Wolfram S Kunz

Wolfram S Kunz

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Wolfram S Kunz

Publications by authors named "Wolfram S Kunz"

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Replication fork rescue in mammalian mitochondria.

Sci Rep 2019 Jun 19;9(1):8785. Epub 2019 Jun 19.

Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101, Joensuu, Finland.

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http://dx.doi.org/10.1038/s41598-019-45244-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584726PMC
June 2019

Distinct segregation of the pathogenic m.5667G>A mitochondrial tRNA mutation in extraocular and skeletal muscle in chronic progressive external ophthalmoplegia.

Neuromuscul Disord 2019 May 25;29(5):358-367. Epub 2019 Feb 25.

Division of Neurochemistry, Institute of Experimental Epileptology and Cognition Research, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany; Department of Epileptology, University of Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2019.02.009DOI Listing
May 2019

Retinoencephalopathy with occipital lobe epilepsy in an OPA-1 mutation carrier.

Seizure 2019 Mar 30;66:1-3. Epub 2019 Jan 30.

Department of Epileptology, University of Bonn Hospital, Bonn, Germany; Institute of Experimental Epileptology and Cognition Research, University Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2019.01.029DOI Listing
March 2019

Rare coding variants in genes encoding GABA receptors in genetic generalised epilepsies: an exome-based case-control study.

Authors:
Patrick May Simon Girard Merle Harrer Dheeraj R Bobbili Julian Schubert Stefan Wolking Felicitas Becker Pamela Lachance-Touchette Caroline Meloche Micheline Gravel Cristina E Niturad Julia Knaus Carolien De Kovel Mohamad Toliat Anne Polvi Michele Iacomino Rosa Guerrero-López Stéphanie Baulac Carla Marini Holger Thiele Janine Altmüller Kamel Jabbari Ann-Kathrin Ruppert Wiktor Jurkowski Dennis Lal Raffaella Rusconi Sandrine Cestèle Benedetta Terragni Ian D Coombs Christopher A Reid Pasquale Striano Hande Caglayan Auli Siren Kate Everett Rikke S Møller Helle Hjalgrim Hiltrud Muhle Ingo Helbig Wolfram S Kunz Yvonne G Weber Sarah Weckhuysen Peter De Jonghe Sanjay M Sisodiya Rima Nabbout Silvana Franceschetti Antonietta Coppola Maria S Vari Dorothée Kasteleijn-Nolst Trenité Betul Baykan Ugur Ozbek Nerses Bebek Karl M Klein Felix Rosenow Dang K Nguyen François Dubeau Lionel Carmant Anne Lortie Richard Desbiens Jean-François Clément Cécile Cieuta-Walti Graeme J Sills Pauls Auce Ben Francis Michael R Johnson Anthony G Marson Bianca Berghuis Josemir W Sander Andreja Avbersek Mark McCormack Gianpiero L Cavalleri Norman Delanty Chantal Depondt Martin Krenn Fritz Zimprich Sarah Peter Marina Nikanorova Robert Kraaij Jeroen van Rooij Rudi Balling M Arfan Ikram André G Uitterlinden Giuliano Avanzini Stephanie Schorge Steven Petrou Massimo Mantegazza Thomas Sander Eric LeGuern Jose M Serratosa Bobby P C Koeleman Aarno Palotie Anna-Elina Lehesjoki Michael Nothnagel Peter Nürnberg Snezana Maljevic Federico Zara Patrick Cossette Roland Krause Holger Lerche

Lancet Neurol 2018 08 17;17(8):699-708. Epub 2018 Jul 17.

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http://dx.doi.org/10.1016/S1474-4422(18)30215-1DOI Listing
August 2018

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.

Nat Commun 2018 04 30;9(1):1727. Epub 2018 Apr 30.

Institute of Experimental Epileptology and Cognition Research, University of Bonn, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany.

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http://dx.doi.org/10.1038/s41467-018-04131-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928156PMC
April 2018

Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?

Genes (Basel) 2018 Mar 21;9(4). Epub 2018 Mar 21.

