Publications by authors named "Wyatt W Yue"

73Publications

Novel homozygous variant of carbonic anhydrase 8 gene expanding the phenotype of cerebellar ataxia, mental retardation, and disequilibrium syndrome subtype 3.

Am J Med Genet A 2020 Aug 18. Epub 2020 Aug 18.

Department of Pediatric Neurology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.1002/ajmg.a.61805DOI Listing
August 2020

Naturally occurring cobalamin (B) analogs can function as cofactors for human methylmalonyl-CoA mutase.

Biochimie 2020 Jul 10. Epub 2020 Jul 10.

Department of Plant & Microbial Biology, University of California, Berkeley, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2020.06.014DOI Listing
July 2020

Bi-allelic Variants in TKFC Encoding Triokinase/FMN Cyclase Are Associated with Cataracts and Multisystem Disease.

Am J Hum Genet 2020 02 30;106(2):256-263. Epub 2020 Jan 30.

Mitochondrial Research Group, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK; Metabolic Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010975PMC
February 2020

15-deoxy-Δ-Prostaglandin J inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.

Commun Biol 2019 17;2:188. Epub 2019 May 17.

1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK.

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http://dx.doi.org/10.1038/s42003-019-0426-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525171PMC
April 2020

Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.

Kidney Int 2019 05 8;95(5):1138-1152. Epub 2019 Mar 8.

Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, UK; Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1016/j.kint.2018.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481288PMC
May 2019

4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function.

Medchemcomm 2019 Feb 8;10(2):209-220. Epub 2019 Jan 8.

Rare Disease Research Unit , Worldwide Research and Development , Pfizer Inc. , 610 Main Street , Cambridge , MA 02139 , USA . Email:

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http://dx.doi.org/10.1039/c8md00489gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390692PMC
February 2019

Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency.

Biochim Biophys Acta Mol Basis Dis 2019 06 22;1865(6):1265-1272. Epub 2019 Jan 22.

Division of Metabolism and Children's Research Center, University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525113PMC
June 2019

Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screening.

J Inherit Metab Dis 2019 05 11;42(3):565-574. Epub 2019 Mar 11.

Department of Pediatrics, Section of Clinical Genetics and Metabolism, University of Colorado School of Medicine, Aurora, Colorado.

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http://dx.doi.org/10.1002/jimd.12059DOI Listing
May 2019

Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.

Free Radic Biol Med 2019 01 31;130:151-162. Epub 2018 Oct 31.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183127
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.10.447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339520PMC
January 2019

Guaiacol as a drug candidate for treating adult polyglucosan body disease.

JCI Insight 2018 09 6;3(17). Epub 2018 Sep 6.

Columbia University Medical Center Department of Neurology, Houston Merritt Neuromuscular diseases research center, New York, New York, USA.

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http://dx.doi.org/10.1172/jci.insight.99694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171812PMC
September 2018

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.

Biochimie 2018 Sep 20;152:211-218. Epub 2018 Jul 20.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098246PMC
September 2018

Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein.

Biochim Biophys Acta Mol Basis Dis 2017 12 7;1863(12):3294-3302. Epub 2017 Sep 7.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, OX3 7DQ Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.09.002DOI Listing
December 2017

RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.

Am J Hum Genet 2017 Sep;101(3):466-477

Manchester Centre for Genomic Medicine, St. Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9WL, UK; Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591022PMC
September 2017

IDUA mutational profile and genotype-phenotype relationships in UK patients with Mucopolysaccharidosis Type I.

Hum Mutat 2017 11 17;38(11):1555-1568. Epub 2017 Aug 17.

Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester Academic Health Science Centre (MAHSC), Manchester, UK.

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http://dx.doi.org/10.1002/humu.23301DOI Listing
November 2017

Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria.

Hum Mutat 2017 08 6;38(8):988-1001. Epub 2017 Jun 6.

Division of Metabolism and Children's Research Center, University Children's, Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1002/humu.23251DOI Listing
August 2017

Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.

Hum Mol Genet 2016 06 22;25(11):2234-2244. Epub 2016 Mar 22.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ , UK

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http://dx.doi.org/10.1093/hmg/ddw091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081055PMC
June 2016

From structural biology to designing therapy for inborn errors of metabolism.

