Publications by authors named "Wolfgang Wurst"

100Publications

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

EMBO Rep 2020 Sep 14:e50241. Epub 2020 Sep 14.

Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.15252/embr.202050241DOI Listing
September 2020

β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons.

EMBO J 2020 Sep 15:e104472. Epub 2020 Sep 15.

Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.15252/embj.2020104472DOI Listing
September 2020

Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis.

Sci Rep 2020 02 6;10(1):1984. Epub 2020 Feb 6.

Stem Cells in Neural Development and Disease group, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Munich-Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41598-019-56877-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005302PMC
February 2020

Alpha-synuclein fragments trigger distinct aggregation pathways.

Cell Death Dis 2020 02 3;11(2):84. Epub 2020 Feb 3.

Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), 81377, Munich, Germany.

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http://dx.doi.org/10.1038/s41419-020-2285-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997403PMC
February 2020

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.

Biochim Biophys Acta Mol Basis Dis 2020 03 23;1866(3):165622. Epub 2019 Nov 23.

Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland; radiz - Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165622DOI Listing
March 2020

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4.

Sci Rep 2019 03 14;9(1):4515. Epub 2019 Mar 14.

Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University Clinic Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1038/s41598-019-40808-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418296PMC
March 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons.

Neuropharmacology 2019 05 4;149:13-26. Epub 2019 Feb 4.

Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), D-81377, Munich, Germany; Department of Neurology, Technical University of Munich (TUM), D-81675, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig Maximilians University (LMU), D-81377, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.01.023DOI Listing
May 2019

A Customizable Protocol for String Assembly gRNA Cloning (STAgR).

J Vis Exp 2018 12 26(142). Epub 2018 Dec 26.

MCN Junior Research Group, Munich Center for Neurosciences, Ludwig Maximilian Universitat, BioMedical Center; Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health;

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https://www.jove.com/video/58556/a-customizable-protocol-for
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http://dx.doi.org/10.3791/58556DOI Listing
December 2018

The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis.

Cell Rep 2018 12;25(12):3241-3251.e5

Institute of Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany; Department for Cell Biology and Anatomy, Biomedical Center of LMU, 82152 Planegg, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183181
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http://dx.doi.org/10.1016/j.celrep.2018.11.055DOI Listing
December 2018

Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice.

Mol Neurobiol 2019 Jun 6;56(6):4215-4230. Epub 2018 Oct 6.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, 85764, Neuherberg, Germany.

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http://link.springer.com/10.1007/s12035-018-1365-5
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http://dx.doi.org/10.1007/s12035-018-1365-5DOI Listing
June 2019

Author Correction: Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception.

Nat Commun 2018 07 17;9(1):2859. Epub 2018 Jul 17.

Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-018-05323-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050316PMC
July 2018

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.

Cell Death Dis 2018 07 9;9(7):757. Epub 2018 Jul 9.

Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), D-81377, Munich, Germany.

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http://dx.doi.org/10.1038/s41419-018-0816-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037700PMC
July 2018

Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception.

Nat Commun 2018 02 23;9(1):802. Epub 2018 Feb 23.

Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-018-03090-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824813PMC
February 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis.

BMC Genomics 2017 Nov 25;18(1):905. Epub 2017 Nov 25.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1186/s12864-017-4285-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702081PMC
November 2017

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.

Behav Brain Res 2018 10 29;352:187-196. Epub 2017 Sep 29.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter-Landstr. 1, 85764 Neuherberg, Germany; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Alte Akademie 8, 85354 Freising, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.09.048DOI Listing
October 2018

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.

Neuroscience 2017 08 13;357:241-254. Epub 2017 Jun 13.

Research Unit NeuroBiology of Diabetes, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg 85764, Germany; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg 85764, Germany; German Center for Diabetes Research (DZD), Neuherberg 85764, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.05.050DOI Listing
August 2017

Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism.

Biochim Biophys Acta Mol Basis Dis 2017 09 22;1863(9):2220-2228. Epub 2017 May 22.

Institute of Human Genetics, Technical University Munich, Trogerstr. 32, 81675 Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum Munich, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.05.018DOI Listing
September 2017

Analysis of locomotor behavior in the German Mouse Clinic.

J Neurosci Methods 2018 04 5;300:77-91. Epub 2017 May 5.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstaedter Landstr.1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.jneumeth.2017.05.005DOI Listing
April 2018

Control of gene editing by manipulation of DNA repair mechanisms.

Mamm Genome 2017 Aug 3;28(7-8):262-274. Epub 2017 Apr 3.

Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13125, Berlin, Germany.

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http://dx.doi.org/10.1007/s00335-017-9688-5DOI Listing
August 2017

Gene editing in mouse zygotes using the CRISPR/Cas9 system.

Methods 2017 05 2;121-122:55-67. Epub 2017 Mar 2.

Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle Str. 10, 13125 Berlin, Germany; Berlin Institute of Health, Kapelle-Ufer 2, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.02.008DOI Listing
May 2017

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.

Nucleic Acids Res 2017 04;45(6):3031-3045

Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/nar/gkw1222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389484PMC
April 2017

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.

Development 2016 11 11;143(22):4279-4287. Epub 2016 Oct 11.

