Wolfgang Sadee

Wolfgang Sadee

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Wolfgang Sadee

Publications by authors named "Wolfgang Sadee"

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Ligand-Free Estrogen Receptor (ESR1) as Master Regulator for the Expression of CYP3A4 and Other Cytochrome P450 Enzymes in the Human Liver.

Mol Pharmacol 2019 Oct 9;96(4):430-440. Epub 2019 Aug 9.

Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida (D.W.); Department of Clinical Sciences, Bioinformatics Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas (R.L.); and Mathematical Bioscience Institute, (G.R.) and Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine (W.S.), Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1124/mol.119.116897DOI Listing
October 2019

Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population.

Ann Hum Genet 2019 Sep 26;83(5):367-372. Epub 2019 Apr 26.

University Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, Pakistan.

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http://dx.doi.org/10.1111/ahg.12322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699898PMC
September 2019

Association of Genetic Polymorphisms in the Beta-1 Adrenergic Receptor with Recovery of Left Ventricular Ejection Fraction in Patients with Heart Failure.

J Cardiovasc Transl Res 2019 Aug 12;12(4):280-289. Epub 2019 Feb 12.

Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, USA.

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http://dx.doi.org/10.1007/s12265-019-09866-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690812PMC
August 2019

CYP2D6 haplotypes with enhancer single-nucleotide polymorphism rs5758550 and rs16947 (*2 allele): implications for CYP2D6 genotyping panels.

Pharmacogenet Genomics 2019 Feb;29(2):39-47

Department of Cancer Biology and Genetics, Center for Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1097/FPC.0000000000000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441960PMC
February 2019

Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.

BMC Genomics 2018 Nov 20;19(1):826. Epub 2018 Nov 20.

Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, 1004 Biomedical Research Tower, 460 W 12th Avenue, Columbus, OH, USA.

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https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12864-018-5219-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245894PMC
November 2018

Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.

Circ Genom Precis Med 2018 10;11(10):e002082

Department of Cancer Biology and Genetics, Center for Pharmacogenomics, College of Medicine, Ohio State University, Columbus (D.W., K.H., W.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002082
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http://dx.doi.org/10.1161/CIRCGEN.118.002082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211808PMC
October 2018

Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

BMC Med Genomics 2018 Jun 20;11(1):55. Epub 2018 Jun 20.

Center for Pharmacogenomics, Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, P.O.Box 100484, Gainesville, FL, 32610-0486, USA.

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http://dx.doi.org/10.1186/s12920-018-0370-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011347PMC
June 2018

Alpha-synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3'UTR.

Mol Genet Genomic Med 2018 May 6. Epub 2018 May 6.

Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1002/mgg3.407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081226PMC
May 2018

Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).

Circ Genom Precis Med 2018 04;11(4):e001854

Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics (C.W.M., O.M., A.C.C.S., N.M.E.R., M.K.-S., M.S., J.G.G., R.M.C.-D., Y.G., J.A.J.), Department of Pharmaceutical Outcomes and Policy (C.D.), Department of Pharmaceutics, College of Pharmacy (A.N.D., R.S.P.S.), Genetics & Genomics Graduate Program, Genetics Institute (A.C.C.S., Y.S.), Department of Biology, College of Liberal Arts and Sciences (W.M.), Department of Community Health and Family Medicine, College of Medicine (J.G.G.), and Division of Cardiovascular Medicine, Department of Medicine (R.M.C.-D., J.A.J.), University of Florida, Gainesville; School of Pharmacy, College of Health Professions, Pacific University, Hillsboro, OR (M.K.-S.); Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (M.S.); Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (K.R.B.) and Division of Nephrology and Hypertension, Department of Medicine (S.T.T.), Mayo Clinic, Rochester, MN; Human Genetics Center, Institute of Molecular Medicine, University of Texas Health Science Center, Houston (E.B.); Section of Nephrology, Department of Medicine, University of Chicago, IL (A.B.C.); Department of Biomedical Informatics, Center for Pharmacogenomics (A.W.) and Department of Cancer Biology and Genetics, College of Medicine (W.S.), Ohio State University, Columbus; and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX (S.E.S.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901893PMC
April 2018

Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research.

Clin Transl Sci 2018 03 23;11(2):153-161. Epub 2017 Oct 23.

Center for Pharmacogenomics & Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1111/cts.12511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866981PMC
March 2018

Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile.

