Xavier Coumoul

Xavier Coumoul

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Xavier Coumoul

Xavier Coumoul

Publications by authors named "Xavier Coumoul"

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Associations between persistent organic pollutants and risk of breast cancer metastasis.

Environ Int 2019 Aug 2;132:105028. Epub 2019 Aug 2.

INSERM UMR-S 1124, 45 rue des Saints-Pères, 75006 Paris, France; Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2019.105028DOI Listing
August 2019

Microplastic freshwater contamination: an issue advanced by science with public engagement.

Environ Sci Pollut Res Int 2019 Jun 4;26(17):16904-16905. Epub 2019 May 4.

Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain.

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http://dx.doi.org/10.1007/s11356-019-05300-0DOI Listing
June 2019

A forum where french-speaking faculty can exchange research on teaching.

Biochem Mol Biol Educ 2019 May 29. Epub 2019 May 29.

Université de Strasbourg, CNRS UMR7156, Strasbourg, France.

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http://dx.doi.org/10.1002/bmb.21258DOI Listing
May 2019

Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.

Environ Health Perspect 2019 Apr;127(4):47005

1 University Paris Descartes , ComUE Sorbonne Paris Cité, Paris, France.

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https://ehp.niehs.nih.gov/doi/10.1289/EHP4200
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http://dx.doi.org/10.1289/EHP4200DOI Listing
April 2019

AhR signaling pathways and regulatory functions.

Biochim Open 2018 Dec 11;7:1-9. Epub 2018 Jun 11.

INSERM UMR-S 1124, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 rue des Saints-Pères, 75006 Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S22140085183000
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http://dx.doi.org/10.1016/j.biopen.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039966PMC
December 2018

Release and toxicity of adipose tissue-stored TCDD: Direct evidence from a xenografted fat model.

Environ Int 2018 12 31;121(Pt 2):1113-1120. Epub 2018 Oct 31.

INSERM UMR-S1124, Toxicologie Pharmacologie et Signalisation cellulaire, France; Université Paris Descartes, 45 rue des Saints-Pères, 75006 Paris, France; Sorbonne Paris Cité, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183138
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http://dx.doi.org/10.1016/j.envint.2018.10.027DOI Listing
December 2018

Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta.

Int J Mol Sci 2018 Nov 27;19(12). Epub 2018 Nov 27.

National Institute for Health and Medical Research, UMR-S 1139, Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, F-75006 Paris, France.

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http://dx.doi.org/10.3390/ijms19123762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321474PMC
November 2018

Integration of the human exposome with the human genome to advance medicine.

Biochimie 2018 Sep 28;152:155-158. Epub 2018 Jun 28.

INSERM UMR_S1138, Sorbonne Universités, Université Pierre & Marie Curie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Imperial College London, Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, London, United Kingdom; McGill University and Genome Quebec Innovation Centre, Montréal, Canada.

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http://dx.doi.org/10.1016/j.biochi.2018.06.023DOI Listing
September 2018

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.

ACS Chem Biol 2018 08 22;13(8):2067-2073. Epub 2018 Jun 22.

Chemistry of RNA, Nucleosides, Peptides and Heterocycles, CNRS UMR8601 , Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France.

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http://dx.doi.org/10.1021/acschembio.8b00250DOI Listing
August 2018

The Aryl Hydrocarbon Receptor and the Nervous System.

Int J Mol Sci 2018 Aug 24;19(9). Epub 2018 Aug 24.

Toxicologie Pharmacologie et Signalisation Cellulaire, INSERM UMR-S 1124, 45 rue des Saints-Pères, 75006 Paris, France.

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http://dx.doi.org/10.3390/ijms19092504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163841PMC
August 2018

Characterization of GMO or glyphosate effects on the composition of maize grain and maize-based diet for rat feeding.

Metabolomics 2018 02 17;14(3):36. Epub 2018 Feb 17.

UMR1332 Biologie du Fruit et Pathologie, INRA, Univ. Bordeaux, Centre INRA de Nouvelle Aquitaine - Bordeaux, 71 av Edouard Bourlaux, 33140, Villenave d'Ornon, France.

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http://dx.doi.org/10.1007/s11306-018-1329-9DOI Listing
February 2018

Aryl hydrocarbon receptor upregulates IL-1β expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure.

Toxicol In Vitro 2017 Jun 8;41:200-204. Epub 2017 Mar 8.

INSERM, UMR-S 1144, Paris F-75006, France; Université Paris Descartes, UMR-S 1144, Paris F-75006, France; Université Paris Diderot, UMR-S 1144, Paris F-75013, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08872333173006
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http://dx.doi.org/10.1016/j.tiv.2017.03.001DOI Listing
June 2017

Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model.

