Xavier Soberon

Xavier Soberon

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Xavier Soberon

Xavier Soberon

Publications by authors named "Xavier Soberon"

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Microbiome-MX 2018: microbiota and microbiome opportunities in Mexico, a megadiverse country.

Res Microbiol 2019 Jun - Aug;170(4-5):235-241. Epub 2019 Mar 25.

Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos, 62210, Mexico. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09232508193003
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http://dx.doi.org/10.1016/j.resmic.2019.03.001DOI Listing
August 2019

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Authors:
Jason Flannick Josep M Mercader Christian Fuchsberger Miriam S Udler Anubha Mahajan Jennifer Wessel Tanya M Teslovich Lizz Caulkins Ryan Koesterer Francisco Barajas-Olmos Thomas W Blackwell Eric Boerwinkle Jennifer A Brody Federico Centeno-Cruz Ling Chen Siying Chen Cecilia Contreras-Cubas Emilio Córdova Adolfo Correa Maria Cortes Ralph A DeFronzo Lawrence Dolan Kimberly L Drews Amanda Elliott James S Floyd Stacey Gabriel Maria Eugenia Garay-Sevilla Humberto García-Ortiz Myron Gross Sohee Han Nancy L Heard-Costa Anne U Jackson Marit E Jørgensen Hyun Min Kang Megan Kelsey Bong-Jo Kim Heikki A Koistinen Johanna Kuusisto Joseph B Leader Allan Linneberg Ching-Ti Liu Jianjun Liu Valeriya Lyssenko Alisa K Manning Anthony Marcketta Juan Manuel Malacara-Hernandez Angélica Martínez-Hernández Karen Matsuo Elizabeth Mayer-Davis Elvia Mendoza-Caamal Karen L Mohlke Alanna C Morrison Anne Ndungu Maggie C Y Ng Colm O'Dushlaine Anthony J Payne Catherine Pihoker Wendy S Post Michael Preuss Bruce M Psaty Ramachandran S Vasan N William Rayner Alexander P Reiner Cristina Revilla-Monsalve Neil R Robertson Nicola Santoro Claudia Schurmann Wing Yee So Xavier Soberón Heather M Stringham Tim M Strom Claudia H T Tam Farook Thameem Brian Tomlinson Jason M Torres Russell P Tracy Rob M van Dam Marijana Vujkovic Shuai Wang Ryan P Welch Daniel R Witte Tien-Yin Wong Gil Atzmon Nir Barzilai John Blangero Lori L Bonnycastle Donald W Bowden John C Chambers Edmund Chan Ching-Yu Cheng Yoon Shin Cho Francis S Collins Paul S de Vries Ravindranath Duggirala Benjamin Glaser Clicerio Gonzalez Ma Elena Gonzalez Leif Groop Jaspal Singh Kooner Soo Heon Kwak Markku Laakso Donna M Lehman Peter Nilsson Timothy D Spector E Shyong Tai Tiinamaija Tuomi Jaakko Tuomilehto James G Wilson Carlos A Aguilar-Salinas Erwin Bottinger Brian Burke David J Carey Juliana C N Chan Josée Dupuis Philippe Frossard Susan R Heckbert Mi Yeong Hwang Young Jin Kim H Lester Kirchner Jong-Young Lee Juyoung Lee Ruth J F Loos Ronald C W Ma Andrew D Morris Christopher J O'Donnell Colin N A Palmer James Pankow Kyong Soo Park Asif Rasheed Danish Saleheen Xueling Sim Kerrin S Small Yik Ying Teo Christopher Haiman Craig L Hanis Brian E Henderson Lorena Orozco Teresa Tusié-Luna Frederick E Dewey Aris Baras Christian Gieger Thomas Meitinger Konstantin Strauch Leslie Lange Niels Grarup Torben Hansen Oluf Pedersen Philip Zeitler Dana Dabelea Goncalo Abecasis Graeme I Bell Nancy J Cox Mark Seielstad Rob Sladek James B Meigs Steve S Rich Jerome I Rotter David Altshuler Noël P Burtt Laura J Scott Andrew P Morris Jose C Florez Mark I McCarthy Michael Boehnke

Nature 2019 06 22;570(7759):71-76. Epub 2019 May 22.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

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http://www.nature.com/articles/s41586-019-1231-2
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http://dx.doi.org/10.1038/s41586-019-1231-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699738PMC
June 2019

Fate of uptaken host proteins in and cysticerci.

Biosci Rep 2018 08 6;38(4). Epub 2018 Jul 6.

Department of Immunology, Institute for Biomedical Research, Universidad Nacional Autónoma de México, Ciudad de México, México

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http://dx.doi.org/10.1042/BSR20180636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435539PMC
August 2018

Identification and characterization of Taenia solium enolase as a plasminogen-binding protein.

