Publications by authors named "Xiangming Hu"

40 Publications

Association between the Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis: A Retrospective Study.

J Diabetes Res 2021 10;2021:9238566. Epub 2021 Nov 10.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080 Guangdong, China.

Background: Diabetes mellitus (DM) and dyslipidemia are the main risk factors for atherosclerosis. Elevated glycosylated hemoglobin A1c (HbA1c) and reduced high-density lipoprotein cholesterol (HDL-C) are associated with the progression of atherosclerosis. The aim of this study is at exploring the relationship between the HbA1c/HDL-C ratio and atherosclerosis evaluated using carotid artery intima-media thickness (cIMT) and carotid artery plaque.

Methods: In this retrospective study, we enrolled 1304 patients who had multiple cardiovascular risk factors or symptoms of suspected coronary artery disease. cIMT and carotid artery plaque were measured using ultrasonography. Logistic regression was used to explore the correlation between the HbA1c/HDL-C ratio and cIMT or carotid artery plaque. We used restricted cubic spline curves to assess nonlinear relationships between the HbA1c/HDL-C ratio and cIMT or carotid artery plaque.

Results: With increased quartiles of HbA1c/HDL-C, patients had higher cIMT and a greater carotid plaque burden. After adjusting for other relevant clinical covariates, patients with the highest HbA1c/HDL-C ratio (quartile 4 (Q4)) had a 2.88 times (95% confidence interval (CI): 2.02-4.10, < 0.001) more abnormal mean cIMT, 3.72 times (95% CI: 2.55-5.44, < 0.001) more abnormal maximum cIMT, and 2.58 times (95% CI: 1.70-3.91, < 0.001) greater carotid artery plaque burden compared with patients who had the lowest HbA1c/HDL-C ratio (Q1). Moreover, the association of HbA1c/HDL-C with atherosclerosis remained significant in a subsample of patients with and without DM.

Conclusion: As a novel compound indicator for evaluating blood glucose homeostasis and dyslipidemia, the HbA1c/HDL-C ratio was positively correlated with carotid atherosclerosis evaluated using the mean and maximum cIMT as well as the carotid artery plaque burden.
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http://dx.doi.org/10.1155/2021/9238566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598339PMC
November 2021

Elevated uric acid is related to the no-/slow-reflow phenomenon in STEMI undergoing primary PCI.

Eur J Clin Invest 2021 Nov 20:e13719. Epub 2021 Nov 20.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: No-/slow-reflow phenomenon (NRP) is a severe complication in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). This study aimed to explore the relationship between elevated serum uric acid (SUA) and NRP in patients with STEMI undergoing pPCI, focusing on inflammation and angiographic findings.

Methods: A total of 610 patients who received pPCI for STEMI were retrospectively enrolled. Patients were divided into a hyperuricaemia group and a non-hyperuricaemia group according to SUA levels. Clinical information and angiographic indicators were compared between the two groups. Thrombolysis in myocardial infarction (TIMI) flow and TIMI myocardial perfusion grade (TMPG) <3 after stent implantation were defined as TIMI-NRP and TMPG-NRP, respectively. A logistic model was used to analyse the relationship between hyperuricaemia and NRP.

Results: The hyperuricaemia group had a higher incidence of TIMI-NRP (24.9% vs 14.0%, p < .001) and TMPG-NRP (33.0% vs 24.9%, p = .03), higher levels of C-reactive protein (7.2 vs 4.1 mg/L, p < .001) and worse left ventricular ejection fraction (51.5% vs 54.0%, p = .002) than the non-hyperuricaemia group. As for angiographic findings, there was no significant difference between the two groups in terms of lesion characteristics measured by quantitative coronary angiography. After multivariable adjustment, elevated SUA was significantly associated with TIMI-NRP (odds ratio: 1.94, 95% confidence interval: 1.24-3.01, p = .003). Subgroup analysis showed that the effect of hyperuricaemia in TIMI-NRP was more pronounced in patients with delayed perfusion as well as in patients with diabetes mellitus.

Conclusions: Elevated SUA is associated with severe inflammation and has higher incidence of TIMI-NRP in patients with STEMI undergoing pPCI, especially in those with delayed perfusion or diabetes mellitus.
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http://dx.doi.org/10.1111/eci.13719DOI Listing
November 2021

Non-stenting strategy is not inferior to stent implantation in patients with acute ST-segment elevated myocardial infarction and high thrombus burden and intermediate stenotic culprit lesion.

Ann Palliat Med 2021 10;10(10):10849-10860

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: According to European Society of Cardiology (ESC) as well as American College of Cardiology/American Heart Association (ACC/AHA) guidelines, primary stenting is recommended for patients with acute ST-segment elevation myocardial infarction (STEMI); however, in-stent thrombosis is a life-threatening early adverse event that could lead to acute myocardial infarction (AMI) or even cardiac death. On the other hand, in-stent restenosis is a late adverse event that could result in recurrent readmission and revascularization. We compared a non-stenting (NS) strategy to a stenting (S) strategy in terms of incidence of major adverse cardiac events (MACEs) for patients with acute STEMI and high thrombus burden.

Methods: We performed a post hoc analysis of our prior multicenter, prospective cohort study (ChiCTR1800019923) among 51 eligible patients with acute STEMI and high thrombus burden. All participants received percutaneous coronary intervention (PCI) with a deferred-stenting strategy (second procedure performed within 48-72 h after primary PCI). Either NS or S strategies were carried out among patients. Primary outcomes were follow-ups of MACEs at 1, 3, 6, and 12 months. Intravenous ultrasound (IVUS) and quantitative flow ratio (QFR) evaluation were performed.

