Publications by authors named "Xavier Montalban"

100Publications

Multiple sclerosis and nutrition: back to the future?

Ther Adv Neurol Disord 2020 31;13:1756286420936165. Epub 2020 Jul 31.

Department of Neurology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1177/1756286420936165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432976PMC
July 2020

Menopause and multiple sclerosis: Influence on prognosis and role of disease-modifying drugs and hormonal replacement therapy.

Mult Scler 2020 Aug 28:1352458520952022. Epub 2020 Aug 28.

Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458520952022DOI Listing
August 2020

Ofatumumab versus Teriflunomide in Multiple Sclerosis.

N Engl J Med 2020 08;383(6):546-557

From the UCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco (S.L.H.); the Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.B.-O.); the Department of Neurology, Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland (J.A.C.); the Institute of Experimental Neurology and Multiple Sclerosis Center IRCCS, San Raffaele Hospital, Milan (G.C.); the Department of Neurology, Fleni, Buenos Aires (J.C.); the Department of Neurology, Stony Brook University, Stony Brook, NY (P.K.C.); Washington University School of Medicine, St. Louis (A.H.C.); the University Hospital of Strasburg and Clinical Investigation Center INSERM 1434, Strasburg, France (J.S.); University Hospital Basel (D.L.), Novartis Pharma (C.K., R.W., A.K., D.T., D.A.H., K.R., M.M.), and the Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital and University of Basel (L.K.) - all in Basel, Switzerland; the Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari Vall d'Hebron, Barcelona (X.M.); the University of Warmia and Mazury, Olsztyn, and the Center of Neurology, Lodz - both in Poland (K.S.); the Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany (H.W.); and Novartis Pharmaceuticals, East Hanover, NJ (B.L., A.G., R.P.).

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http://dx.doi.org/10.1056/NEJMoa1917246DOI Listing
August 2020

The apparently milder course of multiple sclerosis: changes in the diagnostic criteria, therapy and natural history.

Brain 2020 Sep;143(9):2637-2652

Department of Neurology, Hospital General Universitari Vall D'Hebron, Cemcat, Barcelona, Spain.

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http://dx.doi.org/10.1093/brain/awaa145DOI Listing
September 2020

Five years of ocrelizumab in relapsing multiple sclerosis: OPERA studies open-label extension.

Neurology 2020 Sep 20;95(13):e1854-e1867. Epub 2020 Jul 20.

From the Department of Neurology (S.L.H.), University of California, San Francisco; Neurologic Clinic and Policlinic (L.K.), Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Switzerland; NeuroRx Research (D.L.A.); Departments of Neurology and Neurosurgery (D.L.A.), McGill University, Montreal, Canada; Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics (A.B.-O.), University of Pennsylvania, Philadelphia; Department of Neurology (B.B.), CHU de Bordeaux, France; Department of Neurology (R.T.N.), Washington University School of Medicine, St. Louis, MO; Division of Neurology (A.T.), Department of Medicine, University of British Columbia, Vancouver, Canada; Department of Neurology (J.S.W.), McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth); F. Hoffmann-La Roche Ltd (S.B., H.K., M.M., F.M., S.H.), Basel, Switzerland; Genentech, Inc. (V.L., L.M.), South San Francisco, CA; Division of Neurology (X.M.), University of Toronto, Canada; and Department of Neurology-Neuroimmunology (X.M.), Vall d'Hebron University Hospital, Barcelona, Spain. During completion of the work related to this article, S.B. and L.M. were employees of F. Hoffmann-La Roche Ltd; current affiliations are Biogen (S.B.), Cambridge, MA; and Alder Biopharmaceuticals Inc. (L.M.), Bothell, WA.

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http://dx.doi.org/10.1212/WNL.0000000000010376DOI Listing
September 2020

Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.

