Publications by authors named "Xiangli Liu"

72 Publications

Simultaneously enhancing redox kinetics and inhibiting the polysulfide shuttle effect using MOF-derived CoSe hollow sphere structures for advanced Li-S batteries.

Nanoscale 2021 Jun;13(24):10849-10861

Research Centre of Printed Flexible Electronics, School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen 518055, China. and State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen 518055, China.

Lithium-sulfur (Li-S) batteries generally suffer from a serious "shuttle effect" during the charging/discharging process, resulting in the loss of active components and sluggish redox reaction kinetics that hinder the cycle life and rate performance of the battery. To address this, CoSe/C hollow structures (CoSe/C HSs) were prepared via a simple hydrothermal strategy and used as a sulfur host for Li-S batteries. The battery with CoSe/C HSs exhibited a high initial specific discharge capacity of 1405 mA h g-1 with a coulombic efficiency of 99.8% at 0.1C. Additionally, [email protected]/C HS cathodes with a high sulfur loading of 5.1 mg cm-2 delivered a considerable specific discharge capacity of 1256.1 mA h g-1 and maintained a high capacity of 1120 mA h g-1 after 100 cycles with a capacity decay rate of 0.11% per cycle at 0.1C. The unique raspberry-like structure of CoSe/C HSs prevents polysulfides from escaping the cathode host via both physical containment and the formation of Co-S and Se-Li chemical bonds, and it also enhances the polysulfide redox kinetics. Furthermore, the peculiar raspberry-like structure can withstand volume changes during charging/discharging to better protect the cathode.
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http://dx.doi.org/10.1039/d1nr02044gDOI Listing
June 2021

Effects of oxygen vacancy defect on microwave pyrolysis of biomass to produce high-quality syngas and bio-oil: Microwave absorption and in-situ catalytic.

Waste Manag 2021 Jun 14;128:200-210. Epub 2021 May 14.

Shenzhen Engineering Laboratory of Aerospace Detection and Imaging, Department of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.

This paper proposed to use ferric oxide (FeO) and ferroferric oxide (FeO) as catalysts with both microwave absorption and catalytic properties. Carbon dioxide (CO) was introduced as the reaction atmosphere to further improve the quality of biofuel produced by microwave pyrolysis of food waste (FW). The results showed the bio-gas yield and the syngas concentration (H + CO) increased to 70.34 wt% and 61.50 mol%, respectively, using FeO as the catalyst. The content of aliphatic hydrocarbons in bio-oil produced with the catalyst FeO increased to 67.48% and the heating value reached 30.45 MJ/kg. Compared with FeO catalyst, FeO exhibited better microwave absorption properties and catalytic properties. Transmission electron microscopy (TEM) and Electron paramagnetic resonance (EPR) characterizations confirmed that the crystal surface of FeO formed more oxygen vacancy defects and unpaired electrons. Additionally, according to the X-ray photoelectron spectroscopy (XPS) analysis, the content of lattice oxygen in FeO was 14.11%, a value that was much lower than FeO (38.54%). The oxygen vacancy defects not only improved the efficient utilization of microwave energy but also provided the reactive sites for the reaction between the volatile organic compounds (VOCs) and CO to generate CO. This paper provides a new perspective for selecting catalysts that have both microwave absorption and catalytic properties during the microwave pyrolysis of biomass.
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http://dx.doi.org/10.1016/j.wasman.2021.05.002DOI Listing
June 2021

A primate-specific RNA-binding protein (RBMXL3) is involved in glucocorticoid regulation of human pulmonary surfactant protein B (SP-B) mRNA stability.

Am J Physiol Lung Cell Mol Physiol 2021 05 10;320(5):L942-L957. Epub 2021 Mar 10.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.

The ability of pulmonary surfactant to reduce alveolar surface tension requires adequate levels of surfactant protein B (SP-B). Dexamethasone (DEX) increases human SP-B expression, in part, through increased SP-B mRNA stability. A 30-nt-long hairpin element (RBE) in the 3'-untranslated region of human SP-B mRNA mediates both DEX-induced and intrinsic mRNA stabilities, but the mechanism is unknown. Proteomic analysis of RBE-interacting proteins identified a primate-specific protein, RNA-binding motif X-linked-like-3 (RBMXL3). siRNA directed against RBMXL3 reduces DEX-induced SP-B mRNA expression in human bronchoalveolar cells. Human SP-B mRNA stability, measured by our dual cistronic plasmid assay, is unaffected by DEX in mouse lung epithelial cells lacking RBMXL3, but DEX increases human SP-B mRNA stability when RBMXL3 is expressed and requires the RBE. In the absence of DEX, RBE interacts with cellular proteins, reducing intrinsic SP-B mRNA stability in human and mouse lung epithelial cells. RBMXL3 specifically binds the RBE in vitro, whereas RNA immunoprecipitation and affinity chromatography analyses indicate that binding is enhanced in the presence of DEX. These results describe a model where intrinsic stability of human SP-B mRNA is reduced through binding of cellular mRNA decay factors to RBE, which is then relieved through DEX-enhanced binding of primate-specific RBMXL3.
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http://dx.doi.org/10.1152/ajplung.00022.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174829PMC
May 2021

Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum.

Sci Rep 2021 Jan 28;11(1):2593. Epub 2021 Jan 28.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin, Suite 3.222, Houston, TX, 77030, USA.