Results: In our post hoc analysis of 51 patients (21 with NS and 30 with S), baseline clinical and interventional characteristics were well matched between the 2 groups, to the exception of culprit lesion length. Incidence of MACEs was not significantly different between the 2 strategies in-hospital (P=0.56) and in follow-ups at 1 (P=0.41), 3 (free of events), 6 (P=0.71), and 12 (P=0.68) months. Culprit lesions of NS tended to be "low-risk" [minimum lumen area (MLA) 4.27±1.02 vs. 3.80±1.32 mm2, P=0.36] and plaque burden (70.79%±6.46% vs. 76.97%±6.76%, P=0.03) when compared with culprit lesions of S in IVUS evaluation. Evaluation of QFR showed more sufficient physiological reperfusion improvement with NS than with S [two-dimensional (2D) QFR: 0.85±0.09 vs. 0.79±0.13, P=0.10 and 3D QFR: 0.86±0.08 vs. 0.78±0.15, P=0.02].

Conclusions: The NS strategy did not increase MACEs in-hospital and at 1, 3, 6, and 12 months. The NS can be a safe option when meeting certain criteria for patients with STEMI and a high thrombus burden.
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http://dx.doi.org/10.21037/apm-21-2612DOI Listing
October 2021

Preparation and evaluation of humic acid-based composite dust suppressant for coal storage and transportation.

Environ Sci Pollut Res Int 2021 Oct 16. Epub 2021 Oct 16.

College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao, 266590, Shandong, China.

To mitigate environmental pollution caused by the escape of dust during coal storage and transportation, humic acid (HA) and grafted acrylamide (AM) were used as raw materials to prepare a composite dust suppressant suitable for coal storage and transportation. Single-factor experiments were used to explore the optimal synthesis conditions of the dust suppressant, and the microstructure of the product was studied using Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (H-NMR), scanning electron microscopy (SEM), and other methods. The wetting effect of the dust suppressant on coal was also investigated by way of molecular dynamics (MD) simulations. The experimental results showed that the dust suppressant had good wind erosion resistance (wind erosion rate 10.2%), shock resistance (loss rate 3.63%), and anti-evaporation performance, while the MD simulation and permeability analysis results showed that the dust suppressant had an excellent wetting effect on the coal surface. SEM images revealed that the dust suppressant can fill the gaps between coal dust particles and bond them together to form a consolidated layer, thereby effectively inhibiting the escape of dust sources during coal storage and transportation.
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http://dx.doi.org/10.1007/s11356-021-16685-2DOI Listing
October 2021

Effect of GP IIb/IIIa inhibitor duration on the clinical prognosis of primary percutaneous coronary intervention in ST-segment elevation myocardial infarction with no-/slow-reflow phenomenon.

Biomed Pharmacother 2021 Nov 21;143:112196. Epub 2021 Sep 21.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China. Electronic address:

Background: In patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) accompanied by the no-/slow-reflow phenomenon, the maintenance duration of GP IIb/IIIa inhibitor (GPI) is controversial. We compare the efficacy and safety of short- and long-term GPI infusion in STEMI patients with the no-/slow-reflow phenomenon.

Methods: From June 2016 to December 2019, we continuously included patients with on-set STEMI who underwent pPCI, accompanied by the no-/slow-reflow, during interventional procedures at Guangdong Provincial People's Hospital and Zhuhai Golden Bay Hospital. The hemorrhage events, heart function, and major adverse cardiovascular events (MACE) were compared between < 24 h and ≥ 24 h GPI duration groups. The Kaplan-Meier curve was used to estimate the 1-year MACE-free survival at different GPI utility times.

Results: In total, 127 patients were divided into two groups based on the duration of tirofiban use (less and more than 24 h). There was no significant difference between two groups in terms of baseline characteristics, plaque condition, and coronary physiological function. The two groups showed similar in-hospital MACE (1 [1.85%] vs. 4 [5.48%], p = 0.394) and 1-year MACE-free survival (log-rank test p = 0.9085). The 1-year MACE remained consistent between the two groups in all subgroups of different risk factors of no-/slow-reflow. There was no significant difference in heart function and in-hospital hemorrhage events (3.7% vs. 1.37%, p = 0.179).

Conclusion: In the real world, prolonging the duration of GPI may not significantly improve the clinical outcome in patients with STEMI with no-/slow-reflow.
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http://dx.doi.org/10.1016/j.biopha.2021.112196DOI Listing
November 2021

Using Latent Class Analysis to Identify Different Risk Patterns for Patients With Masked Hypertension.

Front Cardiovasc Med 2021 25;8:680083. Epub 2021 Aug 25.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, The First Affiliated Hospital of South China University of Technology, Guangzhou, China.

There is controversy whether masked hypertension (MHT) requires additional intervention. The aim of this study is to evaluate whether MHT accompanied with high-risk metabolic syndrome (MetS), as the subphenotype, will have a different prognosis from low-risk MetS. We applied latent class analysis to identify subphenotypes of MHT, using the clinical and biological information collected from High-risk Cardiovascular Factor Screening and Chronic Disease Management Programme. We modeled the data, examined the relationship between subphenotypes and clinical outcomes, and further explored the impact of antihypertensive medication. We included a total of 140 patients with MHT for analysis. The latent class model showed that the two-class (high/low-risk MetS) model was most suitable for MHT classification. The high-risk MetS subphenotype was characterized by larger waist circumference, lower HDL-C, higher fasting blood glucose and triglycerides, and prevalence of diabetes. After four years of follow-up, participants in subphenotype 1 had a higher non-major adverse cardiovascular event (MACE) survival probability than those in subphenotype 2 ( = 0.016). There was no interaction between different subphenotypes and the use of antihypertensive medications affecting the occurrence of MACE. We have identified two subphenotypes in MHT that have different metabolic characteristics and prognosis, which could give a clue to the importance of tracing the clinical correlation between MHT and metabolic risk factors. For patients with MHT and high-risk MetS, antihypertensive therapy may be insufficient.
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http://dx.doi.org/10.3389/fcvm.2021.680083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424076PMC
August 2021

Preparation and performance of a biological dust suppressant based on the synergistic effect of enzyme-induced carbonate precipitation and surfactant.

Environ Sci Pollut Res Int 2021 Sep 6. Epub 2021 Sep 6.

College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao, 266590, Shandong, China.