Neurotherapeutics 2020 Jul 17. Epub 2020 Jul 17.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1007/s13311-020-00885-8DOI Listing
July 2020

A randomized, placebo-controlled, phase 2 trial of laquinimod in primary progressive multiple sclerosis.

Neurology 2020 Aug 10;95(8):e1027-e1040. Epub 2020 Jul 10.

From Barts and The London School of Medicine and Dentistry (G.G.), Blizard Institute, Queen Mary University of London, UK; Teva Pharmaceuticals R&D (V.K.), Teva Pharmaceutical Industries (T.L.), Great Valley, PA; Department of Neurology, Medical Faculty (V.K., H.-P.H.), Heinrich-Heine Universität Düsseldorf, Germany; Teva Pharmaceutical Industries (J.R.S., A.P.T.), Malvern, PA; Corinne Goldsmith Dickinson Center for Multiple Sclerosis (S.K.) and Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY; Departments of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health and Center of Excellence for Biomedical Research (A.U.) and Department of Health Sciences (M.P.S.), University of Genoa; Ospedale Policlinico San Martino-IRCCS (A.U.), Genoa, Italy; Department of Neurology (B.M.J.U.), MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Division of Neurology (X.M.), University of Toronto/MS Centre St Michael's Hospital, Canada; Neurology-Neuroimmunology Department and Neurorehabilitation Unit (X.M.), Multiple Sclerosis Centre of Catalonia; Department of Neurology (X.M.), Hospital Universitari de la Vall d'Hebron, Barcelona, Spain; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco; Radiology & Nuclear Medicine (F.L.), VU University Medical Center, Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000010284DOI Listing
August 2020

Expert opinion on the use of cladribine tablets in clinical practice.

Ther Adv Neurol Disord 2020 24;13:1756286420935019. Epub 2020 Jun 24.

Department of Neurology, Center for Clinical Neuroplasticity, Medical Park Loipl, Bischofswiesen, University of Erlangen, Germany.

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http://dx.doi.org/10.1177/1756286420935019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318823PMC
June 2020

Optical coherence tomography measures correlate with brain and spinal cord atrophy and multiple sclerosis disease-related disability.

Eur J Neurol 2020 Jun 30. Epub 2020 Jun 30.

Servicio de Neurologia-Neuroinmunologia. Centro de Esclerosis Múltiple de Cataluña (Cemcat), Hospital Universitario Vall d'Hebron, Barcelona, España.

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http://dx.doi.org/10.1111/ene.14421DOI Listing
June 2020

Keeping standards of multiple sclerosis care through the COVID-19 pandemic.

Mult Scler 2020 09 19;26(10):1153-1156. Epub 2020 Jun 19.

Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Edifici Cemcat, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458520931785DOI Listing
September 2020

Chitinase 3-like 1 is neurotoxic in primary cultured neurons.

Sci Rep 2020 04 28;10(1):7118. Epub 2020 Apr 28.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41598-020-64093-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188887PMC
April 2020

Vitamin D, smoking, EBV, and long-term cognitive performance in MS: 11-year follow-up of BENEFIT.

Neurology 2020 05 16;94(18):e1950-e1960. Epub 2020 Apr 16.

