Publications by authors named "Xianbao Wang"

85 Publications

Enhanced Steam Temperature Enabled by a Simple Three-Tier Solar Evaporation Device.

Glob Chall 2021 Apr 18;5(4):2000092. Epub 2021 Feb 18.

Key Laboratory for the Green Preparation and Application of Functional Materials Ministry of Education Hubei Key Laboratory of Polymer Materials School of Materials Science and Engineering Hubei University Wuhan 430062 China.

Interfacial water evaporation technology by using solar energy provides one of the promising pathways for freshwater shortage management. However, current research mainly focuses on the improvement of evaporation efficiency by macro or microregulations, ignoring the steam temperature, which is a manifestation of the quality of water. Herein not only is a high-rate solar evaporation achieved but also steam temperature is enhanced by a simple three-tier (wet absorber-air gap-dry absorber) device. In a routine interfacial evaporation test, the evaporator achieves a stable evaporation rate up to 2.15 kg m h under one sun, demonstrating a competitive evaporation rate compared with other reports. With the three-tier device, the steam temperature can increase 33.7%, 41.13%, and 47% without dry absorber under one sun, two sun, and three sun illumination, respectively. At the same time, the steam temperature can be as high as 95.5 °C under three sun intensities. This work provides the possibility of using a simple three-tier device for high-temperature steam generation without extra energy input, which contributes to an idea for future research on the production high-quality water.
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http://dx.doi.org/10.1002/gch2.202000092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025398PMC
April 2021

A novel role of claudin-5 in prevention of mitochondrial fission against ischemic/hypoxic stress in cardiomyocytes.

Can J Cardiol 2021 Apr 7. Epub 2021 Apr 7.

Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, CA 92697, USA. Electronic address:

Background: Downregulation of claudin-5 in the heart is associated with the end-stage heart failure. However, the underlying mechanism of claudin-5 is unclear. Here we investigated the molecular actions of claudin-5 in perspective of mitochondria in cardiomyocytes to better understand the role of claudin-5 in cardioprotection during ischemia.

Methods And Results: Claudin-5 was detected in the murine heart tissue and the neonatal rat cardiomyocytes (NRCM). Its protein level was severely decreased after myocardial ischemia/reperfusion (I/R; 30 min/24 h) or hypoxia/reoxygenation (H/R; 24 h/4 h). Claudin-5 was present in the mitochondria of NRCM as determined by confocal microscopy. H/R-induced downregulation of claudin-5 was accompanied by mitochondrial fragmentation. The protein level of mitofusin 2 (Mfn2) was dramatically decreased while the expression of dynamin-related protein (Drp) 1 was significantly increased after H/R. H/R-induced mitochondrial swelling and fission were observed by transmission electron microscope (TEM). Overexpression of claudin-5 by adenoviral infection reversed these structural disintegration of mitochondria. The mitochondria-centered intrinsic pathway of apoptosis triggered by H/R and indicated by the expression of cytochrome c and cleaved caspase 3 in the cytoplasm of NRCMs was also reduced by overexpressing claudin-5. Overexpression of claudin-5 in mouse heart also significantly decreased cleaved caspase 3 expression and the infarct size in ischemic heart with improved systolic function.

Conclusion: We demonstrated for the first time the presence of claudin-5 in the mitochondria in cardiomyocytes and provided the firm evidence for the cardioprotective role of claudin-5 in the preservation of mitochondrial dynamics and cell fate against hypoxia- or ischemia-induced stress.
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http://dx.doi.org/10.1016/j.cjca.2021.03.021DOI Listing
April 2021

Reasonably Introduced ZnInS@C to Mediate Polysulfide Redox for Long-Life Lithium-Sulfur Batteries.

ACS Appl Mater Interfaces 2021 Mar 22;13(12):14169-14180. Epub 2021 Mar 22.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Overseas Expertise Introduction Center for Discipline Innovation (D18025), Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.

In consideration of the inferior rate performance and low sulfur utilization of lithium-sulfur batteries (LSBs), an effective strategy via combining polar materials with the conductive carbon sulfur host is widely applied. Herein, metal organic framework-derived in situ-developed ZnInS@C is innovatively synthesized to mediate lithium polysulfide (LPS) conversion based on high electron conductivity and strong chemical interactions for advanced LSBs. Polar ZnInS possesses strong chemisorption in keeping with the DFT calculation results and catalytic for LPSs, ensuring a high sulfur utilization. Meanwhile, the hollow non-polar carbon frame possessing hierarchical pores not only provides internal space to contain active species but also accommodates efficient electronic transferring and diffusion of lithium ions in the process of cycling. The above advantages make the electrode possess promising stability and good rate performances, achieving long-term and high-rate cycling. Thus, under a sulfur loading of 1.5 mg cm, after 500 cycles, at 2 and 5 C, the as-prepared ZnInS@C@S delivers reversible capacities of 734 mA h g (75.7% of the initial capacity with a dropping rate of 0.015% per cycle) and 504 mA h g (68.5% of the primal capacity with a dropping rate of 0.029% per cycle), respectively. Even at a high sulfur loading of 5.0 mg cm, at 5 C, 65.6% of the initial capacity can be maintained with a low fading rate of 0.430% per cycle after 500 loops with a high Coulombic efficiency of around 99.8%.
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http://dx.doi.org/10.1021/acsami.0c22597DOI Listing
March 2021

The recent progress on metal-organic frameworks for phototherapy.