Tuberculosis (Edinb) 2017 12 18;107:156-167. Epub 2017 Sep 18.

Grupo de Inmunología Celular e Inmunogenética (GICIG), Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia., Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2017.08.012DOI Listing
December 2017

A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.

Am J Respir Cell Mol Biol 2017 10;57(4):487-498

3 Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, and.

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http://dx.doi.org/10.1165/rcmb.2016-0321OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650085PMC
October 2017

Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits.

PLoS One 2017 15;12(6):e0179020. Epub 2017 Jun 15.

Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine and Public Health, Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179020PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472281PMC
September 2017

Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart.

Pharm Res 2017 Aug 24;34(8):1648-1657. Epub 2017 Jan 24.

Center for Pharmacogenomics and Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, 1005 BRT, 460 West 12th Ave, Columbus, Ohio, 43210, USA.

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http://dx.doi.org/10.1007/s11095-017-2102-xDOI Listing
August 2017

CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure.

Pharm Res 2017 Aug 8;34(8):1615-1625. Epub 2017 Feb 8.

Center for Pharmacogenomics, Ohio State University College of Medicine, Columbus, Ohio, USA.

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http://dx.doi.org/10.1007/s11095-017-2104-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500390PMC
August 2017

Personalized Therapeutics and Pharmacogenomics: Integral to Personalized Health Care.

Authors:
Wolfgang Sadee

Pharm Res 2017 08 10;34(8):1535-1538. Epub 2017 May 10.

Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1007/s11095-017-2170-yDOI Listing
August 2017

Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq.

Eur J Pharm Sci 2017 May 7;103:47-51. Epub 2017 Feb 7.

College of Medicine, Center for Pharmacogenomics, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.02.010DOI Listing
May 2017

The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.

Hum Mutat 2017 01 7;38(1):112-119. Epub 2016 Nov 7.

Center for Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1002/humu.23135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154896PMC
January 2017

Erratum to: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles.

BMC Genomics 2016 12 2;17(1):988. Epub 2016 Dec 2.

College of Medicine Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, Biomedical Research Tower, 460 W 12th Avenue, Columbus, OH, USA.

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http://dx.doi.org/10.1186/s12864-016-3349-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135797PMC
December 2016

Gene expression profiling of brain samples from patients with Lewy body dementia.

Biochem Biophys Res Commun 2016 Oct 22;479(4):875-880. Epub 2016 Sep 22.

Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079284PMC
http://dx.doi.org/10.1016/j.bbrc.2016.09.114DOI Listing
October 2016

Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles.

BMC Genomics 2016 09 17;17(1):738. Epub 2016 Sep 17.

College of Medicine Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, Biomedical Research Tower, 460 W 12th Avenue, Columbus, OH, USA.

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http://dx.doi.org/10.1186/s12864-016-3075-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027110PMC
September 2016

The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics.

Pharmacogenomics 2015 4;16(14):1649-69. Epub 2015 Sep 4.

Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.2217/pgs.15.111DOI Listing
July 2016

Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice.

J Pharmacol Exp Ther 2016 07 5;358(1):22-30. Epub 2016 May 5.

Department of Neuroscience (J.O., M.S.Y.), and College of Medicine Center for Pharmacogenomics (W.S.), Wexner Medical Center, and College of Pharmacy, Division of Pharmaceutics and Pharmaceutical Chemistry (Y.L., M.A.P.), The Ohio State University, Columbus, Ohio; and Anatomisches Institut, Anatomie und Zellbiologie (K.S.), Universität Bonn, Bonn, Germany

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http://dx.doi.org/10.1124/jpet.115.231902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931874PMC
July 2016

Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms.

PLoS One 2015 2;10(9):e0136798. Epub 2015 Sep 2.

Center for Pharmacogenomics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America; Department of Medical Genetics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558023PMC
May 2016

Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.

Pharmacogenet Genomics 2016 May;26(5):197-207

aCenter for Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, Ohio bDepartment of Clinical Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821783PMC
May 2016

CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing.

Pharmacogenet Genomics 2016 Jan;26(1):40-3

Center for Pharmacogenomics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674354PMC
January 2016

Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616.

Pharmacogenet Genomics 2015 Aug;25(8):394-401

Department of Pharmacology, Center for Pharmacogenomics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499003PMC
August 2015

Working memory in pregnant women: Relation to estrogen and antepartum depression.

