Xavier Palomer

Xavier Palomer

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Xavier Palomer

Publications by authors named "Xavier Palomer"

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Targeting FGF21 for the Treatment of Nonalcoholic Steatohepatitis.

Trends Pharmacol Sci 2020 Mar 21;41(3):199-208. Epub 2020 Jan 21.

Department of Pharmacology, Toxicology, and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain; Pediatric Research Institute, Hospital Sant Joan de Déu, 08950 Esplugues de Llobregat, Barcelona, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.12.005DOI Listing
March 2020

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.

Signal Transduct Target Ther 2020 28;5:14. Epub 2020 Feb 28.

1Department of Pharmacology, Toxicology and Therapeutic Chemistry, IBUB (Institut de Biomedicina de la Universitat de Barcelona), Research Institute - Pediatric Research Institute, Hospital Sant Joan de Déu, and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41392-020-0114-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046732PMC
February 2020

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.

Signal Transduct Target Ther 2020 Feb 28;5(1):14. Epub 2020 Feb 28.

Department of Pharmacology, Toxicology and Therapeutic Chemistry, IBUB (Institut de Biomedicina de la Universitat de Barcelona), Research Institute - Pediatric Research Institute, Hospital Sant Joan de Déu, and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41392-020-0114-1DOI Listing
February 2020

Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes.

Clin Investig Arterioscler 2019 May - Jun;31(3):111-118. Epub 2019 Apr 13.

Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Spain; Research Institute, Hospital Sant Joan de Déu, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.arteri.2019.01.004DOI Listing
January 2020

Oral administration of a new HRI activator as a new strategy to improve high-fat-diet-induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21.

Br J Pharmacol 2019 07 23;176(13):2292-2305. Epub 2019 May 23.

Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/bph.14678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555855PMC
July 2019

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].

Metabolism 2019 Jul 18;96:101-102. Epub 2019 Apr 18.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.04.009DOI Listing
July 2019

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.

Metabolism 2018 08 9;85:59-75. Epub 2018 Mar 9.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.03.005DOI Listing
August 2018

Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?

Trends Pharmacol Sci 2018 05 28;39(5):452-467. Epub 2018 Mar 28.

Department of Pharmacology, Toxicology, and Therapeutic Chemistry, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain; Research Institute, Hospital Sant Joan de Déu, Barcelona, Spain; Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2018.02.010DOI Listing
May 2018

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus.

Trends Endocrinol Metab 2018 03 28;29(3):178-190. Epub 2017 Dec 28.

Department of Pharmacology, Toxicology, and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Pediatric Research Institute-Hospital Sant Joan de Déu, and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, Avinguda Joan XXIII 27-31, E-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2017.11.009DOI Listing
March 2018

PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders.

Int J Mol Sci 2018 Mar 20;19(3). Epub 2018 Mar 20.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine of the University of Barcelona (IBUB), Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.3390/ijms19030913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877774PMC
March 2018

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease.

Mol Metab 2018 02 19;8:117-131. Epub 2017 Dec 19.

Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, Barcelona, Spain; Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985050PMC
February 2018

VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells.

Diabetologia 2017 11 23;60(11):2262-2273. Epub 2017 Aug 23.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institut de Biomedicina de la Universidad de Barcelona (IBUB), University of Barcelona, Diagonal 643, E-08028, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00125-017-4401-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078195PMC
November 2017

PPARβ/δ and lipid metabolism in the heart.

Biochim Biophys Acta 2016 10 26;1861(10):1569-78. Epub 2016 Jan 26.

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Institut de Biomedicina de la UB (IBUB), Faculty of Pharmacy, University of Barcelona, Barcelona, Spain; Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.01.019DOI Listing
October 2016

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency.

Diabetes 2016 10 2;65(10):3185-99. Epub 2016 Aug 2.

Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Institute of Biomedicine of the University of Barcelona, Barcelona, Spain CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain Pediatric Research Institute, Hospital Sant Joan de Déu, Barcelona, Spain

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http://diabetes.diabetesjournals.org/content/diabetes/early/
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https://dr.ntu.edu.sg/bitstream/handle/10220/41419/Heme-Regu
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http://diabetes.diabetesjournals.org/content/diabetes/65/10/
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http://dx.doi.org/10.2337/db16-0155DOI Listing
October 2016

Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-κB activity.

Acta Diabetol 2016 Feb 5;53(1):109-18. Epub 2015 May 5.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00592-015-0759-3DOI Listing
February 2016

[PPARα attenuates palmitate-induced endoplasmic reticulum stress in human cardiac cells by enhancing AMPK activity].

Clin Investig Arterioscler 2014 Nov-Dec;26(6):255-67. Epub 2014 Apr 5.

Departamento de Farmacología y Química Terapéutica, IBUB (Institut de Biomedicina de la Universitat de Barcelona) y CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Facultad de Farmacia, Universitat de Barcelona, Barcelona, España. Electronic address:

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http://dx.doi.org/10.1016/j.arteri.2014.02.003DOI Listing
November 2015

miR-146a targets Fos expression in human cardiac cells.

