Wouter de Laat

Wouter de Laat

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Wouter de Laat

Publications by authors named "Wouter de Laat"

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Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation.

Cell Rep 2019 Sep;28(10):2704-2714.e5

Amsterdam UMC, University of Amsterdam, Department of Medical Biology, Amsterdam Cardiovascular Sciences, 1105AZ Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.007DOI Listing
September 2019

4C-seq from beginning to end: A detailed protocol for sample preparation and data analysis.

Methods 2019 Jul 26. Epub 2019 Jul 26.

Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2019.07.014DOI Listing
July 2019

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes.

J Am Heart Assoc 2019 May;8(9):e011201

2 Hubrecht Institute (Royal Netherlands Academy of Arts and Sciences (KNAW)) University Medical Center, Utrecht the Netherlands.

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http://dx.doi.org/10.1161/JAHA.118.011201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512097PMC
May 2019

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo.

Dev Cell 2019 03 14;48(6):765-779.e7. Epub 2019 Feb 14.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Cardiomyocyte Renewal Laboratory, Texas Heart Institute, 6770 Bertner Avenue, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Cardiovascular Research Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807193004
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http://dx.doi.org/10.1016/j.devcel.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435425PMC
March 2019

peakC: a flexible, non-parametric peak calling package for 4C and Capture-C data.

Nucleic Acids Res 2018 09;46(15):e91

Oncode Institute and Division of Gene Regulation, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1093/nar/gky443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125690PMC
September 2018

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

Cell 2017 Jul;170(3):522-533.e15

Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785707PMC
July 2017

Can We Just Say: Transcription Second?

Cell 2017 04;169(2):184-185

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.03.026DOI Listing
April 2017

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.

Cell Rep 2017 03;18(10):2359-2372

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston 02215, MA, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston 02215, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609449PMC
March 2017

Regulation of disease-associated gene expression in the 3D genome.

Nat Rev Mol Cell Biol 2016 12 9;17(12):771-782. Epub 2016 Nov 9.

Hubrecht Institute of The Royal Netherlands Academy of Arts and Sciences (KNAW) and the University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nrm.2016.138DOI Listing
December 2016

Polarized regulatory landscape and Wnt responsiveness underlie Hox activation in embryos.

Genes Dev 2016 Sep 15;30(17):1937-42. Epub 2016 Sep 15.

Hubrecht Institute, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1101/gad.285767.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066237PMC
September 2016

The second decade of 3C technologies: detailed insights into nuclear organization.

Genes Dev 2016 06;30(12):1357-82

Hubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, 3584CT Utrecht, the Netherlands.

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http://dx.doi.org/10.1101/gad.281964.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926860PMC
June 2016

Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming.

Cell Stem Cell 2016 05 10;18(5):597-610. Epub 2016 Mar 10.

Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG) and Pompeu Fabra University, Dr Aiguader 88, 08003 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858530PMC
May 2016

Epigenomic annotation of gene regulatory alterations during evolution of the primate brain.

Nat Neurosci 2016 Mar 25;19(3):494-503. Epub 2016 Jan 25.

Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nn.4229DOI Listing
March 2016

CTCF Binding Polarity Determines Chromatin Looping.

Mol Cell 2015 Nov 29;60(4):676-84. Epub 2015 Oct 29.

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.023DOI Listing
November 2015

Architectural hallmarks of the pluripotent genome.

FEBS Lett 2015 Oct 7;589(20 Pt A):2905-13. Epub 2015 May 7.

Hubrecht Institute - KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.04.055DOI Listing
October 2015

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers.

Mol Cell 2015 Oct 1;60(2):328-37. Epub 2015 Oct 1.

Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765150069
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http://dx.doi.org/10.1016/j.molcel.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624327PMC
October 2015

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Genome Biol 2015 Aug 3;16:149. Epub 2015 Aug 3.

Radboud University, Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (RIMLS), 6500HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s13059-015-0698-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546214PMC
August 2015

Getting the genome in shape: the formation of loops, domains and compartments.

Genome Biol 2015 Aug 10;16:154. Epub 2015 Aug 10.

Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s13059-015-0730-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536798PMC
August 2015

A Long-Distance Chromatin Affair.

Cell 2015 Aug;162(5):942-3

Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.022DOI Listing
August 2015

Characterization and dynamics of pericentromere-associated domains in mice.

Genome Res 2015 Jul 16;25(7):958-69. Epub 2015 Apr 16.

Hubrecht Institute-KNAW & University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1101/gr.186643.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484393PMC
July 2015

Large-scale identification of coregulated enhancer networks in the adult human brain.

Cell Rep 2014 Oct 16;9(2):767-79. Epub 2014 Oct 16.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584CT, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.09.023DOI Listing
October 2014

A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system.

Circ Res 2014 Aug 24;115(4):432-41. Epub 2014 Jun 24.

