Publications by authors named "Wolfgang Oertel"

100Publications

Determinants of seeding and spreading of α-synuclein pathology in the brain.

Sci Adv 2020 Nov 11;6(46). Epub 2020 Nov 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/sciadv.abc2487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673735PMC
November 2020

variants in REM sleep behavior disorder: A multicenter study.

Neurology 2020 08 26;95(8):e1008-e1016. Epub 2020 Jun 26.

From the Department of Human Genetics (L.K., U.R., G.A.R., Z.G.-O.), Montreal Neurological Institute (L.K., J.A.R., U.R., E.L., F.A., R.B.P., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (J.A.R., F.A., R.B.P., G.A.R., Z.G.-O.), McGill University, Montréal; Oxford Parkinson's Disease Centre (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK; Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière and Sorbonne Universities, Paris; National Reference Center for Narcolepsy, Sleep Unit (Y.D.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France; Sleep Disorders Unit, Department of Neurology (B.H., A.S.), Medical University of Innsbruck, Austria; Department of Clinical Neurophysiology and Sleep Center (C.C.M.), University Lille North of France, CHU Lille; Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France; Department of Biomedical and Neuromotor Sciences (DIBINEM) (G.P., E.A.), Alma Mater Studiorum, University of Bologna; IRCCS (G.P., E.A.), Istituto delle Scienze Neurologiche, Bologna; Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy; Department of Neurology with Institute of Translational Neurology (A.H.), University of Muenster, Germany; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; UC Gardner Neuroscience Institute and Gardner Family Center for Parkinson's Disease and Movement Disorders (A.J.E.), Cincinnati, OH; Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic, Montpellier; EuroMov (V.C.D.C.), University of Montpellier, France; Paracelsus-Elena-Klinik (B.M., F.S.-D., C.T.), Kassel; Department of Neurology (B.M., C.T.), University Medical Centre Goettingen; Department of Neurology (F.S.-D., W.O.), Philipps University, Marburg, Germany; Department of Neurology and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic; Department of Medical Sciences and Public Health, Sleep Disorder Research Center (M.F., M.P.), University of Cagliari, Italy; Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel, Belgium; Department of Medicine (DAME) (M.T., M.V.), University of Udine, Italy; Department of Clinical and Movement Neurosciences (M.T.), UCL Queen Square Institute of Neurology, London, UK; Clinical Neurology Unit (G.L.G., M.V.), Department of Neurosciences, University Hospital of Udine; DMIF (G.L.G.), University of Udine, Italy; Centre d'Études Avancées en Médecine du Sommeil (J.-F.G., A.D., J.Y.M., R.B.P.), Hôpital du Sacré-Cœur de Montréal; and Departments of Psychology (J.-F.G.), Neurosciences (A.D.), and Psychiatry (J.Y.M.), Université du Québec à Montréal, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000010042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668554PMC
August 2020

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons.

Cell Death Dis 2019 11 14;10(11):865. Epub 2019 Nov 14.

Institute for Pharmacology and Clinical Pharmacy, Biochemical-Pharmacological Center, University of Marburg, Marburg, Germany.

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http://dx.doi.org/10.1038/s41419-019-2091-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856124PMC
November 2019

Reduced central sympathetic activity in Parkinson's disease.

Brain Behav 2019 12 5;9(12):e01463. Epub 2019 Nov 5.

Department of Neurology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1002/brb3.1463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908869PMC
December 2019

Neuronal precursor cells with dopaminergic commitment in the rostral migratory stream of the mouse.

Sci Rep 2019 09 16;9(1):13359. Epub 2019 Sep 16.

Department of Neurology, Technical University of Munich, School of Medicine, Munich, Germany.

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http://dx.doi.org/10.1038/s41598-019-49920-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746949PMC
September 2019

Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?

Mov Disord 2019 10 4;34(10):1406-1422. Epub 2019 Sep 4.

Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1002/mds.27823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879792PMC
October 2019

The locus coeruleus: Another vulnerability target in Parkinson's disease.

Mov Disord 2019 10 10;34(10):1423-1429. Epub 2019 Jul 10.

Department of Neurology, Philipps University Marburg, Marburg, Germany.

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http://dx.doi.org/10.1002/mds.27785DOI Listing
October 2019

Widespread microglial activation in multiple system atrophy.

Mov Disord 2019 04 6;34(4):564-568. Epub 2019 Feb 6.