Institute of Experimental Epileptology and Neurocognition, University Bonn Medical Center, 53105 Bonn, Germany.

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http://dx.doi.org/10.3390/genes9040175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924517PMC
March 2018

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties.

Int J Mol Sci 2018 Jan 25;19(2). Epub 2018 Jan 25.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland.

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http://dx.doi.org/10.3390/ijms19020353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855575PMC
January 2018

Guide to the Pharmacology of Mitochondrial Potassium Channels.

Handb Exp Pharmacol 2017 ;240:103-127

Laboratory of Intracellular Ion Channels, Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.

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http://dx.doi.org/10.1007/164_2016_79DOI Listing
December 2017

Metabolic Epilepsies-Commemorative Issue in Honor of Professor Uwe Heinemann.

Int J Mol Sci 2017 Nov 22;18(11). Epub 2017 Nov 22.

Department of Epileptology and Life & Brain Center, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.3390/ijms18112499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713464PMC
November 2017

Mitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase.

Int J Mol Sci 2017 Sep 6;18(9). Epub 2017 Sep 6.

Department of Epileptology and Life & Brain Center, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.3390/ijms18091912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618561PMC
September 2017

Functional variants in and may contribute to genetic generalized epilepsy.

Epilepsia Open 2017 09 5;2(3):334-342. Epub 2017 Aug 5.

Department of Neurology and Epileptology Hertie-Institute for Clinical Brain-Research University of Tübingen Tübingen Germany.

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http://dx.doi.org/10.1002/epi4.12068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862120PMC
September 2017

Camptocormia and shuffling gait due to a novel mutation: Diagnostic pitfalls.

Neurol Genet 2017 Jun 5;3(3):e147. Epub 2017 Apr 5.

Department of Neurology (J.R., C.K.), Department of Epileptology (W.S.K.), Life and Brain Centre (W.S.K.), and Centre for Rare Diseases Bonn (ZSEB) (C.K.), University Hospital of Bonn, Germany; Department of Neurology (D.L.), University of Halle/S., Germany; and Wellcome Trust Centre for Mitochondrial Research (D.L., S.A.H., G.F., C.V.Y.K., R.L.J., R.W.T.), Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1212/NXG.0000000000000147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384303PMC
June 2017

Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy.

Acta Neuropathol 2016 08 18;132(2):277-88. Epub 2016 Mar 18.

Division of Neurochemistry, Department of Epileptology, University Bonn Medical Center, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00401-016-1561-1DOI Listing
August 2016

Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy.

Epilepsia 2015 Sep 15;56(9):e129-33. Epub 2015 Jul 15.

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1111/epi.13076DOI Listing
September 2015

Mitochondrial dysfunction and seizures: the neuronal energy crisis.

Lancet Neurol 2015 Sep;14(9):956-66

Division of Neurochemistry, Department of Epileptology, and Life & Brain Center, University of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(15)00148-9DOI Listing
September 2015

Do Glut1 (glucose transporter type 1) defects exist in epilepsy patients responding to a ketogenic diet?

Epilepsy Res 2015 Aug 1;114:47-51. Epub 2015 May 1.

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2015.04.012DOI Listing
August 2015

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging.

Cell Metab 2015 May;21(5):667-77

Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, University of Köln, Köln 50931, Germany; Center for Molecular Medicine Cologne (CMMC), University of Köln, Köln 50931, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Köln 50674, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.04.005DOI Listing
May 2015

Epileptic focus and alteration of metabolism.

Int Rev Neurobiol 2014 ;114:209-43

Department of Neurology, The Joseph Sagol Neuroscience Center, The Chaim Sheba Medical Center, Tel HaShomer, Israel; Talpiot Medical Leadership Program, The Chaim Sheba Medical Center, Tel HaShomer, Israel.

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http://dx.doi.org/10.1016/B978-0-12-418693-4.00009-1DOI Listing
March 2015

A homozygous splice-site mutation in CARS2 is associated with progressive myoclonic epilepsy.

Neurology 2014 Dec 31;83(23):2183-7. Epub 2014 Oct 31.

