Publications by authors named "Wolfgang Jahnke"

68Publications

Fragment-to-Lead Medicinal Chemistry Publications in 2019.

Authors:
Wolfgang Jahnke Daniel A Erlanson Iwan J P de Esch Christopher N Johnson Paul N Mortenson Yuji Ochi Tatsuya Urushima

J Med Chem 2020 12 23;63(24):15494-15507. Epub 2020 Nov 23.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.

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December 2020

Correction to: NMR in pharmaceutical discovery and development.

Authors:
Raymond S Norton Wolfgang Jahnke

J Biomol NMR 2020 Nov;74(10-11):477

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Virchow-16.3.249, 4002, Basel, Switzerland.

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November 2020

Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.

Authors:
Robin A Fairhurst Thomas Knoepfel Nicole Buschmann Catherine Leblanc Robert Mah Milen Todorov Pierre Nimsgern Sebastien Ripoche Michel Niklaus Nicolas Warin Van Huy Luu Mario Madoerin Jasmin Wirth Diana Graus-Porta Andreas Weiss Michael Kiffe Markus Wartmann Jacqueline Kinyamu-Akunda Dario Sterker Christelle Stamm Flavia Adler Alexandra Buhles Heiko Schadt Philippe Couttet Jutta Blank Inga Galuba Jörg Trappe Johannes Voshol Nils Ostermann Chao Zou Jörg Berghausen Alberto Del Rio Espinola Wolfgang Jahnke Pascal Furet

J Med Chem 2020 11 1;63(21):12542-12573. Epub 2020 Oct 1.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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November 2020

NMR in pharmaceutical discovery and development.

Authors:
Raymond S Norton Wolfgang Jahnke

J Biomol NMR 2020 Nov 4;74(10-11):473-476. Epub 2020 Sep 4.

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Virchow-16.3.249, 4002, Basel, Switzerland.

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November 2020

Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase.

Authors:
Lena Münzker Joy Kristin Petrick Christian Schleberger Damien Clavel Irina Cornaciu Rainer Wilcken José A Márquez Gerhard Klebe Andreas Marzinzik Wolfgang Jahnke

Chembiochem 2020 Nov 13;21(21):3096-3111. Epub 2020 Jul 13.

Novartis Institutes for Biomedical Research Novartis Campus, 4002, Basel, Switzerland.

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November 2020

Fragment-to-Lead Medicinal Chemistry Publications in 2018.

Authors:
Daniel A Erlanson Iwan J P de Esch Wolfgang Jahnke Christopher N Johnson Paul N Mortenson

J Med Chem 2020 05 22;63(9):4430-4444. Epub 2020 Jan 22.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.

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May 2020

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.

Authors:
Eline Sijbesma Kenneth K Hallenbeck Seppe Leysen Pim J de Vink Lukasz Skóra Wolfgang Jahnke Luc Brunsveld Michelle R Arkin Christian Ottmann

J Am Chem Soc 2019 02 19;141(8):3524-3531. Epub 2019 Feb 19.

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS) , Eindhoven University of Technology , 5600 MB Eindhoven , The Netherlands.

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February 2019

Fragment-Based Drug Discovery: Advancing Fragments in the Absence of Crystal Structures.

Authors:
Daniel A Erlanson Ben J Davis Wolfgang Jahnke

Cell Chem Biol 2019 01 25;26(1):9-15. Epub 2018 Oct 25.

Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Novartis Campus, Basel, Switzerland. Electronic address:

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January 2019

Fragment-to-Lead Medicinal Chemistry Publications in 2017.

Authors:
Paul N Mortenson Daniel A Erlanson Iwan J P de Esch Wolfgang Jahnke Christopher N Johnson

J Med Chem 2019 04 21;62(8):3857-3872. Epub 2018 Nov 21.

Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom.

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April 2019

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Authors:
Joseph Schoepfer Wolfgang Jahnke Giuliano Berellini Silvia Buonamici Simona Cotesta Sandra W Cowan-Jacob Stephanie Dodd Peter Drueckes Doriano Fabbro Tobias Gabriel Jean-Marc Groell Robert M Grotzfeld A Quamrul Hassan Chrystèle Henry Varsha Iyer Darryl Jones Franco Lombardo Alice Loo Paul W Manley Xavier Pellé Gabriele Rummel Bahaa Salem Markus Warmuth Andrew A Wylie Thomas Zoller Andreas L Marzinzik Pascal Furet

J Med Chem 2018 09 7;61(18):8120-8135. Epub 2018 Sep 7.