Horm Behav 2015 Aug 15;74:218-27. Epub 2015 Jul 15.

Women's Health Concerns Clinic, St. Joseph's Healthcare, Department of Psychiatry and Behavioural Neurosciences and Obstetrics & Gynecology, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.yhbeh.2015.07.006DOI Listing
August 2015

Analyzing allele specific RNA expression using mixture models.

BMC Genomics 2015 Aug 1;16:566. Epub 2015 Aug 1.

Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1186/s12864-015-1749-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521363PMC
August 2015

Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations.

J Cardiovasc Pharmacol 2015 Jul;66(1):80-5

*Department of Pharmacology, Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, Columbus, OH; †Children's Hospital Oakland Research Institute, Oakland, CA; ‡Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and §Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA; and ‖Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.

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http://dx.doi.org/10.1097/FJC.0000000000000246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503374PMC
July 2015

Response to paper by Kelly et al "The opioid receptor pharmacology of GSK1521498 compared to other ligands with different effects on compulsive reward-related behaviors" published in Psychopharmacology 232, 305-314, 2014.

Psychopharmacology (Berl) 2015 Apr 6;232(8):1493-4. Epub 2015 Mar 6.

College of Medicine, The Ohio State University, Columbus, OH, USA,

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http://dx.doi.org/10.1007/s00213-015-3892-3DOI Listing
April 2015

Cladograms with Path to Event (ClaPTE): a novel algorithm to detect associations between genotypes or phenotypes using phylogenies.

Comput Biol Med 2015 Mar 24;58:1-13. Epub 2014 Dec 24.

Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223-0001, United States.

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http://dx.doi.org/10.1016/j.compbiomed.2014.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331246PMC
March 2015

DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory.

PLoS One 2014 12;9(5):e95997. Epub 2014 May 12.

IRCCSS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy; Group of Psychiatric Neuroscience, Department of Basic Medical Science, Neuroscience and Sense Organs, Aldo Moro University, Bari, Italy; pRED, NORD DTA, F. Hoffman-La Roche Ltd., Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018353PMC
January 2015

Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.

Circ Res 2014 Dec 17;115(12):1017-25. Epub 2014 Oct 17.

From the Center for Pharmacogenomics, College of Medicine, The Ohio State University, Columbus (E.S.B., J.K.P., W.S.); Department of Human Genetics, Emory University School of Medicine, Atlanta, GA (D.W., J.F.C.); Center for Systems Genomics, Pennsylvania State University, University Park (A.V., S.A.P., M.D.R.); Department of Genetics, University of North Carolina School of Medicine, Chapel Hill (L.A.L.); Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (J.G.W.); The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA (H.K., G.T., D.J.C.); Institute for Personalized Medicine, The Pennsylvania State University College of Medicine, Hershey (G.S.G.); Center for Human Genetics, Marshfield Clinic Research Foundation, WI (M.H.B., S.J.H.); and Department of Psychology, The University of Chicago, IL (G.J.N.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258174PMC
December 2014

Genomic architecture of pharmacological efficacy and adverse events.

Pharmacogenomics 2014 Dec;15(16):2025-48

Department of Bioengineering & Therapeutic Sciences, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.2217/pgs.14.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308414PMC
December 2014

Missing heritability of common diseases and treatments outside the protein-coding exome.

Hum Genet 2014 Oct 9;133(10):1199-215. Epub 2014 Aug 9.

Department of Pharmacology, Center for Pharmacogenomics, College of Medicine, The Ohio State University Wexner Medical Center, 5184A Graves Hall, 333 West 10th Avenue, Columbus, OH, 43210, USA,

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http://dx.doi.org/10.1007/s00439-014-1476-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169001PMC
October 2014

Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder.

Autism Res 2014 Aug 17;7(4):459-67. Epub 2014 Apr 17.

Department of Pharmacology, OSU College of Medicine Center for Pharmacogenomics, The Ohio State University, Columbus, Ohio.

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http://doi.wiley.com/10.1002/aur.1383
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http://dx.doi.org/10.1002/aur.1383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134733PMC
August 2014

Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder.

Res Dev Disabil 2014 Jul 26;35(7):1658-65. Epub 2014 Apr 26.

Department of Pharmacology, Center in Pharmacogenomics, Ohio State University Wexner Medical Center, 333 West 10th Avenue, Columbus 43210, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ridd.2014.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084560PMC
July 2014

Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein.