Levels of intestinal toll-like receptor 4 (TLR4) impact inflammation in the neonatal gastrointestinal tract. While surfactant protein A (SP-A) is known to regulate TLR4 in the lung, it also reduces intestinal damage, TLR4 and inflammation in an experimental model of necrotizing enterocolitis (NEC) in neonatal rats. We hypothesized that SP-A-deficient (SP-A) mice have increased ileal TLR4 and inflammatory cytokine levels compared to wild type mice, impacting intestinal physiology. We found that ileal TLR4 and proinflammatory cytokine levels were significantly higher in infant SP-A mice compared to wild type mice. Gavage of neonatal SP-A mice with purified SP-A reduced ileal TLR4 protein levels. SP-A reduced expression of TLR4 and proinflammatory cytokines in normal human intestinal epithelial cells (FHs74int), suggesting a direct effect. However, incubation of gastrointestinal cell lines with proteasome inhibitors did not abrogate the effect of SP-A on TLR4 protein levels, suggesting that proteasomal degradation is not involved. In a mouse model of experimental NEC, SP-A mice were more susceptible to intestinal stress resembling NEC, while gavage with SP-A significantly decreased ileal damage, TLR4 and proinflammatory cytokine mRNA levels. Our data suggests that SP-A has an extrapulmonary role in the intestinal health of neonatal mice by modulating TLR4 and proinflammatory cytokines mRNA expression in intestinal epithelium.
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http://dx.doi.org/10.1038/s41598-021-82219-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843620PMC
January 2021

Huaier shows anti-cancer activities by inhibition of cell growth, migration and energy metabolism in lung cancer through PI3K/AKT/HIF-1α pathway.

J Cell Mol Med 2021 Feb 30;25(4):2228-2237. Epub 2020 Dec 30.

Department of Thoracic Surgery, the First Affiliated Hospital of China Medical University, Shenyang, China.

Huaier has been verified to have anti-cancer effects on many tumours. However, little information is available about the effects of Huaier on non-small cell lung cancer (NSCLC). We sought to probe the anti-cancer effects and related mechanisms of Huaier on lung cancer. A549 cells were pre-treated with 2, 4 and 8 mg/mL Huaier at different time points. Thereafter, cell viability was analysed by CCK-8 and the migration and invasion were detected by Scratch test and Transwell chamber migration assay. Moreover, ELISA, Western blot, shRNA transfection and RT-PCR were conducted to discover the related gene and protein expressions of energy metabolism and phosphatidylinositol 3-kinase (PI3K)/AKT/hypoxia-inducible factor 1α (HIF-1α) pathway. Furthermore, tumour xenografts were accomplished to inspect the anti-cancer effects of Huaier. Our consequences suggested that Huaier considerably repressed cell viability and migration in a dose-dependent way. In addition, Huaier statistically suppressed glycolysis, glucose transport and lactic acid (LA) accumulation. Besides, we detected that Huaier could inactivate the PI3K/AKT/HIF-1α pathway. The in vivo data confirmed that Huaier obviously decreased tumour volume and tumour growth, reduced the glycolysis, glucose transport and HIF-1α expression in the tumour-bearing tissues. Our results suggested Huaier revealed anti-tumour effects in both in vivo and in vitro possibly through PI3K/AKT/HIF-1α pathway.
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http://dx.doi.org/10.1111/jcmm.16215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882940PMC
February 2021

Integration of small RNA, degradome and proteome sequencing in Oryza sativa reveals a delayed senescence network in tetraploid rice seed.

PLoS One 2020 13;15(11):e0242260. Epub 2020 Nov 13.

State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, China.

Seed of rice is an important strategic resource for ensuring the security of China's staple food. Seed deterioration as a result of senescence is a major problem during seed storage, which can cause major economic losses. Screening among accessions in rice germplasm resources for traits such as slow senescence and increased seed longevity during storage is, therefore, of great significance. However, studies on delayed senescence in rice have been based mostly on diploid rice seed to date. Despite better tolerance have been verified by the artificial aging treatment for polyploid rice seed, the delayed senescence properties and delayed senescence related regulatory mechanisms of polyploid rice seed are rarely reported, due to the lack of polyploid rice materials with high seed set. High-throughput sequencing was applied to systematically investigate variations in small RNAs, the degradome, and the proteome between tetraploid and diploid rice seeds. Degradome sequencing analysis of microRNAs showed that expression of miR-164d, which regulates genes encoding antioxidant enzymes, was changed significantly, resulting in decreased miRNA-mediated cleavage of target genes in tetraploid rice. Comparisons of the expression levels of small RNAs (sRNAs) in the tetraploid and diploid libraries revealed that 12 sRNAs changed significantly, consistent with the findings from degradome sequencing. Furthermore, proteomics also showed that antioxidant enzymes were up-regulated in tetraploid rice seeds, relative to diploids.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242260PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665819PMC
January 2021

Wearable Circuits Sintered at Room Temperature Directly on the Skin Surface for Health Monitoring.

ACS Appl Mater Interfaces 2020 Oct 27;12(40):45504-45515. Epub 2020 Sep 27.

Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

A soft body area sensor network presents a promising direction in wearable devices to integrate on-body sensors for physiological signal monitoring and flexible printed circuit boards (FPCBs) for signal conditioning/readout and wireless transmission. However, its realization currently relies on various sophisticated fabrication approaches such as lithography or direct printing on a carrier substrate before attaching to the body. Here, we report a universal fabrication scheme to enable printing and room-temperature sintering of the metal nanoparticle on paper/fabric for FPCBs and directly on the human skin for on-body sensors with a novel sintering aid layer. Consisting of polyvinyl alcohol (PVA) paste and nanoadditives in the water, the sintering aid layer reduces the sintering temperature. Together with the significantly decreased surface roughness, it allows for the integration of a submicron-thick conductive pattern with enhanced electromechanical performance. Various on-body sensors integrated with an FPCB to detect health conditions illustrate a system-level example.
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http://dx.doi.org/10.1021/acsami.0c11479DOI Listing
October 2020

Positive effects of zeolite powder on aerobic granulation: Nitrogen and phosphorus removal and insights into the interaction mechanisms.