TU Braunschweig, Zoological Institute, Cellular and Molecular Neurobiology, Spielmannstr. 7, Braunschweig 38106, Germany

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http://dx.doi.org/10.1242/dev.122721DOI Listing
November 2016

CRISPR-Cas9 enables conditional mutagenesis of challenging loci.

Sci Rep 2016 09 1;6:32326. Epub 2016 Sep 1.

Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg/Munich, Germany.

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http://dx.doi.org/10.1038/srep32326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007477PMC
September 2016

Animal Models Are Valid to Uncover Disease Mechanisms.

Authors:
Wolfgang Wurst

PLoS Genet 2016 05 26;12(5):e1006013. Epub 2016 May 26.

Helmholtz Zentrum München, German Research Center for Environmental Health Institute of Developmental Genetics, Munich, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1006013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881889PMC
May 2016

CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

Cell Metab 2016 Jun 19;23(6):1185-1199. Epub 2016 May 19.

Department of Neurobiology, The Ruhman Family Laboratory for Research on the Neurobiology of Stress, Weizmann Institute of Science, 76100 Rehovot, Israel; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911344PMC
June 2016

Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease.

J Neurochem 2016 10 27;139 Suppl 1:8-26. Epub 2016 Jun 27.

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany.

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http://dx.doi.org/10.1111/jnc.13670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096020PMC
October 2016

Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.

J Breath Res 2016 Feb 10;10(1):016009. Epub 2016 Feb 10.

Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Munich, Germany. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Munich, Germany. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1088/1752-7155/10/1/016009DOI Listing
February 2016

Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.

Development 2016 Feb 11;143(4):691-702. Epub 2016 Jan 11.

Institute of Clinical Anatomy and Cell Analysis, Department of Anatomy, University of Tübingen, Oesterbergstrasse 3, Tuebingen 72074, Germany

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http://dx.doi.org/10.1242/dev.126748DOI Listing
February 2016

The REST remodeling complex protects genomic integrity during embryonic neurogenesis.

Elife 2016 Jan 8;5:e09584. Epub 2016 Jan 8.

Vollum Institute, Howard Hughes Medical Institute, Oregon Health and Science University, Portland, United States.

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http://dx.doi.org/10.7554/eLife.09584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728133PMC
January 2016

Assessing Cognition in Mice.

Curr Protoc Mouse Biol 2015 Dec 2;5(4):331-358. Epub 2015 Dec 2.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1002/9780470942390.mo150068DOI Listing
December 2015

Tests for Anxiety-Related Behavior in Mice.

Curr Protoc Mouse Biol 2015 Dec 2;5(4):291-309. Epub 2015 Dec 2.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1002/9780470942390.mo150010DOI Listing
December 2015

Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors.

Front Behav Neurosci 2015 12;9:302. Epub 2015 Nov 12.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Germany ; German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Germany.

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http://dx.doi.org/10.3389/fnbeh.2015.00302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642364PMC
November 2015

Genome Editing in Mice Using TALE Nucleases.

Methods Mol Biol 2016 ;1338:229-43

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2932-0_17DOI Listing
July 2016

Fgf15 regulates thalamic development by controlling the expression of proneural genes.

Brain Struct Funct 2016 07 27;221(6):3095-109. Epub 2015 Aug 27.

Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), University of Murcia, 30120, El Palmar, Murcia, Spain.

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http://dx.doi.org/10.1007/s00429-015-1089-5DOI Listing
July 2016

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy.

Hum Gene Ther Methods 2015 Aug 29;26(4):107-22. Epub 2015 Jul 29.

1 Institute of Developmental Genetics , Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1089/hgtb.2014.152DOI Listing
August 2015

Development of an intein-mediated split-Cas9 system for gene therapy.

Nucleic Acids Res 2015 Jul 16;43(13):6450-8. Epub 2015 Jun 16.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 85764, Germany

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http://dx.doi.org/10.1093/nar/gkv601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513872PMC
July 2015

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice.

Neurobiol Dis 2015 Oct 3;82:32-45. Epub 2015 Jun 3.

Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany; Technische Universität München-Weihenstephan, Lehrstuhl für Entwicklungsgenetik c/o Helmholtz Zentrum München, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09699961150018
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http://dx.doi.org/10.1016/j.nbd.2015.05.015DOI Listing
October 2015

Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis.

PLoS One 2015 20;10(5):e0127681. Epub 2015 May 20.

Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127681PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439124PMC
April 2016

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.

J Biol Chem 2015 Jun 28;290(23):14668-78. Epub 2015 Apr 28.

From the Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Ingolstädter Landstrassse 1, 85764 Neuherberg, Germany,

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http://dx.doi.org/10.1074/jbc.M115.656363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505533PMC
June 2015

Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.

Nat Commun 2015 Mar 26;6:6669. Epub 2015 Mar 26.

1] Department of Biology, Institute of Immunology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland [2] Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland BT9 7AE, UK.

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http://dx.doi.org/10.1038/ncomms7669DOI Listing
March 2015

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

Nat Biotechnol 2015 May 24;33(5):543-8. Epub 2015 Mar 24.

1] Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. [2] Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [3] Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1038/nbt.3198DOI Listing
May 2015