Chem Soc Rev 2021 Apr;50(8):5086-5125

School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over the world. The commonly used antibiotic therapy cannot effectively treat these diseases within a short time, and also bring about adverse effects such as drug resistance and immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to treat these diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) or induce a temperature increase, which leads to the death of targeted cells. These two kinds of killing strategies are referred to as photodynamic therapy (PDT) and photothermal therapy (PTT), respectively. So far, many photo-responsive agents have been developed. Among them, the metal-organic framework (MOF) is becoming one of the most promising photo-responsive materials because its structure and chemical compositions can be easily modulated to achieve specific functions. MOFs can have intrinsic photodynamic or photothermal ability under the rational design of MOF construction, or serve as the carrier of therapeutic agents, owing to its tunable porosity. MOFs also provide feasibility for various combined therapies and targeting methods, which improves the efficiency of phototherapy. In this review, we firstly investigated the principles of phototherapy, and comprehensively summarized recent advances of MOF in PDT, PTT and synergistic therapy, from construction to modification. We expect that our demonstration will shed light on the future development of this field, and bring it one step closer to clinical trials.
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http://dx.doi.org/10.1039/d1cs00056jDOI Listing
April 2021

Interfacial engineering of BiS/TiCT MXene based on work function for rapid photo-excited bacteria-killing.

Nat Commun 2021 02 22;12(1):1224. Epub 2021 Feb 22.

School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin, China.

In view of increasing drug resistance, ecofriendly photoelectrical materials are promising alternatives to antibiotics. Here we design an interfacial Schottky junction of BiS/TiCT resulting from the contact potential difference between TiCT and BiS. The different work functions induce the formation of a local electrophilic/nucleophilic region. The self-driven charge transfer across the interface increases the local electron density on TiCT. The formed Schottky barrier inhibits the backflow of electrons and boosts the charge transfer and separation. The photocatalytic activity of BiS/TiCT intensively improved the amount of reactive oxygen species under 808 nm near-infrared radiation. They kill 99.86% of Staphylococcus aureus and 99.92% of Escherichia coli with the assistance of hyperthermia within 10 min. We propose the theory of interfacial engineering based on work function and accordingly design the ecofriendly photoresponsive Schottky junction using two kinds of components with different work functions to effectively eradicate bacterial infection.
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http://dx.doi.org/10.1038/s41467-021-21435-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900204PMC
February 2021

Pseudosolvent Intercalator of Chitin: Self-Exfoliating into Sub-1 nm Thick Nanofibrils for Multifunctional Chitinous Materials.

Adv Mater 2021 Mar 3;33(10):e2007596. Epub 2021 Feb 3.

Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Youyi Road 368, Wuhan, 430062, China.

Traditionally, energy-intensive and time-consuming postmechanical disintegration processes are inevitable in extracting biopolymer nanofibrils from natural materials and thereby hinder their practical applications. Herein, a new, convenient, scalable, and energy-efficient method for exfoliating nanofibrils (ChNFs) from various chitin sources via pseudosolvent-assisted intercalation process is proposed. These self-exfoliated ChNFs possess controllable thickness from 2.2 to 0.8 nm, average diameter of 4-5 nm, high aspect ratio up to 10 and customized surface chemistries. Particularly, compared with elementary nanofibrils, ChNFs with few molecular layers thick exhibit greater potential to construct high-performance structural materials, e.g., ductile nanopapers with large elongation up to 70.1% and toughness as high as 30.2 MJ m , as well as soft hydrogels with typical nonlinear elasticity mimicking that of human-skin. The proposed self-exfoliation concept with unique advantages in the combination of high yield, energy efficiency, scalable productivity, less equipment requirements, and mild conditions opens up a door to extract biopolymer nanofibrils on an industrial scale. Moreover, the present modular ChNFs exfoliation will facilitate researchers to study the effect of thickness on the properties of nanofibrils and provide more insight into the structure-function relationship of biopolymer-based materials.
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http://dx.doi.org/10.1002/adma.202007596DOI Listing
March 2021

Tunable transition metal complexes as hole transport materials for stable perovskite solar cells.

Chem Commun (Camb) 2021 Feb;57(16):2093-2096

CSIRO Energy Centre, Mayfield West, NSW 2304, Australia.

Transition metal complexes offer cost-effective alternatives as hole-transport materials (HTMs) in perovskite solar cells. However, the devices suffer from low performance. We boost the power conversion efficiency of devices with transition metal complex HTMs from 2% to above 10% through energy level tuning. We further demonstrate the excellent photostability of the device based on the additive-free HTM.
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http://dx.doi.org/10.1039/d1cc00060hDOI Listing
February 2021

Nanoenabled Photothermal Materials for Clean Water Production.

Glob Chall 2021 Jan 14;5(1):2000055. Epub 2020 Oct 14.

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer Materials School of Materials Science and Engineering Hubei University Wuhan 430062 P. R. China.