From the Department of Anatomy, Embryology, and Physiology, Academic Medical Center, Amsterdam, The Netherlands (J.H.v.W., I.B., M.v.d.B., S.S., P.B., V.M.C.); Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands (H.J.G.v.d.W., W.d.L.); Department of Cell Biology, Erasmus MC Rotterdam, Rotterdam, The Netherlands (H.J.G.v.d.W.); and Cardiovascular Development and Repair Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain (M.G.-V., C.B.-C., M.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.303591DOI Listing
August 2014

CTCF: the protein, the binding partners, the binding sites and their chromatin loops.

Philos Trans R Soc Lond B Biol Sci 2013 6;368(1620):20120369. Epub 2013 May 6.

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1098/rstb.2012.0369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682731PMC
December 2013

Topology of mammalian developmental enhancers and their regulatory landscapes.

Nature 2013 Oct;502(7472):499-506

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nature12753DOI Listing
October 2013

The pluripotent genome in three dimensions is shaped around pluripotency factors.

Nature 2013 Sep 24;501(7466):227-31. Epub 2013 Jul 24.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nature12420DOI Listing
September 2013

For genomes to stay in shape, insulators must be up to PAR.

Cell 2013 Sep;155(1):15-6

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.cell.2013.09.012DOI Listing
September 2013

Identical cells with different 3D genomes; cause and consequences?

Curr Opin Genet Dev 2013 Apr 14;23(2):191-6. Epub 2013 Feb 14.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Urecht, The Netherlands.

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http://dx.doi.org/10.1016/j.gde.2012.12.010DOI Listing
April 2013

eRNAs are required for p53-dependent enhancer activity and gene transcription.

Mol Cell 2013 Feb 27;49(3):524-35. Epub 2012 Dec 27.

Division of Gene Regulation, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands; Doctoral Programme in Biomedicine and Experimental Biology, Centre for Neuroscience and Cell Biology, 3004-517 Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.molcel.2012.11.021DOI Listing
February 2013

4C technology: protocols and data analysis.

Methods Enzymol 2012 ;513:89-112

Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/B978-0-12-391938-0.00004-5DOI Listing
December 2012

Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: from fixation to computation.

Methods 2012 Nov 17;58(3):221-30. Epub 2012 May 17.

Hubrecht Institute-KNAW, University Medical Centre Utrecht, Utrecht 3584 CT, The Netherlands.

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http://dx.doi.org/10.1016/j.ymeth.2012.04.009DOI Listing
November 2012

3D chromatin conformation correlates with replication timing and is conserved in resting cells.

Nucleic Acids Res 2012 Oct 8;40(19):9470-81. Epub 2012 Aug 8.

Laboratoire Joliot-Curie, Ecole Normale Supérieure de Lyon, CNRS, F-69007 Lyon, France.

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http://dx.doi.org/10.1093/nar/gks736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479194PMC
October 2012

Robust 4C-seq data analysis to screen for regulatory DNA interactions.

Nat Methods 2012 Oct 9;9(10):969-72. Epub 2012 Sep 9.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nmeth.2173DOI Listing
October 2012

Chromatin loops, gene positioning, and gene expression.

Front Genet 2012 17;3:217. Epub 2012 Oct 17.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fgene.2012.00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473233PMC
October 2012

A decade of 3C technologies: insights into nuclear organization.

Genes Dev 2012 Jan;26(1):11-24

Hubrecht Institute-KNAW, University Medical Center Utrecht, CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1101/gad.179804.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258961PMC
January 2012

An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation.

Nat Commun 2011 ;2:310

Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas and Universidad Pablo de Olavide, Carretera de Utrera Km1, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1038/ncomms1301DOI Listing
November 2011

A regulatory archipelago controls Hox genes transcription in digits.

Cell 2011 Nov;147(5):1132-45

National Research Centre, Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2011.10.023DOI Listing
November 2011

The dynamic architecture of Hox gene clusters.

Science 2011 Oct;334(6053):222-5

National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale (EPFL), Lausanne, Switzerland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1207194
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http://dx.doi.org/10.1126/science.1207194DOI Listing
October 2011

The complex transcription regulatory landscape of our genome: control in three dimensions.

EMBO J 2011 Sep 27;30(21):4345-55. Epub 2011 Sep 27.

Hubrecht Insitute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/emboj.2011.344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230377PMC
September 2011

Variegated gene expression caused by cell-specific long-range DNA interactions.

Nat Cell Biol 2011 Jun 26;13(8):944-51. Epub 2011 Jun 26.

Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/ncb2278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151580PMC
June 2011

Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements.

Genome Res 2011 May 6;21(5):697-706. Epub 2011 Apr 6.

Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-5055, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.111153.110
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http://dx.doi.org/10.1101/gr.111153.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083086PMC
May 2011

Interactions among Polycomb domains are guided by chromosome architecture.

PLoS Genet 2011 Mar 24;7(3):e1001343. Epub 2011 Mar 24.

Division of Molecular Genetics and Centre for Biomedical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1001343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063757PMC
March 2011

Genome organization influences partner selection for chromosomal rearrangements.

