Wolfgang Mikulits

Wolfgang Mikulits

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Wolfgang Mikulits

Publications by authors named "Wolfgang Mikulits"

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Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells.

Cancer Lett 2019 07 28;453:95-106. Epub 2019 Mar 28.

Group Inflammatory Carcinogenesis, Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein (UKSH) Campus Kiel, Arnold-Heller-Str. 3, Building 17, 24105, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.03.039DOI Listing
July 2019

LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.

Oncogenesis 2019 May 16;8(6):36. Epub 2019 May 16.

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, Biomedical Center, SE-751 23, Uppsala, Sweden.

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http://dx.doi.org/10.1038/s41389-019-0140-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522550PMC
May 2019

The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection.

Cancers (Basel) 2019 May 29;11(6). Epub 2019 May 29.

Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein (UKSH) Campus Kiel, Arnold-Heller-Str. 3, Building 17, 24105 Kiel, Germany.

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http://dx.doi.org/10.3390/cancers11060745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627672PMC
May 2019

Transforming Growth Factor-β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma.

Hepatology 2019 Jan 20;69(1):222-236. Epub 2018 Dec 20.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.30166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590451PMC
January 2019

Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics.

Int J Mol Sci 2018 Dec 18;19(12). Epub 2018 Dec 18.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/ijms19124111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321118PMC
December 2018

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.

Cell Death Differ 2018 05 11;25(5):885-903. Epub 2017 Dec 11.

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, SE-75123, Uppsala, Sweden.

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http://dx.doi.org/10.1038/s41418-017-0021-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943406PMC
May 2018

Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?

Arch Toxicol 2018 Feb 7;92(2):921-934. Epub 2017 Dec 7.

Department of Internal Medicine I, Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00204-017-2109-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818615PMC
February 2018

Dynamics of CRISPR/Cas9-mediated genomic editing of the locus in hepatocellular carcinoma cells.

Oncol Lett 2018 Feb 13;15(2):2441-2450. Epub 2017 Dec 13.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3892/ol.2017.7605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777348PMC
February 2018

Transforming Growth Factor-β Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells.

Int J Mol Sci 2017 Oct 10;18(10). Epub 2017 Oct 10.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/ijms18102119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666801PMC
October 2017

Transforming growth factor-β-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma.

Cancer Lett 2017 04 2;392:39-50. Epub 2017 Feb 2.

Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain; Department of Physiological Sciences, School of Medicine, University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.01.037DOI Listing
April 2017

Accurate Determination of Soluble Axl by Enzyme-Linked Immunosorbent Assay.

Assay Drug Dev Technol 2016 11 2;14(9):543-550. Epub 2016 Nov 2.

1 Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna, Austria .

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http://dx.doi.org/10.1089/adt.2016.743DOI Listing
November 2016

Role of epithelial to mesenchymal transition in hepatocellular carcinoma.

J Hepatol 2016 10 17;65(4):798-808. Epub 2016 May 17.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.05.007DOI Listing
October 2016

Accuracy of novel diagnostic biomarkers for hepatocellular carcinoma: An update for clinicians (Review).

Oncol Rep 2016 Aug 1;36(2):613-25. Epub 2016 Jun 1.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3892/or.2016.4842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930874PMC
August 2016

Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF.

PLoS One 2015 3;10(11):e0142134. Epub 2015 Nov 3.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142134PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631446PMC
June 2016

The rationale for targeting TGF-β in chronic liver diseases.

Eur J Clin Invest 2016 Apr 12;46(4):349-61. Epub 2016 Mar 12.

Dep. Bioquímica y Biología Molecular II, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1111/eci.12596DOI Listing
April 2016

Neuropilin-2 induced by transforming growth factor-β augments migration of hepatocellular carcinoma cells.

BMC Cancer 2015 Nov 16;15:909. Epub 2015 Nov 16.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1186/s12885-015-1919-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647494PMC
November 2015

Axl activates autocrine transforming growth factor-β signaling in hepatocellular carcinoma.

Hepatology 2015 Mar 28;61(3):930-41. Epub 2015 Jan 28.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.27492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450343PMC
March 2015

The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences.

PLoS One 2013 25;8(9):e75233. Epub 2013 Sep 25.

Institut National de la Santé et de la Recherche Médicale, U892, Nantes, France ; University of Nantes, Nantes, France ; Centre national de la recherche scientifique, UMR 6299, Nantes, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783476PMC
July 2014

STAT3 in hepatocellular carcinoma: new perspectives.

Hepat Oncol 2014 Jan 20;1(1):107-120. Epub 2013 Dec 20.

Medical University Vienna & Comprehensive Cancer Center, Institute for Cancer Research, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.2217/hep.13.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114013PMC
January 2014

Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

Mol Cancer Ther 2013 Oct 12;12(10):1947-57. Epub 2013 Aug 12.

Corresponding Author: Wolfgang Mikulits, Medical University Vienna, Borschkegasse 8a, Vienna 1090, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0263DOI Listing
October 2013

Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression.

PLoS One 2012 10;7(12):e51136. Epub 2012 Dec 10.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519484PMC
June 2013

TGF-β in epithelial to mesenchymal transition and metastasis of liver carcinoma.