Departments of Nulcear Medicine and Geriatric Medicine, University Hospital Essen, Germany.

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http://dx.doi.org/10.1002/mds.27620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659386PMC
April 2019

Reply to: Safety of dopamine agonists for treating restless legs syndrome.

Mov Disord 2019 01;34(1):150-151

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1002/mds.27571DOI Listing
January 2019

Mesencephalic and extramesencephalic dopaminergic systems in Parkinson's disease.

J Neural Transm (Vienna) 2019 04 14;126(4):377-396. Epub 2019 Jan 14.

Department of Neurology, Philipps University Marburg, Baldingerstraße 1, 35043, Marburg, Germany.

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http://dx.doi.org/10.1007/s00702-019-01970-9DOI Listing
April 2019

Validation of a new data-driven automated algorithm for muscular activity detection in REM sleep behavior disorder.

J Neurosci Methods 2019 01 20;312:53-64. Epub 2018 Nov 20.

Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.

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http://dx.doi.org/10.1016/j.jneumeth.2018.11.016DOI Listing
January 2019

A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.

Parkinsonism Relat Disord 2019 03 29;60:43-45. Epub 2018 Sep 29.

Department of Neurology, Saarland University, Homburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.09.032DOI Listing
March 2019

Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017).

Mov Disord 2018 07 14;33(7):1077-1091. Epub 2018 May 14.

CHDI Foundation, Princeton, Princeton, NJ, USA, and the Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal.

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http://dx.doi.org/10.1002/mds.27260DOI Listing
July 2018

LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder.

Parkinsonism Relat Disord 2018 07 21;52:98-101. Epub 2018 Mar 21.

Montreal Neurological Institute, McGill University, Montréal, QC, H3A 0G4, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, H3A 0G4, Canada, Canada; Department of Human Genetics, McGill University, H3A 0G4, Montréal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.03.019DOI Listing
July 2018

Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons.

Mol Cell Neurosci 2018 04 8;88:330-341. Epub 2018 Mar 8.

Institute for Physiology and Pathophysiology, Vegetative Physiology and Marburg Center for Mind, Brain and Behavior - MCMBB, Philipps-University Marburg, 35037 Marburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2018.03.002DOI Listing
April 2018

The Metabolic Pattern of Idiopathic REM Sleep Behavior Disorder Reflects Early-Stage Parkinson Disease.

J Nucl Med 2018 09 23;59(9):1437-1444. Epub 2018 Feb 23.

Department of Neurology, Philipps-Universität Marburg, Marburg, Germany.

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http://dx.doi.org/10.2967/jnumed.117.202242DOI Listing
September 2018

The spectrum of "off" in Parkinson's disease: What have we learned over 40 years?

Parkinsonism Relat Disord 2018 06 2;51:9-16. Epub 2018 Feb 2.

Department of Neurology, Institute for Research and Medical Care, IRCCS San Raffaele Roma, Roma, Italy.

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http://dx.doi.org/10.1016/j.parkreldis.2018.02.001DOI Listing
June 2018

Drug Safety Analysis in a Real-Life Cohort of Parkinson's Disease Patients with Polypharmacy.

CNS Drugs 2017 12;31(12):1093-1102

Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen Str. 17, 81677, Munich, Germany.

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http://dx.doi.org/10.1007/s40263-017-0478-0DOI Listing
December 2017

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

Lancet Neurol 2017 11;16(11):898-907

Institute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany; Neurologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30327-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755468PMC
November 2017

Acylated and unacylated ghrelin confer neuroprotection to mesencephalic neurons.

Neuroscience 2017 Dec 4;365:137-145. Epub 2017 Oct 4.

Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany; Institute of Neurogenetics, University of Lübeck, 23562 Lübeck, Germany; Department of Psychiatry, University of Lübeck, 23562 Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.09.045DOI Listing
December 2017

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder.

Mov Disord 2018 01 26;33(1):88-98. Epub 2017 Aug 26.

Eco-Systems Biology Research Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1002/mds.27105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811909PMC
January 2018

Recent advances in treating Parkinson's disease.

F1000Res 2017 13;6:260. Epub 2017 Mar 13.

Department of Neurology, University Clinic, Philipps Universität Marburg, Marburg, Germany; Institute for Neurogenomics, Helmholtz Center for Health and Environment, Munich, Germany.

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http://dx.doi.org/10.12688/f1000research.10100.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357034PMC
March 2017

Is increased spinal nociception another hallmark for Parkinson's disease?

