPs in selective regions, leading to in-plane heterostructures with various geometries. The intercalation strategy introduced here opens a relatively non-destructive avenue connecting infrared nanophotonics, reconfigurable flat metasurfaces and van der Waals crystals.
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http://dx.doi.org/10.1038/s41467-020-16459-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253429PMC
May 2020

An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China.

Eur Arch Otorhinolaryngol 2020 Oct 25;277(10):2829-2838. Epub 2020 May 25.

Department of Otorhinolaryngology, Head and Neck Surgery, Fenyang Hospital, Shanxi Province, Fenyang, Shanxi, China.

Purpose: Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China.

Methods: This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13.

Results: There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD.

Conclusions: LPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.
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http://dx.doi.org/10.1007/s00405-020-06045-0DOI Listing
October 2020

Muscle type of palatopharyngeal muscle in children with severe obstructive sleep apnea.

J Clin Sleep Med 2020 09;16(9):1523-1529

Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Study Objectives: To investigate the fiber-type distribution in palatopharyngeal muscle via adenosine triphosphatase and quantitative real-time polymerase chain reaction in children with severe obstructive sleep apnea (OSA).

Methods: Study participants were 12 children with severe OSA and 15 children with simple snoring as the control group. Both groups were diagnosed by polysomnography and treated with tonsillectomy. The samples of palatopharyngeus muscle were studied under adenosine triphosphatase staining and quantitative real-time polymerase chain reaction to classify the different fiber types.

Results: There were no differences in baseline age, body mass index, tonsil size, or sleep stage constitution between the 2 groups. Dominance (>60%) of type I fiber was observed both in children with simple snoring (3/15, 20%) and in those with severe OSA (1/12, 8.3%) via adenosine triphosphatase staining. Predominance of type II fibers was seen in 3/15 (20%) in the control group and 6/12 (50%) in the severe OSA group, respectively. Type grouping was also seen in 8/15 (53.3%) in non-OSA and 6/12 (50%) in severe OSA groups, respectively. There was no difference in distribution of subtype fibers assessed by quantitative real-time polymerase chain reaction between the 2 groups; the mean percentages of type I fibers were 25.8% ± 19.5% and 20.9% ± 16.6%, respectively (P > .05), similar to type IIa fibers (35.2% ± 23.4% and 40.9% ± 28.8%) (P > .05). There was a decrease in the percentage of type I fibers between children younger and older than 12 years (P < 0.05), although this was not due to OSA (P > 0.05).

Conclusions: There were no specific changes via adenosine triphosphatase staining or a difference in distribution of subtype fibers via quantitative real-time polymerase chain reaction between children with severe pediatric OSA and those with simple snoring, whereas the percentage of type I fiber decreased dynamically due to age but not OSA.

Clinical Trial Registration: Registry: Chinese Clinical Trials Registry; Name: A study of the mechanism of the conversion of upper airway expasion muscle's fiver types of OSA patient which may be mediated by estrogen-related receptor alpha; URL: https://www.chictr.org.cn/showproj.aspx?proj=6144; Identifier: ChiCTR-CCC-13003415.
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http://dx.doi.org/10.5664/jcsm.8588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970595PMC
September 2020

Comparison of adsorption properties for cadmium removal from aqueous solution by Enteromorpha prolifera biochar modified with different chemical reagents.

Environ Res 2020 07 16;186:109502. Epub 2020 Apr 16.

China-Australia Centre for Sustainable Urban Development, School of Environmental Science and Engineering, Tianjin University, Tianjin, 300350, PR China; Qingdao Institute for Ocean Technology of Tianjin University, Qingdao, 266235, PR China; Tianjin Key Lab of Biomass/Wastes Utilization, Tianjin, 300354, PR China. Electronic address:

Using biochar to remove heavy metals from water is environmentally beneficial. In this study, three kinds of chemical reagents, including ZnCl, HPO and KMnO, were introduced to modify the biochar derived from Enteromorpha prolifera. The performance of these modified biochar in removing Cadmium ions (Cd(II)) from water was investigated. The physicochemical properties of activated biochars were characterized by N-sorption, thermal gravity and differential thermal gravity (TG/DTG), scanning electron microscopy (SEM), elemental analysis and Fourier transform infrared spectroscopy (FTIR). The results showed that the removal rate of Cd(II) from water by EP biochar modified with HPO was significantly increased, and the maximum adsorption capacity of Cd(II) reached to 423 mg/g for PBC. Moreover, the adsorption of Cd(II) from water by phosphoric acid modified biochar was very fast, and the saturation adsorption of Cd(II) was reached within 1 h. Compared with pseudo first-order model, pseudo secondary-order model was much more suitable for analyzing the adsorption kinetics data of Cd(II) onto KBC or ZBC. The adsorption of Cd(II) onto PBC was analyzed by the intra-particle diffusion kinetic model, where the value of R was high as 0.98. The Langmuir model was fit for phosphoric acid modified biochar.
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http://dx.doi.org/10.1016/j.envres.2020.109502DOI Listing
July 2020

Supercritical lens array in a centimeter scale patterned with maskless UV lithography.