From the Department of Epileptology and Life & Brain Center (K.H., G.Z., S.M.-H., C.E.E., W.S.K.), University of Bonn; Department of Neuropediatrics and Muscle Disorders (J.K., R.K.), University of Freiburg; Cologne Center for Genomics (A.-K.R., H.T., P.N., T.S.), Center for Molecular Medicine Cologne (P.N.), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (P.N.), University of Cologne, Germany; Genetic Department (O.O.), Institute of Experimental Medicine (DETAE), Istanbul University, Turkey; Department of Neurology and Epileptology (Y.W., F.B., H.L.), Hertie Institute for Clinical Brain Research, University of Tübingen, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000001055DOI Listing
December 2014

Oxyphil cell metaplasia in the parathyroids is characterized by somatic mitochondrial DNA mutations in NADH dehydrogenase genes and cytochrome c oxidase activity-impairing genes.

Am J Pathol 2014 Nov;184(11):2922-35

Institute for Pathology of the Ludwig-Maximilians-Universität München, Munich, Germany; German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440140043
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http://dx.doi.org/10.1016/j.ajpath.2014.07.015DOI Listing
November 2014

Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.

Epilepsia 2014 Aug 3;55(8):1255-63. Epub 2014 Jul 3.

Institute of Neurophysiology, Charite-University Medicine Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/epi.12713DOI Listing
August 2014

Hemin inhibits the large conductance potassium channel in brain mitochondria: a putative novel mechanism of neurodegeneration.

Exp Neurol 2014 Jul 30;257:70-5. Epub 2014 Apr 30.

Department of Epileptology, University of Bonn, 25 Sigmund-Freud Street, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.expneurol.2014.04.022DOI Listing
July 2014

Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity.

PLoS Genet 2014 Jun 19;10(6):e1004385. Epub 2014 Jun 19.

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, Cologne, Germany; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Cologne Cardiovascular Research Center (CCRC) and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1004385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063685PMC
June 2014

Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.

J Neurosci 2013 Nov;33(46):18270-6

Neural Regeneration Group, Institute of Reconstructive Neurobiology and Division of Neurochemistry, Department of Epileptology, University of Bonn Medical Center, 53127 Bonn, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.2211-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828472PMC
November 2013

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A.

Brain 2013 Oct 6;136(Pt 10):3140-50. Epub 2013 Sep 6.

1 NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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https://academic.oup.com/brain/article/136/10/3140/330027
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http://dx.doi.org/10.1093/brain/awt233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784283PMC
October 2013

Mutation in the mitochondrial tRNA(Ile) gene causes progressive myoclonus epilepsy.

Seizure 2013 Jul 16;22(6):483-6. Epub 2013 Apr 16.

Department of Epileptology and Life&Brain Center, University of Bonn, Germany.

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http://dx.doi.org/10.1016/j.seizure.2013.03.003DOI Listing
July 2013

Neuroimaging characteristics in mitochondrial encephalopathies associated with the m.3243A>G MTTL1 mutation.

J Neurol 2013 Apr 30;260(4):1071-80. Epub 2012 Nov 30.

Department of Radiology (Neuroradiology), University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1007/s00415-012-6763-4DOI Listing
April 2013

Mitochondrial involvement in neurodegenerative diseases.

IUBMB Life 2013 Mar 22;65(3):263-72. Epub 2013 Jan 22.

Department of Epileptology and Life and Brain Center, University Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/iub.1126DOI Listing
March 2013

Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.

Hum Mol Genet 2012 Dec 4;21(24):5359-72. Epub 2012 Sep 4.

Institute for Medical Biometry, Informatic and Epidemiology, University of Bonn, Bonn, Germany.

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http://hmg.oxfordjournals.org/content/21/24/5359.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds373
Publisher Site
http://dx.doi.org/10.1093/hmg/dds373DOI Listing
December 2012

The contribution of thioredoxin-2 reductase and glutathione peroxidase to H(2)O(2) detoxification of rat brain mitochondria.

Biochim Biophys Acta 2012 Oct 28;1817(10):1901-6. Epub 2012 Feb 28.

