Wujuan Zhang

Wujuan Zhang

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Wujuan Zhang

Publications by authors named "Wujuan Zhang"

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Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study.

JPEN J Parenter Enteral Nutr 2019 Feb 23;43(2):263-270. Epub 2018 Jul 23.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/jpen.1316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344318PMC
February 2019

Plasma glucosylceramides and cardiovascular risk in incident hemodialysis patients.

J Clin Lipidol 2018 Nov - Dec;12(6):1513-1522.e4. Epub 2018 Jul 30.

Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Division of Nephrology, Department of Pediatrics and Medicine, The Hospital for Sick Children, University Health Network and University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacl.2018.07.011DOI Listing
July 2018

Effect of bariatric surgery on urinary sphingolipids in adolescents with severe obesity.

Surg Obes Relat Dis 2018 04 29;14(4):446-451. Epub 2017 Dec 29.

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.soard.2017.12.017DOI Listing
April 2018

Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry.

SLAS Discov 2017 12 17;22(10):1218-1228. Epub 2017 Jul 17.

3 Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1177/2472555217719372DOI Listing
December 2017

Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.

J Pediatr Gastroenterol Nutr 2017 11;65(5):561-568

*The Department of Pediatrics, Jinshan Hospital, Fudan University, Shanghai, China †Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH ‡Center for Pediatric Liver Diseases, Children's Hospital of Fudan University §Department of Pediatrics, Shanghai Medical College of Fudan University, Shanghai, China ||Institut für Pathologie, Medizinische Universität Graz, Graz, Austria.

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http://Insights.ovid.com/crossref?an=00005176-201711000-0001
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http://dx.doi.org/10.1097/MPG.0000000000001730DOI Listing
November 2017

A convenient approach to facilitate monitoring Gaucher disease progression and therapeutic response.

Analyst 2017 Sep;142(18):3380-3387

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1039/c7an00938kDOI Listing
September 2017

Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease.

PLoS One 2016 6;11(9):e0162367. Epub 2016 Sep 6.

Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162367PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012639PMC
August 2017

Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease.

Nature 2017 03 22;543(7643):108-112. Epub 2017 Feb 22.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1038/nature21368DOI Listing
March 2017

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

EBioMedicine 2016 Nov 24;13:212-224. Epub 2016 Oct 24.

Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, United States; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964163046
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http://dx.doi.org/10.1016/j.ebiom.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264254PMC
November 2016

Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents.

Obesity (Silver Spring) 2016 11 12;24(11):2377-2383. Epub 2016 Sep 12.

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, California, USA.

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http://dx.doi.org/10.1002/oby.21658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846337PMC
November 2016

Long-Term Ursodeoxycholic Acid Therapy Does Not Alter Lithocholic Acid Levels in Patients with Cystic Fibrosis with Associated Liver Disease.

J Pediatr 2016 10 11;177:59-65.e1. Epub 2016 Jun 11.

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

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http://dx.doi.org/10.1016/j.jpeds.2016.05.008DOI Listing
October 2016

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.

Sci Transl Med 2016 09;8(357):357ra122

Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive Northeast, Atlanta, GA 30322, USA. Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056562PMC
http://dx.doi.org/10.1126/scitranslmed.aaf4823DOI Listing
September 2016

Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?

Dig Dis 2015 27;33(3):440-6. Epub 2015 May 27.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, and Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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https://www.karger.com/Article/FullText/371699
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http://dx.doi.org/10.1159/000371699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062006PMC
March 2016

A peptide-linked recombinant glucocerebrosidase for targeted neuronal delivery: Design, production, and assessment.

J Biotechnol 2016 Mar 18;221:1-12. Epub 2016 Jan 18.

Research Service, Veterans Affairs Maryland Health Care Service, Baltimore, MD, USA; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.jbiotec.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381155PMC
March 2016

Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology.

PLoS One 2015 30;10(3):e0118771. Epub 2015 Mar 30.

Division of Human Genetics, Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Synageva BioPharma Corp., Lexington, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118771PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378893PMC
February 2016

Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model.

Hum Mol Genet 2015 Dec 29;24(24):7031-48. Epub 2015 Sep 29.

Division of Human Genetics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA

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http://dx.doi.org/10.1093/hmg/ddv404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654057PMC
December 2015

Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model.

PLoS One 2014 31;9(12):e116023. Epub 2014 Dec 31.

The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America; The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281226PMC
October 2015

Ursodeoxycholyl lysophosphatidylethanolamide protects against hepatic ischemia and reperfusion injury in mice.