Environ Res 2020 12 28;191:110098. Epub 2020 Aug 28.

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, China.

Aerobic granular sludge is considered one of the most promising biological wastewater treatment technologies of the 21st century. However, the long granulation time and poor treatment effect on N and P have severely limited its popularity and large-scale application. In this study, we systematically examine the strengthening effects of zeolite powder on granulation, N and P removal, and their interaction mechanisms. The addition of zeolite powder decreased sludge granulation time to 18 d, and improved average N and P removal rates by 4.48% and 2.22%, respectively. The multi-pore and nutrient-rich environment of the zeolite powder is beneficial for maintaining microbial activity and granular stability. Moreover, its adsorption to N and P enriches their respective removal strains, improving their removal efficiency.
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http://dx.doi.org/10.1016/j.envres.2020.110098DOI Listing
December 2020

Effect of different ash/organics and C/H/O ratios on characteristics and reaction mechanisms of sludge microwave pyrolysis to generate bio-fuels.

Waste Manag 2020 Nov 26;117:188-197. Epub 2020 Aug 26.

Shenzhen Engineering Laboratory of Aerospace Detection and Imaging, Department of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.

To study the effects of different ash/organics and C/H/O ratios on bio-fuel characteristics and energy efficiency, four kinds of sludge with different properties were used for microwave pyrolysis (800 °C). Moreover, the microwave pyrolysis reaction mechanisms of different sludge were also explored. The results showed that high-ash sludge could accelerate the frequency of polar molecule rotation in the microwave field due to the presence of oxides with dielectric properties in ash, thereby achieving faster heating rates and higher temperatures. However, compared with high-organic sludge, high-ash sludge exhibited lower bio-gas yield and higher bio-char yield. As the H/C ratio increased from 0.127 to 0.148, the bio-gas yield increased from 15.41% to 40.01%, and the content of H in bio-gas and aliphatics in bio-oil increased to 36.69 vol% and 26.54 wt%, respectively. When the O/C ratio was reduced to 1.31, the content of CO and oxygenated compound in bio-oil increased to 31.25 vol% and 40.04 wt%, which lowered the quality of the bio-oil. Those consequences also determined that a mixture of sludge with different ash/organic ratios could be pyrolyzed to obtain high-quality bio-fuels and high energy efficiency. Differences in C/H/O ratios in the mixed sludge greatly affected the microwave pyrolysis heating process, which affected the pyrolysis reactions and the quality of the bio-fuels. Therefore, this study provides a theoretical basis to elevate the quality of bio-fuels and reduce microwave pyrolysis costs.
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http://dx.doi.org/10.1016/j.wasman.2020.08.017DOI Listing
November 2020

An internal amino-terminal FLAG-tag octapeptide alters oligomerization of expressed surfactant protein-A.

Protein Expr Purif 2020 12 22;176:105727. Epub 2020 Aug 22.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA; Department of Pediatrics, Pediatric Research Center, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Electronic address:

Pulmonary surfactant protein-A (SP-A) is expressed by lung alveolar and bronchiolar epithelial cells and plays a critical role in innate immunity of the lung. Exposure of the lung to various environmental insults alters SP-A homeostasis. To investigate the cellular mechanisms involved in these alterations, we added the FLAG octapeptide (DYKDDDDK) to the carboxy-terminus (SP-A/C-FLAG) or near the amino-terminus (SP-A/N-FLAG) of mouse SP-A (WT-SP-A) to tag specific pools of protein. We hypothesized that addition of FLAG would have negligible effects on SP-A expression, oligomerization and secretion. Analysis of Chinese hamster ovary cells expressing these proteins indicated that tagged SP-A mRNA could be distinguished from WT-SP-A by northern analysis and RT-PCR using sequence-specific oligonucleotides. Tagged SP-A protein could be differentiated from WT-SP-A by western analysis using antibodies specific for the FLAG epitope. Subcellular fractionation and immunocytochemistry indicated the majority of each protein was present in punctuate (presumably endocytic) vesicles, and all forms of SP-A protein were secreted. These results suggest that a FLAG epitope added to the carboxy-terminus or inserted into the amino-terminus of the mature SP-A protein has little effect on its expression and cellular processing. However, disruptions of the amino-terminal end of SP-A prevents proper oligomerization, suggesting that this region of mature SP-A is critical in proper oligomeric assembly and is not useful for studies intended to define mechanisms underlying SP-A homeostasis.
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http://dx.doi.org/10.1016/j.pep.2020.105727DOI Listing
December 2020

Effects of Process Parameters on Sulfur Migration and HS Generation during Supercritical Water Gasification of Sludge.

J Hazard Mater 2021 02 15;403:123678. Epub 2020 Aug 15.

Shenzhen Engineering Laboratory of Aerospace Detection and Imaging, Department of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.

The generation of sulfur-containing pollution products affects the quality of biofuels obtained from the supercritical water gasification (SCWG) of sludge. This study investigates the effects of the gasification temperature, moisture content, and reaction atmosphere on the evolution of sulfur-containing compounds. The results showed that temperature was the key parameter causing the migration of sulfur from sludge to biogas and liquid products. The sludge decomposition reaction was dominated by ionic reactions at 360 °C, while the decomposition of organic matter was converted to free radical reactions as the temperature increased from 380 °C to 440 °C. The mercaptan and thioether contents of the bio-oil decreased to 0.3% at 440 °C. Correspondingly, the concentration of HS increased from 6.7 ppm to 38.0 ppm. The decomposition of organic sulfur with an unstable structure (S-H bond and S-C bond) was the main cause of the increase in the content of HS. Additionally, the solubility and oxidation properties of supercritical water were extremely strong. Some sulfur-containing organic compounds were converted into SO via hydrolysis and oxidation reactions, forming sulfate crystals with heavy metals in the bio-char, which aided in achieving the synergistic immobilization of sulfur and heavy metals.
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http://dx.doi.org/10.1016/j.jhazmat.2020.123678DOI Listing
February 2021

The factors influencing sludge incineration residue (SIR)-based magnesium potassium phosphate cement and the solidification/stabilization characteristics and mechanisms of heavy metals.

