Xiangping Huang

Xiangping Huang

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Xiangping Huang

Xiangping Huang

Publications by authors named "Xiangping Huang"

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11Publications

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Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.

Bioorg Med Chem Lett 2018 08 26;28(15):2605-2610. Epub 2018 Jun 26.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.

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http://dx.doi.org/10.1016/j.bmcl.2018.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085084PMC
August 2018

Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs.

Mol Ther 2018 05 10;26(5):1313-1326. Epub 2018 Mar 10.

Hough Ear Institute, Oklahoma City, OK 73112, USA; Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; Departments of Physiology and Otolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Otologic Pharmaceutics Inc., Oklahoma City, OK 73104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993961PMC
May 2018

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.

Bioorg Med Chem Lett 2017 06 8;27(11):2432-2438. Epub 2017 Apr 8.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States.

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http://dx.doi.org/10.1016/j.bmcl.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479133PMC
June 2017

Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.

Chem Sci 2016 May 4;7:3117-3122. Epub 2016 Feb 4.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 (USA); Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907 (USA); Department of Biochemistry, Purdue University, West Lafayette, IN 47907 (USA).

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http://dx.doi.org/10.1039/C5SC03718BDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916918PMC
May 2016

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.

Bioorg Med Chem Lett 2015 Feb 6;25(3):668-72. Epub 2014 Dec 6.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Protein Studies Program, Oklahoma Medical Research Foundation, United States; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States.

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http://dx.doi.org/10.1016/j.bmcl.2014.11.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297543PMC
February 2015

Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP).

Biochim Biophys Acta 2013 Jun 19;1833(6):1562-71. Epub 2013 Mar 19.

Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2013.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753662PMC
June 2013

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.

FASEB J 2011 Feb 8;25(2):775-84. Epub 2010 Nov 8.

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1096/fj.10-167213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023390PMC
February 2011

Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications.

Acta Biochim Biophys Sin (Shanghai) 2004 Dec;36(12):787-92

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1093/abbs/36.12.787DOI Listing
December 2004