Opt Lett 2020 Apr;45(7):1798-1801

Microlens arrays (MLAs) are widely used in optical imaging, dense wavelength division multiplexing, optical switching, and microstructure patterning, etc. However, the light modulation capability for both the conventional refractive-type MLA and planar diffractive-type MLA is still staying at the diffraction-limited scale. Here we propose and experimentally demonstrate a high numerical aperture (NA) supercritical lens (SCL) array which could achieve a sub-diffraction-limited focal spot lattice in the far field. The intensity distribution for all the focal spots has good uniformity with the lateral size around ${0.45}\lambda {\rm /NA}$0.45λ/NA (0.75X Airy unit). The elementary unit in the SCL array composes a series of concentric belts with a feature size in micrometer scale. By utilizing an ultrafast ultraviolet lithography technique, a centimeter scale SCL array could be successfully patterned within 10 mins. Our results may provide possibilities for the applications in optical nanofabrication, super-resolution imaging, and ultrafine optical manipulation.
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http://dx.doi.org/10.1364/OL.389702DOI Listing
April 2020

Influence of Er concentration and Ln on the Judd-Ofelt parameters in LnOCl (Ln = Y, La, Gd) phosphors.

Phys Chem Chem Phys 2020 Apr;22(15):7844-7852

Key Laboratory of Photo-electronic Materials, Ningbo University, Ningbo, Zhejiang 315211, P. R. China.

The optical transition properties of trivalent rare earth (RE3+) doped luminescent materials have received extensive attention. The Judd-Ofelt theory is an effective tool for exploring the optical transition properties for the 4f-4f transitions of lanthanides. The aim of this work is to discover the effect of Er3+ concentration and different Ln3+ ions on the Judd-Ofelt parameters in LnOCl:Er3+ (Ln = Y, La, Gd) phosphors. Oxychloride LnOCl:Er3+ (Ln = Y, La, Gd) phosphors were produced via a single displacement reaction technique. The Judd-Ofelt calculation procedure for RE3+ doped powders was modified and then adopted to obtain the Judd-Ofelt parameters of Er3+ in the studied phosphors. Meanwhile, a new route for examining the Judd-Ofelt calculation quality was proposed and used. It was found that the Er3+ doping concentration slightly affects the optical transition properties of Er3+ in YOCl and LaOCl, but greatly affects the optical transition properties in GdOCl. Moreover, it was also found that the optical transition properties of Er3+ depend also on Ln3+ (Ln = Y, La, Gd) though the crystal structure of these compounds is similar. The Judd-Ofelt parameters of Er3+ are the smallest in LaOCl:Er3+, medium in YOCl:Er3+, but the biggest in GdOCl:Er3+ when the doping concentration is the same.
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http://dx.doi.org/10.1039/c9cp06755hDOI Listing
April 2020

Development of the psychosomatic symptom scale (PSSS) and assessment of its reliability and validity in general hospital patients in China.

Gen Hosp Psychiatry 2020 May - Jun;64:1-8. Epub 2020 Feb 1.

Department of Psychosomatics and Psychiatry, Affiliated ZhongDa Hospital of Southeast University, Medical School of Southeast University, Nanjing, China. Electronic address:

Objectives: To develop and verify the Psychosomatic Symptom Scale (PSSS) among psychosomatic patients and the cut-off value of PSSS in distinguishing psychosomatic patients from health controls.

Methods: The PSSS was drafted by an expert workgroup. 996 patients and 366 controls from 14 general hospitals in China were recruited to complete PSSS, Patient Health Questionnaire-15 (PHQ-15) and Symptom Checklist-90 (SCL-90). Student's t-test, Kruskal-Wallis test, Cronbach's α, Spearman's correlation, and confirmatory factor analysis (CFA) were used to verify the PSSS. Receiver operating characteristic (ROC) analyses were used to determine the cut-off value.

Results: Cronbach α of PSSS was 0.907. The PSSS was significantly correlated with SCL-90 somatization subscale (r = 0.682, P < 0.001) and PHQ-15 (r = 0.724, P < 0.001). CFA supported the theoretical two-factor structure of the PSSS, with comparative fit index (CFI) = 0.979, Tucker-Lewis index (TLI) = 0.977, root mean square error of approximation (RMSEA) = 0.039 (90% CI: 0.035-0.042), and standardized root mean residual (SRMR) = 0.054. As the sum score of PSSS was significantly higher in female, cut-off values were determined as 11 in females and 10 in males respectively.

Conclusions: The PSSS is a reliable and valid instrument for measuring psychosomatic symptoms.
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http://dx.doi.org/10.1016/j.genhosppsych.2020.01.008DOI Listing
February 2020