Chemosphere 2020 Dec 26;261:127789. Epub 2020 Jul 26.

Shenzhen Engineering Laboratory of Aerospace Detection and Imaging, Department of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China.

Magnesium potassium phosphate cement (MKPC) is prepared from MgO and KHPO through an acid-base reaction and has been widely used in the rapid repairs of building structures and the solidification/stabilization (S/S) of heavy metals (HMs). The use of sludge incineration residue (SIR) rich in phosphorus resources to prepare SIR-based MKPC can achieve the reclamation of SIR and efficient HM S/S. Herein, based on the exploration of the optimal MKPC magnesia/phosphate ratio (M/P), the effects of SIR and HMs on the performance of the matrix and its interaction mechanism were comprehensively investigated. The results indicated that the compressive strength of the SIR-based MKPC increased first and then decreased with the gradual increase of SIR incorporation; the optimal was reached at 40.31 MPa when the SIR incorporation was 5 wt%. The peak signal and crystal lattice of Pb(PO) indicated that there is a mixed effect between HMs (in SIR) and KHPO. The Visual MINTEQ analysis results also indicated that HMs are precipitated as HM phosphates. The formation of HM phosphates not only increases the M/P (with 30 wt% SIR, M/P increased by 0.019), affecting the microstructure and changing the compressive strength of the matrix, but also promotes the transformation of HMs from the bioavailable to the more stable residual forms. The residual forms of the six HMs were all above 84% after S/S. Therefore, the SIR-based MKPC preparation significantly immobilized the HMs; particularly, the leaching toxicities of Cu (96.6%) and Zn (96.3%) were alleviated.
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http://dx.doi.org/10.1016/j.chemosphere.2020.127789DOI Listing
December 2020

PRRX1 isoform PRRX1A regulates the stemness phenotype and epithelial-mesenchymal transition (EMT) of cancer stem-like cells (CSCs) derived from non-small cell lung cancer (NSCLC).

Transl Lung Cancer Res 2020 Jun;9(3):731-744

Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang 110001, China.

Backgrounds: The 2 isoforms of paired-related homeobox 1 (PRRX1), PRRX1A and PRRX1B, are critical in regulating several kinds of cancers, and figure prominently in the maintenance of stemness and progression of epithelial-mesenchymal transition (EMT). However their differential expression in non-small cell lung cancer (NSCLC) clinical samples and exact regulatory roles in cancer stem-like cells (CSCs) remain unknown.

Methods: and experiments were employed to investigate the molecular mechanism. Using CSCs, mouse models, and clinical tissues, we obtained a general picture of the relatively higher level of PRRX1A compared to PRRX1B, and PRRX1A thus promoting EMT and maintaining stemness of CSCs.

Results: PRRX1A but not PRRX1B was upregulated in lung cancer tissues and was positively correlated with TGF-β expression. In CSCs, overexpressed PRRX1A promoted malignant behaviors via transcriptional activation of TGF-β depending on TGF-β/TGF-βR signaling pathway. PRRX1A knockdown decreased self-renewal capacity accompanied by a decrease in stemness factor expression independent of the TGF-β/TGF-βR signaling pathway. Furthermore, PRRX1A was found to tightly bind to and stabilize SOX2. PRRX1A promoted sphere formation not only by enhancing stemness via stabilizing SOX2 but also by promoting cell proliferation.

Conclusions: PRRX1A, but not PRRX1B, was demonstrated to have important roles in the regulation of the stemness and metastatic potential of lung cancer, which suggests the potential application of PRRX1A in cancer treatment.
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http://dx.doi.org/10.21037/tlcr-20-633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354111PMC
June 2020

Ultrasonic-accelerated metallurgical reaction of Sn/Ni composite solder: Principle, kinetics, microstructure, and joint properties.

Ultrason Sonochem 2020 Sep 25;66:105090. Epub 2020 Mar 25.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology at Shenzhen, Shenzhen 518055, Guangdong, China; Flexible Printing Electronic Technology Center, Harbin Institute of Technology at Shenzhen, Shenzhen 518055, China. Electronic address:

The high-melting-point joints by transient-liquid-phase are increasingly playing a crucial role in the die bonding for the high temperature electronic components. In this study, three kinds of Sn/Ni composite solder pastes composed of different sizes of Ni particles were synthesized to accelerate metallurgical reaction among Sn/Ni interfaces under the ultrasonic-assisted transient liquid phase (U-TLP) soldering. The temperature evolution, microstructure and mechanical property in joints composed by these composite solder pastes with or without ultrasonic energy were systemically investigated. The intermetallic joint consisted of high-melting-point sole NiSn intermetallic compound with a little residual Ni was obtained under the conditions of no pressure and lower power (200 W) in a high-temperature duration of only 10 s, its shear strength was up to 45.3 MPa. Ultrasonic effects significantly accelerated the reaction among the interfaces of liquid Sn and solid Ni, which attributed to the temperature rise caused by acoustic cavitation because of large number of liquid/solid interfaces during U-TLP, resulting in accelerated solid/liquid interfacial diffusion and growth of intermetallic compounds. This intermetallic joint formed by U-TLP soldering has a promising potential for applications in high-power device packaging.
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http://dx.doi.org/10.1016/j.ultsonch.2020.105090DOI Listing
September 2020

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy .

