Wolfgang Wick

Wolfgang Wick

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Wolfgang Wick

Publications by authors named "Wolfgang Wick"

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Automated brain extraction of multisequence MRI using artificial neural networks.

Hum Brain Mapp 2019 12 12;40(17):4952-4964. Epub 2019 Aug 12.

Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1002/hbm.24750DOI Listing
December 2019

Emerging intersections between neuroscience and glioma biology.

Nat Neurosci 2019 Dec 12;22(12):1951-1960. Epub 2019 Nov 12.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 400, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41593-019-0540-yDOI Listing
December 2019

Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas.

Acta Neuropathol Commun 2019 Dec 5;7(1):201. Epub 2019 Dec 5.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 460, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-019-0851-yDOI Listing
December 2019

Bevacizumab versus alkylating chemotherapy in recurrent glioblastoma.

J Cancer Res Clin Oncol 2019 Nov 21. Epub 2019 Nov 21.

Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00432-019-03086-9DOI Listing
November 2019

A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma.

J Neurooncol 2019 Nov 27. Epub 2019 Nov 27.

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), and Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-019-03337-2DOI Listing
November 2019

cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma.

J Neurooncol 2019 Nov 28. Epub 2019 Nov 28.

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-019-03348-zDOI Listing
November 2019

Susceptibility-weighted imaging in malignant melanoma brain metastasis.

J Magn Reson Imaging 2019 Oct 21;50(4):1251-1259. Epub 2019 Feb 21.

Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jmri.26692DOI Listing
October 2019

Anti-Angiogenics: Their Role in the Treatment of Glioblastoma.

Oncol Res Treat 2018 23;41(4):181-186. Epub 2018 Mar 23.

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http://dx.doi.org/10.1159/000488258DOI Listing
August 2019

Quantitative MR neurography biomarkers in 5q-linked spinal muscular atrophy.

Neurology 2019 Aug 10;93(7):e653-e664. Epub 2019 Jul 10.

From the Department of Neuroradiology (J.K., T.H., A.P., M.J., S.H., M.B.), Division of Child Neurology and Metabolic Medicine (A.Z., A.S.), Center for Child and Adolescent Medicine, Department of Neurology (G.S., W.W., M.W.), and Department of Neuroradiology (S.H.), Division of Experimental Radiology, Heidelberg University Hospital, Germany; Department of Neurology (J.M.H.), University of Michigan, Ann Arbor; Medical Faculty (M.J.), University of Tübingen; and German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ) (W.W.), Heidelberg, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000007945DOI Listing
August 2019

EANO Guideline on the Diagnosis and Treatment of Vestibular Schwannoma.

Neuro Oncol 2019 Aug 28. Epub 2019 Aug 28.

Department of Neurosurgery Ludwig-Maximilians-Universität and DKTK partner site, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1093/neuonc/noz153DOI Listing
August 2019

Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study.

Neurology 2019 Jun 10;92(24):e2754-e2763. Epub 2019 May 10.

From the University Medical Center & German Cancer Research Center (M.N., F.S., I.H., P.K., M.P., M.B., W.W.), Heidelberg, Germany; EORTC Headquarters (T.G., V.G.), Brussels, Belgium; Brain Tumor Center at Erasmus MC Cancer Institute (J.E.C.B., W.T., M.J.v.d.B.), Rotterdam, the Netherlands; Medical Oncology Department (A.A.B.), AUSL-Bologna-IRCCS Scienze Neurologiche, Bologna, Italy; Haaglanden Medical Center (M.J.B.T.), the Hague; Leiden University Medical Center (M.J.B.T.), the Netherlands; Institut Gustave Roussy (J.D.), Villejuif; Sorbonne Université (A.I.), Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris; Institut de Cancerologie de l'Ouest (ICO)-Centre Rene Gauducheau (M.C.), Saint-Herblain, France; Leuven Cancer Institute-KU Leuven (P.M.C.), Belgium; Department of Neurology and Brain Tumor Center (M.W.), University Hospital and University of Zurich, Switzerland; Institut Régional du Cancer Montpellier (M.F.); University of Lille (E.L.R.), U-1192, Inserm; CHU Lille (E.L.R.), General and Stereotaxic Neurosurgery Service; Oscar Lambret Center (E.L.R.), Neurology, Lille, France; Department of Neurology (M.P.), Medical Faculty Mannheim, Heidelberg University, Germany; and Department of Neurology (M.N.), Medical University Innsbruck, Austria.