Curr Pharm Des 2012 ;18(27):4135-47

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Austria.

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http://dx.doi.org/10.2174/138161212802430477DOI Listing
March 2013

PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition.

Nucleic Acids Res 2012 Oct 16;40(19):9738-49. Epub 2012 Aug 16.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gks760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479205PMC
October 2012

M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues.

J Hepatol 2012 Aug 17;57(2):337-43. Epub 2012 Apr 17.

Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Muthgasse 18, A-1190 Vienna, Austria.

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http://dx.doi.org/10.1016/j.jhep.2012.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401376PMC
August 2012

La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition.

Nucleic Acids Res 2012 Jan 6;40(1):290-302. Epub 2011 Sep 6.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1093/nar/gkr717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245933PMC
January 2012

Initial steps of metastasis: cell invasion and endothelial transmigration.

Mutat Res 2011 Jul-Oct;728(1-2):23-34. Epub 2011 May 12.

Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.mrrev.2011.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028085PMC
October 2011

p19(ARF) /p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma.

Hepatology 2011 Jul;54(1):164-72

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.24329DOI Listing
July 2011

A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression.

Mol Cancer Ther 2011 May 1;10(5):850-60. Epub 2011 Mar 1.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0917DOI Listing
May 2011

The crosstalk of RAS with the TGF-β family during carcinoma progression and its implications for targeted cancer therapy.

Curr Cancer Drug Targets 2010 Dec;10(8):849-57

Department of Medicine I, Division, Institute of Cancer Research, Medical University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044462PMC
http://dx.doi.org/10.2174/156800910793357943DOI Listing
December 2010

Natural immunity enhances the activity of a DR5 agonistic antibody and carboplatin in the treatment of ovarian cancer.

Mol Cancer Ther 2010 Apr 6;9(4):1007-18. Epub 2010 Apr 6.

Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-09-0933DOI Listing
April 2010

Hepatospheres: Three dimensional cell cultures resemble physiological conditions of the liver.

World J Hepatol 2010 Jan;2(1):1-7

Franziska van Zijl, Wolfgang Mikulits, Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.4254/wjh.v2.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998947PMC
January 2010

Epithelial-mesenchymal transition in hepatocellular carcinoma.

Future Oncol 2009 Oct;5(8):1169-79

Department of Medicine I, Division: Institute of Cancer Research, Medical University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.2217/fon.09.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963061PMC
October 2009

The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells.

Int J Cancer 2009 Jun;124(11):2559-67

Institute of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Vienna, Austria.

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http://doi.wiley.com/10.1002/ijc.24236
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http://dx.doi.org/10.1002/ijc.24236DOI Listing
June 2009

NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A.

Cancer Res 2009 Jan;69(1):235-42

Department of Medicine I, Division: Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, Vienna, Austria.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2144DOI Listing
January 2009

Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview.

Br J Nutr 2008 May;99 E Suppl 1:ES3-52

Institute of Cancer Research, Inner Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1017/S0007114508965752DOI Listing
May 2008

The leader region of Laminin B1 mRNA confers cap-independent translation.

Nucleic Acids Res 2007 29;35(8):2473-82. Epub 2007 Mar 29.

Department of Medicine I, Division Institute of Cancer Research, Medical University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Boehringer Ingelheim Austria.

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http://dx.doi.org/10.1093/nar/gkm096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885646PMC
June 2007

TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells.

Comp Hepatol 2007 Feb 20;6. Epub 2007 Feb 20.

Department of Medicine I, Division Institute of Cancer Research, Medical University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1186/1476-5926-6-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804283PMC
February 2007

Impact of constitutive IGF1/IGF2 stimulation on the transcriptional program of human breast cancer cells.

Carcinogenesis 2007 Jan 14;28(1):49-59. Epub 2006 Jun 14.

Department of Obstetrics and Gynecology, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1093/carcin/bgl091DOI Listing
January 2007

The plasticity of p19 ARF null hepatic stellate cells and the dynamics of activation.

Biochim Biophys Acta 2005 May 21;1744(1):76-87. Epub 2005 Jan 21.

Department of Medicine I, Division: Institute of Cancer Research, Medical University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.bbamcr.2004.12.009DOI Listing
May 2005

beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition.

Oncogene 2004 Apr;23(15):2672-2680

Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, University of Vienna, Vienna, Austria.

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http://www.nature.com/articles/1207416
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http://dx.doi.org/10.1038/sj.onc.1207416DOI Listing
April 2004

Immortalized p19ARF null hepatocytes restore liver injury and generate hepatic progenitors after transplantation.

Hepatology 2004 Mar;39(3):628-34

Institute of Cancer Research, University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1002/hep.20084DOI Listing
March 2004

Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis.

Mutat Res 2004 Jan;566(1):9-20

Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/s1383-5742(03)00033-4DOI Listing
January 2004

The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis.

Oncogene 2003 Oct;22(43):6725-38

Institute of Cancer Research, University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1038/sj.onc.1206781DOI Listing
October 2003

Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.

J Cell Sci 2002 Mar;115(Pt 6):1189-202

Institute of Cancer Research, University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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March 2002