From the Department of Nutrition (M.C., K.L.M, A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Global Public Health and Primary Care (M.C.), University of Bergen, Bergen, Norway; Department of Neurology (E.H.M.-L.), Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain; Departments of Medicine, Biomedicine and Clinical Research (C.B., L.K., J.K.), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Basel, Switzerland; CHU Hôpital Pontchaillou (G.E.), Rennes, France; University of Ottawa and Ottawa Hospital Research Institute (M.S.F.), Ottawa, Canada; Department of Neurology (H.-P.H.), Medical Faculty, Heinrich-Heine Universität, Düsseldorf, Germany; St. Michael's Hospital (X.M.), University of Toronto, Canada and Multiple Sclerosis Center of Catalonia (Cemcat) (X.M.), Vall d'Hebron University Hospital, Barcelona, Spain; Ferkauf Graduate School of Psychology (F.W.F.), Yeshiva University, New York, NY; Department of Neurology (I.K.P.), Medical Faculty, Heinrich-Heine Universität, Düsseldorf and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.K.P.), Düsseldorf, Germany; Technical University of Munich (B.H.), School of Medicine and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany; Central Texas Neurology Consultants (E.J.F.), Round Rock, TX; Neuroimmunology and Multiple Sclerosis Research (S.S.), Department of Neurology, University Hospital Zurich, University of Zurich and Center for Neuroscience Zurich (S.S.), Federal Institute of Technology (ETH), Zurich, Switzerland; Bayer AG (E.-M.W.), Berlin, Germany; Department of Epidemiology (A.A.), Harvard T.H. Chan School of Public Health, Boston, MA and Channing Division of Network Medicine (A.A.); and Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000009371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274920PMC
May 2020

A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.

Cells 2020 Apr 7;9(4). Epub 2020 Apr 7.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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http://dx.doi.org/10.3390/cells9040906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226819PMC
April 2020

A validation study of manual atrophy measures in patients with Multiple Sclerosis.

Neuroradiology 2020 Aug 3;62(8):955-964. Epub 2020 Apr 3.

Section of Neuroradiology and Magnetic Resonance Unit, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00234-020-02401-3DOI Listing
August 2020

Targeted resequencing reveals rare variants enrichment in multiple sclerosis susceptibility genes.

Hum Mutat 2020 Jul 1;41(7):1308-1320. Epub 2020 Apr 1.

Servei de Neurologia-Neuroimmunologia, Center d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/humu.24016DOI Listing
July 2020

A New Risk Variant for Multiple Sclerosis at 11q23.3 Is Associated with Expansion of Circulating Regulatory T Cells.

J Clin Med 2020 Feb 26;9(3). Epub 2020 Feb 26.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat). Institut de Recerca Vall d'Hebron (VHIR). Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.

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http://dx.doi.org/10.3390/jcm9030625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141122PMC
February 2020

Associations of paediatric demyelinating and encephalitic syndromes with myelin oligodendrocyte glycoprotein antibodies: a multicentre observational study.

Lancet Neurol 2020 03 10;19(3):234-246. Epub 2020 Feb 10.

Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Catalan Institute for Research and Advanced Studies, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30488-0DOI Listing
March 2020

Biosensors to monitor MS activity.

Mult Scler 2020 04 22;26(5):605-608. Epub 2020 Jan 22.

MS Centre, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1352458519888178DOI Listing
April 2020

CNS demyelination after initiating the tyrosine kinase inhibitor imatinib: A report of two cases.

Mult Scler 2020 Aug 17;26(9):1121-1124. Epub 2019 Dec 17.

Division of Oncology, Department of Medicine, University of Toronto and Princess Margaret Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1352458519892914DOI Listing
August 2020

Differential item functioning of the Arm function in Multiple Sclerosis Questionnaire (AMSQ) by language, a study in six countries.

Mult Scler 2019 Dec 17:1352458519895450. Epub 2019 Dec 17.

Department of Epidemiology and Biostatistics, Amsterdam UMC, Location VUmc and Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458519895450DOI Listing
December 2019

Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS.

Neurology 2019 11 14;93(20):e1852-e1866. Epub 2019 Oct 14.