Solar-powered water evaporation is a primitive technology but interest has revived in the last five years due to the use of nanoenabled photothermal absorbers. The cutting-edge nanoenabled photothermal materials can exploit a full spectrum of solar radiation with exceptionally high photothermal conversion efficiency. Additionally, photothermal design through heat management and the hierarchy of smooth water-flow channels have evolved in parallel. Indeed, the integration of all desirable functions into one photothermal layer remains an essential challenge for an effective yield of clean water in remote-sensing areas. Some nanoenabled photothermal prototypes equipped with unprecedented water evaporation rates have been reported recently for clean water production. Many barriers and difficulties remain, despite the latest scientific and practical implementation developments. This Review seeks to inspire nanoenvironmental research communities to drive onward toward real-time solar-driven clean water production.
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http://dx.doi.org/10.1002/gch2.202000055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788632PMC
January 2021

Ultrasonic Interfacial Engineering of Red Phosphorous-Metal for Eradicating MRSA Infection Effectively.

Adv Mater 2021 Feb 22;33(5):e2006047. Epub 2020 Dec 22.

School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin, 300072, China.

Sonodynamic therapy (SDT) is considered to be a potential treatment for various diseases including cancers and bacterial infections due to its deep penetration ability and biosafety, but its SDT efficiency is limited by the hypoxia environment of deep tissues. This study proposes creating a potential solution, sonothermal therapy, by developing the ultrasonic interfacial engineering of metal-red phosphorus (RP), which has an obviously improved sonothermal ability of more than 20 °C elevation under 25 min of continuous ultrasound (US) excitation as compared to metal alone. The underlying mechanism is that the mechanical energy of the US activates the motion of the interfacial electrons. US-induced electron motion in the RP can efficiently transfer the US energy into phonons in the forms of heat and lattice vibrations, resulting in a stronger US absorption of metal-RP. Unlike the nonspecific heating of the cavitation effect induced by US, titanium-RP can be heated in situ when the US penetrates through 2.5 cm of pork tissue. In addition, through a sonothermal treatment in vivo, bone infection induced by multidrug-resistant Staphylococcus aureus (MRSA) is successfully eliminated in under 20 min of US without tissue damage. This work provides a new strategy for combating MRSA by strong sonothermal therapy through US interfacial engineering.
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http://dx.doi.org/10.1002/adma.202006047DOI Listing
February 2021

Super Hydrophilic Activated Carbon Decorated Nanopolymer Foam for Scalable, Energy Efficient Photothermal Steam Generation, as an Effective Desalination System.

Nanomaterials (Basel) 2020 Dec 14;10(12). Epub 2020 Dec 14.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Clean water scarcity is still an intense, prolonged global issue that needs to be resolved urgently. The solar steam generation has shown great potential with a high energy conversion efficiency for clean water production from seawater and wastewater. However, the high evaporation rate of water cannot be preserved due to the inevitable fouling of solar absorbers. Herein, a self-floatable and super hydrophilic solar-driven steam generator composed of activated carbon coated melamine foam (ACM). The deposited ACM photothermal layer exhibits outstanding solar absorption (92%) and an efficient evaporation rate of 1.27 kg m h, along with excellent photothermal conversion efficiency (80%) as compared to commercially available primitive solar stills. The open porous assembly of melamine foam equipped with 80% flexibility (0.8 MPa) enabled smooth water transport and sustain heat accumulation within the matrix. The thermal insulation of ACM is 10 times greater than pure water. Moreover, open porous assembly of designed solar-powered steam generator rejects salt ions as well as volatile organic compounds efficiently. The low-cost and facile fabrication of photothermal based water production presents a potential solution to single step drinking water supply from various resources of the sea, the lakes and mixtures of emulsified oil and industrial wastewater.
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http://dx.doi.org/10.3390/nano10122510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765040PMC
December 2020

Biomass-Derived Bilayer Solar Evaporator with Enhanced Energy Utilization for High-Efficiency Water Generation.

ACS Appl Mater Interfaces 2020 Dec 9;12(51):57155-57164. Epub 2020 Dec 9.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, P.R. China.

Solar-driven evaporation has been recognized as a promising approach to address global crises of drinking water via virtue of abundant and green solar energy. However, a great challenge still exists for achieving efficient usage of solar energy combined with fast water evaporation. Here, a double-structural solar evaporator consists of an upper copper sulfide (CuS) agar-based aerogel and a bottom molybdenum carbide/carbon (MoCC) composite of cotton fibers-derived aerogel (CuSAA/MoCCFA), which is constructed for solar evaporation. The CuS layer performs as a solar-thermal converter with efficient light adsorption and prominent thermally localized ability, while the bottom layer (superhydrophilic porous aerogel) guarantees sufficient water transportation and excellent thermal insulation. The fully integrative solar evaporator has an attractive water evaporation rate of 2.44 kg m h with a superb solar-thermal conversion efficiency of 92.77% under 1 sun illumination. More notably, the bilayer aerogel exhibits long-term durability in high-salinity media during solar-driven desalination. In addition, a solar absorber assisted with low-temperature phase change materials comprise the solar evaporation system, which is aimed at solar-thermal energy storage and reutilization for conquering solar intermittence. Such superior performance of a comprehensive solar desalination system provides a new avenue for highly efficient and suitable clean water production under natural sunlight conditions.
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http://dx.doi.org/10.1021/acsami.0c18671DOI Listing
December 2020

Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection.