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http://dx.doi.org/10.1212/WNL.0000000000007643DOI Listing
June 2019

Differential Effects of Ang-2/VEGF-A Inhibiting Antibodies in Combination with Radio- or Chemotherapy in Glioma.

Cancers (Basel) 2019 Mar 6;11(3). Epub 2019 Mar 6.

Neurology Clinic and Neurooncology Program at the National Center for Tumor Disease, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cancers11030314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468722PMC
March 2019

Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients.

Int J Radiat Oncol Biol Phys 2018 12 31;102(5):1472-1480. Epub 2018 Jul 31.

Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.07.2004DOI Listing
December 2018

Perspectives of immunotherapy in isocitrate dehydrogenase-mutant gliomas.

Curr Opin Oncol 2018 11;30(6):368-374

German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ).

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http://dx.doi.org/10.1097/CCO.0000000000000478DOI Listing
November 2018

Steroid-Responsive Relapsing-Remitting Neutrophilic Encephalitis: A Case Report.

J Neuropathol Exp Neurol 2018 11;77(11):993-996

Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.

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https://academic.oup.com/jnen/article/77/11/993/5123646
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http://dx.doi.org/10.1093/jnen/nly088DOI Listing
November 2018

Associations of anticoagulant use with outcome in newly diagnosed glioblastoma.

Eur J Cancer 2018 09 20;101:95-104. Epub 2018 Jul 20.

Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ejca.2018.06.029DOI Listing
September 2018

Gd contrast administration is dispensable in patients with MS without new T2 lesions on follow-up MRI.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 16;5(5):e480. Epub 2018 Jul 16.

Department of Neuroradiology (K.K.-J., D.S., M.B., M.O.B.), University Hospital Heidelberg, Im Neuenheimer Feld 400; Neurology Clinic (B.W., R.D., W.W.), University Hospital Heidelberg, Im Neuenheimer Feld 400; Division of Biostatistics (T.H.), German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280; and Clinical Cooperation Unit Neurooncology (W.W.), German Cancer Consortium, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053940PMC
September 2018

First results on the DCVax phase III trial: raising more questions than providing answers.

Neuro Oncol 2018 09;20(10):1283-1284

Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1093/neuonc/noy125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120355PMC
September 2018

New glioblastoma heterogeneity atlas - a shared resource.

Nat Rev Neurol 2018 Aug;14(8):453-454

Neurology Clinic, University of Heidelberg and Clinical Cooperation Unit Neurooncology, German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41582-018-0038-3DOI Listing
August 2018

Understanding and Treating Glioblastoma.

Neurol Clin 2018 08;36(3):485-499

Department of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ncl.2018.04.006DOI Listing
August 2018

Regimen of procarbazine, lomustine, and vincristine versus temozolomide for gliomas.

Cancer 2018 07 26;124(13):2674-2676. Epub 2018 Apr 26.

Neurology Clinic, University of Heidelberg; Clinical Cooperation Unit Neurooncology, German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/cncr.31371DOI Listing
July 2018

Treatment of glioblastoma in adults.

Ther Adv Neurol Disord 2018 25;11:1756286418790452. Epub 2018 Jul 25.

Neurology Clinic, University of Heidelberg, Clinical Cooperation Unit (CCU) Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1177/1756286418790452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071154PMC
July 2018

cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC).

Acta Neuropathol 2018 03 25;135(3):481-484. Epub 2018 Jan 25.

The Brain Tumor Center at Erasmus MC Cancer Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-018-1808-0DOI Listing
March 2018

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry.

Acta Neuropathol Commun 2018 03 2;6(1):21. Epub 2018 Mar 2.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-018-0523-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834865PMC
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Harmful networks in the brain and beyond.

Science 2018 Mar;359(6380):1100-1101

Neurology Clinic, University Medical Center, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1126/science.aar5555DOI Listing
March 2018

Vaccine Strategies in Gliomas.

Curr Treat Options Neurol 2018 Mar 28;20(5):11. Epub 2018 Mar 28.

Department of Neurology, Heidelberg Medical Center, University of Heidelberg, INF 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11940-018-0498-1DOI Listing
March 2018

Neuro-Oncology.

Semin Neurol 2018 02 16;38(1):3-4. Epub 2018 Mar 16.

Department of Neurology and Neuro-oncology, Neurology Clinic, Heidelberg University Medical Center, Heidelberg, Germany.

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http://dx.doi.org/10.1055/s-0038-1635105DOI Listing
February 2018

What's New in Grade II and Grade III Gliomas?

Semin Neurol 2018 02 16;38(1):41-49. Epub 2018 Mar 16.

