Xiang-Ding Chen

Xiang-Ding Chen

Xiang-Ding Chen

Xiang-Ding Chen

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Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.

Bone 2018 12 30;117:6-14. Epub 2018 Aug 30.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; School of Basic Medical Sciences, Central South University, Changsha, Hunan 410013, China; Center of Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183032
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http://dx.doi.org/10.1016/j.bone.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364698PMC
December 2018

Genome-wide association study of lncRNA polymorphisms with bone mineral density.

Ann Hum Genet 2018 09 16;82(5):244-253. Epub 2018 Apr 16.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

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http://dx.doi.org/10.1111/ahg.12247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298226PMC
September 2018

Integration of summary data from GWAS and eQTL studies identified novel causal BMD genes with functional predictions.

Bone 2018 08 12;113:41-48. Epub 2018 May 12.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; Center of Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA; Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2018.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346739PMC
August 2018

Inferring causal relationships between phenotypes using summary statistics from genome-wide association studies.

Hum Genet 2018 Mar 19;137(3):247-255. Epub 2018 Feb 19.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China.

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http://dx.doi.org/10.1007/s00439-018-1876-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343668PMC
March 2018

Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.

J Clin Endocrinol Metab 2018 01;103(1):125-138

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

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http://dx.doi.org/10.1210/jc.2017-01531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061219PMC
January 2018

Bivariate genome-wide association analyses identified genetic pleiotropic effects for bone mineral density and alcohol drinking in Caucasians.

J Bone Miner Metab 2017 Nov 23;35(6):649-658. Epub 2016 Dec 23.

Key Lab of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, China.

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https://pdfs.semanticscholar.org/4261/e4a43ad34587861e337385
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http://dx.doi.org/10.1007/s00774-016-0802-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812284PMC
November 2017

Functional relevance for associations between osteoporosis and genetic variants.

PLoS One 2017 3;12(4):e0174808. Epub 2017 Apr 3.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174808PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378394PMC
August 2017

Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk.

J Genet Genomics 2017 06 8;44(6):327-330. Epub 2017 May 8.

Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China; Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822710PMC
June 2017

SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population.

Sci Rep 2017 03 8;7:43939. Epub 2017 Mar 8.

Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.

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http://dx.doi.org/10.1038/srep43939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341019PMC
March 2017

Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk.

Sci Rep 2016 07 28;6:30558. Epub 2016 Jul 28.

Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.

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http://dx.doi.org/10.1038/srep30558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964617PMC
July 2016

Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation.

PLoS One 2015 21;10(9):e0138524. Epub 2015 Sep 21.

Center of Genomics and Bioinformatics, Tulane University, New Orleans, Louisiana, 70112, United States of America; Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, Louisiana, 70112, United States of America; Laboratory of Molecular and Statistical Genetics, Hunan Normal University, Changsha, Hunan, 410081, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138524PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577125PMC
May 2016

Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche.

J Clin Endocrinol Metab 2015 Nov 27;100(11):E1457-66. Epub 2015 Aug 27.

Laboratory of Molecular and Statistical Genetics (L.-J.T., Z.-E.W., K.-H.W., X.-D.C., H.Z., S.L., H.-W.D.), College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; Center of Bioinformatics and Genomics (Q.T., H.-W.D.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; School of Life Science and Technology (X.-G.L.), Xi'an Jiaotong University, Xi'an, Shanxi, People's Republic of China; and Department of Basic Medical Science (C.J.P.), School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri 64108.

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http://dx.doi.org/10.1210/jc.2015-2095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702453PMC
November 2015

Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies.

Hum Mol Genet 2015 Aug 4;24(16):4710-27. Epub 2015 May 4.

Center for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA, Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P. R. China,

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https://hmg.oxfordjournals.org/content/early/2015/06/11/hmg.
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512621PMC
August 2015

Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.

PLoS One 2014 30;9(5):e96149. Epub 2014 May 30.

Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China; School of Public Health and Tropical Medicine and/or School of Medicine, Tulane University, New Orleans, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096149PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039436PMC
January 2015

Genome wide association study: searching for genes underlying body mass index in the Chinese.

Biomed Environ Sci 2014 May;27(5):360-70

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, China; Systematic Biomedicine Research Center, University of Shanghai for Science and Technology, Shanghai 200093, China; Center for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.3967/bes2014.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537185PMC
May 2014

SNP rs6265 regulates protein phosphorylation and osteoblast differentiation and influences BMD in humans.

J Bone Miner Res 2013 Dec;28(12):2498-507

Center of Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Suzhou, Jiangsu, PR China; Center for Bioinformatics and Genomics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA; Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

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http://doi.wiley.com/10.1002/jbmr.1997
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http://dx.doi.org/10.1002/jbmr.1997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127979PMC
December 2013

Genome-wide association study identified CNP12587 region underlying height variation in Chinese females.

PLoS One 2012 5;7(9):e44292. Epub 2012 Sep 5.

Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, College of Medicine, Xi'an Jiaotong University, Xi'an, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044292PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434125PMC
February 2013

An integrative study ascertained SOD2 as a susceptibility gene for osteoporosis in Chinese.