Sci Adv 2020 Nov 13;6(46). Epub 2020 Nov 13.

School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

Preventing multidrug-resistant bacteria-related infection and simultaneously improving osseointegration are in great demand for orthopedic implants. However, current strategies are still limited to a combination of non-U.S. Food and Drug Administration-approved antibacterial and osteogenic agents. Here, we develop a food-grade probiotic-modified implant to prevent methicillin-resistant (MRSA) infection and accelerate bone integration. is cultured on the surface of alkali heat-treated titanium (Ti) substrates and inactivated by ultraviolet irradiation to avoid sepsis induced by viable bacteria. This inactivated biofilm shows excellent 99.98% antibacterial effectiveness against MRSA due to the production of lactic acid and bacteriocin. In addition, the polysaccharides in the biofilm stimulate macrophages to secrete abundant osteogenic cytokines such as oncostatin M and improve osseointegration of the Ti implant. Inactivated probiotics modification can be a promising strategy to endow implants with both excellent self-antibacterial activity and osteointegration ability.
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http://dx.doi.org/10.1126/sciadv.aba5723DOI Listing
November 2020

Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury.

Life Sci 2021 Jan 22;264:118628. Epub 2020 Oct 22.

Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, NO. 253, Gongye Avenue, 510282 Guangzhou, China; Guangdong Provincial Biomedical Engineering Technology Research Center for cardiovascular Disease, 510282 Guangzhou, China; Sino-Japanese cooperation Platform for Translational Research in Heart Failure, 510282 Guangzhou, China; Laboratory of Heart Center, Zhujiang Hospital, Southern Medical University, 510282 Guangzhou, China. Electronic address:

Acute myocardial infarction is associated with high rates of morbidity and mortality and can cause irreversible myocardial damage. Timely reperfusion is critical to limit infarct size and salvage the ischemic myocardium. However, reperfusion may exacerbate lethal tissue injury, a phenomenon known as myocardial ischemia/reperfusion (I/R) injury. Pharmacological postconditioning (PPC), a strategy involving medication administration before or during the early minutes of reperfusion, is more efficient and flexible than preconditioning or ischemic conditioning. Previous studies have shown that various mechanisms are involved in the effects of PPC. In this review, we summarize the relative effects and potential underlying mechanisms of PPC to provide a foundation for future research attempting to develop novel treatments against myocardial I/R injury.
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http://dx.doi.org/10.1016/j.lfs.2020.118628DOI Listing
January 2021

Photoelectrons Mediating Angiogenesis and Immunotherapy through Heterojunction Film for Noninvasive Disinfection.

Adv Sci (Weinh) 2020 Sep 25;7(17):2000023. Epub 2020 Jul 25.

The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China School of Materials Science and Engineering Tianjin University Tianjin 300072 China.

A light-inspired hydroxyapatite (Hap)/nitrogen-doped carbon dots (NCDs) modified graphene oxide (GO) heterojunction film is developed, which shows a promoted separation of interfacial electrons and holes and an inhibited recombination efficiency via hole depletion. The metabolism of bacteria on this film is significantly inhibited under light irradiation, due to the enhanced photocatalytic and photothermal effects. In addition, the electron transfer from the plasmonic membrane to the GO/NCD/Hap film further inhibits the adenosine triphosphate process of bacteria, thus leading to the synergetic antibacterial efficacy. Meanwhile, the electron transfer between film and cell membrane induces the Ca flow after irradiation, which can promote the migration and proliferation of cells and alkaline phosphatase enhancement, thus favoring the tissue reconstruction. An in vivo test discloses that the vascular injury repair is achieved through the Ca-activated PLC1/ERK pathway, identified by the enhanced CD31 expression. Moreover, the increased CD4/CD8 lymphocytes are ameliorative by activating the PI3K/P-AKT pathway. Consequently, the electron transfer boosts the synergic photodynamic and photothermal therapeutic effects for bacterial infection by Ca flow for immunotherapy. This mild phototherapy approach with GO/NCDs/Hap, which can simultaneously repair injured vessels and relieve inflammation reactions, will increase the clinical application of noninvasive phototherapy in the near future.
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http://dx.doi.org/10.1002/advs.202000023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507565PMC
September 2020

Lignin-derived red-emitting carbon dots for colorimetric and sensitive fluorometric detection of water in organic solvents.

Anal Methods 2020 07;12(25):3218-3224

Key Lab of Materials Chemistry for Energy Conversion and Storage of Ministry of Education (HUST), School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, P. R. China.