Drug Deliv 2020 Dec;27(1):180-190

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.

In this work, a pH-sensitive liposome-polymer nanoparticle (NP) composed of lipid, hyaluronic acid (HA) and poly(β-amino ester) (PBAE) was prepared using layer-by-layer (LbL) method for doxorubicin (DOX) targeted delivery and controlled release to enhance the cancer treatment efficacy. The NP with pH-sensitivity and targeting effect was successfully prepared by validation of charge reversal and increase of hydrodynamic diameter after each deposition of functional layer. We further showed the DOX-loaded NP had higher drug loading capacity, suitable particle size, spherical morphology, good uniformity, and high serum stability for drug delivery. We confirmed that the drug release profile was triggered by low pH with sustained release manner . Confocal microscopy research demonstrated that the NP was able to effectively target and deliver DOX into human non-small cell lung carcinoma (A549) cells in comparison to free DOX. Moreover, the blank NP showed negligible cytotoxicity, and the DOX-loaded NP could efficiently induce the apoptosis of A549 cells as well as free DOX. Notably, experiment results showed that the DOX-loaded NPs effectively inhibited the growth of tumor, enhanced the survival of tumor-bearing mice and improved the therapeutic efficacy with reduced side-effect comparing with free drug. Therefore, the NP could be a potential intelligent anticancer drug delivery carrier for cancer chemotherapy, and the LbL method might be a useful strategy to prepare multi-functional platform for drug delivery.
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http://dx.doi.org/10.1080/10717544.2019.1709922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008239PMC
December 2020

GINS2 facilitates epithelial-to-mesenchymal transition in non-small-cell lung cancer through modulating PI3K/Akt and MEK/ERK signaling.

J Cell Physiol 2020 11 4;235(11):7747-7756. Epub 2019 Nov 4.

Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, China.

Non-small-cell lung cancer (NSCLC) is a cancer with high morbidity and mortality. We aimed to define the effect of Go-Ichi-Ni-San complex subuint 2 (GINS2) acting on NSCLC. The expressions of GINS2 in NSCLC tissues and cells were detected using real-time quantitative polymerase chain reaction, western blot, and immunohistochemistry (IHC). The relationship between GINS2 expression and NSCLC prognosis or clinicopathologic features was analyzed through statistical analysis. The overexpressed or downexpressed plasmids of GINS2 were transfected into NSCLC cell lines, and then cell proliferation, invasion, and migration viability were, respectively, determined by Cell Counting Kit-8 assay, transwell, and wound healing assay. The epithelial-mesenchymal transition (EMT) was observed and the EMT-related proteins were measured using IHC and western blot. The function of GINS2 in vivo was assessed by mice model. The related proteins of mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) pathways were evaluated using western blot. GINS2 expression was upregulated in NSCLC tissues and cell lines, and its high expression was correlated with the poor prognosis and several clinicopathologic features, such as TMN stages (tumor size, lymph node, and metastasis) and clinical stages. GINS2 enhanced NSCLC cell proliferation, migration, and invasion viability in vivo and in vitro. GINS2 also promoted NSCLC cells EMT. In addition, GINS2 could regulate phosphorylated proteins of PI3K p85, Akt, MEK, and ERK expressions, it revealed that GINS2 effected on PI3K/Akt and MEK/ERK pathways. GINS2 promoted cell proliferation, migration, invasion, and EMT via modulating PI3K/Akt and MEK/ERK signaling pathways. It might be a target in NSCLC treatment.
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http://dx.doi.org/10.1002/jcp.29381DOI Listing
November 2020

RETRACTION: TaCYP78A5 regulates seed size in wheat (Triticum aestivum).

J Exp Bot 2020 09;71(18):5716

College of Life Sciences, Northwest A & F University, Yangling, Shaanxi, China.

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http://dx.doi.org/10.1093/jxb/erz371DOI Listing
September 2020

Fabrication Of Dual pH/redox-Responsive Lipid-Polymer Hybrid Nanoparticles For Anticancer Drug Delivery And Controlled Release.

Int J Nanomedicine 2019 3;14:8001-8011. Epub 2019 Oct 3.

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.

Background: The development of biocompatible nanocarriers that can efficiently encapsulate and deliver anticancer drug to the tumor site and provide controlled release of cargos in response to the specific cues for cancer therapy is of great significance.

Methods: In this work, dual pH/redox-responsive fabrication of hybrid lipid-polymer nanoparticles (LPNPs) self-assembled from amphiphilic polymer poly(ethylene glycol) methyl ether-grafted disulfide-poly(-amino esters) (PBAE-ss-mPEG) and PEGylated lipid were prepared and used as drug delivery carriers. The optimization of PEGylated lipid modification was confirmed by analysis of particle size, polydispersity index (PDI), cellular uptake, serum stability, and drug loading capacity. The p value of LPNPs was determined as 6.55, indicating the pH-sensitivity. The critical micelle concentration (CMC) values and zeta-potential of LPNPs at different pH values were investigated to confirm its pH-sensitivity. The morphology of LPNPs before and after incubation with reducing agent was imaged to study the redox-responsibility.

Results: The in vitro results showed that the drug had controlled release from LPNPs triggered by low pH and high concentration of reducing agent. Furthermore, the cytotoxicity of LPNPs was very low, and the doxorubicin (DOX)-loaded LPNPs could efficiently induce the death of tumor cells in comparison to free DOX.

Conclusion: All results demonstrated that the fabricated LPNPs could be potential anticancer drug delivery carriers with a pH/redox-triggered drug release profile, and PEGylated lipid modification might be a useful method to fabricate the drug delivery platform.
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http://dx.doi.org/10.2147/IJN.S226798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788345PMC
December 2019

Gemcitabine, cisplatin, prednisone, and thalidomide for relapse and refractory peripheral T-cell lymphoma: a retrospective study from China.