To control the dust pollution caused by open-pit coal mining and reduce or avoid the secondary hazards of existing dust suppressants to the environment, a biological dust suppressant was prepared through the synergistic effect of a surfactant and an enzyme-induced carbonate precipitation. The optimal ratio of biological dust suppressant was determined, and the dust suppressive effect and dust consolidation mechanism of the biological dust suppressant were investigated. The results showed that the optimal biological dust suppressant had an alkyl polyglycoside (APG) concentration of 0.3 wt.%, a urea-CaCl concentration of 0.6 mol/L, and a urease to urea-CaCl volume ratio of 1:3. The wind erosion resistance of coal dust treated with this dust suppressant was enhanced by 86.69%. The adsorption of the biological dust suppressant by coal dust was mainly due to the electrostatic interaction between the surfactant and coal dust. The mineralization product of the dust suppressant was calcite-type CaCO, which consolidated coal dust due to the formation of intermolecular hydrogen bonds between CaCO and coal dust.
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http://dx.doi.org/10.1007/s11356-021-16307-xDOI Listing
September 2021

A green, environment-friendly, high-consolidation-strength composite dust suppressant derived from xanthan gum.

Environ Sci Pollut Res Int 2021 Sep 2. Epub 2021 Sep 2.

College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.

To solve issues of low consolidation strength, poor dust suppression effect, and secondary pollution of the current coal dust suppressors, a greener and higher-consolidation-strength composite dust suppressor was synthesized by the radical polymerization of xanthan gum (XG) as the graft substrate, methyl acrylate (MA), and vinyl acetate (VAc) as the graft monomers. Taking compressive strength as the main optimization index and viscosity and surface tension as the secondary indices, the optimum ratio of MA:VAc was 3:5 and the optimum solid content was 2%. Experiments reveal that the prepared dust suppressant can naturally infiltrate into coal to form a hard solidified layer. At a wind speed of 10 m/s, the solidified layer still maintained structural integrity, indicating that the dust suppressant exhibits a good dust fixation effect. The dust suppressant can not only maintain relatively stable performance for a period of time but also degrade naturally. Furthermore, molecular dynamics simulation reveals not only the interaction mechanism between coal molecules and the dust suppressor but also the wetting mechanism of the dust suppressor. Experimental and simulation results reveal that as a multifunctional dust suppressor with excellent performance, the as-prepared dust suppressor demonstrates the immense potential for the control of coal dust. Graphical abstract.
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http://dx.doi.org/10.1007/s11356-021-16258-3DOI Listing
September 2021

Zolpidem improves patients' sleep quality after surgical treatment for infective endocarditis: a prospective observational study.

Sleep Breath 2021 Aug 27. Epub 2021 Aug 27.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.

Purpose: The objective of this study was to investigate the efficacy of zolpidem for improving post-operative sleep quality among patients with infective endocarditis (IE) and to identify the potential risk factors for impaired sleep quality at 6 months after surgery.

Methods: Patients with IE who underwent surgical treatment were divided into two groups according to zolpidem usage. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were used to evaluate patients' sleep quality and daytime sleepiness at baseline, which was the second day after transferal, and at 6 months after surgery. Logistic regression was used to identify potential risk factors.

Results: There were 32 patients in the zolpidem group and 42 in the control group. The PSQI and ESS scores at 6 months after surgery were significantly lower than those at baseline in both groups (P = 0.04). Additionally, 9 patients (28%) in the zolpidem group and 22 patients (52%) in the control group suffered poor sleep quality. Multivariate analysis identified age (odds ratio [OR] = 1.26, 95% confidence interval [CI]: 1.12-1.42), baseline PSQI score (OR = 2.66, 95%CI: 1.55-4.65), and no zolpidem usage (OR = 45.48, 95%CI: 3.01-691.23) as independent factors for poor sleep quality.

Conclusions: Poor sleep quality after IE surgery was prevalent among patients even 6 months after IE surgery. Age, baseline PSQI score and no zolpidem usage were independently associated with poor sleep quality. Therefore, zolpidem has the potential to be an effective part of a treatment arsenal for poor sleep quality after surgical treatment for IE.
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http://dx.doi.org/10.1007/s11325-021-02479-wDOI Listing
August 2021

Durable hydrophobic Enteromorpha design for controlling oil spills in marine environment prepared by organosilane modification for efficient oil-water separation.

J Hazard Mater 2022 01 5;421:126824. Epub 2021 Aug 5.

College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao, Shandong 266590, China.

Hydrophobic and oleophilic materials are attractive candidates for efficient oil collection due to their excellent oil-water separation. However, the most of currently reported oil adsorption materials are limited resources or require complicated preparation steps, which causes high energy consumption and not be practical for large-scale application. Herein, we report a facile strategy to modify the wettability of Enteromorpha from hydrophilic to hydrophobic, which not only greatly reduces energy consumption but also shows the outstanding capacity for oil-water separation with the maximum adsorption capacities is 11.4 g/g and the contact angle reaches 137°. The successful modification of the Enteromorpha is achieved by grafting n-octyltriethoxysilane on the surface of the pristine Enteromorpha. The hydrophobic and superoleophilic Enteromorpha guarantee adequate voids in the fibrous bundles only for oil adsorption and the oil floating on the seawater is removed by the formation of hydrogen bonding between oil and modified Enteromorpha. By optimizing test, the optimal adsorption conditions are adsorption time of 60 min, oil-water ratio of 1:10 and pH of 7. Our reported hydrophobic organosilane modified Enteromorpha will open a new avenue to control marine oil pollution and suppress the damage of Enteromorpha to the marine ecology system.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126824DOI Listing
January 2022

Environment-friendly dual-network hydrogel dust suppressant based on xanthan gum, polyvinyl alcohol and acrylic acid.

J Environ Manage 2021 Oct 23;295:113139. Epub 2021 Jun 23.

Shandong Energy Group Company Limited, Jinan, 250014, China.