Water contained in organic solvents or products in chemical industries, as contaminants, poses an adverse risk in chemical reaction, life or environmental safety. However, conventional fluorescent water sensing suffers from drawbacks, including limited organic solvents, narrow linear range, lack of visual detection, single detection strategy, and others. Herein, a novel type of red-emitting carbon dots (RCDs) has been created via one-step solvothermal synthesis based on biomass (e.g., lignin) as the carbon source and p-phenylenediamine (PPD) as the nitrogen source. Colorimetric and fluorometric detection of water in organic solvents has been demonstrated. The RCDs showed excitation-independent photoluminescence (PL) in different solvents and solvatochromic behavior, red in water, orange in ethanol, yellow in N,N-dimethyl formamide (DMF), and green in acetone. Remarkably, detection of water content in six organic solvents, including polar solvents (ethanol, acetone, dimethyl sulfoxide (DMSO), tetrahydrofuran (THF), and DMF) and apolar solvent (ether), was performed. With increasing water content in solvents, emission colors changed from green to red, or yellow to red, offering qualitative sensing of water. Furthermore, a broad linear detection range (10-90%), low limits of detection (LOD) (e.g., 0.36% for ethanol and 0.082% for acetone), and good generality for various organic solvent systems were realized. Particularly, dual sensing strategies, including PL quenching and shift with water in various solvents, were achieved simultaneously, showing great potential for the development of advanced optical sensors with high performance.
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http://dx.doi.org/10.1039/d0ay00485eDOI Listing
July 2020

Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing.

Nat Commun 2020 09 7;11(1):4446. Epub 2020 Sep 7.

School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin, 300072, China.

Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive FeO/CNT and the chemotherapy agent gentamicin (Gent). This system, FeO/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from FeO/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections.
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http://dx.doi.org/10.1038/s41467-020-18268-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477539PMC
September 2020

Neuregulin‑1, a microvascular endothelial‑derived protein, protects against myocardial ischemia‑reperfusion injury (Review).

Int J Mol Med 2020 Sep 26;46(3):925-935. Epub 2020 Jun 26.

Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.

As regards acute myocardial infarction, great success has been achieved in therapies that reduce the effects of myocardial ischemic injury, while few interventions have achieved satisfactory outcomes for myocardial ischemia‑reperfusion (IR) injury. Thus, new research is urgently required to achieve breakthroughs in promising treatments. Neuregulin‑1 (NRG‑1), which is an endothelium‑derived protein and the ligand of ErbB receptors, exerts cardioprotective effects and is rapidly upregulated during IR. NRG‑1/ErbB activates several downstream signaling pathways in response to myocardial IR injury. Previous studies have revealed the protective effects of NRG‑1 during heart failure, and numerous experiments have explored the mechanisms underlying the NRG‑1‑induced cardioprotective effects against myocardial IR injury. In the present review, the progress made in the research of NRG‑1 as a cardioprotective agent during IR and related conditionings is summarized. Furthermore, the potential benefits of NRG‑1 against myocardial IR injury are listed with the prospective use of NRG‑1 in clinical applications.
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http://dx.doi.org/10.3892/ijmm.2020.4662DOI Listing
September 2020

Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Biofilm Infection on Bone Implant.

ACS Nano 2020 07 1;14(7):8157-8170. Epub 2020 Jul 1.

The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China.

Clinically, methicillin-resistant (MRSA) biofilm infection inevitably induces the failure of bone implants. Herein, a hydrophilic and viscous hydrogel of poly(vinyl alcohol) modified with chitosan, polydopamine, and NO release donor was formed on a red phosphorus nanofilm deposited on a titanium implant (Ti-RP/PCP/RSNO). Under the irradiation of near-infrared light (NIR), peroxynitrite (ONOO) was formed by the reaction between the released NO and superoxide (O) produced by the RP nanofilm. Specifically, we revealed the antibacterial mechanism of the ONOO against the MRSA biofilm. In addition, osteogenic differentiation was promoted and inflammatory polarization was regulated by the released NO without NIR irradiation through upregulating the expression of and genes and TNF-α. The MRSA biofilm was synergistically eradicated by ONOO, hyperthermia, and O under NIR irradiation as well as the immunoreaction of the M1 polarization. The results also confirmed the excellent osteogenesis and biofilm eradication by released NO from the RP/PCP/RSNO system under NIR irradiation, indicating the noninvasive tissue reconstruction of MRSA-infected tissues through phototherapy and immunotherapy.
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http://dx.doi.org/10.1021/acsnano.0c01486DOI Listing
July 2020

Facile synthesis of CoMnO/C nanocages as an efficient sulfur host for lithium-sulfur batteries with enhanced rate performance.

Dalton Trans 2020 Jun;49(25):8591-8600

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.

Capacity reduction mainly caused by the shuttle effect and low conductivity restricts the commercial application of lithium-sulfur batteries (LSBs). Herein, we developed a method to overcome these two obstacles synchronously by designing nitrogenous carbon decorated hollow Co3-xMnxO4/C nanocages as hosts of sulfur. These hosts were derived from manganese doped ZIF-67 by a facile sintering method, which provided polar surface to anchor lithium polysulfides and considerable electronic conductivity. The polar material Co3-xMnxO4 and special hollow frame contribute to efficient synergistic sulfur-fixation, resulting in great cycling stabilities. The manganese elements ensure an efficient conversion among LSPs. At the same time, N-doped carbon provides excellent electrical conductivity, thereby leading to splendid rate performances. Thus, a battery with great stability and high capacity could be achieved. As a result, Co3-xMnxO4/C/S with 66 wt% sulfur content delivered a high initial capacity of 1082 mA h g-1 at 1C, together with a slow average capacity decay of 0.056% per cycle at 10C over 500 cycles. When the average sulfur loading is 1.3 mg cm-2, a capacity of 628 mA h g-1 can be maintained at 5C after 500 cycles.
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http://dx.doi.org/10.1039/d0dt01620aDOI Listing
June 2020

Wettability Control of Interfaces for High-Performance Organic Thin-Film Transistors by Soluble Insulating Polymer Films.

