Publications by authors named "X Li"

131,556 Publications

Sex Difference in Outcomes Following Transcatheter Aortic Valve Replacement in Bicuspid Aortic Stenosis.

JACC Cardiovasc Interv 2022 Aug;15(16):1652-1660

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address:

Background: It is unknown whether the sex difference whereby female transcatheter aortic valve replacement (TAVR) candidates had a lower risk profile, a higher incidence of in-hospital complications, but more favorable short- and long-term survival observed in tricuspid cohorts undergoing TAVR would persist in patients with bicuspid aortic valves (BAVs).

Objectives: The aim of this study was to reexamine the impact of sex on outcomes following TAVR in patients with BAVs.

Methods: In this single-center study, patients with BAVs undergoing TAVR for severe aortic stenosis from 2012 to 2021 were retrospectively included. Baseline characteristics, aortic root anatomy, and in-hospital and 1-year valve hemodynamic status and survival were compared between sexes.

Results: A total of 510 patients with BAVs were included. At baseline, women presented with fewer comorbidities. Men had a greater proportion of Sievers type 1 BAV, higher calcium volumes (549.2 ± 408.4 mm vs 920.8 ± 654.3 mm; P < 0.001), and larger aortic root structures. Women experienced more vascular complications (12.9% vs 4.9%; P = 0.002) and bleeding (11.1% vs 5.3%; P = 0.019) and higher residual gradients (16.9 ± 7.7 mm Hg vs 13.2 ± 6.4 mm Hg; P < 0.001), while men were more likely to undergo second valve implantations during index TAVR (6.3% vs 15.9%; P = 0.001). Death at 1 year was not significantly different between sexes (HR: 1.15; 95% CI: 0.56-2.35; P = 0.70). Bleeding (adjusted HR: 4.62; 95% CI: 1.51-14.12; P = 0.007) was the single independent predictor of 1-year death for women.

Conclusions: In patients with BAVs undergoing TAVR, women presented with fewer comorbidities, while men had a greater proportion of type 1 BAV, more calcification, and larger aortic roots. In-hospital outcomes favored men, with fewer complications except for the need for second valve implantation, but 1-year survival was comparable between sexes.
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http://dx.doi.org/10.1016/j.jcin.2022.06.036DOI Listing
August 2022

The seasonal variations and potential sources of nitrous acid (HONO) in the rural North China Plain.

Environ Pollut 2022 Aug 15:119967. Epub 2022 Aug 15.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Nitrous acid (HONO), an essential precursor of hydroxyl radicals (OH) in the troposphere, plays an integral role in atmospheric photochemistry. However, potential HONO sources remain unclear, particularly in rural areas, where long-term (including seasonal) measurements are scarce. HONO and related parameters were measured at a rural site in the North China Plain (NCP) during the winter of 2017 and summer and autumn of 2020. The mean HONO level was higher in winter (1.79 ± 1.44 ppbv) than in summer (0.67 ± 0.50 ppbv) and autumn (0.83 ± 0.62 ppbv). Source analysis revealed that the heterogeneous conversion (including photo-enhanced conversion) of NO on the ground surface dominated the daytime HONO production in the three seasons (43.1% in winter, 54.3% in summer, and 62.0% in autumn), and the homogeneous reaction of NO and OH contributed 37.8, 12.2, and 28.4% of the daytime HONO production during winter, summer, and autumn, respectively. In addition, the total contributions of other sources (direct vehicle emissions, particulate nitrate photolysis, NO uptake and its photo-enhanced reaction on the aerosol surface) to daytime HONO production were less than 5% in summer and autumn and 12.0% in winter. Unlike winter and autumn, an additional HONO source was found in summer (0.45 ± 0.21 ppbv h, 31.4% to the HONO formation), which might be attributed to the HONO emission from the fertilized field. Among the primary radical sources (photolysis of HONO, O, and formaldehyde), HONO photolysis was dominant, with contributions of 82.6, 49.3, and 63.2% in winter, summer, and autumn, respectively. Our findings may aid in understanding HONO formation in different seasons in rural areas and may highlight the impact of HONO on atmospheric oxidation capacity.
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http://dx.doi.org/10.1016/j.envpol.2022.119967DOI Listing
August 2022

The adsorption of arsenic on micro- and nano-plastics intensifies the toxic effect on submerged macrophytes.

