Publications by authors named "X Shirley Liu"

87,580 Publications

Characteristics of malnutrition according to Global Leadership Initiative on Malnutrition criteria in non-surgical patients with irritable bowel disease.

Nutrition 2021 Oct 14;94:111514. Epub 2021 Oct 14.

Department of Clinical Nutrition, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Electronic address:

Objective: Malnutrition is common in patients with inflammatory bowel disease (IBD). The Global Leadership Initiative on Malnutrition (GLIM) was proposed to assess the severity and characteristics of malnutrition. Thus, we aimed to use the latest consensus on the diagnosis of malnutrition, GLIM criteria, to evaluate malnutrition in patients with IBD.

Methods: We performed a retrospective cohort study of 73 adult patients with IBD (48 with Crohn disease and 25 with ulcerative colitis). Demographic data, clinical characteristics, and nutrition status defined by Nutritional Risk Screening (NRS) 2002 and GLIM criteria were recorded at enrollment.

Results: According to the GLIM criteria, 43 (58.90%) patients were identified with malnutrition, and the incidence of mild to moderate malnutrition and severe malnutrition was 28.77% (21 of 73 patients) and 30.14% (22 of 73 patients), respectively. The severity of malnutrition in patients with IBD increased with the cumulative number of phenotypic criteria they met (P < 0.01). The difference in the number of etiologic indicators was only identified between patients with severe malnutrition and those without malnutrition (P < 0.05). Patients with Crohns disease had a significantly higher rate of muscle mass loss than patients with ulcerative colitis (P = 0.038) but a lower incidence of reduced food intake or assimilation (P = 0.039).

Conclusion: The prevalence of malnutrition according to the GLIM criteria was high in non-surgical patients with IBD, and as the degree of malnutrition worsened, more phenotypes and etiologic types appeared. The phenotypic and etiologic characteristics of GLIM were different in patients with Crohn disease than in those with ulcerative colitis.
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http://dx.doi.org/10.1016/j.nut.2021.111514DOI Listing
October 2021

Comparative analysis of physiological, agronomic and transcriptional responses to drought stress in wheat local varieties from Mongolia and Northern China.

Plant Physiol Biochem 2021 Nov 17;170:23-35. Epub 2021 Nov 17.

Key Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China. Electronic address:

Drought is one of the major abiotic stresses that threaten wheat production worldwide, especially in the Mongolian Plateau and adjacent regions. This study aims to find local wheat varieties with high yields and drought resistance at various developmental stages based on agronomic traits and drought resistance indices analysis and explore the underlining molecular mechanisms by transcriptome analysis. Our results revealed that drought stress started at the seedling stage has a greater impact on crop yields. Four types of drought responses were found among the tested varieties. Type 1 and type 2 show low tolerance to drought stress despite high or low yield in control condition, type 3 exhibits high yield under control condition but dropped significantly after drought, and type 4 displays relatively high and stable yields under control and drought conditions. Transcriptome analysis performed with the representative varieties of the four types revealed GO terms and KEGG pathways enriched among drought-triggered differential expressed genes (DEGs). A network containing 18 modules was constructed using weighted gene co-expression analysis (WGCNA). Ten modules were significantly correlated to yield by module-trait correlation, and 3 modules showed Darkhan 144 specific gene expression patterns. C2H2 zinc finger factor-recognized motifs were identified from the promoters of genes in these modules. qRT-PCR confirmed several key DEGs with specific expression patterns and physiological measurements validated the relatively low oxidative damage and high antioxidant capacity in the drought tolerant variety Dankhan 144. These findings provide an important basis for local agriculture and breeding of drought-tolerant high yield wheat varieties.
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http://dx.doi.org/10.1016/j.plaphy.2021.11.026DOI Listing
November 2021

One-step fabrication of novel MIL-53(Fe, Al) for synergistic adsorption-photocatalytic degradation of tetracycline.

Chemosphere 2021 Nov 26:133032. Epub 2021 Nov 26.

School of Urban Construction, Wuhan University of Science and Technology, Wuhan, 430065, PR China. Electronic address:

Bimetallic MOFs (MIL-53 (Fe, Al)) were successfully fabricated via a facile one-step solvothermal method for the removal of tetracycline (TC) from aqueous solutions. Tetracycline adsorption and photocatalytic experiments indicate that the optimum bimetallic synthetic molar ratio is 3:2 (40%MIL-53(Fe, Al)). The adsorption data are well fitted by the Freundlich model and pseudo-second-order adsorption kinetics. 40%MIL-53(Fe, Al) has an adsorption capacity of up to 402.033 mg/g. After the dark adsorption phase, 10 mg of 40%MIL-53(Fe, Al) can remove 94.33% of the tetracycline in a 70 mL aqueous solution (20 mg/L) under 50 min irradiation, while only 71.39% and 81.82% of the tetracycline are removed by MIL-53(Fe) and MIL-53(Al) under the same conditions. In addition, 40%MIL-53(Fe, Al) exhibits a significant adsorption-photocatalytic synergy (under direct irradiation without a dark adsorption phase), in which the pseudo-first-order kinetic constant increases by a factor of 3.11. Quenching experiments and ESR characterization indicate that ·O, ·OH, and h are the main active species in the photocatalytic process. Meanwhile, 40%MIL-53(Fe, Al) demonstrates good stability, with a tetracycline removal rate that still reaches 83.70% after 4 cycles. These results suggest that the prepared 40%MIL-53(Fe, Al) catalyst is a novel adsorption-photocatalytic material that can be used for the efficient treatment of tetracycline.
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http://dx.doi.org/10.1016/j.chemosphere.2021.133032DOI Listing
November 2021