ACS Omega 2020 May 6;5(19):10891-10899. Epub 2020 May 6.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials, Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.

Organic small-molecule semiconductors have higher carrier mobility compared to polymer semiconductors, while the actual performances of these materials are susceptible to morphological defects and misalignment of crystalline grains. Here, a new strategy is explored to control the crystallization and morphologies of a solution-processed organic small-molecule semiconductor 2,7-dioctyl[1]benzothieno[3,2-][1]benzothiophene (C8-BTBT) using soluble polymer films to control the wettability of substrates. Different from the traditional surface modification method, the polymer layer as a modification layer is soluble in the semiconductor solution during the fabrication of organic thin-film transistors (OTFTs). The dissolved polymer alters the state of the semiconductor solution, which in turn, changes the crystallographic morphologies of the semiconductor films. By controlling the solubility and thickness of the polymer modification layers, it is possible to regulate the grain boundary and domain size of C8-BTBT films, which determine the performances of OTFTs. The bottom-gate transistors modified by a thick PS layer exhibit a mobility of >7 cm/V·s and an on/off ratio of >10. It is expected that this new modification method will be applicable to high-performance OTFTs based on other small molecular semiconductors and dielectrics.
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http://dx.doi.org/10.1021/acsomega.0c00548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241009PMC
May 2020

Solution-gated transistors of two-dimensional materials for chemical and biological sensors: status and challenges.

Nanoscale 2020 Jun;12(21):11364-11394

Institute of Microscale Optoelectronics, Collaborative Innovation Centre for Optoelectronic Science & Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, P. R. China.

Two-dimensional (2D) materials have been the focus of materials research for many years due to their unique fascinating properties and large specific surface area (SSA). They are very sensitive to the analytes (ions, glucose, DNA, protein, etc.), resulting in their wide-spread development in the field of sensing. New 2D materials, as the basis of applications, are constantly being fabricated and comprehensively studied. In a variety of sensing applications, the solution-gated transistor (SGT) is a promising biochemical sensing platform because it can work at low voltage in different electrolytes, which is ideal for monitoring body fluids in wearable electronics, e-skin, or implantable devices. However, there are still some key challenges, such as device stability and reproducibility, that must be faced in order to pave the way for the development of cost-effective, flexible, and transparent SGTs with 2D materials. In this review, the device preparation, device physics, and the latest application prospects of 2D materials-based SGTs are systematically presented. Besides, a bold perspective is also provided for the future development of these devices.
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http://dx.doi.org/10.1039/d0nr01125hDOI Listing
June 2020

Overcoming Multidrug-Resistant MRSA Using Conventional Aminoglycoside Antibiotics.

Adv Sci (Weinh) 2020 May 14;7(9):1902070. Epub 2020 Mar 14.

Hubei Key Laboratory of Polymer Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science & Engineering Hubei University Wuhan 430062 China.

Global multidrug-resistant (MDR) bacteria are spreading rapidly and causing a great threat to human health due to the abuse of antibiotics. Determining how to resensitize MDR bacteria to conventional inefficient antibiotics is of extreme urgency. Here, a low-temperature photothermal treatment (PTT, 45 °C) is utilized with red phosphorus nanoparticles to resensitize methicillin-resistant (MRSA) to conventional aminoglycoside antibiotics. The antibacterial mechanism is studied by the proteomic technique and molecular dynamics (MD) simulation, which proves that the aminoglycoside antibiotics against MRSA can be selectively potentiated by low-temperature PTT. The catalytic activity of 2-aminoglycoside phosphotransferase (APH (2″))-a modifying enzyme-is demonstrated to be obviously inhibited via detecting the consumption of adenosine triphosphate (ATP) in the catalytic reaction. It is also found that the active site of aspartic acid (ASP) residues in APH (2″) is thermally unstable from the results of molecular dynamics simulation. Its catalytic ability is inhibited by preventing the deprotonating procedure for the target -OH of gentamycin. The combined therapy also exhibits great biocompatibility and successfully treats MRSA infections in vivo. This low-temperature PTT strategy has the potential to be an exogenous-modifying enzyme inhibitor for the treatment of MDR bacterial infection.
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http://dx.doi.org/10.1002/advs.201902070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201259PMC
May 2020

Hierarchical Fusiform Microrods Constructed by Parallelly Arranged Nanoplatelets of LiCoO Material with Ultrahigh Rate Performance.

ACS Appl Mater Interfaces 2020 Apr 31;12(15):17376-17384. Epub 2020 Mar 31.

Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.

