Publications by authors named "X Li"

112,195 Publications

CT Radiomics for the Prediction of Synchronous Distant Metastasis in Clear Cell Renal Cell Carcinoma.

J Comput Assist Tomogr 2021 Aug 2. Epub 2021 Aug 2.

From the Departments of Medical Ultrasound Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region Department of GE Healthcare Global Research, GE Healthcare, Shanghai, China.

Purpose: The aim of this study was to construct and verify a computed tomography (CT) radiomics model for preoperative prediction of synchronous distant metastasis (SDM) in clear cell renal cell carcinoma (ccRCC) patients.

Methods: Overall, 172 patients with ccRCC were enrolled in the present research. Contrast-enhanced CT images were manually sketched, and 2994 quantitative radiomic features were extracted. The radiomic features were then normalized and subjected to hypothesis testing. Least absolute shrinkage and selection operator (LASSO) was applied to dimension reduction, feature selection, and model construction. The performance of the predictive model was validated through analysis of the receiver operating characteristic curve. Multivariate and subgroup analyses were performed to verify the radiomic score as an independent predictor of SDM.

Results: The patients randomized into a training (n = 104) and a validation (n = 68) cohort in a 6:4 ratio. Through dimension reduction using LASSO regression, 9 radiomic features were used for the construction of the SDM prediction model. The model yielded moderate performance in both the training (area under the curve, 0.89; 95% confidence interval, 0.81-0.97) and the validation cohort (area under the curve, 0.83; 95% confidence interval, 0.69-0.95). Multivariate analysis showed that the CT radiomic signature was an independent risk factor for clinical parameters of ccRCC. Subgroup analysis revealed a significant connection between the SDM and radiomic signature, except for the lower pole of the kidney subgroup.

Conclusions: The CT-based radiomics model could be used as a noninvasive, personalized approach for SDM prediction in patients with ccRCC.
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http://dx.doi.org/10.1097/RCT.0000000000001211DOI Listing
August 2021

A Progressive Generative Adversarial Method for Structurally Inadequate Medical Image Data Augmentation.

IEEE J Biomed Health Inform 2021 Aug 4;PP. Epub 2021 Aug 4.

The generation-based data augmentation method can overcome the challenge caused by the imbalance of medical image data to a certain extent. However, most of the current research focus on images with unified structure which are easy to learn. What is different is that ultrasound images are structurally inadequate, making it difficult for the structure to be captured by the generative network, resulting in the generated image lacks structural legitimacy. Therefore, a Progressive Generative Adversarial Method for Structurally Inadequate Medical Image Data Augmentation is proposed in this paper, including a network and a strategy. Our Progressive Texture Generative Adversarial Network alleviates the adverse effect of completely truncating the reconstruction of structure and texture during the generation process and enhances the implicit association between structure and texture. The Image Data Augmentation Strategy based on Mask-Reconstruction overcomes data imbalance from a novel perspective, maintains the legitimacy of the structure in the generated data, as well as increases the diversity of disease data interpretably. The experiments prove the effectiveness of our method on data augmentation and image reconstruction on Structurally Inadequate Medical Image both qualitatively and quantitatively. Finally, the weakly supervised segmentation of the lesion is the additional contribution of our method.
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http://dx.doi.org/10.1109/JBHI.2021.3101551DOI Listing
August 2021

Combustion characteristics and kinetic analysis of oil sludge with CaO additive.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2021 Aug 4:1-9. Epub 2021 Aug 4.

Shandong Sunshine Garden Construction Co., Ltd, Dongying, China.

Combustion of High-sulfur oil sludge (OS) blended with CaO can significantly reduce the emission of sulfur gas pollutants, but its combustion and kinetic characteristics need to be further studied. TGA experiments showed the combustion characteristics of OS were significantly changed after adding CaO. As reflected by comprehensive combustion index (), the combustion performance of OS decreased after adding CaO, and significantly improved with the increase of heating rate. The kinetic parameters of the main combustion process of OS with CaO were calculated by the iso-conversion methods of Friedman, FWO, and Starink, respectively. Kinetic analysis results indicated the energy required for OS combustion with CaO first increased and then decreased with deepening of reaction degree. The thermodynamic parameters of Δ, Δ and Δ were determined on the basis of kinetics. The negative Δ, positive Δ, and negative Δ validated the combustion of OS with CaO was an exothermic and nonspontaneous process.
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http://dx.doi.org/10.1080/10934529.2021.1943245DOI Listing
August 2021

Reconfigurable Tunneling Transistors Heterostructured by an Individual Carbon Nanotube and MoS.

Nano Lett 2021 Aug 4. Epub 2021 Aug 4.

State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University, Beijing 100084, People's Republic of China.

Low-dimensional semiconductors have shown great potential in switches for their atomically thin geometries and unique properties. It is significant to achieve new tunneling transistors by the efficient stacking methodology with low-dimensional building blocks. Here, we report a one-dimensional (1D)-two-dimensional (2D) mixed-dimensional van der Waals (vdW) heterostructure, which was efficiently fabricated by stacking an individual semiconducting carbon nanotube (CNT) and 2D MoS. The CNT-MoS heterostructure shows specific reconfigurable electrical transport behaviors and can be set as a nn junction, pn diode, and band-to-band tunneling (BTBT) transistor by gate voltage. The transport properties, especially BTBT, could be attributed to the electron transfer from MoS to CNT through the ideal vdW interface and the 1D nature of the CNT. The progress suggests a new solution for tunneling transistors by making 1D-2D heterostructures from the rich library of low-dimensional nanomaterials. Furthermore, the reconfigurable functions and nanoscaled junction show that it is prospective to apply CNT-MoS heterostructures in future nanoelectronics and nano-optoelectronics.
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http://dx.doi.org/10.1021/acs.nanolett.1c01833DOI Listing
August 2021

Aptamer-Functionalized DNA-Silver Nanocluster Nanofilm for Visual Detection and Elimination of Bacteria.

ACS Appl Mater Interfaces 2021 Aug 4. Epub 2021 Aug 4.

Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.

As a new type of nanomaterial, DNA-templated silver nanoclusters (DNA-AgNCs) have been widely studied because of their fluorescence and antibacterial properties. In this study, we combined the DNA-AgNCs with aptamers of bacteria to achieve a novel approach for the visual detection and effective elimination of bacteria. The aptamers of () were linked to G-rich sequences to achieve fluorescence enhancement when approaching the DNA-AgNCs. The capture of aptamers not only realized the visual monitoring of bacteria but also promoted the antibacterial effects. Additionally, a fluorescent nanofilm with excellent selectivity and antibacterial activity in the detection and elimination of was developed based on the DNA-AgNCs. These aptamer-functionalized DNA-AgNCs show significant potential for many applications in food packaging and biomedical engineering.
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http://dx.doi.org/10.1021/acsami.1c05751DOI Listing
August 2021
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