Environ Pollut 2022 Aug 15;311:119896. Epub 2022 Aug 15.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan, 430074, China. Electronic address:

Currently little is known about the adsorption behaviors of metalloids on microplastics (MPs) and their complex toxic effects on aquatic plants. Herein, we investigated the adsorption behaviors of arsenic (As(III) and As(V)) on three types of MPs (polystyrene, polyvinyl chloride, and polyethylene) with four different particle sizes (100, 10, 1, and 0.1 μm). Compared with the short-term exposure experiment, co-toxicity of polystyrene nanoplastics (PS-NPs) and As on two submerged macrophytes (Vallisneria denseserrulata and Potamogeton crispus) were explored through two relatively longer 14-day-cultivation experiments in summer and spring, respectively. The adsorption results showed that As entered the internal surface adsorption site of MPs at 24 h and fully combined to reach equilibrium. The adsorption capacity also enhanced with the increase of MPs concentrations, which generated more adsorption sites for binding with MPs. The presence of PS-NPs increased the absorption of As on macrophytes by 36.2-47.2%. More serious damage of leaf structure by combined PS-NPs and As was observed by transmission electron microscope. The larger harms by the co-toxicity of MPs and As were also reflected by the changes in physiochemical characteristics (e.g. photosynthesis) and the enhancement of oxidative damage of macrophytes. This work provides a clear theoretical basis for the behavior of PS-NPs as carrier with other contaminants on submerged macrophytes, and clearly evaluates the co-toxicity of NPs and metalloids in complex aquatic environments.
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http://dx.doi.org/10.1016/j.envpol.2022.119896DOI Listing
August 2022

Disproportionate loss of threatened terrestrial mammals along anthropogenic disturbance gradients.

Sci Total Environ 2022 Aug 15:158038. Epub 2022 Aug 15.

State Key Laboratory of Genetic Resources and Evolution & Yunnan Key Laboratory of Biodiversity and Ecological Security of Gaoligong Mountain, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

Tens of thousands of species are increasingly confronted with habitat degradation and threatened with local extirpation and global extinction as a result of human activities. Understanding the local processes that shape the regional distribution patterns of at-risk species is useful in safeguarding species against threats. However, there is only limited understanding of the processes that shape the regional distribution patterns of threatened species. We explored the drivers and patterns of species richness of threatened, non-threatened and total terrestrial mammals by employing multi-region multi-species occupancy models based on data from a broad camera trapping survey at 1096 stations stratified across different levels of human activities in 54 mountain forests in southwest China. We compared correlates between total and threatened species richness and examined relationships of human impact variables with the proportion of threatened species and the site's local contribution to β diversity (LCBD). We found that threatened species richness was negatively related to human modification and human presence. However, both non-threatened and total species richness increased as human modification increased. Predicted proportions of threatened species were strongly and positively related to LCBD but negatively related to human modification and human presence. Our results indicate that human impacts can lead to disproportionate loss of threatened terrestrial mammals and highlight the importance of considering threatened species diversity independently from total species richness for directing conservation resources. Our approach represents one of the highest-resolution analyses of different types of human impacts on regional diversity patterns of threatened terrestrial mammals available to inform conservation policy.
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http://dx.doi.org/10.1016/j.scitotenv.2022.158038DOI Listing
August 2022

[Research Progress of Short Chain Fatty Acids in the Pathogenesis of Immune Thrombocytopenia--Review].

Authors:
Xiao-Na Li Wen Qu

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2022 Aug;30(4):1296-1300

Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China. E-mail:

The gut microbiota is an important part of the human body, and it's also the largest genome in the human body. Recent studies on the gut microbiota have found that it plays an important role in human immune diseases. In recent years, the methods of sequencing gut microbiota has teen improved, thus dysregulation of the gut microbiota is found in many immune diseases, and the most widely studied mechanism is the short-chain fatty acids (SCFA), which is a metabolite of gut microbiota. The role of short-chain fatty acids in intestinal barrier, IgA immunity, dendritic cells and regulatory T cells has become increasingly clear. The mechanisms of short-chain fatty acids in regulating immunity and its role in the pathogenesis of immune thrombocytopenia were covered in this review, so as to provide a new idea for the treatment of immune thrombocytopenia in the future.
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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2022.04.053DOI Listing
August 2022
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