From the Neuroimaging Research Unit (M.A.R., P.V., A.M., P.P., M.F.) and Neurology Unit (M.A.R., P.P., G.C., M.F.), Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Neurology (C.G., C.Z.), Neurocenter of Southern Switzerland, Regional Hospital Lugano (EOC), Lugano; Faculty of Biomedical Sciences (C.G., C.Z.), Università della Svizzera Italiana, Lugano, Switzerland; Section of Neuroradiology and MRI Unit, Department of Radiology (A.R.), and Department of Neurology/Neuroimmunology (X.M.), Multiple Sclerosis Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; NMR Research Unit (H.K., O.C.), Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London; Nuffield Department of Clinical Neurosciences (L.M., J.P.), University of Oxford, UK; Department of Advanced Medical and Surgical Sciences, and 3T MRI Center, (A.G., A.B.), University of Campania "Luigi Vanvitelli," Naples, Italy; Department of Neurology (A.G., P.E.), Universitätsmedizin Mannheim, University of Heidelberg, Germany; Department of Radiology and Nuclear Medicine (C.L., B.B.) and Institute of Neuroradiology (C.L., B.B.), St. Josef Hospital, Ruhr-University Bochum, Germany; Department of Radiology and Nuclear Medicine (F.B., H.V.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; and Vita-Salute San Raffaele University (P.P., G.C., M.F.), Milan, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000008466DOI Listing
November 2019

The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS.

Mult Scler 2019 Oct 15:1352458519877810. Epub 2019 Oct 15.

Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Servei de Neurologia/Neuroimmunologia, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain/Division of Neurology, University of Toronto, St Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1352458519877810DOI Listing
October 2019

Head-to-head drug comparisons in multiple sclerosis: Urgent action needed.

Neurology 2019 10 7;93(18):793-809. Epub 2019 Oct 7.

From the Department of Neuroinflammation (C.T.), Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, University College London, UK; Neurology/Neuroimmunology Department (C.T., M.T., X.M.), Multiple Sclerosis Centre of Catalonia, Vall d'Hebron University Hospital, Barcelona, Spain; Department of Medicine (T.K.), CORe, University of Melbourne, Australia; Department of Neurology (T.K.), Royal Melbourne Hospital, Australia; Division of Neurology (J.O., X.M.), University of Toronto, St Michael's Hospital, Canada; Department of Health Sciences (DISSAL) (M.P.S.), University of Genoa, Italy; and Central Clinical School (H.B.), Alfred Centre, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000008319DOI Listing
October 2019

A pharmacogenetic study implicates in the response to Interferon-β in multiple sclerosis.

Mult Scler 2020 Aug 21;26(9):1074-1082. Epub 2019 Jun 21.

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, Milan, Italy/Department of Biomedical Sciences for Health, University of Milan, Milan, Italy/Department of Neurology, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

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http://dx.doi.org/10.1177/1352458519851428DOI Listing
August 2020

Oligoclonal bands do not represent dissemination in time in the 2017 revisions to the McDonald criteria.

Mult Scler 2019 10 16;25(12):1690-1691. Epub 2019 May 16.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://journals.sagepub.com/doi/10.1177/1352458519846103
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http://dx.doi.org/10.1177/1352458519846103DOI Listing
October 2019

Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis.

N Engl J Med 2019 06 10;380(25):2406-2417. Epub 2019 May 10.

From Vall d'Hebron University Hospital, Barcelona (X.M.); St. Michael's Hospital, University of Toronto, Toronto (X.M.), and Montreal Neurological Institute and NeuroRx Research, Montreal (D.L.A.) - both in Canada; the Institute of Neuropathology and the Department of Neurology, University Medical Center, Göttingen, Germany (M.S.W.); the Department of Neurology, Acibadem City Clinic Tokuda Hospital, Sofia, Bulgaria (I.S.); the Department of Histology and Embryology, Poznan University of Medical Science, Poznan, Poland (K.P.-S.); the Global Clinical Development Center, EMD Serono Research and Development Institute, Billerica, MA (J.W., E.M., F.D., S.S.); and McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.).

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http://dx.doi.org/10.1056/NEJMoa1901981DOI Listing
June 2019

Reaching an evidence-based prognosis for personalized treatment of multiple sclerosis.

Nat Rev Neurol 2019 May;15(5):287-300

Division of Neurology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41582-019-0170-8DOI Listing
May 2019

Does attendance at the ECTRIMS congress impact on therapeutic decisions in multiple sclerosis care?