Shock 2015 Apr;43(4):379-86

*Internal Medicine IV, Gastroenterology and Hepatology, University Heidelberg Hospital, Heidelberg, Germany; †Department of General Surgery and Laparoscopic Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; ‡Mass Spectrometry Laboratory, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1097/SHK.0000000000000312DOI Listing
April 2015

Treatment of bile acid amidation defects with glycocholic acid.

Hepatology 2015 Jan 23;61(1):268-74. Epub 2014 Dec 23.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH; Clinical and Translational Research Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.

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http://dx.doi.org/10.1002/hep.27401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280294PMC
January 2015

The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice.

Obesity (Silver Spring) 2014 Nov;22(11):2301-11

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/oby.20890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286402PMC
November 2014

Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency.

J Steroid Biochem Mol Biol 2014 Oct 19;144 Pt B:348-60. Epub 2014 Jun 19.

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center and Department of Pediatrics of the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2014.06.008DOI Listing
October 2014

The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.

Nat Commun 2014 Sep 26;5:4993. Epub 2014 Sep 26.

Department of Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1038/ncomms5993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431623PMC
September 2014

Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice.

Hum Mol Genet 2014 Aug 5;23(15):3943-57. Epub 2014 Mar 5.

The Division of Human Genetics and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA Synageva BioPharma, Lexington, MA 02421, USA

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http://dx.doi.org/10.1093/hmg/ddu105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082362PMC
August 2014

Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner.

Obesity (Silver Spring) 2014 Feb 5;22(2):390-400. Epub 2013 Sep 5.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/oby.20548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836901PMC
February 2014

Gaucher disease: chemotactic factors and immunological cell invasion in a mouse model.

Mol Genet Metab 2014 Feb 10;111(2):163-71. Epub 2013 Sep 10.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192130031
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http://dx.doi.org/10.1016/j.ymgme.2013.09.002DOI Listing
February 2014

Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease.

Sci Transl Med 2013 Oct;5(206):206ra137

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070735PMC
October 2013

Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease.

Mol Genet Metab 2012 Jul 30;106(3):310-22. Epub 2012 Apr 30.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229‐3039, USA.

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http://dx.doi.org/10.1016/j.ymgme.2012.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382074PMC
July 2012

Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease.

J Biol Chem 2012 Feb 13;287(6):4275-87. Epub 2011 Dec 13.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1074/jbc.M111.280016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281716PMC
February 2012

Fragmentation of β-hydroxy hydroperoxides.

J Org Chem 2012 Feb 24;77(3):1554-9. Epub 2012 Jan 24.

Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1021/jo201910gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337853PMC
February 2012

An (1)O2 route to γ-hydroxyalkenal phospholipids by vitamin E-induced fragmentation of hydroperoxydiene-derived endoperoxides.

Chem Res Toxicol 2011 Jul 31;24(7):1080-93. Epub 2011 May 31.

Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1021/tx200093mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141739PMC
July 2011

Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.

PLoS One 2011 Apr 20;6(4):e19037. Epub 2011 Apr 20.

The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080394PMC
April 2011

Lysophosphatidylcholine is generated by spontaneous deacylation of oxidized phospholipids.

Chem Res Toxicol 2011 Jan 25;24(1):111-8. Epub 2010 Oct 25.

Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1021/tx100305bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021597PMC
January 2011

Global gene expression profile progression in Gaucher disease mouse models.

BMC Genomics 2011 Jan 11;12:20. Epub 2011 Jan 11.

The Division of Human Genetics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1186/1471-2164-12-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032697PMC
January 2011

Fe2+ catalyzes vitamin E-induced fragmentation of hydroperoxy and hydroxy endoperoxides that generates gamma-hydroxy alkenals.

J Am Chem Soc 2007 May 19;129(19):6088-9. Epub 2007 Apr 19.

Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1021/ja0689785DOI Listing
May 2007

Preparative singlet oxygenation of linoleate provides doubly allylic dihydroperoxides: putative intermediates in the generation of biologically active aldehydes in vivo.

J Org Chem 2006 Jul;71(15):5607-15

Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA.

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http://dx.doi.org/10.1021/jo0605795DOI Listing
July 2006

Oxidized phospholipids, isolevuglandins, and atherosclerosis.

Mol Nutr Food Res 2005 Nov;49(11):1050-62

Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106-7078, USA.

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http://dx.doi.org/10.1002/mnfr.200500056DOI Listing
November 2005