Publications by authors named "Wolfgang Jahnke"

68Publications

Fragment-to-Lead Medicinal Chemistry Publications in 2019.

J Med Chem 2020 12 23;63(24):15494-15507. Epub 2020 Nov 23.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.

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December 2020

Correction to: NMR in pharmaceutical discovery and development.

J Biomol NMR 2020 Nov;74(10-11):477

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Virchow-16.3.249, 4002, Basel, Switzerland.

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November 2020

NMR in pharmaceutical discovery and development.

J Biomol NMR 2020 Nov 4;74(10-11):473-476. Epub 2020 Sep 4.

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Virchow-16.3.249, 4002, Basel, Switzerland.

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November 2020

Fragment-to-Lead Medicinal Chemistry Publications in 2018.

J Med Chem 2020 05 22;63(9):4430-4444. Epub 2020 Jan 22.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.

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May 2020

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.

J Am Chem Soc 2019 02 19;141(8):3524-3531. Epub 2019 Feb 19.

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS) , Eindhoven University of Technology , 5600 MB Eindhoven , The Netherlands.

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February 2019

Fragment-Based Drug Discovery: Advancing Fragments in the Absence of Crystal Structures.

Cell Chem Biol 2019 01 25;26(1):9-15. Epub 2018 Oct 25.

Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Novartis Campus, Basel, Switzerland. Electronic address:

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January 2019

Fragment-to-Lead Medicinal Chemistry Publications in 2017.

J Med Chem 2019 04 21;62(8):3857-3872. Epub 2018 Nov 21.

Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom.

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April 2019

Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.

Cell Chem Biol 2018 11 16;25(11):1327-1336.e4. Epub 2018 Aug 16.

Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address:

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November 2018

Fragment-to-Lead Medicinal Chemistry Publications in 2016.

J Med Chem 2018 03 31;61(5):1774-1784. Epub 2017 Oct 31.

Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom.

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March 2018

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.

Biochemistry 2017 08 21;56(30):3972-3982. Epub 2017 Jul 21.

Department of Biomedical Engineering, Laboratory of Chemical Biology, and Institute for Complex Molecular Systems, Eindhoven University of Technology , P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

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August 2017

F-NMR-Based Dual-Site Reporter Assay for the Discovery and Distinction of Catalytic and Allosteric Kinase Inhibitors.

ACS Med Chem Lett 2017 Jun 6;8(6):632-635. Epub 2017 Apr 6.

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

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June 2017

NMR in drug discovery: A practical guide to identification and validation of ligands interacting with biological macromolecules.

Prog Nucl Magn Reson Spectrosc 2016 11 30;97:82-125. Epub 2016 Sep 30.

Novartis Institutes for BioMedical Research, Novartis Campus, 4002 Basel, Switzerland.

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November 2016

Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches.

Curr Top Med Chem 2017 ;17(1):59-70

Novartis Institutes for Biomedical Research, Basel, Switzerland.

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February 2017

Twenty years on: the impact of fragments on drug discovery.

Nat Rev Drug Discov 2016 09 15;15(9):605-619. Epub 2016 Jul 15.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK.

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September 2016

Contributions of Biomolecular NMR to Allosteric Drug Discovery.

Chimia (Aarau) 2015 ;69(7-8):421-4

Novartis Institutes for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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December 2015