Mult Scler J Exp Transl Clin 2019 Jan-Mar;5(1):2055217319835226. Epub 2019 Mar 18.

Department of Medicine, St. Michael's Hospital, Toronto, Canada.

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http://dx.doi.org/10.1177/2055217319835226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423673PMC
March 2019

Safety of cladribine tablets in the treatment of patients with multiple sclerosis: An integrated analysis.

Mult Scler Relat Disord 2019 Apr 20;29:157-167. Epub 2018 Nov 20.

Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.msard.2018.11.021DOI Listing
April 2019

Brain regional volume estimations with NeuroQuant and FIRST: a study in patients with a clinically isolated syndrome.

Neuroradiology 2019 Jun 5;61(6):667-674. Epub 2019 Mar 5.

Neuroradiology Section, Department of Radiology, Vall d'Hebron University Hospital and Research Institute (VHIR), Autonomous University, Psg. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00234-019-02191-3DOI Listing
June 2019

Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis.

Neurology 2019 03 1;92(13):e1507-e1516. Epub 2019 Mar 1.

From the Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology (M.I.Z., S.O.-R., G.A., L.N., I.G., J.R., M.C., C.N., M.J.A., A.V.-J., J.C., B.R., L.M., P.M., J.S.-G., X.M., M.T.), and Unitat de RM, Servei de Radiologia (M.I.Z., A.R., L.N., R.M., C.A., X.M.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona; Unitat d'Estadística i Bioinformàtica (UEB) (M.I.Z., S.P.-H., L.N., X.M.), Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; Servicio de Neurología (M.I.Z., L.N., X.M.), Instituto Neurológico de Colombia, Medellín, Colombia; Raul Carrea Institute for Neurological Research (L.N., X.M.), FLENI, Buenos Aires, Argentina; and Division of Neurology (X.M.), St. Michael's Hospital, University of Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000007178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453769PMC
March 2019

Ocrelizumab efficacy in subgroups of patients with relapsing multiple sclerosis.

J Neurol 2019 May 28;266(5):1182-1193. Epub 2019 Feb 28.

Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

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http://link.springer.com/10.1007/s00415-019-09248-6
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http://dx.doi.org/10.1007/s00415-019-09248-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469695PMC
May 2019

Simultaneous CMV and infection following alemtuzumab treatment for multiple sclerosis.

Neurology 2019 02 26;92(6):296-298. Epub 2018 Dec 26.

From the Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat) (A.P., L.M., J.C., P.M., A.V.-J., G.A., B.R.-A., J.S.-G., J.R., M.C., I.G., M.T., X.M.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; Department of Internal Medicine (C.P.B.R.) and Center of Biomedical Research in Network on Neurodegenerative Diseases (CIBERNED) (C.P.B.R.), Sant Joan d'Alacant University Hospital, Alicante, Spain; Department of Neurology (A.P.), Hospital Italiano, Buenos Aires, Argentina; Department of Infectious Diseases (C.P.B.R., A.A.P., I.R.C.) and Microbiology Department (M.L.), Vall d'Hebron University Hospital, Barcelona, Spain; and Division of Neurology (X.M.), University of Toronto, St Michael's Hospital, Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000006801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382059PMC
February 2019

Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge.

Neurology 2019 01 26;92(4):180-192. Epub 2018 Dec 26.