Department of Epileptology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2012.02.023DOI Listing
October 2012

Primary skin fibroblasts as a model of Parkinson's disease.

Mol Neurobiol 2012 Aug 19;46(1):20-7. Epub 2012 Feb 19.

Experimental Neurology, Department of Neurology, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s12035-012-8245-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443476PMC
August 2012

A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes.

Sci Signal 2012 Aug 28;5(239):ra62. Epub 2012 Aug 28.

Institute of Pharmacology and Toxicology, University of Bonn, 53105 Bonn, Germany.

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http://dx.doi.org/10.1126/scisignal.2002867DOI Listing
August 2012

Mitochondrial dysfunction in epilepsy.

Mitochondrion 2012 Jan 20;12(1):35-40. Epub 2011 Apr 20.

Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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January 2012

Changes in mitochondrial reactive oxygen species synthesis during differentiation of skeletal muscle cells.

Mitochondrion 2012 Jan 20;12(1):144-8. Epub 2011 Jul 20.

Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland.

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January 2012

POLG mutations cause decreased mitochondrial DNA repopulation rates following induced depletion in human fibroblasts.

Biochim Biophys Acta 2011 Mar 5;1812(3):321-5. Epub 2010 Dec 5.

Mitochondrial Research Group, Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK.

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http://dx.doi.org/10.1016/j.bbadis.2010.11.012DOI Listing
March 2011

Complex III-dependent superoxide production of brain mitochondria contributes to seizure-related ROS formation.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):1163-70. Epub 2010 Mar 6.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.bbabio.2010.03.001DOI Listing
January 2011

The cytoprotective action of the potassium channel opener BMS-191095 in C2C12 myoblasts is related to the modulation of calcium homeostasis.

Cell Physiol Biochem 2010 24;26(2):235-46. Epub 2010 Aug 24.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Warsaw, Poland.

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http://dx.doi.org/10.1159/000320523DOI Listing
December 2010

Mitochondrial dysfunction in neurological disorders with epileptic phenotypes.

J Bioenerg Biomembr 2010 Dec;42(6):443-8

Division of Neurochemistry, Department of Epileptology, University Bonn Medical Center, Sigmund-Freud-Str. 25, D53105, Bonn, Germany.

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December 2010

Distinct patterns of mitochondrial genome diversity in bonobos (Pan paniscus) and humans.

BMC Evol Biol 2010 Sep 2;10:270. Epub 2010 Sep 2.

Division of Neurochemistry, Department of Epileptology and Life&Brain Center, University Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1186/1471-2148-10-270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942848PMC
September 2010

Mitochondrial potassium channels and reactive oxygen species.

FEBS Lett 2010 May 16;584(10):2043-8. Epub 2010 Jan 16.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur st., 02-093 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.febslet.2010.01.013DOI Listing
May 2010

Mitochondrial involvement in temporal lobe epilepsy.

Exp Neurol 2009 Aug 5;218(2):326-32. Epub 2009 Mar 5.

Department of Epileptology, University Bonn Medical Center, Germany.

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http://dx.doi.org/10.1016/j.expneurol.2009.02.014DOI Listing
August 2009

Single channel studies of the ATP-regulated potassium channel in brain mitochondria.

J Bioenerg Biomembr 2009 Aug 10;41(4):323-34. Epub 2009 Oct 10.

Department of Biophysics, Warsaw University of Life Sciences SGGW, 159 Nowoursynowska St., 02-776, Warsaw, Poland.

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August 2009

Chapter 23 Quantification of superoxide production by mouse brain and skeletal muscle mitochondria.

Methods Enzymol 2009 ;456:419-37

Division of Neurochemistry, Department of Epileptology and Life & Brain Center, University Bonn, Bonn, Germany.

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June 2009

Behavioral changes in G72/G30 transgenic mice.

Eur Neuropsychopharmacol 2009 May 1;19(5):339-48. Epub 2009 Feb 1.

Institute of Molecular Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2008.12.009DOI Listing
May 2009

Clonal expansion of different mtDNA variants without selective advantage in solid tumors.

