Publications by authors named "Xavier Graña"

31Publications

Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase.

Prostate Cancer Prostatic Dis 2020 Sep 1. Epub 2020 Sep 1.

Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41391-020-00274-4DOI Listing
September 2020

Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle.

J Cell Sci 2019 10 18;132(20). Epub 2019 Oct 18.

Department of Bioengineering, Temple University, Philadelphia, PA 19122, USA

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http://dx.doi.org/10.1242/jcs.227116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826011PMC
October 2019

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer.

Adv Cancer Res 2019 12;144:55-93. Epub 2019 Apr 12.

Fels Institute for Cancer Research and Molecular Biology and Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2019.03.009DOI Listing
June 2020

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.

Cell Cycle 2015 ;14(1):18-30

a Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry; Temple University School of Medicine ; Philadelphia , PA USA.

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http://dx.doi.org/10.4161/15384101.2014.985069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612414PMC
September 2015

CDK9 inhibition strategy defines distinct sets of target genes.

BMC Res Notes 2014 May 16;7:301. Epub 2014 May 16.

Fels Institute for Cancer Research and Molecular Biology, AHP bldg,, room 308, 3307 North Broad St,, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1186/1756-0500-7-301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045923PMC
May 2014

Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Mol Cell Biol 2013 Aug 17;33(16):3330-42. Epub 2013 Jun 17.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.00082-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753905PMC
August 2013

PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer.

Genes Cancer 2012 Nov;3(11-12):739-48

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1947601912473479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636755PMC
November 2012

Monographs editor.

Authors:
Xavier Graña

Genes Cancer 2012 Nov;3(11-12):611

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http://dx.doi.org/10.1177/1947601912473480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636750PMC
November 2012

Complex effects of flavopiridol on the expression of primary response genes.

Cell Div 2012 Mar 29;7:11. Epub 2012 Mar 29.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, AHP bldg,, room 308, 3307 North Broad St, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1186/1747-1028-7-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339560PMC
March 2012

PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates.

Gene 2012 May 22;499(1):1-7. Epub 2012 Feb 22.

Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.gene.2012.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527233PMC
May 2012

B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.

J Biol Chem 2010 Sep 27;285(39):29863-73. Epub 2010 Jul 27.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1074/jbc.M110.162354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943288PMC
September 2010

Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation.

Genes Cancer 2010 Jan;1(1):69-80

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1947601909358105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904236PMC
January 2010

Selective control of gene expression by CDK9 in human cells.

J Cell Physiol 2010 Jan;222(1):200-8

Fels Institute for Cancer Research and Molecular Biology, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1002/jcp.21938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783197PMC
January 2010

Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.

J Biol Chem 2009 May 25;284(21):14126-35. Epub 2009 Mar 25.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M900687200
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http://dx.doi.org/10.1074/jbc.M900687200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682861PMC
May 2009

Downregulation of the phosphatase nuclear targeting subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines.

Authors:
Xavier Graña

Cancer Biol Ther 2008 Jun 14;7(6):842-4. Epub 2008 May 14.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.4161/cbt.7.6.6298DOI Listing
June 2008

Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.

J Biol Chem 2008 Apr 14;283(17):11280-92. Epub 2008 Feb 14.

Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1074/jbc.M709055200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431056PMC
April 2008

Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.

Gene 2007 Dec 19;405(1-2):65-78. Epub 2007 Sep 19.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.gene.2007.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222555PMC
December 2007

p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts.

Cancer Res 2007 May;67(9):4130-7

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0499DOI Listing
May 2007

Mechanisms controlling CDK9 activity.

Front Biosci 2006 Sep 1;11:2598-613. Epub 2006 Sep 1.

Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.2741/1994DOI Listing
September 2006

Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis.

Cancer Res 2005 Nov;65(22):10174-8

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2639DOI Listing
November 2005

Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes.

J Immunol 2005 Nov;175(10):6402-11

Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.4049/jimmunol.175.10.6402DOI Listing
November 2005

A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.

Cell Cycle 2004 Oct 15;3(10):1320-30. Epub 2004 Oct 15.

Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.4161/cc.3.10.1183DOI Listing
October 2004

Cellular control of gene expression by T-type cyclin/CDK9 complexes.

Gene 2004 Aug;337:15-23

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad St., Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.gene.2004.05.007DOI Listing
August 2004

CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.

Mol Cell Biol 2003 Aug;23(15):5165-73

Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165719PMC
http://dx.doi.org/10.1128/mcb.23.15.5165-5173.2003DOI Listing
August 2003

SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells.

Oncogene 2003 Apr;22(16):2443-51

Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1038/sj.onc.1206339DOI Listing
April 2003

G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression.

J Biol Chem 2002 Dec 24;277(52):50263-74. Epub 2002 Oct 24.

Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1074/jbc.M209181200DOI Listing
December 2002

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells.

Blood 2002 Oct;100(8):2753-62

Department of Biochemistry and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1182/blood.V100.8.2753DOI Listing
October 2002