From the Department of Neurosciences (C.G., L.P.), San Camillo-Forlanini Hospital, Rome, Italy; Centre d'Esclerosi Multiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology (M.T., J.R., J.S.-G., X.M.), and Magnetic Resonance Unit, Department of Radiology (A.R.), Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Biostatistics Unit (M.P.S.), Department of Health Sciences, University of Genoa; Neuroimaging Research Unit (M.F., M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Nuffield Department of Clinical Neurosciences (J.P.), West Wing, John Radcliffe Hospital, Oxford; Institutes of Neurology & Healthcare Engineering (O.C., F.B.), University College London (O.C.), UK; Amsterdam Neuroscience and Department of Radiology and Nuclear Medicine (F.B., H.V.), VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology (J.L.F.), Rigshospitalet Glostrup and University of Copenhagen, Denmark; Neuroradiological Academic Unit (T.A.Y.), Institute of Neurology, London, UK; Department of Neurology (C.E.), Medical University of Graz, Austria; Neurologic Clinic and Policlinic, Department of Medicine (L.K.), Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Switzerland; Department of Neurology and Psychiatry (C.P.), Sapienza University, Rome; and Neurology and Neurometabolic Unit, Department of Neurological and Behavioral Sciences (N.D.S.), University of Siena, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000006810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345120PMC
January 2019

Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions.

Am J Pathol 2019 03 13;189(3):665-676. Epub 2018 Dec 13.

Neurology-Neuroimmunology Department, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Barcelona, Spain; Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.11.007DOI Listing
March 2019

Circulating EZH2-positive T cells are decreased in multiple sclerosis patients.

J Neuroinflammation 2018 Oct 26;15(1):296. Epub 2018 Oct 26.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12974-018-1336-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202809PMC
October 2018

The Multiple Sclerosis Care Unit.

Mult Scler 2019 04 23;25(5):627-636. Epub 2018 Oct 23.

Department of Neurology and Institute of Experimental Neurology, Vita-Salute San Raffaele University, San Raffaele Hospital, Milan, Italy.

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http://dx.doi.org/10.1177/1352458518807082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439947PMC
April 2019

Therapeutic Inertia in Multiple Sclerosis Care: A Study of Canadian Neurologists.

Front Neurol 2018 24;9:781. Epub 2018 Sep 24.

Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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https://www.frontiersin.org/article/10.3389/fneur.2018.00781
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http://dx.doi.org/10.3389/fneur.2018.00781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165907PMC
September 2018

Multiple sclerosis: clinical aspects.

Curr Opin Neurol 2018 12;31(6):752-759

Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://Insights.ovid.com/crossref?an=00019052-900000000-9908
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http://dx.doi.org/10.1097/WCO.0000000000000622DOI Listing
December 2018

Myasthenia gravis following alemtuzumab therapy for multiple sclerosis.

Neurology 2018 09 24;91(13):622-624. Epub 2018 Aug 24.

From the Servei de Neurologia/Neuroimmunologia, Multiple Sclerosis Centre of Catalonia (CEM-Cat) (L.M., J.S.-G., X.M., M.T.), Servei de Neurofisiologia Clínica, Unitat d'Electromiografia (M.G., N.R.), and Servei de Neurologia (E.C.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), University of Toronto, St Michael's Hospital, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000006251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161544PMC
September 2018

Usability of an Educational Intervention to Overcome Therapeutic Inertia in Multiple Sclerosis Care.

Front Neurol 2018 10;9:522. Epub 2018 Jul 10.

Healthcare Analytics Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fneur.2018.00522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048250PMC
July 2018

Cladribine tablets added to IFN-β in active relapsing MS: The ONWARD study.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 11;5(5):e477. Epub 2018 Jul 11.

Department of Neurology-Neuroimmunology (X.M.), Multiple Sclerosis Center of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Department of Neurology (X.M.), St. Michael's Hospital, University of Toronto, Ontario, Canada; Division of Clinical Neuroimmunology (T.P.L.), Jefferson University, Comprehensive MS Center, Philadelphia, PA; Department of Neurology (B.A.C.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurology (H.M.), Vanderbilt University Medical Center, Nashville, TN; inScience Communications (J.C.), Springer Healthcare, Chester, United Kingdom; Research and Development Global BioStatistics (C.H.), Merck KGaA, Darmstadt, Germany; and Global Clinical Development Center (F.D.), EMD Serono Inc., Billerica, MA.