J Neurol 2017 Mar 24;264(3):570-575. Epub 2017 Jan 24.

Department of Neurology, Philipps University, Baldingerstrasse, 35043, Marburg, Germany.

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http://dx.doi.org/10.1007/s00415-016-8390-yDOI Listing
March 2017

Scientific Panel for Health: better research for better health.

Lancet 2016 Aug 25;388(10047):865-6. Epub 2016 Aug 25.

Charles University in Prague, Prague, Czech Republic.

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http://dx.doi.org/10.1016/S0140-6736(16)31426-XDOI Listing
August 2016

Current and experimental treatments of Parkinson disease: A guide for neuroscientists.

J Neurochem 2016 10 30;139 Suppl 1:325-337. Epub 2016 Aug 30.

Department of Neurology, University Hospital, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1111/jnc.13750DOI Listing
October 2016

Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.

Front Aging Neurosci 2016 22;8:147. Epub 2016 Jun 22.

Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of TübingenTübingen, Germany; German Center for Neurodegenerative Diseases, University of TübingenTübingen, Germany; Department of Neurology, Christian-Albrechts-UniversityKiel, Germany.

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http://dx.doi.org/10.3389/fnagi.2016.00147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916171PMC
July 2016

Reduced intraepidermal nerve fiber density in patients with REM sleep behavior disorder.

Parkinsonism Relat Disord 2016 08 6;29:10-6. Epub 2016 Jun 6.

Department of Neurology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany; Jülich Aachen Research Alliance (JARA) BRAIN Institute II, Research Center Jülich GmbH and RWTH Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.06.003DOI Listing
August 2016

Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.

Front Aging Neurosci 2016 27;8:121. Epub 2016 May 27.

Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of TuebingenTuebingen, Germany; German Center for Neurodegenerative Diseases, University of TuebingenTuebingen, Germany; Department of Neurology, Christian-Albrechts UniversityKiel, Germany.

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http://dx.doi.org/10.3389/fnagi.2016.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882324PMC
June 2016

Rotigotine's effect on PLM-associated blood pressure elevations in restless legs syndrome: An RCT.

Neurology 2016 May 13;86(19):1785-93. Epub 2016 Apr 13.

From the Munich University Clinic and DZHK (German Centre for Cardiovascular Research) (A.B.); Philipps Universität Marburg (W.C., K.K., W.O.); Somni Bene Institut für Medizinische Forschung und Schlafmedizin (H.B.), Schwerin; Medical Center (H.B.), Rostock University, Germany; Emory University (D.R.), Atlanta, GA; Virginia Commonwealth University (D.S.), Richmond; Massachusetts General Hospital (J.W.W.), Boston; UCB Pharma (L.B., F.G., L.J., E.S.), Monheim am Rhein, Germany; UCB Pharma (K.M.), Smyrna, GA; UCB Pharma (J.W.), Raleigh, NC; Evidence Scientific Solutions (H.C.C.), Horsham, UK; Vanderbilt University School of Medicine (A.S.W.), Nashville, TN; Hertie Foundation (W.O.), Frankfurt am Main; and Department of Neurosurgery (C.T.), University Medical Center, Göttingen and Paracelsus-Elena-Klinik, Kassel, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000002649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862252PMC
May 2016

Transformation of Ulva mutabilis (Chlorophyta) by vector plasmids integrating into the genome.

J Phycol 2015 Oct 18;51(5):963-79. Epub 2015 Sep 18.

Institute of Biochemistry, Genetics and Microbiology (Department of Genetics), University of Regensburg, Universitätsstraße 31, Regensburg, 93040, Germany.

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http://dx.doi.org/10.1111/jpy.12336DOI Listing
October 2015

[The Competence Network Parkinson (CNP)].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016 Apr;59(4):420-9

Klinik für Neurologie, Abteilung Hertie-Senior Forschungsprofessur, Philipps-Universität Marburg, Baldingerstraße, 35043, Marburg, Deutschland.

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http://dx.doi.org/10.1007/s00103-016-2312-0DOI Listing
April 2016

Biceps electromyography in dialeptic and automotor seizures with and without secondary generalization.

Clin Neurophysiol 2016 Feb 20;127(2):1163-1169. Epub 2015 Oct 20.

Epilepsy Center, Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.clinph.2015.10.034DOI Listing
February 2016

A concerted action of L- and T-type Ca(2+) channels regulates locus coeruleus pacemaking.