Cancer Manag Res 2019 9;11:8277-8284. Epub 2019 Sep 9.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, People's Republic of China.

Background: Peripheral T-cell lymphoma (PTCL) is often prone to relapse and progression even after formal first-line treatment, and there is no standard regimen for second-line treatment. What is more, the activity of thalidomide against this type of lymphoma is unknown.

Purpose: The objective of this study was to evaluate the efficacy and safety of GDPT regimen in the treatment of relapsed/refractory peripheral T-cell lymphoma.

Patients And Methods: In this retrospective study, gemcitabine, cisplatin, prednisone, and thalidomide (GDPT) combination regimen was used as salvage protocol for PTCL that failed in first-line treatment for 29 patients and it was scheduled to give 6 cycles of GDPT therapy in order to better evaluate the efficacy unless there was evidence of disease progression, unacceptable toxicities, or refusal by the patient.

Results: After a total of 106 cycles of GDPT regimen were administered, the result showed that the disease control rate (DCR) achieved 82.8% and overall response rate (ORR) reached 69.0% with 34.5% complete remission (CR) and 34.5% partial remission (PR). The median progression-free survival (PFS) was 10.0 months (95% CI 6.6-13.4) and median OS was 28.0 months (95% CI 19.2-36.8). And the 1-year PFS rate and 1-year OS rate were 43.6% and 64.6%, respectively. Both hematologic and non-hematologic toxicities were moderate and well tolerated. There was no treatment-related death.

Conclusion: Thalidomide in combination with gemcitabine, cisplatin, prednisone regimen is a new promising approach to treating patients with relapse and refractory PTCL.
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http://dx.doi.org/10.2147/CMAR.S215585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749983PMC
September 2019

Global transcriptome analysis uncovers the gene co-expression regulation network and key genes involved in grain development of wheat (Triticum aestivum L.).

Funct Integr Genomics 2019 Nov 21;19(6):853-866. Epub 2019 May 21.

College of Life Sciences, Northwest A & F University, Yangling, 712100, Shaanxi, China.

Wheat grain development is a robust biological process that largely determines grain quality and yield. In this study, we investigated the grain transcriptome of winter wheat cv. Xiaoyan-6 at four developmental stages (5, 10, 15, and 20 days post-anthesis), using high-throughput RNA sequencing (RNA-Seq). We identified 427 grain-specific transcription factors (TFs) and 1653 differentially expressed TFs during grain development as well as a grain co-expression regulation network (GrainNet) of the TFs and their predicted co-expressed genes. Our study identified ten putative key TFs and the predicted regulatory genes of these TFs in wheat grain development of Xiaoyan-6. The analysis was given a firm basis through the study of additional wheat tissues, including root, stem, leaf, flag leaf, grain, spikes (from wheat plants at booting or heading stages) to provide a dataset of 92,478 high-confidence protein-coding genes that were mostly evenly distributed among subgenomes, but unevenly distributed across each of the chromosomes or each of the seven homeologous groups. Within this larger framework of the transcriptomes, we identified 4659 grain-specific genes (SEGs) and 26,500 differentially expressed genes (DEGs) throughout grain development stages tested. The SEGs identified mainly associate with regulation and signaling-related biological processes, while the DEGs mainly involve in cellular component organization or biogenesis and nutrient reservoir activity during grain development of Xiaoyan-6. This study establishes new targets for modifying genes related to grain development and yield, to fine-tune expression in different varieties and environments.
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http://dx.doi.org/10.1007/s10142-019-00678-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797667PMC
November 2019

Exploring optical resonances of nanoparticles excited by optical Skyrmion lattices.

Opt Express 2019 Mar;27(5):7009-7022

Recently, optical Skyrmion lattices (OSLs) have been realized in evanescent electromagnetic fields. OSLs possess topologically stable field configurations, which promise many optics and photonics applications. Here, we demonstrate that OSLs can serve as versatile structured optical near-fields to assist with studies of a variety of photonic modes in nanoparticles. We firstly show that OSL is capable of selectively exciting electric and magnetic multipole modes by placing a nanoparticle at different positions in the lattice. We then disclose that OSLs can efficiently excite some intriguing resonant modes, including toroidal and plasmonic dark modes, in dielectric or metal nanoparticles. Our results may enhance understanding of the interaction between OSLs and nanoparticles and find applications associated with precise control over resonant modes in nanostructures.
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http://dx.doi.org/10.1364/OE.27.007009DOI Listing
March 2019

Identification and Functional Characterization of Promoter Binding Protein-Like Gene in Wheat ( L.).

Front Plant Sci 2019 22;10:212. Epub 2019 Feb 22.

College of Life Sciences, Northwest A&F University, Yangling, China.

Wheat ( L.) is one of the most important crops in the world. promoter binding protein-like (SPL) proteins are plant-specific transcript factors and play critical roles in plant growth and development. The functions of many gene family members were well characterized in and rice, in contrast, research on wheat genes is lagging behind. In this study, we cloned and characterized , an orthologous gene of rice , in wheat. Three homoeologs are located on the short arms of chromosome 7A, 7B, and 7D, and share more than 96% sequence identity with each other. All the homoeologs have three exons and two introns, with a miR156 binding site in their last exons. They encode putative proteins of 407, 409, and 414 amino acid residues, respectively. Subcellular localization showed TaSPL16 distribution in the cell nucleus, and transcription activity of TaSPL16 was validated in yeast. Analysis of the spatiotemporal expression profile showed that is highly expressed in young developing panicles, lowly expressed in developing seeds and almost undetectable in vegetative tissues. Ectopic expression of in causes a delay in the emergence of vegetative leaves (3-4 days late), promotes early flowering (5-7 days early), increases organ size, and affects yield-related traits. These results demonstrated the regulatory roles of in plant growth and development as well as seed yield. Our findings enrich the existing knowledge on genes in wheat and provide valuable information for further investigating the effects of on plant architecture and yield-related traits of wheat.
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http://dx.doi.org/10.3389/fpls.2019.00212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401658PMC
February 2019

Primary hyperparathyroidism due to ectopic parathyroid adenoma in an adolescent: a case report and review of the literature.