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http://nn.neurology.org/lookup/doi/10.1212/NXI.0000000000000
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http://dx.doi.org/10.1212/NXI.0000000000000477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047834PMC
September 2018

Restoring Axonal Function with 4-Aminopyridine: Clinical Efficacy in Multiple Sclerosis and Beyond.

CNS Drugs 2018 07;32(7):637-651

Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

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http://dx.doi.org/10.1007/s40263-018-0536-2DOI Listing
July 2018

Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis.

Mult Scler 2019 10 9;25(11):1535-1538. Epub 2018 Jul 9.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458518786055DOI Listing
October 2019

Ocrelizumab: a new milestone in multiple sclerosis therapy.

Ther Adv Neurol Disord 2018 10;11:1756286418773025. Epub 2018 May 10.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Edif. Antiga EUI, Pl 2, Barcelona, 08035, SpainDivision of Neurology, University of Toronto, 190 Elizabet Street R. Fraser Elliott Building, 3-805, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1756286418773025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952271PMC
May 2018

Disease-modifying therapy in multiple sclerosis: Two guidelines (almost) passing in the night.

Mult Scler 2018 04;24(5):558-562

Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron University Hospital, Barcelona, Spain; Division of Neurology, University of Toronto, St Michael's Hospital, Toronto, ON, Canada.

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http://journals.sagepub.com/doi/10.1177/1352458518767323
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http://dx.doi.org/10.1177/1352458518767323DOI Listing
April 2018

Therapeutic Inertia in the New Landscape of Multiple Sclerosis Care.

Front Neurol 2018 20;9:174. Epub 2018 Mar 20.

Outcomes and Decision Neuroscience lab, Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fneur.2018.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869922PMC
March 2018

Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials.

Mult Scler 2019 04 9;25(4):565-573. Epub 2018 Mar 9.

Department of Neurology, Klinikum rechts der Isar, Technische Universität München, München, Germany/German Competence Network Multiple Sclerosis (KKNMS), München, Germany/Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

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http://dx.doi.org/10.1177/1352458518763089DOI Listing
April 2019

Severe hypertriglyceridemia associated with teriflunomide in a patient with multiple sclerosis: A case report.

Mult Scler 2018 09 23;24(10):1383-1385. Epub 2018 Feb 23.

Servei de Neurología-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458518761185DOI Listing
September 2018

The value of oligoclonal bands in the multiple sclerosis diagnostic criteria.

Brain 2018 04;141(4):1075-1084

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1093/brain/awy006DOI Listing
April 2018

Classic Block Design "Pseudo"-Resting-State fMRI Changes After a Neurorehabilitation Program in Patients with Multiple Sclerosis.

J Neuroimaging 2018 05 5;28(3):313-319. Epub 2018 Feb 5.

Section of Neuroradiology, Department of Radiology, University Hospital Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1111/jon.12500DOI Listing
May 2018

Quantitative spinal cord MRI in radiologically isolated syndrome.

Neurol Neuroimmunol Neuroinflamm 2018 Mar 17;5(2):e436. Epub 2018 Jan 17.

Division of Neurology (P.A.-L., K.C., S.S., C.C., M.H., D.S., X.M., J.O.), Department of Medicine; Division of Neuroradiology (P.A.-L., G.L., A.B.), Department of Medical Imaging; Division of Neurosurgery (A.B.), Department of Surgery, St. Michael's Hospital, University of Toronto, Ontario, Canada; Department of Neurology-Neuroimmunology Neurorehabilitation Unit (X.M.), Multiple Sclerosis Center of Catalonia (Cemcat), Barcelona, Spain; and Department of Neurology (J.O.), Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1212/NXI.0000000000000436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773843PMC
March 2018

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.

Mult Scler 2018 02 20;24(2):96-120. Epub 2018 Jan 20.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458517751049DOI Listing
February 2018

Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study.