Authors:
Wyatt W Yue

J Inherit Metab Dis 2016 07 30;39(4):489-98. Epub 2016 May 30.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1007/s10545-016-9923-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920855PMC
July 2016

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain.

Sci Rep 2016 Apr 6;6:23748. Epub 2016 Apr 6.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, UK OX3 7DQ.

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http://dx.doi.org/10.1038/srep23748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822156PMC
April 2016

Role of reverse phenotyping in interpretation of next generation sequencing data and a review of INPP5E related disorders.

Eur J Paediatr Neurol 2016 Mar 18;20(2):286-295. Epub 2015 Dec 18.

Manchester Centre for Genomic Medicine, St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Manchester Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2015.11.012DOI Listing
March 2016

Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity.

Chembiochem 2016 Mar 16;17(6):471-3. Epub 2016 Feb 16.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cbic.201500644DOI Listing
March 2016

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Chem Biol 2015 Dec 10;22(12):1643-52. Epub 2015 Dec 10.

Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.10.014DOI Listing
December 2015

Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking.

J Biol Chem 2015 Dec 19;290(49):29167-77. Epub 2015 Oct 19.

the Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom, and

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http://dx.doi.org/10.1074/jbc.M115.683268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705923PMC
December 2015

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.

Mol Cell Proteomics 2015 Nov 28;14(11):3056-71. Epub 2015 Aug 28.

From the Ben May Department of Cancer Research, University of Chicago, Chicago, Illinois 60637, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China,

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http://dx.doi.org/10.1074/mcp.M115.048850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638046PMC
November 2015

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.

Ann Rheum Dis 2016 06 24;75(6):1255-61. Epub 2015 Jul 24.

Kennedy institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2015-20765
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http://dx.doi.org/10.1136/annrheumdis-2015-207656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893104PMC
June 2016

Carnosine metabolism in diabetes is altered by reactive metabolites.

Amino Acids 2015 Nov 17;47(11):2367-76. Epub 2015 Jun 17.

Centre for Paediatric and Adolescence Medicine, University of Heidelberg, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00726-015-2024-z
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http://dx.doi.org/10.1007/s00726-015-2024-zDOI Listing
November 2015

Functional characterization and categorization of missense mutations that cause methylmalonyl-CoA mutase (MUT) deficiency.

Hum Mutat 2014 Dec;35(12):1449-58

Division for Metabolic Disorders and Children's Research Center, University Children's Hospital, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland.

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http://dx.doi.org/10.1002/humu.22633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441004PMC
December 2014

Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria.

Eur J Hum Genet 2015 Mar 18;23(3):302-9. Epub 2014 Jun 18.

1] Division of Metabolism, University Children's Hospital, Zürich, Switzerland [2] Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany.

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http://www.nature.com/articles/ejhg2014114
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http://dx.doi.org/10.1038/ejhg.2014.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326710PMC
March 2015

Enzymatic and structural characterization of rTSγ provides insights into the function of rTSβ.

Biochemistry 2014 Apr 15;53(16):2732-8. Epub 2014 Apr 15.

Departments of Biochemistry and Chemistry, Institute for Genomic Biology, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

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http://pubs.acs.org/doi/10.1021/bi500349e
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http://dx.doi.org/10.1021/bi500349eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010280PMC
April 2014

Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.

Ann Rheum Dis 2015 Jun 17;74(6):1249-56. Epub 2014 Jan 17.

Faculty of Medical and Human Sciences, Manchester Centre for Genomic Medicine, Institute of Human Development, University of Manchester, Manchester Academic Health Science Centre (MAHSC), Manchester, UK Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, MAHSC, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2013-204309DOI Listing
June 2015

A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency.

J Inherit Metab Dis 2013 Nov 19;36(6):983-7. Epub 2013 Feb 19.

Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1007/s10545-013-9589-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825524PMC
November 2013

3-methylcrotonyl-CoA carboxylase deficiency: clinical, biochemical, enzymatic and molecular studies in 88 individuals.

Orphanet J Rare Dis 2012 May 29;7:31. Epub 2012 May 29.