Hydrogen bonding interactions among poly vinyl alcohol (PVA), xanthan gum (XG) and acrylic acid (AA) molecules have been utilized to prepare an environment-friendly interpenetrating double-network hydrogel dust suppressant (PVA-XG-PAA/SDBS) with the aim of enhancing the poor mechanical performance of current hydrogel dust suppressants. A single factor test was used to determine the optimal formulation conditions for the PVA-XG-PAA/SDBS, and the viscosity, surface tension, compression strength, wind resistance, water retention and biodegradability of the samples were measured. The results showed that the hydrogel with optimal usage contained 1.5 g, 0.1 g, and 6 g of PVA, XG and AA, respectively and the optimal reaction temperature was 55 °C. Under the optimal conditions, the viscosity was 45 mPa s, the surface tension was 30 mN/m, the compression strength of the dust suppressant-solidified coal pillar reached 126 kPa, and the degradation rate at the 8th cycle (40 days) after being buried in soil was 34%. Compared with a conventional hydrogel dust suppressant, like poly acrylic acid (PAA), and the dust suppressant sodium dodecyl benzene sulfonate (SDBS), the PVA-XG-PAA/SDBS showed better water retention, wind erosion resistance, and dust-solidifying properties. On the basis of these remarkable properties, the PVA-XG-PAA/SDBS is applicable for dust prevention during coal mining, transport, and storage, which enhances the dust suppression efficiency obviously and has significant meaning to the sustainable development of the coal mining industry while protecting the environment.
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http://dx.doi.org/10.1016/j.jenvman.2021.113139DOI Listing
October 2021

Relationship Between Masked Hypertension Measured by Ambulatory Blood Pressure Monitoring and Left Ventricular Global Longitudinal Strain: A Retrospective Study.

Int J Gen Med 2021 25;14:2053-2061. Epub 2021 May 25.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China.

Purpose: Masked hypertension (MHT), as an independent clinical entity, the cardiac dysfunction caused by it can be early detected through left ventricular global longitudinal strain (GLS), yet the quantitative relation between MHT and GLS is still unclear. Therefore, we tried to conduct a community-based retrospective study to define this relationship.

Patients And Methods: A total of 308 enrolled participants from Dongguan, China, were divided into non-hypertension (NHT) and MHT groups. Baseline characteristics were recorded, and echocardiography and 24-hour ambulatory blood pressure monitoring were performed. Linear regression analysis and receiver-operating characteristic (ROC) curve analysis were used to assess the associations between MHT and GLS in univariate and multivariate models, and the dose-response curve was plotted to demonstrate their relationship.

Results: The mean age of the NHT and MHT groups was 57 and 60 years, respectively. Signs of left ventricular diastolic function, E/A was reduced and E/e' was increased in the MHT group while those of the NHT group were nearly normal. The MHT group also showed a significantly lower ("worse") GLS than NHT (-15.2% vs -19.9%, P < 0.001) while left ventricular ejection fraction (LVEF) did not differ between the groups. Worse GLS was independently and significantly associated with MHT both in univariate (odds ratio [OR]: 1.97, P < 0.001) and stepwise multivariate regression analysis (OR: 1.99, P < 0.001). Comparison of ROC curve results showed that area under curve of GLS was larger than that of E/e' both in unadjusted (0.8673 vs 0.6831) and adjusted model (0.9178 vs 0.8284). Further analysis showed adjusted nonlinear correlation between MHT and GLS.

Conclusion: Based on the relationship between MHT and GLS, in clinical practice, GLS measurement could facilitate diagnosis for suspected MHT patients and could define the extent of left ventricular dysfunction for diagnosed MHT patients.
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http://dx.doi.org/10.2147/IJGM.S310414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164706PMC
May 2021

The outcomes in STEMI patients with high thrombus burden treated by deferred versus immediate stent implantation in primary percutaneous coronary intervention: a prospective cohort study.

Ann Transl Med 2021 Apr;9(7):573

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: No-/slow-reflow indicates worse outcomes in ST-elevation myocardial infarction (STEMI) patients with high thrombus burden. We examined whether deferred stenting (DS) strategy reduces no-/slow-reflow or major adverse cardiovascular events (MACEs) in primary percutaneous coronary intervention (pPCI) for patients with acute STEMI and high thrombus burden.

Methods: We performed an open-label, multi-center, prospective cohort study among eligible patients with acute STEMI and high thrombus burden who further received pPCI. All participants received PCI with DS (second procedure performed within 48-72 h) or immediate-stenting (IS) strategy. The primary outcome was the incidence of no-/slow-reflow. We evaluated MACEs and bleeding events during hospitalization and at 30- and 90-day follow-ups.

Results: We recruited 245 patients to this study, including 51 with DS and 194 with IS. Baseline clinical characters were comparable between the 2 strategies. Incidence of no-/slow-reflow defined by thrombolysis in myocardial infarction (TIMI) flow grade was not significantly different between the 2 strategies [DS: 5 (9.8%), IS: 33 (17.0%), P=0.21]. No-/slow-reflow by TIMI myocardial perfusion grade (TMPG) was less prevalent in DS [20 (39.2%) 107 (55.2%), P=0.04]. No significant differences were found in recurrence of myocardial infarction (P=0.56), cardiac death (P=0.37), all-cause mortality (P=0.37), heart failure-induced readmission (P=0.35), or bleeding (P=0.61) between the 2 strategies in-hospital, and at 30- and 90-day follow-up.

Conclusions: In STEMI patients with high thrombus burden who underwent pPCI, DS strategy reduced no-/slow-reflow of microcirculation. However, DS strategy did not reduce incidence of MACEs or bleeding.
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http://dx.doi.org/10.21037/atm-21-1130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105830PMC
April 2021

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.

JCI Insight 2021 04 8;6(7). Epub 2021 Apr 8.

Department of Biochemistry.

