Wooyoung Hur

Wooyoung Hur

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Wooyoung Hur

Wooyoung Hur

Publications by authors named "Wooyoung Hur"

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32Publications

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Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors.

Bioorg Med Chem Lett 2018 12 11;28(23-24):3761-3765. Epub 2018 Oct 11.

Chemical Kinomics Research Center, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 02792, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.10.013DOI Listing
December 2018

Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators.

Eur J Med Chem 2018 Sep 8;157:691-704. Epub 2018 Aug 8.

Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.020DOI Listing
September 2018

First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.

J Med Chem 2018 09 11;61(18):8353-8373. Epub 2018 Sep 11.

KU-KIST Graduate School of Converging Science and Technology , Korea University , 145 Anam-ro, Seongbuk-gu , Seoul 02841 , Republic of Korea.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00882
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http://dx.doi.org/10.1021/acs.jmedchem.8b00882DOI Listing
September 2018

Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs.

Chem Biol Drug Des 2018 02 13;91(2):575-587. Epub 2017 Nov 13.

Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Korea.

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http://dx.doi.org/10.1111/cbdd.13122DOI Listing
February 2018

Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors.

Eur J Med Chem 2017 Sep 9;137:545-557. Epub 2017 Jun 9.

High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, PR China; CHMFL-HCMTC Target Therapy Joint Laboratory, 350 Shushanhu Road, Hefei Anhui 230031, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.06.016DOI Listing
September 2017

Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion.

Biochim Biophys Acta Gen Subj 2017 Apr 1;1861(4):947-957. Epub 2017 Feb 1.

Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.01.034DOI Listing
April 2017

Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277.

J Med Chem 2017 02 6;60(4):1495-1508. Epub 2017 Feb 6.

KU-KIST Graduate School of Converging Science and Technology, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.6b01679
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http://dx.doi.org/10.1021/acs.jmedchem.6b01679DOI Listing
February 2017

A benzo[b]thiophene-based selective type 4 S1P receptor agonist.

Bioorg Med Chem Lett 2017 01 18;27(1):1-5. Epub 2016 Nov 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 360 Longwood Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.11.050DOI Listing
January 2017

Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells.

Mol Cancer Ther 2015 Oct 20;14(10):2292-302. Epub 2015 Aug 20.

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seongbuk-gu, Seoul, Republic of Korea. Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seongbuk-gu, Seoul, Republic of Korea.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0032DOI Listing
October 2015

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.

Chem Biol Drug Des 2015 Aug 28;86(2):144-55. Epub 2014 Nov 28.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, 450 Technology Drive, Pittsburgh, PA, 15219, USA.

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http://dx.doi.org/10.1111/cbdd.12473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444405PMC
August 2015

Identification of Novel ROS Inducers: Quinone Derivatives Tethered to Long Hydrocarbon Chains.

J Med Chem 2015 May 15;58(9):3739-50. Epub 2015 Apr 15.

†KU-KIST Graduate School of Converging Science and Technology, 145 Anam-ro, Seongbuk-gu, Seoul, 136-713, Republic of Korea.

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http://dx.doi.org/10.1021/jm501846yDOI Listing
May 2015

Discovery of a selective irreversible BMX inhibitor for prostate cancer.

ACS Chem Biol 2013 Jul 26;8(7):1423-8. Epub 2013 Apr 26.

High Magnetic Field laboratory, Chinese Academy of Sciences , P.O. Box 1110, Hefei, Anhui 230031, P. R. China.

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http://dx.doi.org/10.1021/cb4000629DOI Listing
July 2013

Small molecule modulators of antioxidant response pathway.

Curr Opin Chem Biol 2011 Feb 30;15(1):162-73. Epub 2010 Dec 30.

Department of Cancer Biology, Dana-Farber Cancer Institute, 250 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cbpa.2010.12.009DOI Listing
February 2011

A small-molecule inducer of the antioxidant response element.

Chem Biol 2010 May;17(5):537-47

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.chembiol.2010.03.013DOI Listing
May 2010

Antimitotic agents of natural origin.

Curr Drug Targets 2006 Mar;7(3):305-26

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.2174/138945006776054933DOI Listing
March 2006

Allosteric inhibitors of Bcr-abl-dependent cell proliferation.

Nat Chem Biol 2006 Feb 15;2(2):95-102. Epub 2006 Jan 15.

Biological Chemistry Department, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.

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http://dx.doi.org/10.1038/nchembio760DOI Listing
February 2006

Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library.

J Am Chem Soc 2006 Feb;128(7):2182-3

Departments of Chemistry and Cell Biology, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1021/ja0567485DOI Listing
February 2006

Synthesis and target identification of hymenialdisine analogs.

Chem Biol 2004 Feb;11(2):247-59

Genomics Institute of the Novartis Research Foundation, Department of Chemistry, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10745521040002
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http://dx.doi.org/10.1016/j.chembiol.2004.01.015DOI Listing
February 2004

Synthetic small molecules that control stem cell fate.

Proc Natl Acad Sci U S A 2003 Jun 6;100(13):7632-7. Epub 2003 Jun 6.

Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0732087100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164638PMC
June 2003