Endocrine 2019 04 25;64(1):38-42. Epub 2019 Feb 25.

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

Purpose: Primary hyperparathyroidism (PHPT) is a common endocrine disorder and is usually diagnosed in adults. PHPT due to ectopic parathyroid adenoma in adolescents is rare.

Methods: We describe the case of a 15-year-old boy with PHPT due to ectopic parathyroid adenoma. A review of the literature of PHPT in adolescents was performed, focusing on etiology, clinical presentation, preoperative localization methods, pathology, and treatment.

Results: The patient was successfully treated with surgery and was followed up for 5 years with no signs or symptoms of hyperparathyroidism. By reviewing the literature, only seven cases of PHPT associated with ectopic parathyroid lesions in adolescents have been reported. Parathyroidectomy is the only known curative treatment. Accurate preoperative localization of the target lesion is critical.

Conclusions: This study should raise awareness of the diagnosis and treatment of PHPT due to ectopic parathyroid adenoma/carcinoma in adolescents.
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http://dx.doi.org/10.1007/s12020-019-01875-3DOI Listing
April 2019

Long non-coding RNA DLEU1 exerts an oncogenic function in non-small cell lung cancer.

Biomed Pharmacother 2019 Jan 5;109:985-990. Epub 2018 Nov 5.

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China. Electronic address:

Objective: To explore the role of long non-coding RNA DLEU1 in the tumorigenesis and progression of non-small cell lung cancer (NSCLC) and the underlying mechanisms.

Methods: The expression of DLEU1 in NSCLC tumor tissues and adjacent normal tissues was evaluated using bioinformatics analysis and qPCR. The effects of DLEU1 overexpression or deficiency on cell proliferation, apoptosis, migration and invasion were explored experimentally. Additionally, the impact of DLEU1 up-regulation on tumourigenesis was also assessed in vivo.

Results: The expression of DLEU1 was up-regulated in NSCLC tumor tissues. DLEU1 overexpression promoted the proliferation, migration, and invasion, but inhibited the apoptosis of NSCLC cells by upregulating CDK1 expression, binding with SRC and altering the expression of P70(S6K), MMP2 and E-cadherin. Besides, xenograft tumors in nude mice demonstrated that DLEU1 overexpression accelerated tumor growth.

Conclusions: DLEU1 promoted tumorigenesis and progression of NSCLC, and might be a promising therapeutic target for NSCLC.
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http://dx.doi.org/10.1016/j.biopha.2018.10.175DOI Listing
January 2019

Linear free energy relationship analysis of permeability across polydimethylsiloxane (PDMS) membranes and comparison with human skin permeation in vitro.

Eur J Pharm Sci 2018 Oct 11;123:524-530. Epub 2018 Aug 11.

Department of Chemistry, University College London, London WC1H 0AJ, UK.

The aim of the present work is to evaluate the similarity between PDMS membranes and human skin in vitro in permeation study by linear free energy relationship (LFER) analyses. The values of the permeability coefficient log K (cm/s) under reliable experimental conditions were collected from the literature for a set of 94 compounds including both neutral and ionic species, which cover a broad range of structural diversity. The values of log K (cm/s) have been correlated with Abraham descriptors to yield an equation with R = 0.952 and SD = 0.38 log units. The established LFER model for log K (cm/s) across PDMS membranes showed no close analogy with that through human skin in vitro. A further critical analysis of the coefficients of the LFER models confirmed that the PDMS permeation system is a very poor model for human skin permeation.
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http://dx.doi.org/10.1016/j.ejps.2018.08.012DOI Listing
October 2018

Development of a mitochondria targetable ratiometric time-gated luminescence probe for biothiols based on lanthanide complexes.

J Mater Chem B 2018 Mar 13;6(12):1844-1851. Epub 2018 Mar 13.

State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, P. R. China.

A mitochondria targetable ratiometric luminescence probe based on a mixture of Eu and Tb complexes, Mito-NSTTA-Eu/Tb, has been developed for the specific recognition and time-gated luminescence detection of biothiols in aqueous and living samples. This probe was synthesized by conjugating a mitochondria-anchoring motif, triphenylphosphonium, with a biothiol-responsive terpyridine derivative, [4'-(2,4-dinitrobenzenesulfonyloxy)-2,2':6',2''-terpyridine-6,6''-diyl] bis(methylenenitrilo) tetrakis(acetic acid), for coordinating with Eu and Tb ions. When the probe interacts with biothiols, the cleavage of the 2,4-dinitrobenzenesulfonyl moiety leads to a remarkable enhancement of the Tb emission at 540 nm, while the Eu emission at 610 nm is unchanged, which allows Mito-NSTTA-Eu/Tb to be used as a ratiometric probe for the time-gated luminescence detection of biothiols, with the luminescence intensity ratio of I/I as a signal. The triphenylphosphonium group enables the probe molecules to be specifically driven into the mitochondria after cell loading for responding to biothiols therein. Mito-NSTTA-Eu/Tb showed high selectivity and sensitivity for the detection of biothiols under physiological conditions, with detection limits of 0.098 μM for glutathione (GSH) and 0.14 μM for cysteine (Cys). In cell imaging experiments, Mito-NSTTA-Eu/Tb displayed an excellent mitochondria-localization feature, which allowed biothiols in the mitochondria of live cells to be successfully imaged under ratiometric and time-gated luminescence modes. In addition, biothiols in living Daphnia magna were also imaged using Mito-NSTTA-Eu/Tb as a probe. All of the results suggested that Mito-NSTTA-Eu/Tb could serve as a useful tool for monitoring biothiols in vitro and in vivo with high specificity and sensitivity.
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http://dx.doi.org/10.1039/c8tb00030aDOI Listing
March 2018

Partition of Neutral Molecules and Ions from Water to -Nitrophenyl Octyl Ether and of Neutral Molecules from the Gas Phase to -Nitrophenyl Octyl Ether.