The past few decades have witnessed the unprecedented success of the commercialized LiCoO layered cathode in consumer electronics, but it still faces the poor rate capability and cycling performance because of its hexagonal layered α-NaFeO structure and the high energy of electrochemically active crystal planes. In a bid to address these problems, we report the delicate design and synthesis of hierarchical fusiform LiCoO microrods constructed by directionally assembled nanoplatelets along the [001] direction via a self-template route (PAHF-LCO). Remarkably, it is the first time that almost all the exposed surfaces of layered cathodes are dominated by the consistent {010} facets, which enable the express channels of Li diffusion to penetrate throughout the entire fusiform microrods. The as-obtained PAHF-LCO cathode material delivers specific capacities of 113 and 106 mA h g at 10 and 20 C after 200 cycles, respectively. Even under the high rate of 50 C, the discharge capacity initializes around 105 mA h g and ends around 80 mA h g after 200 cycles. The improvement mechanisms to the high-rate performance through crystal habit tuning have also been unraveled. The enhanced electrochemical performance can be attributed to the hierarchical fusiform structure as well as the coordinated crystal orientation of {010} facets.
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http://dx.doi.org/10.1021/acsami.9b21526DOI Listing
April 2020

Rapid Photo-Sonotherapy for Clinical Treatment of Bacterial Infected Bone Implants by Creating Oxygen Deficiency Using Sulfur Doping.

ACS Nano 2020 02 31;14(2):2077-2089. Epub 2020 Jan 31.

School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China , Tianjin University , Tianjin 300072 , China.

Periprosthetic infection is considered the main cause of implant failure, which is expected to be solved by fabricating an antibacterial coating on the surface of the implant. Nevertheless, systemic antibiotic treatment still represents the mainstream method for preventing infection, and few antibacterial coatings are applied clinically. This is because the externally introduced traditional antibacterial coatings suffer from the risk of invalidation and tissue toxicity induced by the consumption of antibacterial agents, degradation, and shedding. In this work, we proposed a rapid photo-sonotherapy by creating an oxygen deficiency on a titanium (Ti) implant through sulfur (S)-doping (Ti-S-TiO), which endowed the implants with great sonodynamic and photothermal ability. Without introducing an external antibacterial coating, it reached a high antibacterial efficiency of 99.995% against under 15 min near-infrared light and ultrasound treatments. Furthermore, bone infection was successfully treated after combination treatments, and improved osseointegration was observed. Importantly, the S-doped Ti implant immersed in water for 6 months showed an unchanged structure and properties, suggesting that the Ti implant with intrinsic modification showed stable antibacterial performance under exogenous stimuli with a high antibacterial performance . This photo-sonotherapy based on sulfur doping is also promising for cancer therapy with biosafety.
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http://dx.doi.org/10.1021/acsnano.9b08686DOI Listing
February 2020

Chinese hydrangea lantern-like CoS@MoS composites with enhanced lithium-ion battery properties.

Nanoscale 2020 Feb 28;12(5):3435-3442. Epub 2020 Jan 28.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.

Chinese hydrangea lantern-like CoS@MoS composites are prepared by a facile solvothermal method. Ultra-thin MoS nanosheets as the shells grow tightly and uniformly on the surface of the CoS core. Due to their unique hierarchical core-shell structure and novel morphology, the composites show excellent electrochemical performance as the anode materials of lithium-ion batteries. They can deliver reversible discharge capacities of around 1298, 1150, 1089, 1018 and 941 mA h g at the current densities of 0.1, 0.5, 1, 1.5 and 2.0 A g, respectively. Moreover, the CoS@MoS composites can still maintain a discharge capacity of 1048 mA h g after 300 cycles at a current density of 1.0 A g.
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http://dx.doi.org/10.1039/c9nr09260aDOI Listing
February 2020

Functional Carbon Quantum Dots for Highly Sensitive Graphene Transistors for Cu Ion Detection.

ACS Appl Mater Interfaces 2020 Jan 17;12(4):4797-4803. Epub 2020 Jan 17.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials, Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering , Hubei University , Wuhan 430062 , China.

Cu ions play essential roles in various biological events that occur in the human body. It is important to establish an efficient and reliable detection of Cu ions for people's health. The solution-gated graphene transistors (SGGTs) have been extensively investigated as a promising platform for chemical and biological sensing applications. Herein, highly sensitive and highly selective sensor for Cu ion detection is successfully constructed based on SGGTs with gate electrodes modified by functional carbon quantum dots (CQDs). The sensing mechanism of the sensor is that the coordination of CQDs and Cu ions induces the capacitance change of the electrical double layer (EDL) near the gate electrode and then results in the change of channel current. Compared to other metal ions, Cu ions have an excellent binding nature with CQDs that make it an ultrahigh selective sensor. The CQD-modified sensor achieves excellent Cu ion detection with a minimal level of concentration (1 × 10 M), which is several orders of magnitude lower than the values obtained from other conventional detection methods. Interestingly, the device also displays a quick response time on the order of seconds. Due to the functionalized nature of CQDs, SGGTs with CQD-modified gate show good prospects to achieve multifunctional sensing platform in biochemical detections.
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http://dx.doi.org/10.1021/acsami.9b20785DOI Listing
January 2020

Non-invasive detection of glucose via a solution-gated graphene transistor.

Analyst 2020 Feb;145(3):887-896

Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, Faculty of Materials Science and Engineering, Hubei University, No. 368 Youyi Avenue, Wuchang, Wuhan 430062, China.