Environ Health Perspect 2017 03 7;125(3):428-436. Epub 2016 Oct 7.

INSERM UMR (Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche)-S1124, Paris, France.

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http://dx.doi.org/10.1289/EHP316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332187PMC
March 2017

Dimethyl-Benz(a)anthracene: A mammary carcinogen and a neuroendocrine disruptor.

Biochim Open 2016 Dec 8;3:49-55. Epub 2016 Oct 8.

INSERM UMR-S 1124, Université Paris Descartes, PRES Sorbonne Paris Cité, Pharmacologie Toxicologie et Signalisation Cellulaire, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints Pères, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.biopen.2016.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801823PMC
December 2016

Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration.

Toxicol Sci 2016 Jan 9;149(1):158-66. Epub 2015 Oct 9.

*INSERM UMR-S 1124, Toxicologie Pharmacologie et Signalisation cellulaire, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France;

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http://dx.doi.org/10.1093/toxsci/kfv221DOI Listing
January 2016

Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites.

Arch Toxicol 2015 Dec 17;89(12):2403-12. Epub 2014 Sep 17.

CNRS EAC 4413, Biologie Fonctionnelle et Adaptative, Université Paris Diderot, Sorbonne Paris Cité, 4 rue Marie-Andrée Lagroua Weill Hallé, 75213, Paris, France.

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http://dx.doi.org/10.1007/s00204-014-1367-7DOI Listing
December 2015

Editorial.

Authors:
Xavier Coumoul

Biochim Open 2015 14;1:60. Epub 2015 Nov 14.

Biochemistry and Toxicology, University Paris Descartes, INSERM UMR-S 1124, Pharmacology, Toxicology and Cell Signaling, France.

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http://dx.doi.org/10.1016/j.biopen.2015.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889471PMC
November 2015

Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case-control study in Guadeloupe (French West Indies).

Environ Health Perspect 2015 Apr 21;123(4):317-23. Epub 2014 Nov 21.

Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1085, IRSET, Pointe à Pitre, Guadeloupe, France.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1408407
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http://dx.doi.org/10.1289/ehp.1408407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384204PMC
April 2015

Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.

J Med Chem 2015 Jan 11;58(1):237-51. Epub 2014 Sep 11.

Chemistry & Biology, Nucleo(s)tides & Immunology for Therapy (CBNIT), CNRS UMR8601, Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale , 45 rue des Saints-Pères, 75270 Cedex 06 Paris, France.

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http://pubs.acs.org/doi/10.1021/jm500784e
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http://dx.doi.org/10.1021/jm500784eDOI Listing
January 2015

Citrulline reduces glyceroneogenesis and induces fatty acid release in visceral adipose tissue from overweight rats.

Mol Nutr Food Res 2014 Dec 31;58(12):2320-30. Epub 2014 Oct 31.

Université Paris Descartes, Sorbonne Paris Cité, France; Institut National de la Santé et de la Recherche Médicale UMR-S 1124, Faculté des Sciences Fondamentales et Biomédicales, Pharmacologie Toxicologie et Signalisation Cellulaire, Paris, France.

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http://dx.doi.org/10.1002/mnfr.201400507DOI Listing
December 2014

Oculomotor deficits in aryl hydrocarbon receptor null mouse.

PLoS One 2013 3;8(1):e53520. Epub 2013 Jan 3.

INSERM UMR-S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, Centre universitaire des Saints-Pères, Paris, France ; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536739PMC
August 2013

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications.

Drug Discov Today 2013 May 6;18(9-10):479-86. Epub 2012 Dec 6.

INSERM UMR-S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 rue des Saints Pères, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.drudis.2012.11.014DOI Listing
May 2013

Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.

Biochem Pharmacol 2012 Mar 16;83(5):627-32. Epub 2011 Dec 16.

INSERM UMR-S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 Rue des Saints Pères, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.bcp.2011.12.013DOI Listing
March 2012

The aryl hydrocarbon receptor system.

Drug Metabol Drug Interact 2012 Jan 31;27(1):3-8. Epub 2012 Jan 31.

INSERM UMR, Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1515/dmdi-2011-0035DOI Listing
January 2012

NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes.

Eur J Immunol 2011 Dec 10;41(12):3574-85. Epub 2011 Nov 10.

INSERM U986, Hôpital Cochin/Saint-Vincent de Paul, Paris, France.

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http://dx.doi.org/10.1002/eji.201141751DOI Listing
December 2011

Understanding SOS (Son of Sevenless).

Biochem Pharmacol 2011 Nov 20;82(9):1049-56. Epub 2011 Jul 20.