Division of Metabolism and Children's Research Center (CRC), University Children's Hospital Zurich, and Zürich Center for Integrative Human Physiology (ZHIP), University of Zürich, Steinwiesstraße 75, 8032, Zürich, Switzerland.

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http://dx.doi.org/10.1186/1750-1172-7-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495011PMC
May 2012

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.

Biochemistry 2012 Jun 14;51(25):5083-90. Epub 2012 Jun 14.

Structural Genomics Consortium, NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.1021/bi300150yDOI Listing
June 2012

The role of protein structural analysis in the next generation sequencing era.

Top Curr Chem 2014 ;336:67-98

Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK,

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http://dx.doi.org/10.1007/128_2012_326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121836PMC
May 2014

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.

Biochem Biophys Res Commun 2012 Mar 14;419(3):485-9. Epub 2012 Feb 14.

Structural Genomics Consortium, Oxford, UK.

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http://dx.doi.org/10.1016/j.bbrc.2012.02.038DOI Listing
March 2012

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.

Proc Natl Acad Sci U S A 2011 Dec 12;108(52):21028-33. Epub 2011 Dec 12.

Structural Genomics Consortium, Old Road Research Campus Building, Oxford, United Kingdom OX3 7DQ.

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http://dx.doi.org/10.1073/pnas.1113921108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248551PMC
December 2011

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

J Biol Chem 2011 Dec 13;286(48):41616-25. Epub 2011 Sep 13.

Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA.

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http://dx.doi.org/10.1074/jbc.M111.283689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308871PMC
December 2011

Structural basis of fumarate hydratase deficiency.

J Inherit Metab Dis 2011 Jun 29;34(3):671-6. Epub 2011 Mar 29.

Structural Genomics Consortium, University of Oxford, Old Road Campus, Headington OX3 7DQ, UK.

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http://dx.doi.org/10.1007/s10545-011-9294-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109261PMC
June 2011

High-throughput structural biology of metabolic enzymes and its impact on human diseases.

J Inherit Metab Dis 2011 Jun 22;34(3):575-81. Epub 2011 Feb 22.

Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.

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http://link.springer.com/10.1007/s10545-011-9296-6
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http://dx.doi.org/10.1007/s10545-011-9296-6DOI Listing
June 2011

Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.

Biochemistry 2010 Jun;49(22):4687-94

Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1.

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http://dx.doi.org/10.1021/bi901612yDOI Listing
June 2010

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

J Mol Biol 2010 May 25;398(4):497-506. Epub 2010 Mar 25.

Structural Genomics Consortium, University of Oxford, Oxford OX3 7DU, UK.

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http://dx.doi.org/10.1016/j.jmb.2010.03.034DOI Listing
May 2010

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

FEBS Lett 2010 Feb 12;584(4):825-30. Epub 2010 Jan 12.

Structural Genomics Consortium, University of Oxford, Headington, United Kingdom.

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http://dx.doi.org/10.1016/j.febslet.2009.12.055DOI Listing
February 2010

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.

J Mol Biol 2009 May 1;388(5):997-1008. Epub 2009 Apr 1.

Structural Genomics Consortium, Old Road Research Campus Building, Oxford, UK.

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http://dx.doi.org/10.1016/j.jmb.2009.03.064DOI Listing
May 2009

Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.

Mol Cell 2007 Nov;28(3):371-85

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.molcel.2007.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944837PMC
November 2007

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.

EMBO J 2007 Oct 20;26(20):4402-12. Epub 2007 Sep 20.

Cancer Research-UK DNA Repair Enzyme Research Group, Section of Structural Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034666PMC
October 2007

Recognition of iron-free siderophores by TonB-dependent iron transporters.

Mol Microbiol 2004 Oct;54(1):14-22

Département des Récepteurs et Protéines Membranaires, UPR 9050, CNRS, ESBS, Bld Sébastien Brant, F-67 400 Illkirch, Strasbourg, France.

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http://dx.doi.org/10.1111/j.1365-2958.2004.04241.xDOI Listing
October 2004

Structural evidence for iron-free citrate and ferric citrate binding to the TonB-dependent outer membrane transporter FecA.

J Mol Biol 2003 Sep;332(2):353-68

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/s0022-2836(03)00855-6DOI Listing
September 2003