Biochem Biophys Res Commun 2014 Jan 3;443(4):1270-4. Epub 2014 Jan 3.

Center for Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University Wexner Medical Center, 5184A Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.bbrc.2013.12.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929938PMC
January 2014

Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study.

Arch Womens Ment Health 2013 Dec 7;16(6):499-509. Epub 2013 Aug 7.

Department of Pharmacology and Program in Pharmacogenomics, The Ohio State University College of Medicine, 333 West 10th Ave, Columbus, OH, 43214, USA,

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http://dx.doi.org/10.1007/s00737-013-0373-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833886PMC
December 2013

Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example.

Authors:
Wolfgang Sadee

J Pharm Sci 2013 Sep 21;102(9):2924-9. Epub 2013 Feb 21.

Program in Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/jps.23483DOI Listing
September 2013

Bridging material and biological sciences: the legacy of Hans Peter Merkle.

Authors:
Wolfgang Sadee

Eur J Pharm Biopharm 2013 Sep;85(1):3-4

Program in Pharmacogenomics, Department of Pharmacology, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.ejpb.2013.06.026DOI Listing
September 2013

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.

Clin Pharmacol Ther 2013 Aug 19;94(2):207-10. Epub 2013 Mar 19.

Program in Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/clpt.2013.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720847PMC
August 2013

Whole transcriptome RNA-Seq allelic expression in human brain.

BMC Genomics 2013 Aug 22;14:571. Epub 2013 Aug 22.

Department of Pharmacology, Program in Pharmacogenomics; College of Medicine, The Ohio State University Wexner Medical Center, 5184A Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1186/1471-2164-14-571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765493PMC
August 2013

Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.

Pharmacogenet Genomics 2013 May;23(5):269-78

Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32835ff536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132188PMC
May 2013

Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.

Biol Psychiatry 2013 Mar 13;73(6):546-54. Epub 2012 Nov 13.

Department of Pharmacology, Program in Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.biopsych.2012.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582836PMC
March 2013

Innate immune gene polymorphisms in tuberculosis.

Infect Immun 2012 Oct 23;80(10):3343-59. Epub 2012 Jul 23.

Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1128/IAI.00443-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457569PMC
October 2012

The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy.

J Pers Med 2012 Oct;2(4):175-91

Program in Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3390/jpm2040175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901424PMC
October 2012

mRNA transcript diversity creates new opportunities for pharmacological intervention.

Mol Pharmacol 2012 May 7;81(5):620-30. Epub 2012 Feb 7.

Program in Pharmacogenomics, Department of Pharmacology, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1124/mol.111.076604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336806PMC
May 2012

Human N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity.

Pharmacogenet Genomics 2011 Oct;21(10):652-64

Department of Pharmacology, Program in Pharmacogenomics, School of Biomedical Science, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283498ee9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172334PMC
October 2011

Genomics and personalized medicine.

Authors:
Wolfgang Sadee

Int J Pharm 2011 Aug 23;415(1-2):2-4. Epub 2011 Apr 23.

Program in Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, OH 43210-1239, USA.

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http://dx.doi.org/10.1016/j.ijpharm.2011.04.048DOI Listing
August 2011

Synaptic signaling and aberrant RNA splicing in autism spectrum disorders.

Front Synaptic Neurosci 2011 26;3. Epub 2011 Jan 26.

Program in Pharmacogenomics, Department of Pharmacology, The Ohio State University Columbus, OH, USA.

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http://dx.doi.org/10.3389/fnsyn.2011.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059609PMC
July 2011

Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder.

Neuropsychopharmacology 2011 Jul 27;36(8):1644-55. Epub 2011 Apr 27.

Department of Pharmacology, The Ohio State University, Columbus, OH 43210-1239, USA.

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http://dx.doi.org/10.1038/npp.2011.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138671PMC
July 2011

Pharmacogenomic biomarkers: validation needed for both the molecular genetic mechanism and clinical effect.

Authors:
Wolfgang Sadee

Pharmacogenomics 2011 May;12(5):675-80

Program in Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.2217/pgs.11.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141324PMC
May 2011

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others.

Cleve Clin J Med 2011 Apr;78(4):243-57

Department of Pharmacology, Division of Clinical Trials, College of Medicine, The Ohio State University, Columbus, USA.