Macrophage-mediated inflammatory response has been implicated in the pathogenesis of obesity and insulin resistance. Brd4 has emerged as a key regulator in the innate immune response. However, the role of Brd4 in obesity-associated inflammation and insulin resistance remains uncharacterized. Here, we demonstrated that myeloid lineage-specific Brd4 knockout (Brd4-CKO) mice were protected from high-fat diet-induced (HFD-induced) obesity with less fat accumulation, higher energy expenditure, and increased lipolysis in adipose tissue. Brd4-CKO mice fed a HFD also displayed reduced local and systemic inflammation with improved insulin sensitivity. RNA-Seq of adipose tissue macrophages (ATMs) from HFD-fed WT and Brd4-CKO mice revealed that expression of antilipolytic factor Gdf3 was significantly decreased in ATMs of Brd4-CKO mice. We also found that Brd4 bound to the promoter and enhancers of Gdf3 to facilitate PPARγ-dependent Gdf3 expression in macrophages. Furthermore, Brd4-mediated expression of Gdf3 acted as a paracrine signal targeting adipocytes to suppress the expression of lipases and the associated lipolysis in cultured cells and mice. Controlling the expression of Gdf3 in ATMs could be one of the mechanisms by which Brd4 modulates lipid metabolism and diet-induced obesity. This study suggests that Brd4 could be a potential therapeutic target for obesity and insulin resistance.
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http://dx.doi.org/10.1172/jci.insight.143379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119191PMC
April 2021

Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips.

J Cell Biol 2021 03;220(3)

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL.

NLRC4 inflammasome activation and the subsequent maturation of IL-1β and IL-18 are critical for protection against infection by bacterial pathogens. The epigenetic regulator Brd4 has emerged as a key player in inflammation by regulating the expression of inflammatory cytokines. However, whether Brd4 has any role in inflammasome activation remains undetermined. Here, we demonstrated that Brd4 is an important regulator of NLRC4 inflammasome activation in response to Salmonella typhimurium infection. Brd4-deficient bone marrow-derived macrophages (BMDMs) displayed impaired caspase-1 activation, ASC oligomerization, IL-1β maturation, gasdermin-D cleavage, and pyroptosis in response to S.typhimurium infection. RNA sequencing and RT-PCR results revealed that the transcription of Naips was decreased in Brd4-deficient BMDMs. Brd4 formed a complex with IRF8/PU.1 and bound to the IRF8 and PU.1 binding motifs on the promoters of Naips to maintain the expression of Naips. Furthermore, myeloid lineage-specific Brd4 conditional knockout mice were more susceptible to S.typhimurium infection with increased mortality, bacterial loads, and tissue damage; impaired inflammasome-dependent cytokine production; and pyroptosis. Our studies identify a novel function of Brd4 in innate immunity by controlling inflammasome-mediated cytokine release and pyroptosis to effectively battle S.typhimurium infection.
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http://dx.doi.org/10.1083/jcb.202005148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863722PMC
March 2021

BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination.

JCI Insight 2020 12 8;6(1). Epub 2020 Dec 8.

Department of Molecular and Integrative Physiology and.

Activation of farnesoid X receptor (FXR) by obeticholic acid (OCA) reduces hepatic inflammation and fibrosis in patients with primary biliary cholangitis (PBC), a life-threatening cholestatic liver failure. Inhibition of bromodomain-containing protein 4 (BRD4) also has antiinflammatory, antifibrotic effects in mice. We determined the role of BRD4 in FXR function in bile acid (BA) regulation and examined whether the known beneficial effects of OCA are enhanced by inhibiting BRD4 in cholestatic mice. Liver-specific downregulation of BRD4 disrupted BA homeostasis in mice, and FXR-mediated regulation of BA-related genes, including small heterodimer partner and cholesterol 7 alpha-hydroxylase, was BRD4 dependent. In cholestatic mice, JQ1 or OCA treatment ameliorated hepatotoxicity, inflammation, and fibrosis, but surprisingly, was antagonistic in combination. Mechanistically, OCA increased binding of FXR, and the corepressor silencing mediator of retinoid and thyroid hormone receptor (SMRT) decreased NF-κB binding at inflammatory genes and repressed the genes in a BRD4-dependent manner. In patients with PBC, hepatic expression of FXR and BRD4 was significantly reduced. In conclusion, BRD4 is a potentially novel cofactor of FXR for maintaining BA homeostasis and hepatoprotection. Although BRD4 promotes hepatic inflammation and fibrosis in cholestasis, paradoxically, BRD4 is required for the antiinflammatory, antifibrotic actions of OCA-activated FXR. Cotreatment with OCA and JQ1, individually beneficial, may be antagonistic in treatment of liver disease patients with inflammation and fibrosis complications.
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http://dx.doi.org/10.1172/jci.insight.141640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821603PMC
December 2020

Effects of Overlap Length on Flammability and Fire Hazard of Vertical Polymethyl Methacrylate (PMMA) Plate Array.

Polymers (Basel) 2020 Nov 27;12(12). Epub 2020 Nov 27.

Key Laboratory of Mining Disaster Prevention and Control, Qingdao 266590, China.

Polymethyl methacrylate (PMMA) plates are widely used in buildings or factories for natural lighting. Commonly PMMA plates are installed as a discrete array. However, PMMA plates are very susceptible to fire. Therefore, experimental study on flammability and fire hazard of vertical PMMA plate array with different overlap length () was conducted in this work. The average flame height (Hf) increases first and then decreases with an increase in the overlap length, and reaches the maximum when = 40 mm. The discrete flame spread speed (Vf) also rises first and then drops with the increase of , which is mainly due to the heat transfer from the PMMA flame to the next plate. A model for predicting the flame spread rate of discrete PMMA array is established. The predicted results are consistent with experimental ones, with a predicted error smaller than 15%. The average temperature of flame zone rises first and then drops as increases, reaching the maximum when = 40 mm. This leads to the same changing trend of radiative heat flux. Results obtained in this work provide a reference for fire hazard evaluation and fire safety design of PMMA plates employed in buildings or industrial sites.
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http://dx.doi.org/10.3390/polym12122826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760985PMC
November 2020

Degradable self-adhesive epidermal sensors prepared from conductive nanocomposite hydrogel.

Nanoscale 2020 Sep 3;12(36):18771-18781. Epub 2020 Sep 3.

College of Safety and Environmental Engineering, Shandong University of Science and Technology Qingdao, Shandong 266590, China.