J Bone Miner Res 2011 Nov;26(11):2695-701

Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, People's Republic of China.

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http://dx.doi.org/10.1002/jbmr.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375319PMC
November 2011

Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function.

Immunogenetics 2010 Apr 9;62(4):237-51. Epub 2010 Mar 9.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China.

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http://dx.doi.org/10.1007/s00251-010-0431-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925024PMC
April 2010

Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians.

J Bone Miner Res 2010 Feb;25(2):339-55

Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, Peoples Republic of China.

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http://dx.doi.org/10.1359/jbmr.090724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153389PMC
February 2010

An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass.

Bone 2009 May 28;44(5):1010-4. Epub 2008 May 28.

Laboratory of Molecular and Statistical Genetics, The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China.

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http://dx.doi.org/10.1016/j.bone.2008.05.016DOI Listing
May 2009

Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population.

J Hum Genet 2009 Apr 20;54(4):199-202. Epub 2009 Feb 20.

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China.

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http://dx.doi.org/10.1038/jhg.2009.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733232PMC
April 2009

Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.

Am J Hum Genet 2009 Mar 5;84(3):418-23. Epub 2009 Mar 5.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an Shaanxi, P R China.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970900066
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http://dx.doi.org/10.1016/j.ajhg.2009.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668008PMC
March 2009

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.

Hum Genet 2009 Feb 23;125(1):1-9. Epub 2008 Nov 23.

Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, People's Republic of China.

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http://dx.doi.org/10.1007/s00439-008-0590-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730511PMC
February 2009

Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis.

Am J Hum Genet 2008 Dec 6;83(6):663-74. Epub 2008 Nov 6.

Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China.

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http://dx.doi.org/10.1016/j.ajhg.2008.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667994PMC
December 2008

Anthropometric indices as the predictors of trunk obesity in Chinese young adults: receiver operating characteristic analyses.

Ann Hum Biol 2008 May-Jun;35(3):342-8

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China.

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http://dx.doi.org/10.1080/03014460802027049DOI Listing
August 2008

Evaluating the correlation and prediction of trunk fat mass with five anthropometric indices in Chinese females aged 20-40 years.

Nutr Metab Cardiovasc Dis 2007 Nov 26;17(9):676-83. Epub 2006 Sep 26.

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.

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http://dx.doi.org/10.1016/j.numecd.2006.04.007DOI Listing
November 2007

AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families.

Eur J Epidemiol 2007 8;22(8):527-32. Epub 2007 Jun 8.

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China.

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http://dx.doi.org/10.1007/s10654-007-9140-3DOI Listing
November 2007

Establishment of peak bone mineral density in Southern Chinese males and its comparisons with other males from different regions of China.

J Bone Miner Metab 2007 26;25(2):114-21. Epub 2007 Feb 26.

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China.

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http://dx.doi.org/10.1007/s00774-006-0737-5DOI Listing
May 2007

Receiver-operating characteristic analyses of body mass index, waist circumference and waist-to-hip ratio for obesity: Screening in young adults in central south of China.

Clin Nutr 2006 Dec 1;25(6):1030-9. Epub 2006 Aug 1.

Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China.

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http://dx.doi.org/10.1016/j.clnu.2006.04.009DOI Listing
December 2006

Correlation and prediction of trunk fat mass with four anthropometric indices in Chinese males.

Br J Nutr 2006 Nov;96(5):949-55

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China.

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http://dx.doi.org/10.1017/bjn20061820DOI Listing
November 2006

Linkage exclusion mapping with bone size in 79 Caucasian pedigrees.

J Bone Miner Metab 2006 ;24(4):337-43

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, China.

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http://dx.doi.org/10.1007/s00774-006-0692-1DOI Listing
September 2006

Exclusion mapping of chromosomes 1, 4, 6 and 14 with bone mineral density in 79 Caucasian pedigrees.

Bone 2006 Mar 24;38(3):450-5. Epub 2005 Oct 24.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China.

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http://dx.doi.org/10.1016/j.bone.2005.09.001DOI Listing
March 2006

Linkage exclusion analysis of two important chromosomal regions for height.

Biochem Biophys Res Commun 2005 Oct;335(4):1287-92

Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.027DOI Listing
October 2005

Absence of linkage to 8q23.3-q24.1 and 2p11.1-q12.2 in a new BAFME pedigree in China: indication of a third locus for BAFME.

Epilepsy Res 2005 Jul;65(3):147-52

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China.

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http://dx.doi.org/10.1016/j.eplepsyres.2005.05.006DOI Listing
July 2005

Association and haplotype analyses of the COL1A2 and ER-alpha gene polymorphisms with bone size and height in Chinese.

Bone 2005 Mar;36(3):533-41

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P. R. China.

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http://dx.doi.org/10.1016/j.bone.2004.11.002DOI Listing
March 2005

Lack of evidence for a major gene in the Mendelian transmission of BMI in Chinese.

Obes Res 2004 Dec;12(12):1967-73

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, People's Republic of China.

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http://dx.doi.org/10.1038/oby.2004.247DOI Listing
December 2004