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http://dx.doi.org/10.3949/ccjm.78a.10145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351041PMC
April 2011

Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.

Neuropsychopharmacology 2011 Mar 8;36(4):753-62. Epub 2010 Dec 8.

Program in Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210-1239, USA.

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http://dx.doi.org/10.1038/npp.2010.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055737PMC
March 2011

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.

Eur J Hum Genet 2011 Jan 11;19(1):76-83. Epub 2010 Aug 11.

Neuroscience Graduate Studies Program, Department of Pharmacology, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1038/ejhg.2010.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995013PMC
January 2011

Allele-specific tumor spectrum in pten knockin mice.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):5142-7. Epub 2010 Mar 1.

Department of Molecular Genetics, College of Biological Sciences, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0912524107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841921PMC
March 2010

Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility.

Authors:
Wolfgang Sadee

Genome Med 2009 Dec 22;1(12):116. Epub 2009 Dec 22.

Program in Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1186/gm116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808732PMC
December 2009

6beta-naltrexol preferentially antagonizes opioid effects on gastrointestinal transit compared to antinociception in mice.

Life Sci 2009 Sep 5;85(11-12):413-20. Epub 2009 Jul 5.

AIKO Biotechnology, Portland, ME 04101, United States.

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http://dx.doi.org/10.1016/j.lfs.2009.06.016DOI Listing
September 2009

Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins.

Pharm Res 2009 Apr 10;26(4):936-45. Epub 2008 Dec 10.

Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, 91766, USA.

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http://dx.doi.org/10.1007/s11095-008-9796-8DOI Listing
April 2009

Drug therapy and personalized health care: pharmacogenomics in perspective.

Authors:
Wolfgang Sadee

Pharm Res 2008 Dec 26;25(12):2713-9. Epub 2008 Aug 26.

Department of Pharmacology, Program in Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, OH 43210-1239, USA.

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http://dx.doi.org/10.1007/s11095-008-9702-4DOI Listing
December 2008

Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.

Neurosci Lett 2008 Dec 15;448(1):120-4. Epub 2008 Oct 15.

Program in Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210-1239, United States.

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http://dx.doi.org/10.1016/j.neulet.2008.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612539PMC
December 2008

The re-emerging concept of personalized healthcare.

Per Med 2008 Sep;5(5):457-469

Ohio State University, Center for Personalized Healthcare, College of Medicine, 333 West 10th Ave, Columbus, OH 43210, USA.

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http://dx.doi.org/10.2217/17410541.5.5.457DOI Listing
September 2008

Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.

Blood 2008 Aug 3;112(4):1013-21. Epub 2008 Jun 3.

Department of Pharmacology, Program in Pharmacogenetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1182/blood-2008-03-144899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515137PMC
August 2008

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.

Am J Physiol Lung Cell Mol Physiol 2008 Jun 4;294(6):L1127-36. Epub 2008 Apr 4.

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, 473 W. 12th Ave., Rm. 405A, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1152/ajplung.00057.2008DOI Listing
June 2008

Genotyping panel for assessing response to cancer chemotherapy.

BMC Med Genomics 2008 Jun 11;1:24. Epub 2008 Jun 11.

Program in Pharmacogenomics, Department of Pharmacology, Comprehensive Cancer Center, College of Medicine and Public Health, The Ohio State University, 5072 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210-1239, USA.

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http://bmcmedgenomics.biomedcentral.com/articles/10.1186/175
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http://dx.doi.org/10.1186/1755-8794-1-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442111PMC
June 2008

MicroRNAs modulate the chemosensitivity of tumor cells.

Mol Cancer Ther 2008 Jan 9;7(1):1-9. Epub 2008 Jan 9.

Program of Pharmacogenomics, Department of Pharmacology, Ohio State University, 333 West Tenth Street, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0573DOI Listing
January 2008

Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.

Mol Pharmacol 2007 Dec 17;72(6):1637-46. Epub 2007 Sep 17.

Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.03
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http://dx.doi.org/10.1124/mol.107.039644DOI Listing
December 2007

MicroRNA expression profiles for the NCI-60 cancer cell panel.

Mol Cancer Ther 2007 May 4;6(5):1483-91. Epub 2007 May 4.

Program of Pharmacogenomics, Department of Pharmacology and the Comprehensive Cancer Center, College of Medicine, The Ohio State University, 5072 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0009DOI Listing
May 2007