Conductive hydrogel-based epidermal sensors are attracting significant interest due to their great potential in soft robotics, electronic skins, bioelectronics and personalized healthcare monitoring. However, the conventional conductive hydrogel-based epidermal sensors cannot be degraded, resulting in the significant problem of waste, which will gradually increase the burden on the environment. Herein, degradable adhesive epidermal sensors were assembled using conductive nanocomposite hydrogels, which were prepared via the conformal coating of cellulose nanofiber (CNF) networks and supramolecular interaction among CNF, polydopamine (PDA), Fe, and polyacrylamide (PAM). They exhibited superior mechanical properties, reliable degradability (30 days in water), and excellent self-adhesiveness. The obtained hydrogels could be assembled as self-adhesive, degradable epidermal sensors for real-time human motion monitoring. Air could be sucked into the hydrogels during their swelling process, thereby oxidizing the tris-catechol-Fe complexes and releasing Fe. Finally, the polymer networks were degraded via a Fenton-like reaction dominated by SO and Fe(ii/iii) with the help of the catechol groups of PDA. This work paves the way for the potential fabrication of degradable, and self-adhesive epidermal sensors for applications in human-machine interactions, implantable bioelectronics, and personalized healthcare monitoring.
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http://dx.doi.org/10.1039/d0nr04666cDOI Listing
September 2020

H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis.

Cell Death Dis 2020 08 21;11(8):667. Epub 2020 Aug 21.

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, 61801, IL, USA.

H. pylori infection is one of the leading causes of gastric cancer and the pathogenicity of H. pylori infection is associated with its ability to induce chronic inflammation and apoptosis resistance. While H. pylori infection-induced expression of pro-inflammatory cytokines for chronic inflammation is well studied, the molecular mechanism underlying the apoptosis resistance in infected cells is not well understood. In this study, we demonstrated that H. pylori infection-induced apoptosis resistance in gastric epithelial cells triggered by Raptinal, a drug that directly activates caspase-3. This resistance resulted from the induction of cIAP2 (encoded by BIRC3) since depletion of BIRC3 by siRNA or inhibition of cIAP2 via BV6 reversed H. pylori-suppressed caspase-3 activation. The induction of cIAP2 was regulated by H. pylori-induced BIRC3 eRNA synthesis. Depletion of BIRC3 eRNA decreased H. pylori-induced cIAP2 and reversed H. pylori-suppressed caspase-3 activation. Mechanistically, H. pylori stimulated the recruitment of bromodomain-containing factor Brd4 to the enhancer of BIRC3 and promoted BIRC3 eRNA and mRNA synthesis. Inhibition of Brd4 diminished the expression of BIRC3 eRNA and the anti-apoptotic response to H. pylori infection. Importantly, H. pylori isogenic cagA-deficient mutant failed to activate the synthesis of BIRC3 eRNA and the associated apoptosis resistance. Finally, in primary human gastric epithelial cells, H. pylori also induced resistance to Raptinal-triggered caspase-3 activation by activating the Brd4-dependent BIRC3 eRNA synthesis in a CagA-dependent manner. These results identify a novel function of Brd4 in H. pylori-mediated apoptosis resistance via activating BIRC3 eRNA synthesis, suggesting that Brd4 could be a potential therapeutic target for H. pylori-induced gastric cancer.
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http://dx.doi.org/10.1038/s41419-020-02894-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441315PMC
August 2020

Lipoprotein (a) as a residual risk factor for atherosclerotic renal artery stenosis in hypertensive patients: a hospital-based cross-sectional study.

Lipids Health Dis 2020 Jul 23;19(1):173. Epub 2020 Jul 23.

Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, #96 Dongchuan Road, Guangzhou, 510080, Guangdong, China.

Background: Low-density lipoprotein cholesterol (LDL-c) has been proven to be a risk factor for atherosclerotic cardiovascular disease (CVD), while lipoprotein (a) (Lp(a)) is a residual risk factor for CVD, even though LDL-c is well controlled by statin use. Importantly, the role of Lp(a) in atherosclerotic renal artery stenosis (ARAS) is still unknown.

Methods: For this hospital-based cross-sectional study, patients who simultaneously underwent coronary and renal angiography were examined. ARAS was defined as a 50% reduction in the cross-sectional (two-dimensional plane) area of the renal artery. Data were collected and compared between ARAS and non-ARAS groups, including clinical history and metabolite profiles. Univariate analysis, three tertile LDL-c-based stratified analysis, and multivariate-adjusted logistic analysis were conducted, revealing a correlation between Lp(a) and ARAS.

Results: A total of 170 hypertensive patients were included in this study, 85 with ARAS and 85 with non-RAS. Baseline information indicated comparability between the two groups. In the univariate and multivariate analysis, common risk factors for atherosclerosis were not significantly different. Stratified analysis of LDL-c revealed a significant increase in the incidence of ARAS in patients who had high Lp(a) concentrations at low LDL-c levels (odds ratio (OR): 4.77, 95% confidence interval (CI): 1.04-21.79, P = 0.044). Further logistic analysis with adjusted covariates also confirmed the result, indicating that high Lp(a) levels were independently associated with ARAS (adjusted OR (aOR): 6.14, 95%CI: 1.03-36.47, P = 0.046). This relationship increased with increasing Lp(a) concentration based on a curve fitting graph. These results were not present in the low and intermediate LDL-c-level groups.

Conclusion: In hypertensive patients who present low LDL-c, high Lp(a) was significantly associated with atherosclerotic renal artery stenosis and thus is a residual risk factor.
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http://dx.doi.org/10.1186/s12944-020-01272-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379345PMC
July 2020

Phase control of reservoir engineering for quantum entanglement.

Opt Express 2020 Jun;28(12):17757-17772

It is shown that the reservoir engineering can be controlled by the collective phase Φ of three coherent fields interacting with a closed Δ-type atom. We find that the atomic system acts as a one-channel dissipation reservoir when Φ = 0(π), but it behaves as a two-channel dissipation reservoir for Φ ≠ 0(π). The phase-dependent reservoir engineering provides a convenient way to produce robust two-mode squeezing and entanglement, which may find potential applications in quantum information processing.
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http://dx.doi.org/10.1364/OE.390647DOI Listing
June 2020

Pinning Down the Transcription: A Role for Peptidyl-Prolyl Isomerase Pin1 in Gene Expression.