J Solution Chem 2018 16;47(2):293-307. Epub 2018 Feb 16.

3School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford, BD7 1DP UK.

We have set out an equation for partition of 87 neutral molecules from water to -nitrophenyl octyl ether, NPOE, an equation for partition of the 87 neutral molecules and 21 ionic species from water to NPOE, and an equation for partition of 87 neutral molecules from the gas phase to NPOE. Comparison with equations for partition into other solvents shows that, as regards partition of neutral (nonelectrolyte) compounds, NPOE would be a good model for 1,2-dichloroethane and for nitrobenzene. In terms of partition of ions and ionic species, NPOE is quite similar to 1,2-dichloroethane and not far away from other aprotic solvents such as nitrobenzene.
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http://dx.doi.org/10.1007/s10953-018-0717-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830486PMC
February 2018

Structural properties governing drug-plasma protein binding determined by high-performance liquid chromatography method.

J Pharm Biomed Anal 2018 Feb 28;149:16-21. Epub 2017 Oct 28.

School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford, BD7 1DP, UK. Electronic address:

The high-performance liquid chromatography (HPLC) method employing stationary phases immobilized with plasma proteins was used for this study to investigate the structural properties governing drug-plasma protein binding. A set of 65 compounds with a broad range of structural diversity (in terms of volume, hydrogen-bonding, polarity and electrostatic force) were selected for this purpose. The Abraham linear free energy relationship (LFER) analyses of the retention factors on the immobilized HSA (human serum albumin) and AGP (α-acid glycoprotein) stationary phases showed that McGowan's characteristic molecular volume (V), dipolarity/polarizability (S) and hydrogen bond basicity (B) are the three significant molecular descriptors of solutes determining the interaction with immobilized plasma proteins, whereas excess molar refraction (E) is less important and hydrogen bond acidity (A) is not of statistical significance in both systems, for electrically neutral compounds. It was shown that ionised acids, as carboxylate anions, bind very strongly to the immobilized HSA stationary phase and that ionised bases, as cations bind strongly to the AGP stationary phase. This is the first time that the effect of ionised species on plasma protein binding has been determined quantitatively; the increased binding of acids to HSA is due almost entirely to acids in their ionised form.
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http://dx.doi.org/10.1016/j.jpba.2017.10.022DOI Listing
February 2018

Synthesis and application of a highly selective copper ions fluorescent probe based on the coumarin group.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Feb 13;190:116-120. Epub 2017 Sep 13.

Department of Forensic Medicine, Xinxiang Medical University, Jinsui Road No. 601, Xinxiang 453003, Henan Province, PR China.

A highly selective copper ions fluorescent probe based on the coumarin-type Schiff base derivative 1 (probe) was produced by condensation reaction between coumarin carbohydrazide and 1H-indazole-3-carbaldehyde. The UV-vis spectroscopy showed that the maximum absorption peak of compound 1 appeared at 439nm. In the presence of Cu ions, the maximum peak decreased remarkably compared with other physiological important metal ions and a new absorption peak at 500nm appeared. The job's plot experiments showed that complexes of 1:2 binding mode were formed in CHCN:HEPES (3:2, v/v) solution. Compound 1 exhibited a strong blue fluorescence. Upon addition of copper ions, the fluorescence gradually decreased and reached a plateau with the fluorescence quenching rate up to 98.73%. The detection limit for Cu ions was estimated to 0.384ppm. Fluorescent microscopy experiments demonstrated that probe 1 had potential to be used to investigate biological processes involving Cu ions within living cells.
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http://dx.doi.org/10.1016/j.saa.2017.09.028DOI Listing
February 2018

Effect of defects controlled by preparation condition and heat treatment on the ferromagnetic properties of few-layer graphene.

Sci Rep 2017 07 19;7(1):5877. Epub 2017 Jul 19.

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China.

Magnetism in graphene has stimulated extensive studies to search for novel metal-free magnetic device. In this paper, we use a synthesis method far from equilibrium state named self-propagating high temperature synthesis (SHS) to produce few-layer graphene with different defect contents and then use a heat treatment process (vacuum-annealing and air-cooling) to further control the defects in graphene. We find that the type and content of defects in graphene can be controlled by adjusting the mole ratio of reactants (Mg: CaCO) for SHS reaction and the temperature of the subsequent heat treatment. The deviation of the ratio of reactants from stoichiometric ratio benefits the production of graphene with higher concentration of defects. It is indicated that the temperature of the heat treatment has remarkable influences on the structure of graphene, Raman-sensitive defects can be recovered partly by heat treatment while IR-sensitive defects are closely related with the oxidation and decomposition of the oxygen-containing groups at elevated temperature. This work indicates that SHS is a promising method to produce graphene with special magnetism, and the heat treatment is an effective way to further adjust the magnetism of graphene. This work sheds light on the study to develop carbon materials with controlled ferromagnetism.
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http://dx.doi.org/10.1038/s41598-017-06224-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517599PMC
July 2017