Xavier Xifró

Xavier Xifró

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Xavier Xifró

Xavier Xifró

Publications by authors named "Xavier Xifró"

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Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression.

Biochim Biophys Acta Gen Subj 2018 09 30;1862(9):1852-1861. Epub 2018 May 30.

New Therapeutic Targets Group (TargetsLab), Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, E-17071 Girona, Spain; Departament de Biomedicina, Institut de Neurociències, Facultat de Medicina, Universitat de Barcelona, E-08036 Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), E-08036 Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03044165183014
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http://dx.doi.org/10.1016/j.bbagen.2018.05.017DOI Listing
September 2018

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity.

Neurobiol Dis 2016 Nov 11;95:22-34. Epub 2015 Sep 11.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Casanova, 143, 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Casanova, 143, 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.09.001DOI Listing
November 2016

Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.

Biochim Biophys Acta 2016 07 6;1862(7):1255-66. Epub 2016 Apr 6.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; TargetsLab, Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.04.002DOI Listing
July 2016

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.

Pain 2016 Feb;157(2):377-86

aDepartament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalonia, Spain bInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain cCentro de Investigaciones Biomédicas en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain dDepartment of Neurosciences, School of Medicine and Dentistry, University of the Basque Country (UPV/EHU), Bizkaia, Spain eDepartament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Catalonia, Spain fDepartment of Chemistry, Yale University, New Haven, CT, USA gChild Study Center, Yale School of Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809206PMC
February 2016

Novel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in mice.

PLoS One 2015 9;10(4):e0123122. Epub 2015 Apr 9.

Grupo de Investigación de Anatomía Clínica, Embriología, Neurociencia y Oncología Molecular (NEOMA), Departamento de Ciencias Médicas, Facultad de Medicina, Universitat de Girona (UdG), Girona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123122PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391943PMC
December 2015

Delineating the factors and cellular mechanisms involved in the survival of cerebellar granule neurons.

Cerebellum 2015 Jun;14(3):354-9

Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, C/ Emili Grahit, 77, 17071, Girona, Spain,

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http://dx.doi.org/10.1007/s12311-015-0646-zDOI Listing
June 2015

Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease.

Mol Neurobiol 2014 Apr 7;49(2):784-95. Epub 2013 Nov 7.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-013-8556-xDOI Listing
April 2014

Ras protein activation is a key event in activity-dependent survival of cerebellar granule neurons.

J Biol Chem 2014 Mar 12;289(12):8462-72. Epub 2014 Feb 12.

From the Institut de Neurociencies and Department of Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain.

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http://dx.doi.org/10.1074/jbc.M113.536375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961671PMC
March 2014

[Diagnosis and pharmacological treatment of neuropathic pain in spinal cord injury subjects: from laboratory to clinical trial].

Med Clin (Barc) 2013 Feb 21;140(4):175-81. Epub 2012 Nov 21.

Grupo de Investigación de Anatomía Clínica, Embriología, Neurociencia y Oncología Molecular, Departamento de Ciencias Médicas, Facultad de Medicina, Universitat de Girona, Girona, Spain.

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http://dx.doi.org/10.1016/j.medcli.2012.09.014DOI Listing
February 2013

Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease.

J Neurochem 2012 May 28;121(4):639-48. Epub 2012 Mar 28.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07711.xDOI Listing
May 2012

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.

Hum Mol Genet 2011 Nov 11;20(21):4232-47. Epub 2011 Aug 11.

Departament de Biologia Cel.lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1093/hmg/ddr351DOI Listing
November 2011

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Mol Neurodegener 2011 Oct 31;6:74. Epub 2011 Oct 31.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Spain.

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http://dx.doi.org/10.1186/1750-1326-6-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217046PMC
October 2011

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.

J Neurosci 2011 Jun;31(22):8150-62

Departament de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi-Sunyer, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.3446-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472648PMC
June 2011

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

J Neurochem 2010 Oct 12;115(1):153-67. Epub 2010 Aug 12.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06912.xDOI Listing
October 2010

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

Neurobiol Dis 2009 Dec 4;36(3):461-9. Epub 2009 Sep 4.

Departament de Biologia Cel.lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E-08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.nbd.2009.08.012DOI Listing
December 2009

Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway.

Mol Biol Cell 2009 Dec;20(24):5051-63

Institut de Neurociencies and Departament de Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Spain.

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http://dx.doi.org/10.1091/mbc.e09-05-0424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793283PMC
December 2009

Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus.

Mol Biol Cell 2009 Mar 14;20(5):1478-92. Epub 2009 Jan 14.

Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, E-08036 Barcelona, Spain.

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http://dx.doi.org/10.1091/mbc.e08-07-0726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649260PMC
March 2009

Estradiol facilitates neurite maintenance by a Src/Ras/ERK signalling pathway.

Mol Cell Neurosci 2008 Oct 14;39(2):143-51. Epub 2008 Jun 14.

Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Spain.

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http://dx.doi.org/10.1016/j.mcn.2008.06.001DOI Listing
October 2008

Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells.

J Neurochem 2008 Jun 24;105(5):1596-612. Epub 2008 Jan 24.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05252.xDOI Listing
June 2008

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease.

J Neurosci Res 2007 Sep;85(12):2756-69

Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Barcelona, Spain.

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http://dx.doi.org/10.1002/jnr.21258DOI Listing
September 2007

17beta-estradiol does not protect cerebellar granule cells from excitotoxicity or apoptosis.

J Neurochem 2007 Jul;102(2):354-64

Institut de Neurociencies i Department Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04475.xDOI Listing
July 2007

PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression.

J Neurochem 2006 Nov 5;99(4):1237-50. Epub 2006 Oct 5.

INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, University of Rouen, Mont-Saint-Aignan, France.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04148.xDOI Listing
November 2006

N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells.

J Biol Chem 2006 Mar 27;281(10):6801-12. Epub 2005 Dec 27.

Institut de Neurociencies i Dpt. Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M504571200DOI Listing
March 2006

Contribution of caspase-mediated apoptosis to the cell death caused by oxygen-glucose deprivation in cortical cell cultures.

Neurobiol Dis 2005 Oct;20(1):27-37

Institut de Neurociències i Dpt. Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.nbd.2005.01.028DOI Listing
October 2005

Brief exposure to NMDA produces long-term protection of cerebellar granule cells from apoptosis.

Eur J Neurosci 2005 Feb;21(4):827-40

Institut de Neurociències i Department Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1460-9568.2005.03935.xDOI Listing
February 2005

Histamine H2-receptor antagonist ranitidine protects against neural death induced by oxygen-glucose deprivation.

Stroke 2004 Oct 19;35(10):2396-401. Epub 2004 Aug 19.

Institut de Neurociènces and Unitat de Bioquímica de Medicina, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Spain.

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http://dx.doi.org/10.1161/01.STR.0000141160.66818.24DOI Listing
October 2004