Novartis Institutes for BioMedical Research, Novartis Campus , CH-4056 Basel , Switzerland.

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September 2018

Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.

Authors:
Zhenhao Fang Christopher B Marshall Tadateru Nishikawa Alvar D Gossert Johanna M Jansen Wolfgang Jahnke Mitsuhiko Ikura

Cell Chem Biol 2018 11 16;25(11):1327-1336.e4. Epub 2018 Aug 16.

Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address:

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November 2018

Fragment-to-Lead Medicinal Chemistry Publications in 2016.

Authors:
Christopher N Johnson Daniel A Erlanson Wolfgang Jahnke Paul N Mortenson David C Rees

J Med Chem 2018 03 31;61(5):1774-1784. Epub 2017 Oct 31.

Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom.

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March 2018

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.

Authors:
Eline Sijbesma Lukasz Skora Seppe Leysen Luc Brunsveld Uwe Koch Peter Nussbaumer Wolfgang Jahnke Christian Ottmann

Biochemistry 2017 08 21;56(30):3972-3982. Epub 2017 Jul 21.

Department of Biomedical Engineering, Laboratory of Chemical Biology, and Institute for Complex Molecular Systems, Eindhoven University of Technology , P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

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August 2017

F-NMR-Based Dual-Site Reporter Assay for the Discovery and Distinction of Catalytic and Allosteric Kinase Inhibitors.

Authors:
Lukasz Skora Wolfgang Jahnke

ACS Med Chem Lett 2017 Jun 6;8(6):632-635. Epub 2017 Apr 6.

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

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June 2017

Inhibition of prenylated KRAS in a lipid environment.

Authors:
Johanna M Jansen Charles Wartchow Wolfgang Jahnke Susan Fong Tiffany Tsang Keith Pfister Tatiana Zavorotinskaya Dirksen Bussiere Jan Marie Cheng Kenneth Crawford Yumin Dai Jeffrey Dove Eric Fang Yun Feng Jean-Michel Florent John Fuller Alvar D Gossert Mohammad Hekmat-Nejad Chrystèle Henry Julia Klopp William P Lenahan Andreas Lingel Sylvia Ma Arndt Meyer Yuji Mishina Jamie Narberes Gwynn Pardee Savithri Ramurthy Sebastien Rieffel Darrin Stuart Sharadha Subramanian Laura Tandeske Stephania Widger Armin Widmer Aurelie Winterhalter Isabel Zaror Stephen Hardy

PLoS One 2017 6;12(4):e0174706. Epub 2017 Apr 6.

Department of Oncology, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America.

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September 2017

The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

Authors:
Andrew A Wylie Joseph Schoepfer Wolfgang Jahnke Sandra W Cowan-Jacob Alice Loo Pascal Furet Andreas L Marzinzik Xavier Pelle Jerry Donovan Wenjing Zhu Silvia Buonamici A Quamrul Hassan Franco Lombardo Varsha Iyer Michael Palmer Giuliano Berellini Stephanie Dodd Sanjeev Thohan Hans Bitter Susan Branford David M Ross Timothy P Hughes Lilli Petruzzelli K Gary Vanasse Markus Warmuth Francesco Hofmann Nicholas J Keen William R Sellers

Nature 2017 03 22;543(7647):733-737. Epub 2017 Mar 22.

Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA.

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March 2017

NMR in drug discovery: A practical guide to identification and validation of ligands interacting with biological macromolecules.

Authors:
Alvar D Gossert Wolfgang Jahnke

Prog Nucl Magn Reson Spectrosc 2016 11 30;97:82-125. Epub 2016 Sep 30.

Novartis Institutes for BioMedical Research, Novartis Campus, 4002 Basel, Switzerland.

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November 2016

Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches.

Authors:
Henrik Mobitz Wolfgang Jahnke Sandra W Cowan-Jacob

Curr Top Med Chem 2017 ;17(1):59-70

Novartis Institutes for Biomedical Research, Basel, Switzerland.

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February 2017

Twenty years on: the impact of fragments on drug discovery.

Authors:
Daniel A Erlanson Stephen W Fesik Roderick E Hubbard Wolfgang Jahnke Harren Jhoti

Nat Rev Drug Discov 2016 09 15;15(9):605-619. Epub 2016 Jul 15.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK.

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September 2016

Contributions of Biomolecular NMR to Allosteric Drug Discovery.

Authors:
Lukasz Skora Wolfgang Jahnke

Chimia (Aarau) 2015 ;69(7-8):421-4

Novartis Institutes for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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December 2015