One-pot synthesis of oxygen-vacancy-rich Cu-doped UiO-66 for collaborative adsorption and photocatalytic degradation of ciprofloxacin.

Sci Total Environ 2021 Nov 26:151962. Epub 2021 Nov 26.

Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province, School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha 410004, PR China.

UiO-66, as one of the most stable metal-organic frameworks (MOFs), has attracted a lot of attention in the field of adsorption and photocatalysis. However, this application of UiO-66 is still limited due to either the low accessibility of micropores or the poor electron-hole charge separation capability. This study aims to promote UiO-66 accessibility of micropores and charge separation through the construction of oxygen vacancies (OVs) and mesopore defects as well as copper incorporation. Herein, mesopore Cu doped UiO-66 with rich OVs was synthesized by a one-pot method and demonstrated high efficiency for the removal of ciprofloxacin (CIP) from the aquatic system. First of all, denatured mesopore defects were produced in Cu doped UiO-66 which possessed a 58% increase in specific surface area compared to UiO-66, facilitating the adsorption of molecular oxygen. Secondly, e was preferentially trapped by OVs under light irradiation. Electron (e) reacted rapidly with the surface adsorbed oxygen to generate superoxide radical (O). Meanwhile, copper incorporation increased the photocurrent and reduced the interfacial charge transfer resistance, thereby improving the charge separation efficiency. As a result, the adsorption efficiency and photocatalytic performance of mesopore Cu doped UiO-66 with OVs were 8.1 and 3.7 times higher than those of UiO-66, respectively. This study paved a way for the one-step synthesis of MOFs containing OVs and broadened the possibilities of practical applications for photo-induced removal of antibiotics from effluent.
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http://dx.doi.org/10.1016/j.scitotenv.2021.151962DOI Listing
November 2021

chemotaxis is controlled by an unusual phosphorelay network.

J Bacteriol 2021 Nov 29:JB0052721. Epub 2021 Nov 29.

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.

is a nitrogen-fixing bacterium that forms root nodules on its host legume, . This agriculturally significant symbiotic relationship is important in lowland rice cultivation, and allows for nitrogen fixation under flood conditions. Chemotaxis plays an important role in bacterial colonization of the rhizosphere. Plant roots release chemical compounds that are sensed by bacteria, triggering chemotaxis along a concentration gradient toward the roots. This gives motile bacteria a significant competitive advantage during root surface colonization. Although plant-associated bacterial genomes often encode multiple chemotaxis systems, appears to encode only one. The cluster on the genome contains , , , , and . Two other chemotaxis genes, and , are located independently from the operon. Both CheY1 and CheY2 are involved in chemotaxis, with CheY1 being the predominant signaling protein. CheA contains an unusual set of C-terminal domains: a CheW-like/Receiver pair (termed W2-Rec), follows the more common single CheW-like domain. W2-Rec impacts both chemotaxis and CheA function. We found a preference for transfer of phosphoryl groups from CheA to CheY2, rather than to W2-Rec or CheY1, which appears to be involved in flagellar motor binding. Furthermore, we observed increased phosphoryl group stabilities on CheY1 compared to CheY2 or W2-Rec. Finally, CheZ enhanced dephosphorylation of CheY2 substantially more than CheY1, but had no effect on the dephosphorylation rate of W2-Rec. This network of phosphotransfer reactions highlights a previously uncharacterized scheme for regulation of chemotactic responses. Chemotaxis allows bacteria to move towards nutrients and away from toxins in their environment. Chemotactic movement provides a competitive advantage over non-specific motion. CheY is an essential mediator of the chemotactic response with phosphorylated and unphosphorylated forms of CheY differentially interacting with the flagellar motor to change swimming behavior. Previously established schemes of CheY dephosphorylation include action of a phosphatase and/or transfer of the phosphoryl group to another receiver domain that acts as a sink. Here, we propose uses a concerted mechanism in which the Hpt domain of CheA, CheY2, and CheZ function together as a dual sink system to rapidly reset chemotactic signaling. To the best of our knowledge, this mechanism is unlike any that have previously been evaluated. Chemotaxis systems that utilize both receiver and Hpt domains as phosphate sinks likely occur in other bacterial species.
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http://dx.doi.org/10.1128/JB.00527-21DOI Listing
November 2021
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