Owing to its high sensitivity, a solution-gated graphene transistor has rapidly emerged as a cutting edge technology in electrochemical sensing. In this work, composites of gold nanoparticles and reduced graphene oxide were synthesized on a glassy carbon electrode by using the electrodeposition method. A modified glassy carbon electrode was used as the gate electrode and assembled into the solution-gated graphene transistor device along with the graphene channel for a non-invasive glucose detection. The sensing mechanism was based on the change in current in the channel of the device caused by the addition of glucose, of which electro-oxidation on the surface of the gold nanoparticles and reduced graphene oxide led to a change in equivalent gate voltage, and consequently, affected the channel carrier concentration. The self-amplification effect of transistors was utilized in our sensors, which resulted in a detection limit that was 10 times lower than those of conventional electrochemical sensors. Compared to traditional enzymatic transistor sensors, the novel solution-gated graphene transistor nonenzymatic sensors based on gold nanoparticles and reduced graphene oxide demonstrated significant sensing advantages, such as a simple structure, wide linear range from 10 μM to 400 μM and 400 μM to 31 mM, and low detection limit down to 4 μM. The chemicals coexisting in human sweat e.g. sodium chloride, urea, and lactic acid imposed no distinct interference for the glucose detection. Therefore, we achieved a non-invasive detection of glucose in the artificial sweat samples with satisfactory sensing results. This work demonstrates an effective route for non-invasive glucose testing in practical clinical diagnosis by using nonenzymatic, solution-gated graphene transistor devices.
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http://dx.doi.org/10.1039/c9an01754bDOI Listing
February 2020

Resveratrol pretreatment alleviates myocardial ischemia/reperfusion injury by inhibiting STIM1-mediated intracellular calcium accumulation.

J Physiol Biochem 2019 Nov 30;75(4):607-618. Epub 2019 Nov 30.

Department of Cardiology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Previous studies have shown that stromal interaction molecule1 (STIM1)-mediated store-operated Ca entry (SOCE) contributes to intracellular Ca accumulation in H9C2 cells subjected to hypoxia/reoxygenation(H/R) injury. The aim of the present study was to investigate the effect of resveratrol on STIM1-mediated intracellular Ca accumulation and subsequent cell death in the context of myocardial ischemia/reperfusion (I/R) injury. C57 BL/6 mice were fed with either saline or resveratrol (50 mg/kg daily for 2 weeks) and then subjected to myocardial I/R injury. TTC/Evans Blue staining and TUNEL assay were performed to quantify the infarct size and apoptosis index. The cardiac function was evaluated by echocardiography. Neonatal rat ventricular cardiomyocytes (NRVCs) underwent hypoxia/reoxygenation (H/R) to establish the in vitro model. To achieve over-expression, NRVCs were transfected with STIM1-adenovirus vector. Apoptosis was analyzed by TUNEL assay. Cell viability was measured using MTS assay and cell necrosis was determined by LDH release assay. Intracellular Ca concentration was detected by laser scanning confocal microscopy using a Fluo-3AM probe. Resveratrol significantly reduced apoptosis, decreased infarct size, and improved cardiac function in mice subjected to myocardial I/R injury. In NRVCs, resveratrol also downregulated STIM1 expression accompanied by decreased intracellular Ca accumulation elicited by H/R injury. In addition, resveratrol reduced cell apoptosis, upregulated the Bcl-2, decreased Bax, and cleaved caspase-3 expression. Furthermore, the effects of resveratrol on STIM1-mediated intracellular Ca accumulation, apoptotic proteins, and H/R-induced cell injury were exacerbated by STIM1 over-expression and were partly abolished by SOCE inhibitor SKF96365 in NRVCs in vitro. Our findings demonstrate that resveratrol exerts anti-apoptotic activity and improves cardiac functional recovery following myocardial I/R by inhibiting STIM1-induced intracellular Ca accumulation.
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http://dx.doi.org/10.1007/s13105-019-00704-5DOI Listing
November 2019

Photoelectric-Responsive Extracellular Matrix for Bone Engineering.

ACS Nano 2019 11 11;13(11):13581-13594. Epub 2019 Nov 11.

Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering , Hubei University , Wuhan 430062 , People's Republic of China.

Using noninvasive stimulation of cells to control cell fate and improve bone regeneration by optical stimulation can achieve the aim of precisely orchestrating biological activities. In this study, we create a fast and repeatable photoelectric-responsive microenvironment around an implant using a bismuth sulfide/hydroxyapatite (BS/HAp) film. The unexpected increase of photocurrent on the BS/HAp film under near-infrared (NIR) light is mainly due to the depletion of holes through PO from HAp and interfacial charge transfer by HAp compared with BS. The electrons activate the Na channel of mesenchymal stem cells (MSCs) and change the cell adhesion in the intermediate environment. The behavior of MSCs is tuned by changing the photoelectronic microenvironment. RNA sequencing reveals that when photoelectrons transfer to the cell membrane, sodium ions flux and the membrane potential depolarizes to change the cell shape. Meanwhile, calcium ions fluxed and was upregulated. Furthermore, the in the cell nucleus began transcription to regulate the downstream genes involved in osteogenic differentiation, which is performed through the Wnt/Ca signaling pathway. This research has created a biological therapeutic strategy, which can achieve remotely, precisely, and noninvasively controlling cell differentiation behaviors by tuning the photoelectric microenvironment using NIR light.
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http://dx.doi.org/10.1021/acsnano.9b08115DOI Listing
November 2019