Acta Trop 2018 Jun 18;182:69-79. Epub 2018 Feb 18.

Dept. of Immunology, Institute for Biomedical Research, Universidad Nacional Autónoma de México, Mexico City, Mexico.. Electronic address:

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http://dx.doi.org/10.1016/j.actatropica.2018.02.020DOI Listing
June 2018

A Loss-of-Function Splice Acceptor Variant in Is Protective for Type 2 Diabetes.

Diabetes 2017 11 24;66(11):2903-2914. Epub 2017 Aug 24.

Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA

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http://dx.doi.org/10.2337/db17-0187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652606PMC
November 2017

Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins.

Exp Parasitol 2017 Jan 29;172:23-29. Epub 2016 Nov 29.

Dept. of Immunology, Institute for Biomedical Research, Universidad Nacional Autónoma de México, México D.F, 04510, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2016.11.006DOI Listing
January 2017

Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing.

Pharmacogenomics 2017 Jan 15;18(2):121-131. Epub 2016 Dec 15.

Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Delegación Tlalpan, México, D.F. C.P. 14610, Mexico.

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http://dx.doi.org/10.2217/pgs-2016-0072DOI Listing
January 2017

Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis.

Mol Biochem Parasitol 2016 06 24;207(2):61-7. Epub 2016 May 24.

Dept. of Immunology, Institute for Biomedical Research, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2016.05.010DOI Listing
June 2016

Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome.

Comput Struct Biotechnol J 2015 9;13:390-401. Epub 2015 Jun 9.

Unidad de Genómica de Poblaciones Aplicada la Salud, Facultad de Química, UNAM, Instituto Nacional de Medicina Genómica (INMEGEN), México, D.F. 14610, Mexico ; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de Mexico, Avenida Universidad 2001, Cuernavaca C.P. 62210, Mexico.

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http://dx.doi.org/10.1016/j.csbj.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484546PMC
July 2015

Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).

Sci Rep 2015 May 19;5:9683. Epub 2015 May 19.

Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica (INMEGEN), Periférico Sur No. 4809, Col. Arenal Tepepan, Delegación Tlalpan México, D.F. C.P. 14610, México.

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http://dx.doi.org/10.1038/srep09683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437048PMC
May 2015

Genotype frequencies of VKORC1 and CYP2C9 in native and Mestizo populations from Mexico, potential impact for coumarin dosing.

Gene 2015 Mar 2;558(2):235-40. Epub 2015 Jan 2.

Laboratorio de Farmacogenómica, Instituto Nacional de Medicina Genómica (INMEGEN), Periferico Sur 4809, Col. Arenal Tepepan, 14610 Mexico City, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2014.12.068DOI Listing
March 2015

Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity.

J Biol Chem 2012 Aug 5;287(35):29931-9. Epub 2012 Jul 5.

Departamento de Ingeniería Celular y Biocatálisis del Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenue Universidad 2001, Cuernavaca, Morelos, México, P. C. 62210.

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http://dx.doi.org/10.1074/jbc.M112.345660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436175PMC
August 2012

Evolutionary walk between (β/α)(8) barrels: catalytic migration from triosephosphate isomerase to thiamin phosphate synthase.

J Mol Biol 2012 Feb 28;416(2):255-70. Epub 2011 Dec 28.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, AP 510-3, CP 62250, Cuernavaca, Morelos, México.

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http://dx.doi.org/10.1016/j.jmb.2011.12.042DOI Listing
February 2012

Exploring the Structure-Function Loop Adaptability of a (β/α)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.

J Mol Biol 2011 Aug 27;411(1):143-57. Epub 2011 May 27.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Cuernavaca, C.P. 62210, México.

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http://dx.doi.org/10.1016/j.jmb.2011.05.027DOI Listing
August 2011

Identification and analysis of residues contained on beta --> alpha loops of the dual-substrate (beta alpha)8 phosphoribosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activity.

Protein Sci 2010 Mar;19(3):535-43

Evolution of Metabolic Diversity Laboratory, Laboratorio Nacional de Genómica para la Biodiversidad (Langebio), CINVESTAV-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato-León, Irapuato, C.P. 36822, México.

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http://dx.doi.org/10.1002/pro.331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866278PMC
March 2010

Protein design through systematic catalytic loop exchange in the (beta/alpha)8 fold.

J Mol Biol 2009 Apr 20;387(4):949-64. Epub 2009 Feb 20.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apartado Postal 510-3, Cuernavaca, Morelos 62271, México.

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http://dx.doi.org/10.1016/j.jmb.2009.02.022DOI Listing
April 2009

Enhancement of the alcoholytic activity of alpha-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site-directed mutagenesis.

Appl Environ Microbiol 2008 Aug 13;74(16):5168-77. Epub 2008 Jun 13.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, UNAM, Apartado Postal 510-3, Cuernavaca, Morelos, 62271, México.