INSERM UMR-S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 rue des Saints Pères, 75006 Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S00062952110053
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http://dx.doi.org/10.1016/j.bcp.2011.07.072DOI Listing
November 2011

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.

Fluids Barriers CNS 2011 Aug 25;8:23. Epub 2011 Aug 25.

Neuropsychopharmacologie des addictions (CNRS UMR 8206), Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie, Paris, France.

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http://fluidsbarrierscns.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/2045-8118-8-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180256PMC
August 2011

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.

Int J Cancer 2011 Jun 8;128(11):2591-601. Epub 2010 Oct 8.

INSERM UMR-S 747, Université Paris Descartes, Centre Universitaire des Saints-Pères, Paris, France.

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http://doi.wiley.com/10.1002/ijc.25599
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http://dx.doi.org/10.1002/ijc.25599DOI Listing
June 2011

Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation.

Biochem Pharmacol 2011 Jan 13;81(2):304-13. Epub 2010 Oct 13.

INSERM UMR-S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 rue des Saints Pères, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.bcp.2010.10.003DOI Listing
January 2011

BRCA1 affects global DNA methylation through regulation of DNMT1.

Cell Res 2010 Nov 7;20(11):1201-15. Epub 2010 Sep 7.

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/cr.2010.128DOI Listing
November 2010

IGF signaling pathway as a selective target of familial breast cancer therapy.

Curr Mol Med 2008 Dec;8(8):727-40

Genetics of Development and Disease Branch, 10/9N105, Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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December 2008

[Dioxin and estradiol, a "complex" story].

Authors:
Xavier Coumoul

Med Sci (Paris) 2007 Aug-Sep;23(8-9):701-2

INSERM UMR-S 747, Pharmacologie, Toxicologie et Signalisation Cellulaire, Université Paris Descartes, 45, rue des Saints-Pères, 75006 Paris, France.

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http://www.medecinesciences.org/10.1051/medsci/20072389701
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http://dx.doi.org/10.1051/medsci/20072389701DOI Listing
November 2007

RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis.

Nat Genet 2007 Sep 12;39(9):1145-50. Epub 2007 Aug 12.

Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, US National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://www.nature.com/doifinder/10.1038/ng2096
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http://dx.doi.org/10.1038/ng2096DOI Listing
September 2007

Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach.

Carcinogenesis 2007 Jul 15;28(7):1401-7. Epub 2007 Mar 15.

Genetics of Development and Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgm060DOI Listing
July 2007

The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein.

FEBS Lett 2007 Jul 30;581(19):3608-15. Epub 2007 Mar 30.

INSERM, UMR-S 747, 75270 Paris Cedex 06, France.

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http://dx.doi.org/10.1016/j.febslet.2007.03.046DOI Listing
July 2007

RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector.

Int J Biol Sci 2007 Jan 5;3(2):91-9. Epub 2007 Jan 5.

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796951PMC
http://dx.doi.org/10.7150/ijbs.3.91DOI Listing
January 2007

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.

Cancer Res 2006 Jul;66(14):7151-7

Genetics of Development and Disease Branch and Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4570DOI Listing
July 2006

RNAi in mice: a promising approach to decipher gene functions in vivo.

Biochimie 2006 Jun 20;88(6):637-43. Epub 2005 Dec 20.

INSERM UMR-S 490, Unite de Toxicologie Moléculaire, 45, rue des Saints-Pères, 75270 Paris cedex 06, France.

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http://dx.doi.org/10.1016/j.biochi.2005.11.010DOI Listing
June 2006

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.

EMBO J 2006 May 4;25(10):2167-77. Epub 2006 May 4.

Genetics of Development and Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601115
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http://dx.doi.org/10.1038/sj.emboj.7601115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462967PMC
May 2006

Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference.

Nucleic Acids Res 2005 Jun 24;33(11):e102. Epub 2005 Jun 24.

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland, MD 20892, USA.

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http://dx.doi.org/10.1093/nar/gni100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1159121PMC
June 2005

Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system.

Nucleic Acids Res 2004 Jun 15;32(10):e85. Epub 2004 Jun 15.

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/nar/gnh083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC434461PMC
June 2004

Roles of FGF receptors in mammalian development and congenital diseases.

Birth Defects Res C Embryo Today 2003 Nov;69(4):286-304

Genetics of Development and Disease Branch, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://doi.wiley.com/10.1002/bdrc.10025
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http://dx.doi.org/10.1002/bdrc.10025DOI Listing
November 2003

PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides.

Biochem Pharmacol 2002 Nov;64(10):1513-9

INSERM Unit 490, Université René Descartes, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.

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http://dx.doi.org/10.1016/s0006-2952(02)01298-4DOI Listing
November 2002