Publications by authors named "X H Hu"

22,483 Publications

Diketopiperazine Modulates Arabidopsis Thaliana Root System Architecture by Promoting Interactions of Auxin Receptor TIR1 and IAA7/17 Proteins.

Plant Cell Physiol 2021 Sep 17. Epub 2021 Sep 17.

School of Life and Pharmaceutical Sciences, Key Laboratory of Tropical Biological Resources of Ministry Education, Hainan University, Haikou, 571157 China.

Plants can detect the quorum sensing (QS) signaling molecules of microorganisms, such as amino acids, fat derivatives, and diketopiperazines (DKPs), thus allowing the exchange information to promote plant growth and development. Here, we evaluated the effects of 12 synthesized DKPs on Arabidopsis thaliana roots and studied their underlying mechanisms of action. Results showed that, as QS signal molecules, the DKPs promoted lateral root development and root hair formation in Arabidopsis thaliana to differing degrees. The DKPs enhanced the polar transport of the plant hormone auxin from the shoot to root and triggered the auxin-responsive protein IAA7/17 to decrease the auxin response factor (ARF), leading to the accumulation of auxin at the root tip and accelerated root growth. In addition, the DKPs induced the development of lateral roots and root hair in the Arabidopsis thaliana root system architecture via interference with auxin receptor transporter inhibitor response protein 1 (TIR1). A series of TIR1 sites that potentially interact with DKPs were also predicted using molecular docking analysis. Mutations of these sites inhibited the phosphorylation of TIR1 after DKP treatment, thereby inhibiting lateral root formation, especially TIR1-1 site. This study identified several DKP signal molecules in the QS system that can promote the expression of auxin response factors ARF7/19 via interactions of TIR1 and IAA7/17 proteins, thus promoting plant growth and development.
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http://dx.doi.org/10.1093/pcp/pcab142DOI Listing
September 2021

Quantum Speed Limit Quantified by the Changing Rate of Phase.

Phys Rev Lett 2021 Sep;127(10):100404

School of Physics, Shandong University, Jinan 250100, China.

The quantum speed limit is important in determining the minimum evolution time of a quantum system, and thus is essential for quantum community. In this Letter, we derive a novel unified quantum speed limit bound for Hermitian and non-Hermitian quantum systems. The bound is quantified by the changing rate of phase of the quantum system, which represents the transmission mode of the quantum states over their evolution. The bound leads to further insights beyond the previous bounds on concrete evolution modes of the quantum system, such as horizontal or parallel transition or horizontal joining of the two quantum states in Hilbert space. The bound is linked to the feasibility of the evolutions of the state vectors, and provides a tighter upper bound. In addition, the generalized Margolus-Levitin bound is discussed.
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http://dx.doi.org/10.1103/PhysRevLett.127.100404DOI Listing
September 2021

Caged structural water molecules emit tunable brighter colors by topological excitation.

Nanoscale 2021 Sep 17;13(35):15058-15066. Epub 2021 Sep 17.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Laboratory of Interface and Water Science, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

Intrinsically, free water molecules are a colourless liquid. If it is colourful, why and how does it emit the bright colours? We provided direct evidence that when water was trapped into the sub-nanospace of zeolites, the structural water molecules (SWs) exhibited strong tunable photoluminescence (PL) emissions from blue to red colours with unprecedented ultra-long lifetimes up to the second scale at liquid nitrogen temperature. Further controlled experiments and combined characterizations by time-resolved steady-state and ultra-fast femtosecond (fs) transient optical spectroscopy showed that the singly adsorbed hydrated hydroxide complex {OH·HO} as SWs in the confined nanocavity is the true emitter centre, whose PL efficiency strongly depends on the type and stability of the SWs, which is dominated by H-bond interactions, such as the solvent effect, pH value and operating temperature. The emission of SWs exhibits the characteristic of topological excitations (TAs) due to the many-body quantum electron correlations in confined nanocavities, which differs from the local excitation of organic chromophores. Our model not only elucidates the origin of the PL of metal nanoclusters (NCs), but also provides a completely new insight to understand the nature of heterogeneous catalysis and interface bonding (or state) at the molecule level, beyond the metal-centred d band theory.
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http://dx.doi.org/10.1039/d1nr02389fDOI Listing
September 2021

Recent advances in the contribution of circRNAs to cisplatin chemotherapy resistance in cancers.

Neoplasma 2021 Sep 17. Epub 2021 Sep 17.

Department of Pathology, Guangdong Medical University, Dongguan, Guangdong, China.

Worldwide, cancer is a serious threat to the health of citizens of every country, with the incidence and mortality increasing year by year. Cisplatin is the first-line anticancer drug commonly used in clinics and is widely used for the treatment of solid tumors including lung, gastric, liver, bladder, and ovarian cancer. Although cisplatin-based chemotherapy has a high clinical response efficacy, patients will inevitably develop drug resistance after repeated using, leading to severe restrictions of its application. Circular RNAs (circRNAs) are a promising class of non-coding RNAs capable of promoting or suppressing cancer via functioning as miRNAs sponges. Recently, an increasing amount of evidence shows that circRNAs are closely related to the cisplatin resistance of cancers. Therefore, standing at the perspective of the cisplatin chemotherapy resistance, this paper reviews the research progress of circRNAs related to cisplatin resistance of various cancers.
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http://dx.doi.org/10.4149/neo_2021_210624N846DOI Listing
September 2021

Daidzein ameliorated concanavalin A-induced liver injury through the Akt/GSK-3β/Nrf2 pathway in mice.

Ann Transl Med 2021 Aug;9(15):1228

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Daidzein is a soybean isoflavone that has been shown in previous studies to have anti-inflammatory and antioxidant effects. However, it remains unknown whether daidzein plays a protective role against concanavalin A (Con A)-induced autoimmune hepatitis (AIH).

Methods: In this study, an animal model of AIH was constructed by intravenous injection of Con A (15 mg/kg). Daidzein (200 mg/kg/d) was intraperitoneally administered to mice for 3 days before the Con A injection. Alpha mouse liver 12 (AML-12) cells were incubated in the absence or presence of daidzein to determine whether daidzein can alleviate Con A-induced hepatotoxicity.

Results: The findings showed that pretreatment with daidzein significantly reduced Con A-induced oxidative stress and hepatocyte apoptosis in Con A-induced liver injury. Pretreatment with daidzein significantly prevented the decrease of intrahepatic protein levels of phosphorylated Akt (p-Akt), phosphorylated GSK3β (p-GSK3β), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NOQ1 (NAD(P)H quinone dehydrogenase 1) in response to Con A administration. Meanwhile, malondialdehyde (MDA) production was reduced, and glutathione peroxidase (GPX), superoxide dismutase (SOD) activity, and SOD2 mRNA expression were elevated in daidzein-pretreated livers. In experiments, daidzein pretreatment prevented Con A-induced murine hepatocyte death. This effect was partly diminished by an inhibitor of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.

Conclusions: These results indicate that daidzein pretreatment attenuates Con A-induced liver injury through the Akt/GSK3β/Nrf2 pathway. Our findings provide new insights into the use of plant-derived products for AIH treatment beyond immunosuppression.
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http://dx.doi.org/10.21037/atm-21-378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421986PMC
August 2021
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