Dis Model Mech 2015 Sep 25;8(9):1081-91. Epub 2015 Jun 25.

Department of Pharmacology and Therapeutic Chemistry, IBUB (Institut de Biomedicina de la Universitat de Barcelona) and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Faculty of Pharmacy, University of Barcelona, Diagonal 643, Barcelona E-08028, Spain

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http://dx.doi.org/10.1242/dmm.020768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582106PMC
September 2015

Targeting endoplasmic reticulum stress in insulin resistance.

Trends Endocrinol Metab 2015 Aug 12;26(8):438-48. Epub 2015 Jun 12.

Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.05.007DOI Listing
August 2015

PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation.

Biochim Biophys Acta 2015 May 26;1852(5):1049-58. Epub 2015 Feb 26.

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry and Institut de Biomedicina de la UB (IBUB), Faculty of Pharmacy, University of Barcelona, Barcelona, Spain; Lee Kong Chian School of Medicine, Nanyang Technological University, The Academia, 20 College Road, 169856, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.02.010DOI Listing
May 2015

PPAR-β/δ activation promotes phospholipid transfer protein expression.

Biochem Pharmacol 2015 Mar 7;94(2):101-8. Epub 2015 Feb 7.

Institut d'Investigacions Biomèdiques (IIB) Sant Pau, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain; Departament de Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.01.016DOI Listing
March 2015

Remarkable quantitative and qualitative differences in HDL after niacin or fenofibrate therapy in type 2 diabetic patients.

Atherosclerosis 2015 Feb 9;238(2):213-9. Epub 2014 Dec 9.

Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain; Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), CIBERDEM, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.12.006DOI Listing
February 2015

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.

Diabetologia 2014 Oct 26;57(10):2126-35. Epub 2014 Jul 26.

Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Diagonal 643, 08028, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00125-014-3331-8DOI Listing
October 2014

Effect of ovariectomy on inflammation induced by intermittent hypoxia in a mouse model of sleep apnea.

Respir Physiol Neurobiol 2014 Oct 20;202:71-4. Epub 2014 Aug 20.

CIBER de Enfermedades Respiratorias, Madrid, Spain; Unitat Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15699048140020
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http://dx.doi.org/10.1016/j.resp.2014.08.009DOI Listing
October 2014

PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells.

Int J Cardiol 2014 Jun 8;174(1):110-8. Epub 2014 Apr 8.

Department of Pharmacology and Therapeutic Chemistry, IBUB (Institut de Biomedicina de la Universitat de Barcelona), CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Faculty of Pharmacy, University of Barcelona, Diagonal 643, Barcelona E-08028, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273140062
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http://dx.doi.org/10.1016/j.ijcard.2014.03.176DOI Listing
June 2014

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.

Int J Cardiol 2013 Oct 6;168(4):3160-72. Epub 2013 Aug 6.

Department of Pharmacology and Therapeutic Chemistry, IBUB (Institut de Biomedicina de la Universitat de Barcelona), Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Faculty of Pharmacy, University of Barcelona, Diagonal 643, Barcelona E-08028, Spain.

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http://dx.doi.org/10.1016/j.ijcard.2013.07.150DOI Listing
October 2013

Resveratrol induces nuclear factor-κB activity in human cardiac cells.

Int J Cardiol 2013 Sep 27;167(6):2507-16. Epub 2012 Jun 27.

Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of Barcelona and IBUB, Institut de Biomedicina de la Universitat de Barcelona, 643 Diagonal, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ijcard.2012.06.006DOI Listing
September 2013

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.

Biochim Biophys Acta 2013 Aug 16;1832(8):1241-8. Epub 2013 Mar 16.

Unitat de Farmacologia, Department de Farmacologia i Química Terapèutica, Facultat de Farmàcia, Universitat de Barcelona, Institut de Biomedicina de la UB, IBUB, Spain.

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http://dx.doi.org/10.1016/j.bbadis.2013.03.006DOI Listing
August 2013

TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes.

Biochim Biophys Acta 2012 Sep 7;1821(9):1177-85. Epub 2012 Jun 7.

Department of Pharmacology and Therapeutic Chemistry, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.bbalip.2012.05.006DOI Listing
September 2012

Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus.

Expert Opin Ther Targets 2012 Feb 27;16(2):209-23. Epub 2012 Jan 27.

University of Barcelona, Department of Pharmacology and Therapeutic Chemistry, Barcelona, Spain.

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http://www.tandfonline.com/doi/full/10.1517/14728222.2012.65
Publisher Site
http://dx.doi.org/10.1517/14728222.2012.658370DOI Listing
February 2012

The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells.

PLoS One 2011 23;6(5):e19724. Epub 2011 May 23.

Department of Pharmacology and Therapeutic Chemistry, IBUB (Institut de Biomedicina de la Universitat de Barcelona) and CIBERDEM, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019724PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100304PMC
November 2011

The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease.

PPAR Res 2010 27;2010. Epub 2010 Jul 27.

Department of Pharmacology and Therapeutic Chemistry, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Faculty of Pharmacy, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain.