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http://dx.doi.org/10.1128/AEM.00121-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519283PMC
August 2008

Growth rate of a non-fermentative Escherichia coli strain is influenced by NAD+ regeneration.

Biotechnol Lett 2007 Dec 13;29(12):1857-63. Epub 2007 Oct 13.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apartado Postal 510-3, Cuernavaca, Morelos, 62250, Mexico,

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http://dx.doi.org/10.1007/s10529-007-9481-8DOI Listing
December 2007

The effect of amino acid deletions and substitutions in the longest loop of GFP.

BMC Chem Biol 2007 Jun 26;7. Epub 2007 Jun 26.

Departamento de Ingeniería Celular y Biocatálisis. Instituto de Biotecnología, Universidad Nacional Autónoma de México, Ap. Postal 510-3 Cuernavaca, Morelos 62250, México.

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http://dx.doi.org/10.1186/1472-6769-7-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919350PMC
June 2007

Improvement of an unusual twin-arginine transporter leader peptide by a codon-based randomization approach.

Appl Environ Microbiol 2006 May;72(5):3797-801

Instituto de Biotecnología/UNAM, Av. Universidad 2001, Col. Chamilpa, 62210 Cuernavaca, Morelos, México.

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http://dx.doi.org/10.1128/AEM.72.5.3797-3801.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472356PMC
May 2006

An endangered oasis of aquatic microbial biodiversity in the Chihuahuan desert.

Proc Natl Acad Sci U S A 2006 Apr 17;103(17):6565-70. Epub 2006 Apr 17.

Departamento de Ecología Evolutiva, Instituto de Ecología, Universidad Nacional Autónoma de México AP 70-275 Coyoacán, 04510 Mexico D.F., Mexico.

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http://dx.doi.org/10.1073/pnas.0601434103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458923PMC
April 2006

Generation of variability by in vivo recombination of halves of a (beta/alpha)8 barrel protein.

Biomol Eng 2005 Oct;22(4):113-20

Instituto de Biotecnología, UNAM, Apartado Postal 510-3, Cuernavaca, Morelos 62271, México.

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http://dx.doi.org/10.1016/j.bioeng.2005.01.002DOI Listing
October 2005

Combinatorial codon-based amino acid substitutions.

Nucleic Acids Res 2004 Nov 10;32(20):e158. Epub 2004 Nov 10.

Instituto de Biotecnología/UNAM, Ap. Postal 510-3 Cuernavaca, Morelos 62250, México.

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http://dx.doi.org/10.1093/nar/gnh156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534637PMC
November 2004

Protein evolution by codon-based random deletions.

Nucleic Acids Res 2004 Sep 30;32(17):e136. Epub 2004 Sep 30.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología/UNAM, Ap. Postal 510-3 Cuernavaca, Morelos 62250, México.

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http://dx.doi.org/10.1093/nar/gnh135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521680PMC
September 2004

Metabolic engineering and protein directed evolution increase the yield of L-phenylalanine synthesized from glucose in Escherichia coli.

Biotechnol Bioeng 2004 Aug;87(4):516-24

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apdo Postal 510-3. Cuernavaca, Morelos 62250, Mexico.

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http://dx.doi.org/10.1002/bit.20159DOI Listing
August 2004

Production of a fully functional, permuted single-chain penicillin G acylase.

Protein Sci 2004 Jun 7;13(6):1677-83. Epub 2004 May 7.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología/Universidad Nacional Autónoma de México, Apdo. Postal 510-3, Cuernavaca, Morelos 62250, México.

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http://dx.doi.org/10.1110/ps.03436604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279987PMC
June 2004

In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination.

FEBS Lett 2004 Feb;560(1-3):167-72

Instituto de Biotecnología, UNAM, Apartado Postal 510-3, Cuernavaca, Morelos 62271, Mexico.

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http://dx.doi.org/10.1016/S0014-5793(04)00098-5DOI Listing
February 2004

Alpha-amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity.

Protein Eng 2003 Jul;16(7):505-14

Instituto de Biotecnología, UNAM, Apartado Postal 510-3, Cuernavaca, Morelos 62271, México.

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http://dx.doi.org/10.1093/protein/gzg060DOI Listing
July 2003

Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.

Nucleic Acids Res 2002 Aug;30(16):e84

Instituto de Biotecnología/UNAM, Ap. Postal 510-3, Cuernavaca, Morelos 62250, México.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134257PMC
http://dx.doi.org/10.1093/nar/gnf083DOI Listing
August 2002

Improving a circularly permuted TEM-1 beta-lactamase by directed evolution.

Protein Eng 2002 Jun;15(6):463-70

Instituto de Biotecnología, UNAM, Apdo. Postal 510-3 Cuernavaca, Morelos 62250, México.

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http://dx.doi.org/10.1093/protein/15.6.463DOI Listing
June 2002