Front Cell Dev Biol 2020 20;8:179. Epub 2020 Mar 20.

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, United States.

Pin1 is a peptidyl-prolyl isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the isomerization of proline imidic peptide bond, resulting in conformational change of its substrates. Pin1 regulates many biological processes and is also involved in the development of human diseases, like cancer and neurological diseases. Many Pin1 substrates are transcription factors and transcription regulators, including RNA polymerase II (RNAPII) and factors associated with transcription initiation, elongation, termination and post-transcription mRNA decay. By changing the stability, subcellular localization, protein-protein or protein-DNA/RNA interactions of these transcription related proteins, Pin1 modulates the transcription of many genes related to cell proliferation, differentiation, apoptosis and immune response. Here, we will discuss how Pin regulates the properties of these transcription relevant factors for effective gene expression and how Pin1-mediated transcription contributes to the diverse pathophysiological functions of Pin1.
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http://dx.doi.org/10.3389/fcell.2020.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100383PMC
March 2020

Coherent population trapping based atomic reservoir for almost perfect higher-order squeezing.

Opt Express 2019 Oct;27(21):30530-30551

Due to either coherent or dissipative interactions with the coherent population trapping (CPT)-based atoms, the evolutions of the Bogoliubov modes towards the vacuum states have been shown to lead to second-order squeezing of the involved optical fields. Here we push the CPT-based dissipative interactions towards higher-order squeezing, which is not simply determined by second-order squeezing but instead by different criteria involving higher-order moments. It is shown that the CPT-based atomic reservoir supports the dissipative evolution of the Bogoliubov modes almost completely to the vacuum states and then yields almost perfect fourth-order squeezing (90∼100). The present mechanism is robust against spontaneous emission since the atoms stay largely in the ground states. As a by-product, a comparison is given with two-level atoms, in which the excitation of a large fraction reduces the degree of higher-order squeezing.
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http://dx.doi.org/10.1364/OE.27.030530DOI Listing
October 2019

Biomaterials research of China from 2013 to 2017 based on bibliometrics and visualization analysis.

PeerJ 2019 6;7:e6859. Epub 2019 May 6.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Objectives: This study aims to evaluate the changes of development trends and research hotspots of biomaterials research from 2013 to 2017, which can identify the general information of papers and explore the changes of research content, thus providing perspectives for the development of biomaterials in China and other countries.

Methods: Data of the paper were retrieved from the Web of Science Core Collection, and then analyzed by the bibliometric and CiteSpace visualization analysis.

Results: It was found that a total of 3,839 related papers had been published from the year 2013 to 2017. The analysis of the articles showed that the annual quantity and quality of the articles in the biomaterials research have been increasing since 2013, and the Wang L / Chinese Academy of Sciences were the most productive author/institution. Meanwhile, the keywords "in vitro", "scaffold", "nanoparticle" , "mechanical property", and "biocompatibility" have the relatively higher frequency, and the keywords "apatite", "deposition", and "surface modification" have the strongest burst citation.

Conclusions: After statistics and analysis, we found that biomaterials is a promising research field. The study may be helpful in understanding research trends in this field.
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http://dx.doi.org/10.7717/peerj.6859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507895PMC
May 2019

Effect of Silane Treatment on Mechanical Properties of Polyurethane/Mesoscopic Fly Ash Composites.

Polymers (Basel) 2019 Apr 24;11(4). Epub 2019 Apr 24.

State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China.

In view of the accidents such as rock mass breakage, roof fall and coal slide in coal mines, polyurethane/mesoscopic fly ash (PU/MFA) reinforcement materials were produced from polymethylene polyphenylene isocyanate (PAPI), the polyether polyol, flame retardant, and MFA using stannous octanate as a catalyst. 3-Glycidoxypropyltrimethoxysilane (GPTMS) was grafted on MFA surface, aiming to improve the mechanical properties of PU/MFA composites. The analyses of infrared spectroscopy and compression resistance reveal that the GPTMS can be successfully attached to the surface of MFA, and the optimum modification dosage of GPTMS to MFA is 2.5 wt % (weight percent). On this basis, the effect of GPTMS on the mechanical properties of PU/MFA reinforcement materials during the curing process was systematically investigated through a compression test, a fracture toughness test, a three-point bending test, a bond property test, and a dynamic mechanics analysis. The results show that the compression property, fracture toughness, maximum flexural strength, and bond strength of PU/MFA composites increase by 21.6%, 10.1%, 8.8%, and 19.3%, respectively, compared with the values before the modification. Furthermore, the analyses of scanning electron microscope and dynamic mechanics suggest that the coupling agent GPTMS can successfully improve the mechanical properties of PU/MFA composites because it eliminates the stress concentration and exerts a positive effect on the crosslink density and hardness of PU/MFA composites.
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http://dx.doi.org/10.3390/polym11040741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524166PMC
April 2019

Novel sodium silicate/polymer composite gels for the prevention of spontaneous combustion of coal.

J Hazard Mater 2019 06 9;371:643-654. Epub 2019 Mar 9.

College of Mining and Safety Engineering, Shandong University of Science and Technology, Qingdao, Shandong 266590, China; State Key Laboratory of Mining Disaster Prevention and Control Co-found by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao, Shandong 266590, China.