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http://www.hindawi.com/journals/ppar/2010/368467/
Publisher Site
http://dx.doi.org/10.1155/2010/368467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913795PMC
July 2011

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

Endocrinology 2011 May 1;152(5):1848-59. Epub 2011 Mar 1.

Department of Pharmacology and Therapeutic Chemistry, and Institut de Biomedicina de la University of Barcelona, Barcelona. Spain.

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http://dx.doi.org/10.1210/en.2010-1468DOI Listing
May 2011

PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.

Biochim Biophys Acta 2011 Feb 9;1811(2):59-67. Epub 2010 Nov 9.

Department of Pharmacology and Therapeutic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.bbalip.2010.11.002DOI Listing
February 2011

The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1.

Biochem Pharmacol 2011 Feb 10;81(4):534-43. Epub 2010 Dec 10.

Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Institut de Biomedicina de la UB (IBUB), Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S000629521000845
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http://dx.doi.org/10.1016/j.bcp.2010.12.004DOI Listing
February 2011

The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells.

Cardiovasc Res 2010 Aug 7;87(3):449-58. Epub 2010 Mar 7.

Department of Pharmacology and Therapeutic Chemistry, IBUB (Institut de Biomedicina de Universitat de Barcelona)-Instituto de Salud Carlos III, Faculty of Pharmacy, University of Barcelona, Diagonal 643, Barcelona E-08028, Spain.

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http://dx.doi.org/10.1093/cvr/cvq080DOI Listing
August 2010

Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells.

Endocrinology 2010 Feb 18;151(2):537-48. Epub 2009 Dec 18.

Department of Pharmacology and Therapeutic Chemistry and Institut de Biomedicina de la Universitat de Barcelona, Faculty of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1210/en.2009-0874DOI Listing
February 2010

TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model.

Cardiovasc Res 2009 Mar 27;81(4):703-12. Epub 2008 Nov 27.

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, IBUB and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
Publisher Site
http://dx.doi.org/10.1093/cvr/cvn327DOI Listing
March 2009

Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A.

Hepatology 2009 Jan;49(1):106-15

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III, University of Barcelona, Spain.

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http://dx.doi.org/10.1002/hep.22570DOI Listing
January 2009

Peroxisome proliferator-activated receptor (PPAR) beta/delta: a new potential therapeutic target for the treatment of metabolic syndrome.

Curr Mol Pharmacol 2009 Jan;2(1):46-55

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Institut de Biomedicina de la UB University of Barcelona, Diagonal 643, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.2174/1874467210902010046DOI Listing
January 2009

Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.

Diabetes 2008 Aug 28;57(8):2149-57. Epub 2008 Apr 28.

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, Institut de Biomedicina de la UB (IBUB) and CIBERDEM-Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.2337/db08-0176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494695PMC
August 2008

Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.

Biochim Biophys Acta 2008 Jan-Feb;1781(1-2):26-35. Epub 2007 Nov 12.

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, IBUB (Institut de Biomedicina de la UB) and CIBER Diabetes y Enfermedades Metabólicas, Instituto de Salud Carlos III, University of Barcelona, Spain.

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http://dx.doi.org/10.1016/j.bbalip.2007.10.009DOI Listing
April 2008

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells.

J Biol Chem 2008 Apr 14;283(17):11107-16. Epub 2008 Feb 14.

Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M708700200DOI Listing
April 2008

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy.

J Gerontol A Biol Sci Med Sci 2007 Dec;62(12):1326-36

Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, and IBUB, Faculty of Pharmacy, University of Barcelona, Spain.

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http://dx.doi.org/10.1093/gerona/62.12.1326DOI Listing
December 2007

Antiatherogenic role of high-density lipoproteins: insights from genetically engineered-mice.

Front Biosci 2006 May 1;11:1328-48. Epub 2006 May 1.

Servei de Bioquimica, Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, Antoni M. Claret 167, 08025 Barcelona, Spain.

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http://dx.doi.org/10.2741/1887DOI Listing
May 2006

Paradoxical exacerbation of combined hyperlipidemia in human apolipoprotein A-II transgenic mice treated with fenofibrate.

Biochim Biophys Acta 2005 Dec 30;1737(2-3):130-7. Epub 2005 Sep 30.

Servei de Bioquímica i Institut de Recerca, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.bbalip.2005.09.009DOI Listing
December 2005

Direct evidence in vivo of impaired macrophage-specific reverse cholesterol transport in ATP-binding cassette transporter A1-deficient mice.

Biochim Biophys Acta 2005 Dec 27;1738(1-3):6-9. Epub 2005 Dec 27.

Servei de Bioquímica i Institut de Recerca, Hospital de la Santa Creu i Sant Pau, C/Antoni M. Claret 167, 08025 Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810500293
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http://dx.doi.org/10.1016/j.bbalip.2005.11.012DOI Listing
December 2005

[Adiponectin: a new link between obesity, insulin resistance and cardiovascular disease].

Med Clin (Barc) 2005 Mar;124(10):388-95

Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

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http://dx.doi.org/10.1157/13072576DOI Listing
March 2005