Publications by authors named "Wouter H J Vaes"

28Publications

Towards human organ perfusion models to elucidate drug pharmacokinetics in health and disease.

Drug Metab Rev 2020 08 18;52(3):438-454. Epub 2020 Jun 18.

The Netherlands Organisation for Applied Scientific Research (TNO), Zeist, The Netherlands.

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http://dx.doi.org/10.1080/03602532.2020.1772280DOI Listing
August 2020

Proof of Concept: First Pediatric [ C]microtracer Study to Create Metabolite Profiles of Midazolam.

Clin Pharmacol Ther 2020 Nov 27;108(5):1003-1009. Epub 2020 Jun 27.

Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/cpt.1884DOI Listing
November 2020

Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing.

Crit Care Med 2019 12;47(12):e975-e983

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000004032DOI Listing
December 2019

Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life.

Drug Metab Dispos 2016 07 21;44(7):1005-13. Epub 2016 Apr 21.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)

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http://dx.doi.org/10.1124/dmd.115.068577DOI Listing
July 2016

The impact of early human data on clinical development: there is time to win.

Drug Discov Today 2016 06 29;21(6):873-9. Epub 2016 Mar 29.

TNO, PO Box 360, 3700AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1016/j.drudis.2016.03.012DOI Listing
June 2016

To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics.

Clin Pharmacokinet 2016 Jan;55(1):1-15

TNO, Utrechtseweg 48, 3704 HE, Zeist, The Netherlands.

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http://link.springer.com/10.1007/s40262-015-0308-9
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http://dx.doi.org/10.1007/s40262-015-0308-9DOI Listing
January 2016

Automated combustion accelerator mass spectrometry for the analysis of biomedical samples in the low attomole range.

Anal Chem 2014 Aug 25;86(15):7635-41. Epub 2014 Jul 25.

TNO , P.O. Box 360, 3700AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1021/ac5015035DOI Listing
August 2014

Effect of red wine consumption on biomarkers of oxidative stress.

Alcohol Alcohol 2013 Mar-Apr;48(2):153-9. Epub 2012 Aug 2.

TNO, Utrechtseweg 48, 3704 HE Zeist, The Netherlands.

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http://dx.doi.org/10.1093/alcalc/ags086DOI Listing
October 2013

Predicting blood:air partition coefficients using basic physicochemical properties.

Regul Toxicol Pharmacol 2012 Feb 9;62(1):23-8. Epub 2011 Dec 9.

TNO Innovation for Life, Research Group Quality & Safety, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S027323001100248
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http://dx.doi.org/10.1016/j.yrtph.2011.11.019DOI Listing
February 2012

Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli.

J Agric Food Chem 2008 Nov;56(22):10505-9

TNO Quality of Life, AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1021/jf801989eDOI Listing
November 2008

Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status.

J Nutr Biochem 2007 Oct 5;18(10):693-9. Epub 2007 Apr 5.

Department of Internal Medicine and Institute for Cardiovascular Research ICaR-VU, VU University Medical Center, Amsterdam 1007 MB, The Netherlands.

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http://dx.doi.org/10.1016/j.jnutbio.2006.11.010DOI Listing
October 2007

Decreased coenzyme Q10 concentration in plasma of children with cystic fibrosis.

J Pediatr Gastroenterol Nutr 2006 Nov;43(5):646-50

Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, UMC Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/01.mpg.0000233193.77521.66DOI Listing
November 2006

Association between consumption of cruciferous vegetables and condiments and excretion in urine of isothiocyanate mercapturic acids.

J Agric Food Chem 2006 Jul;54(15):5350-8

Business Unit Analytical Research, TNO Quality of Life, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1021/jf060723nDOI Listing
July 2006

Evaluation of Simple Treat 3.0 for two hydrophobic and slowly biodegradable chemicals: polycyclic musks HHCB and AHTN.

Water Res 2003 Nov;37(18):4377-84

Institute for Risk Assessment Sciences, Toxicology Division, University of Utrecht, Yalelaan 2, P.O. Box 80.176, 3508 TD, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/S0043-1354(03)00434-2DOI Listing
November 2003

Removal of two polycyclic musks in sewage treatment plants: freely dissolved and total concentrations.

Environ Sci Technol 2003 Jul;37(14):3111-6

Institute for Risk Assessment Sciences, Toxicology Division, Utrecht University, P.O. Box 80.176, NL-3508 TD Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/es020226xDOI Listing
July 2003

Analysis of isothiocyanate mercapturic acids in urine: a biomarker for cruciferous vegetable intake.

J Agric Food Chem 2003 Jun;51(12):3554-9

Department of Food & Food Supplement Analysis, TNO Nutrition and Food Research, P.O. Box 360, 3700 AJ Zeist, The Netherlands.

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http://dx.doi.org/10.1021/jf0341316DOI Listing
June 2003

Bioconcentration and acute toxicity of polycyclic musks in two benthic organisms (Chironomus riparius and Lumbriculus variegatus).

Environ Toxicol Chem 2003 May;22(5):1086-92

Institute for Risk Assessment Sciences, IRAS, Toxicology Division, Utrecht University, P.O. Box 80.176, NL-3508 TD Utrecht, The Netherlands.

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May 2003

Sorption kinetics and microbial biodegradation activity of hydrophobic chemicals in sewage sludge: model and measurements based on free concentrations.

Environ Sci Technol 2003 Jan;37(1):116-22

Institute for Risk Assessment Sciences, Toxicology Division, Utrecht University, P.O. Box 80.176, NL-3508 TD Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/es020115yDOI Listing
January 2003

Negligible depletion solid-phase microextraction with radiolabeled analytes to study free concentrations and protein binding: an example with [3H]estradiol.

Anal Chem 2002 Dec;74(23):5993-7

Institute for Risk Assessment Sciences (IRAS), Toxicology Division, Utrecht University, P.O. Box 80176, NL-3508 TD Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/ac0204552DOI Listing
December 2002

Determination of liposome/water partition coefficients of organic acids and bases by solid-phase microextraction.

Analyst 2002 Jan;127(1):42-8

Swiss Federal Institute for Environmental Science and Technology (EAWAG), Dübendorf.

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http://dx.doi.org/10.1039/b109355jDOI Listing
January 2002