Mutat Res 2009 Mar 9;662(1-2):28-32. Epub 2008 Dec 9.

Institute of Vegetative Physiology, Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Köln, Germany.

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http://dx.doi.org/10.1016/j.mrfmmm.2008.11.020DOI Listing
March 2009

Mitochondrial potassium channels.

IUBMB Life 2009 Feb;61(2):134-43

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Warsaw, Poland.

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http://dx.doi.org/10.1002/iub.155DOI Listing
February 2009

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells.

Nat Protoc 2008 ;3(6):965-76

Daniel Swarovski Research Laboratory, Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck A6020, Austria.

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http://dx.doi.org/10.1038/nprot.2008.61DOI Listing
September 2008

Sites of generation of reactive oxygen species in homogenates of brain tissue determined with the use of respiratory substrates and inhibitors.

Biochim Biophys Acta 2008 Jul-Aug;1777(7-8):689-95. Epub 2008 May 24.

Division of Neurochemistry, Department of Epileptology, University of Bonn Medical Center, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2008.05.010DOI Listing
August 2008

A novel potassium channel in skeletal muscle mitochondria.

Biochim Biophys Acta 2008 Jul-Aug;1777(7-8):651-9. Epub 2008 May 20.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.

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August 2008

BK channel openers inhibit ROS production of isolated rat brain mitochondria.

Exp Neurol 2008 Aug 20;212(2):543-7. Epub 2008 May 20.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.

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August 2008

Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export.

Circulation 2008 Jun 27;117(22):2912-8. Epub 2008 May 27.

Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.747667DOI Listing
June 2008

Stilbene derivatives inhibit the activity of the inner mitochondrial membrane chloride channels.

Cell Mol Biol Lett 2007 25;12(4):493-508. Epub 2007 Apr 25.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Pasteura 3, 02-093, Warsaw, Poland.

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http://dx.doi.org/10.2478/s11658-007-0019-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275615PMC
May 2008

Concerted action of two novel tRNA mtDNA point mutations in chronic progressive external ophthalmoplegia.

Biosci Rep 2008 Apr;28(2):89-96

Department of Neurology, University of Bonn Medical Center, Bonn, D-53105, Germany.

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April 2008

Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent.

Epilepsy Res 2007 Feb 2;73(2):173-80. Epub 2006 Nov 2.

Department of Epileptology, University of Bonn Medical Center, Sigmund Freud-Strasse 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.eplepsyres.2006.10.001DOI Listing
February 2007

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

Neurobiol Dis 2007 Feb 30;25(2):401-11. Epub 2006 Nov 30.

Section for Molecular Neurogenetics, Clinic for Neurology, University Hospital, Theodor Stern Kai 7, 60590 Frankfurt/M., Germany.

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http://dx.doi.org/10.1016/j.nbd.2006.10.007DOI Listing
February 2007

Mitochondrial DNA damage and the aging process: facts and imaginations.

Free Radic Res 2006 Dec;40(12):1284-94

Faculty of Medicine, Institute of Vegetative Physiology, University of Köln, Köln, Germany.

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http://dx.doi.org/10.1080/10715760600913168DOI Listing
December 2006

Mitochondrial potassium channels: from pharmacology to function.

Biochim Biophys Acta 2006 May-Jun;1757(5-6):715-20. Epub 2006 May 12.

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur st., 02-093 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.bbabio.2006.05.002DOI Listing
September 2006

Antidiabetic sulphonylureas activate mitochondrial permeability transition in rat skeletal muscle.

Br J Pharmacol 2005 Jul;145(6):785-91

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur St., Warsaw 02-093, Poland.

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http://dx.doi.org/10.1038/sj.bjp.0706214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576186PMC
July 2005

Diagnostic value of mitochondrial DNA mutation analysis in juvenile unilateral ptosis.

Graefes Arch Clin Exp Ophthalmol 2005 Apr 13;243(4):380-2. Epub 2004 Oct 13.

Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00417-004-1000-1DOI Listing
April 2005