Novel gel materials are proposed for fire prevention and extinction in coal mines, where spontaneous combustion of coal continues to pose a significant risk. Cationic polyacrylamide (CPAM), anionic polyacrylamide (HPAM), and carboxymethyl cellulose (CMC) were each introduced separately into a sodium silicate (WG) gel, to obtain three gels labeled as CPAM/WG, HPAM/WG, and CMC/WG. A crosslinking agent, aluminum citrate, was subsequently added to the HPAM/WG and CMC/WG gels to afford two novel interpenetrating network hydrogels, HPAM-Al/WG and CMC-Al/WG, respectively. Among the various gels, the HPAM-Al/WG hydrogel exhibits the best seepage capacity, water retention capacity, compressive strength, and inhibition characteristics, which effectively resolve the post-water-loss cracking and pulverization problems commonly associated with inorganic consolidated silica gels. The microstructures of all the gels were investigated by scanning electron microscopy and their inhibitory effects on the oxidation of hydroxyl and methylene groups in coal at high temperatures were analyzed by Fourier transform infrared spectroscopy. Elemental mapping by energy dispersive X-ray spectroscopy indicated that the inorganic silica gel blends uniformly with the polymeric gel. Fire extinction experiments indicated that the HPAM-Al/WG gel reduces the fire-source temperature, heat radiation, and CO generation. Thus, the HPAM-Al/WG gel is an ideal fire prevention and extinction material.
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http://dx.doi.org/10.1016/j.jhazmat.2019.03.041DOI Listing
June 2019

Spontaneous feedback for the simultaneous narrowing and elevation of fluorescence spectral lines.

Opt Express 2018 Feb;26(4):4807-4817

Narrow linewidth and high intensity of the fluorescence spectra are two important elements to improve the accuracy and efficiency of related practical measurements, but so far they have not been achievable simultaneously. We propose a new approach to sharpen the linewidth and to heighten the intensity simultaneously. Rather than double coherent mechanisms, it uses the spontaneous emission of inverted atoms in a cavity below the threshold as a resource for feedback control. The spontaneous feedback is simpler in principle and easier to realize technologically, and represents a kind of new way of controlling spontaneous emission.
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http://dx.doi.org/10.1364/OE.26.004807DOI Listing
February 2018

BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis.

Cell Death Dis 2018 02 12;9(2):203. Epub 2018 Feb 12.

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Small molecules targeting bromodomains of BET proteins possess strong anti-tumor activities and have emerged as potential therapeutics for cancer. However, the underlying mechanisms for the anti-proliferative activity of these inhibitors are still not fully characterized. In this study, we demonstrated that BET inhibitor JQ1 suppressed the proliferation and invasiveness of gastric cancer cells by inducing cellular senescence. Depletion of BRD4, which was overexpressed in gastric cancer tissues, but not other BET proteins recapitulated JQ1-induced cellular senescence with increased cellular SA-β-Gal activity and elevated p21 levels. In addition, we showed that the levels of p21 were regulated at the post-transcriptional level by BRD4-dependent expression of miR-106b-5p, which targets the 3'-UTR of p21 mRNA. Overexpression of miR-106b-5p prevented JQ1-induced p21 expression and BRD4 inhibition-associated cellular senescence, whereas miR-106b-5p inhibitor up-regulated p21 and induced cellular senescence. Finally, we demonstrated that inhibition of E2F suppressed the binding of BRD4 to the promoter of miR-106b-5p and inhibited its transcription, leading to the increased p21 levels and cellular senescence in gastric cancer cells. Our results reveal a novel mechanism by which BRD4 regulates cancer cell proliferation by modulating the cellular senescence through E2F/miR-106b-5p/p21 axis and provide new insights into using BET inhibitors as potential anticancer drugs.
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http://dx.doi.org/10.1038/s41419-017-0181-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833665PMC
February 2018

One-way Einstein-Podolsky-Rosen steering via atomic coherence.

Opt Express 2017 May;25(10):11584-11597

We explore the asymmetric Einstein-Podolsky-Rosen (EPR) steering of field modes via atomic coherent effects. A resonant four-level system in double-cascade configuration is under our consideration, where the atoms are excited by the applied fields from one cascade channel and two cavity modes are generated from the other cascade transition. The results show two cavity modes are suitable for achieving the steady-state one-way EPR steering. We analyze the physics in terms of the dressed-atom Bogoliubov-field-mode approach. It is found that one of two Bogoliubov modes is mediated by the resonant coupling of the dressed atoms and the other is decoupled from them. This leads to the so-called one-channel dissipation, by which the dressed atoms absorb the average excitations from one transformed mode and then two original modes are pulled into the asymmetric correlation. Remarkably, the present scheme is focused on the full-resonant interaction not only between the classical fields, the cavity modes and the bare atoms, but also between the Bogoliubov modes and dressed atoms, which will induce the one-way steering simply via adjusting the intensity of an external field. Furthermore, the EPR steering could occur between the field modes with the large frequency difference, such as optical and microwave fields, which is more useful for the practical quantum communication. Based on the one-channel dissipation, the obtainable one-way EPR steering is rather against the dynamic fluctuations and is regardless of the initial state.
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http://dx.doi.org/10.1364/OE.25.011584DOI Listing
May 2017

Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα.

Proc Natl Acad Sci U S A 2017 05 1;114(20):E3993-E4001. Epub 2017 May 1.

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

Bromodomain-containing factor Brd4 has emerged as an important transcriptional regulator of NF-κB-dependent inflammatory gene expression. However, the in vivo physiological function of Brd4 in the inflammatory response remains poorly defined. We now demonstrate that mice deficient for in myeloid-lineage cells are resistant to LPS-induced sepsis but are more susceptible to bacterial infection. Gene-expression microarray analysis of bone marrow-derived macrophages (BMDMs) reveals that deletion of decreases the expression of a significant amount of LPS-induced inflammatory genes while reversing the expression of a small subset of LPS-suppressed genes, including MAP kinase-interacting serine/threonine-protein kinase 2 (). -deficient BMDMs display enhanced Mnk2 expression and the corresponding eukaryotic translation initiation factor 4E (eIF4E) activation after LPS stimulation, leading to an increased translation of IκBα mRNA in polysomes. The enhanced newly synthesized IκBα reduced the binding of NF-κB to the promoters of inflammatory genes, resulting in reduced inflammatory gene expression and cytokine production. By modulating the translation of IκBα via the Mnk2-eIF4E pathway, Brd4 provides an additional layer of control for NF-κB-dependent inflammatory gene expression and inflammatory response.
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http://dx.doi.org/10.1073/pnas.1700109114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441817PMC
May 2017
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