Lancet Neurol 2018 02 21;17(2):133-142. Epub 2017 Dec 21.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1016/S1474-4422(17)30469-6DOI Listing
February 2018

Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis.

Autoimmun Rev 2018 Feb 28;17(2):165-174. Epub 2017 Nov 28.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain; Universitat Autònoma de Barcelona, 08193, Bellaterra, Cerdanyola del Vallès, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2017.11.019DOI Listing
February 2018

NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.

Mult Scler 2018 10 9;24(11):1507-1510. Epub 2017 Nov 9.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458517739137DOI Listing
October 2018

Multiple sclerosis, and other demyelinating and autoimmune inflammatory diseases of the central nervous system.

Handb Clin Neurol 2017 ;146:67-84

Neurology and Neuroimmunology Service, Multiple Sclerosis Center of Catalunya and Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-804279-3.00005-8DOI Listing
June 2018

Lesion topographies in multiple sclerosis diagnosis: A reappraisal.

Neurology 2017 Dec 3;89(23):2351-2356. Epub 2017 Nov 3.

From Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (CEMCAT) (G.A., M.T., J.R., J.C., A.V.-J., I.G., C.N., M.C., P.M., B.R.-A., L.M., J.S.-G., X.M.), and Magnetic Resonance Unit, Department of Radiology (IDI) (C.A., R.M., A.d.B., A.R.), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital, University of Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000004715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719929PMC
December 2017

The optic nerve should be included as one of the typical CNS regions for establishing dissemination in space when diagnosing MS - No.

Mult Scler 2018 02 23;24(2):123-125. Epub 2017 Oct 23.

Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain/Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1352458517729451DOI Listing
February 2018

Progressive MS trials: Lessons learned.

Mult Scler 2017 Oct;23(12):1583-1592

Department of Neurology-Neuroimmunology and Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458517729460DOI Listing
October 2017

Blood lymphocyte subsets identify optimal responders to IFN-beta in MS.

J Neurol 2018 Jan 12;265(1):24-31. Epub 2017 Oct 12.

Servicio de Inmunología, Hospital Universitario Ramón y Cajal, IRYCIS, Ctra. Colmenar km 9.100, 28034, Madrid, Spain.

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http://dx.doi.org/10.1007/s00415-017-8625-6DOI Listing
January 2018

Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients.

Neurology 2017 Oct 15;89(15):1584-1593. Epub 2017 Sep 15.

From Biogen (T.P., K.K.M., G.K., D.M., K.E., M.S., I.N., Y.C., Q.D., P.-R.H., D.A.), Cambridge, MA; Ashfield Healthcare Communications (A.A.), Middletown, CT; Hôpital Civil (J.D.S.), Strasbourg, France; Mellen Center for Multiple Sclerosis (R.F.), Cleveland Clinic, OH; St. Josef Hospital (R.G.), Ruhr University, Bochum, Germany; Piedmont HealthCare (D.J.), Mooresville, NC; Neurologic Clinic and Policlinic (L.K.), Departments of Medicine, Clinical Research, Biomedicine, and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs MS Center and Pediatric MS Center of Excellence (B.W.-G.), Jacobs Neurological Institute, Buffalo, NY; Department of Neurology (H.-P.H.), Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; and University of California San Francisco Multiple Sclerosis Center (B.A.C.C.).

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http://dx.doi.org/10.1212/WNL.0000000000004485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634662PMC
October 2017

Diagnosis of multiple sclerosis: a multicentre study to compare revised McDonald-2010 and Filippi-2010 criteria.

J Neurol Neurosurg Psychiatry 2018 03 19;89(3):316-318. Epub 2017 Jul 19.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1136/jnnp-2017-315863DOI Listing
March 2018

Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop.

Mult Scler 2018 04 1;24(5):590-603. Epub 2018 Apr 1.

Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1177/1352458516686847DOI Listing
April 2018