Trends Genet 2011 Feb 7;27(2):63-71. Epub 2010 Dec 7.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.tig.2010.11.001DOI Listing
February 2011

High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology.

Nat Methods 2009 Nov 11;6(11):837-42. Epub 2009 Oct 11.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nmeth.1391DOI Listing
November 2009

Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C).

Nat Protoc 2009 30;4(8):1216-29. Epub 2009 Jul 30.

Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nprot.2009.113DOI Listing
October 2009

Tissue- and expression level-specific chromatin looping at maize b1 epialleles.

Plant Cell 2009 Mar 31;21(3):832-42. Epub 2009 Mar 31.

Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, 1098 XH Amsterdam, The Netherlands.

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http://dx.doi.org/10.1105/tpc.108.064329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671708PMC
March 2009

Joining the loops: beta-globin gene regulation.

IUBMB Life 2008 Dec;60(12):824-33

Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/iub.129DOI Listing
December 2008

Beta-globin regulation and long-range interactions.

Adv Genet 2008 ;61:107-42

Department of Cell Biology and Genetics, Erasmus MC, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/S0065-2660(07)00004-1DOI Listing
November 2008

FISH-eyed and genome-wide views on the spatial organisation of gene expression.

Biochim Biophys Acta 2008 Nov 5;1783(11):2052-60. Epub 2008 Aug 5.

Department of Cell Biology, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbamcr.2008.07.020DOI Listing
November 2008

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions.

Nature 2008 Jun 7;453(7197):948-51. Epub 2008 May 7.

Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature06947DOI Listing
June 2008

Three-dimensional organization of gene expression in erythroid cells.

Curr Top Dev Biol 2008 ;82:117-39

Department of Cell Biology and Genetics, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/S0070-2153(07)00005-1DOI Listing
April 2008

An evaluation of 3C-based methods to capture DNA interactions.

Nat Methods 2007 Nov;4(11):895-901

Department of Cell Biology and Genetics, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam.

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http://dx.doi.org/10.1038/nmeth1114DOI Listing
November 2007

Inter-chromosomal gene regulation in the mammalian cell nucleus.

Curr Opin Genet Dev 2007 Oct 20;17(5):456-64. Epub 2007 Sep 20.

Department of Cell Biology, Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gde.2007.07.009DOI Listing
October 2007

Quantitative analysis of chromosome conformation capture assays (3C-qPCR).

Nat Protoc 2007 ;2(7):1722-33

UMR5535 CNRS-UMII, IFR122, Institut de Génétique Moléculaire de Montpellier, IGMM, 1919, Route de Mende, 34293 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1038/nprot.2007.243DOI Listing
September 2007

Beta-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice.

J Biol Chem 2007 Jun 11;282(22):16544-52. Epub 2007 Apr 11.

Department of Cell Biology, Erasmus Medical Center, P. O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M701159200DOI Listing
June 2007

Long-range DNA contacts: romance in the nucleus?

Authors:
Wouter de Laat

Curr Opin Cell Biol 2007 Jun 27;19(3):317-20. Epub 2007 Apr 27.

Department of Cell Biology, Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ceb.2007.04.004DOI Listing
June 2007

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes.

Nat Immunol 2007 Apr 4;8(4):378-87. Epub 2007 Mar 4.

Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London W1T 4JF, UK.

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http://dx.doi.org/10.1038/ni1448DOI Listing
April 2007

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C).

Nat Genet 2006 Nov 8;38(11):1348-54. Epub 2006 Oct 8.

Department of Cell Biology and Genetics, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ng1896DOI Listing
November 2006

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus.

Genes Dev 2006 Sep;20(17):2349-54

Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1101/gad.399506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560409PMC
September 2006

Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.

Genes Dev 2004 Jun;18(12):1495-509

Erasmus University Medical Center, Faculty of Medicine and Health Sciences, MGC Department of Cell Biology and Genetics, Rotterdam, 3000 DR, The Netherlands.

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http://dx.doi.org/10.1101/gad.289704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423198PMC
June 2004

Spatial organization of gene expression: the active chromatin hub.

Chromosome Res 2003 ;11(5):447-59

Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University, Rotterdam, PO Box 1738, 3000DR Rotterdam, The Netherlands.

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April 2004

3C technology: analyzing the spatial organization of genomic loci in vivo.

Methods Enzymol 2004 ;375:493-507

Department of Cell Biology, ErasmusMC, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/s0076-6879(03)75030-7DOI Listing
March 2004

The beta-globin nuclear compartment in development and erythroid differentiation.

Nat Genet 2003 Oct 21;35(2):190-4. Epub 2003 Sep 21.

Department of Cell Biology and Genetics, ErasmusMC, PO Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ng1244DOI Listing
October 2003

Looping and interaction between hypersensitive sites in the active beta-globin locus.

Mol Cell 2002 Dec;10(6):1453-65

Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University, Rotterdam, P.O. Box 1738, 3000DR, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/s1097-2765(02)00781-5DOI Listing
December 2002