Neurology Clinic, Heidelberg University Medical Centre and Neuro-Oncology Programme, National Centre for Tumour Diseases, Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1055/s-0037-1620275DOI Listing
February 2018

Glioblastoma in elderly patients: solid conclusions built on shifting sand?

Neuro Oncol 2018 01;20(2):174-183

Neurology Clinic & German Consortium for Translational Cancer Research (DKTK), Heidelberg University Medical Center & DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777484PMC
January 2018

Drug Repositioning Meets Precision in Glioblastoma.

Clin Cancer Res 2018 01 13;24(2):256-258. Epub 2017 Nov 13.

Neurology Clinic, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2989DOI Listing
January 2018

T1ρ-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain.

Radiology 2017 12 16;285(3):914-922. Epub 2017 Jun 16.

From the Divisions of Radiology (D.P., C.K., S.B., D.B., P. Bäumer, H.P.S., M.Z., A.R.) and Medical Physics in Radiology (P.S., J.W., P. Bachert, M.E.L.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Departments of Neuroradiology (C.K., M.B., A.R.), Neurology (S.M., W.W.), and Neurosurgery (A.U.), University Hospital Heidelberg, Heidelberg, Germany; Faculty of Physics and Astronomy and Faculty of Medicine, University of Heidelberg, Heidelberg, Germany (M.E.L.); and Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany (M.Z.).

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http://dx.doi.org/10.1148/radiol.2017162351DOI Listing
December 2017

Diagnostic challenges in meningioma.

Neuro Oncol 2017 Nov;19(12):1588-1598

University Medical Center, Neurology, and Neurooncology, German Cancer Research Center and German Consortium for Translational Cancer Research, Heidelberg, Germany; Medical University Innsbruck, Department of Neurology, Innsbruck, Austria; Institute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany; Department of Neurology, University of Cologne, Cologne, Germany; Center of Integrated Oncology, Universities of Cologne and Bonn, Cologne, Germany; University Medical Center, Neuroradiology, Heidelberg, Germany; University Medical Center, Neuropathology, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716093PMC
November 2017

Sequential proton boost after standard chemoradiation for high-grade glioma.

Radiother Oncol 2017 11 16;125(2):266-272. Epub 2017 Oct 16.

University Hospital of Heidelberg, Department of Radiation Oncology, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Germany; Heidelberg Institute for Radiation Oncology (HIRO), Germany.

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http://dx.doi.org/10.1016/j.radonc.2017.09.040DOI Listing
November 2017

Lomustine and Bevacizumab in Progressive Glioblastoma.

N Engl J Med 2017 11;377(20):1954-1963

From the University Medical Center and German Cancer Research Center, Heidelberg, Germany (W.W., M.B., F.S., I.H., A.D., M.P.); the European Organization for Research and Treatment of Cancer, Brussels (T.G., V.G.), and Leuven Cancer Institute-KU Leuven, Leuven (P.M.C.) - both in Belgium; Haaglanden Medical Center, The Hague (M.T.), Erasmus MC Cancer Institute, Rotterdam (W.T., J.C.B., M.J.B.), and VU University Medical Center, Amsterdam (M.K.) - all in the Netherlands; the Medical Oncology Department, Azienda Unità Sanitaria Locale di Bologna-IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy (A.A.B.); Institut Gustave Roussy, Villejuif (J.D.), Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, INSERM Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Sorbonne Universités, University Pierre and Marie Curie 06 UMR S1127, and Institut du Cerveau et de la Moelle Épinière, Paris (A.I.), Institut de Cancerologie de l'Ouest-Centre Rene Gauducheau, Saint-Herblain (M.C.), Institut Régional du Cancer Montpellier, Montpellier (M.F.), and Centre Hospitalier Régional Universitaire de Lille, Lille (E.L.R., F.D.) - all in France; and the Departments of Oncology and Neurology, University Hospital and University of Zurich, Zurich, Switzerland (R.S., M.W.).

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http://dx.doi.org/10.1056/NEJMoa1707358DOI Listing
November 2017

Evidence-based management of adult patients with diffuse glioma - Authors' reply.

Lancet Oncol 2017 08 26;18(8):e430-e431. Epub 2017 Jul 26.

Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany; German Consortium of Translational Cancer Research, Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(17)30515-6DOI Listing
August 2017

Outcome of patients with proximal vessel occlusion of the anterior circulation and DWI-PWI mismatch is time-dependent.

Eur J Radiol 2017 Jun 25;91:82-87. Epub 2017 Mar 25.

German Cancer Research Centre, Department of Radiology, Heidelberg, Germany; Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ejrad.2017.03.016DOI Listing
June 2017