Mol Cell Neurosci 2015 Sep 25;68:293-302. Epub 2015 Aug 25.

Institut für Physiologie und Pathophysiologie, Abteilung Vegetative Physiologie, Universität Marburg, 35037 Marburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2015.08.012DOI Listing
September 2015

Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease.

J Neurol Sci 2015 Sep 17;356(1-2):129-36. Epub 2015 Jun 17.

INSERM, CR-ICM, UMR_S1127, 75013 Paris, France; Université Pierre et Marie Curie Paris 06, UMR_S975, 75013 Paris France; CNRS, UMR 7225, CR-ICM, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2015.06.030DOI Listing
September 2015

A new dopaminergic nigro-olfactory projection.

Acta Neuropathol 2015 Sep 14;130(3):333-48. Epub 2015 Jun 14.

Department of Neurology, Technical University Munich, 81377, Munich, Germany,

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http://dx.doi.org/10.1007/s00401-015-1451-yDOI Listing
September 2015

Tau silencing by siRNA in the P301S mouse model of tauopathy.

Curr Gene Ther 2014 ;14(5):343-51

Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Max-Lebsche-Platz 30, 81377 Munich, Germany.

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http://dx.doi.org/10.2174/156652321405140926160602DOI Listing
October 2015

Piericidin A aggravates Tau pathology in P301S transgenic mice.

PLoS One 2014 1;9(12):e113557. Epub 2014 Dec 1.

Dept. of Neurology, Philipps-Universität, Marburg, Germany; German Center for Neurodegenerative Diseases, Dept. for Translational Neurodegeneration, Munich, Germany; Department of Neurology, Technische Universität München, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113557PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249965PMC
September 2015

The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases.

Mov Disord 2014 Dec 5;29(14):1758-66. Epub 2014 Nov 5.

Department of Neurology, Technische Universität München, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Department of Neurology, Philipps Universität, Marburg, Germany.

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http://www.neurokopfzentrum.med.tum.de/pdf/respondek2014.pdf
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http://doi.wiley.com/10.1002/mds.26054
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http://dx.doi.org/10.1002/mds.26054DOI Listing
December 2014

Diesterified derivatives of 5-iodo-2'-deoxyuridine as cerebral tumor tracers.

PLoS One 2014 16;9(7):e102397. Epub 2014 Jul 16.

Experimental Neurology, Department of Neurology, Philipps-University, Marburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Department of Neurology, Technical University, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100890PMC
November 2015

Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome.

Am J Hum Genet 2014 Jul;95(1):85-95

Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany; Institut für Humangenetik, Helmholtz Zentrum München, 85764 Munich, Germany; Institut für Humangenetik, Technische Universität München, 81675 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Department of Neurology and Neurosciences, Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085638PMC
July 2014

Influence of the nonergot dopamine agonist piribedil on vigilance in patients With Parkinson Disease and excessive daytime sleepiness (PiViCog-PD): an 11-week randomized comparison trial against pramipexole and ropinirole.

Clin Neuropharmacol 2014 Jul-Aug;37(4):116-22

*Department of Neurology, Philipps-University of Marburg, Marburg, Germany; †Gera, Germany; ‡Department of Neurology, University of Ulm, Ulm, Germany; §Department of Neurology, Elblandklinikum, Meissen, Germany; ∥Department of Neurology & Stereotactic Neurosurgery, Otto-von-Guericke-University, Magdeburg, Germany; ¶Department of Neurology, Schön Klinik München Schwabing and Technische Universität, München, Germany; #Neuro-Zentrum Steglitz, Berlin, Germany; ** Department of Neurology, Asklepios Fachklinikum, Stadtroda, Germany; ††Department of Neurology, CBF-Charité University Medicine, Berlin, Germany; ‡‡Department of Neurology, Klinik Haag, Haag Germany; §§Parkinson Klinik, Wolfach, Germany; and ∥∥Desitin Arzneimittel GmbH, Hamburg, Germany.

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http://pdfs.journals.lww.com/clinicalneuropharm/2014/07000/I
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WNF.0000000000000041DOI Listing
March 2015

Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease.

J Neuroinflammation 2014 May 8;11:86. Epub 2014 May 8.

CR-ICM, INSERM UMR_S1127, Université Pierre et Marie Curie Paris 06 UMR_S1127, CNRS UMR 7225, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France.

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http://dx.doi.org/10.1186/1742-2094-11-86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018945PMC
May 2014