Publications by authors named "Wolfgang Bergmeier"

104 Publications

Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin.

Authors:
Christopher Michael Hoover Yuji Kondo Bojing Shao Michael McDaniel Robert Lee Samuel McGee Sidney W Whiteheart Wolfgang Bergmeier Rodger P McEver Lijun Xia

Blood 2021 Feb 22. Epub 2021 Feb 22.

University of Oklahoma Health Sciences Center, United States.

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February 2021

Specifications of the variant curation guidelines for ITGA2B/ITGB3: ClinGen Platelet Disorder Variant Curation Panel.

Authors:
Justyne E Ross Bing M Zhang Kristy Lee Shruthi Mohan Brian R Branchford Paul Bray Stefanie N Dugan Kathleen Freson Paula G Heller Walter H A Kahr Michele P Lambert Lori Luchtman-Jones Minjie Luo Juliana Perez Botero Matthew T Rondina Gabriella Ryan Sarah Westbury Wolfgang Bergmeier Jorge Di Paola

Blood Adv 2021 Jan;5(2):414-431

Division of Pediatric Hematology Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.

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January 2021

Platelet transfusion for patients with platelet dysfunction: effectiveness, mechanisms, and unanswered questions.

Authors:
Robert H Lee Raj S Kasthuri Wolfgang Bergmeier

Curr Opin Hematol 2020 Nov;27(6):378-385

UNC Blood Research Center.

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November 2020

Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids.

Authors:
Anita Eckly Cyril Scandola Antoine Oprescu Deborah Michel Jean-Yves Rinckel Fabienne Proamer David Hoffmann Nicolas Receveur Catherine Léon James E Bear Dorsaf Ghalloussi Gabriel Harousseau Wolfgang Bergmeier Francois Lanza Frédérique Gaits-Iacovoni Henri de la Salle Christian Gachet

J Thromb Haemost 2020 11 25;18(11):2987-3001. Epub 2020 Aug 25.

Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS, Strasbourg, France.

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November 2020

Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress.

Authors:
Robert Ariens Cecilia Becattini Markus Bender Wolfgang Bergmeier Elisabetta Castoldi Katrien Devreese Martin Ellis David Gailani Vera Ignjatovic Paula D James Steven Kerrigan Michele Lambert Lai Heng Lee Marcel Levi Norma Maugeri Joost Meijers Juan Melero-Martin Alan D Michelson Federico Mingozzi Keith Neeves Heyu Ni Anna-Karin Olsson Zoltán Prohászka Marie Ranson Nicoletta Riva Yotis Senis Cornelia H van Ommen Douglas E Vaughan John Weisel

Res Pract Thromb Haemost 2020 Jul 12;4(5):680-713. Epub 2020 Jul 12.

Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.

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July 2020

Talin-1 is the principal platelet Rap1 effector of integrin activation.

Authors:
Frederic Lagarrigue David S Paul Alexandre R Gingras Andrew J Valadez Hao Sun Jenny Lin Monica N Cuevas Jailal N Ablack Miguel Alejandro Lopez-Ramirez Wolfgang Bergmeier Mark H Ginsberg

Blood 2020 Sep;136(10):1180-1190

Department of Medicine, University of California, San Diego, La Jolla, CA.

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September 2020

Novel Mouse Model for Studying Hemostatic Function of Human Platelets.

Authors:
David S Paul Wolfgang Bergmeier

Arterioscler Thromb Vasc Biol 2020 08 4;40(8):1891-1904. Epub 2020 Jun 4.

From the Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill (D.S.P., W.B.).

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August 2020

Development of Optimized Tissue-Factor-Targeted Peptide Amphiphile Nanofibers to Slow Noncompressible Torso Hemorrhage.

Authors:
Mia K Klein Hussein Aziz Kassam Robert H Lee Wolfgang Bergmeier Erica B Peters David C Gillis Brooke R Dandurand Jessica R Rouan Mark R Karver Mark D Struble Tristan D Clemons Liam C Palmer Brian Gavitt Timothy A Pritts Nick D Tsihlis Samuel I Stupp Melina R Kibbe

ACS Nano 2020 06 3;14(6):6649-6662. Epub 2020 Jun 3.

Department of Surgery and Center for Nanotechnology in Drug Delivery, University of North Carolina, Chapel Hill, North Carolina 27599, United States.

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June 2020

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis.

Authors:
Elisa d'Alessandro Christian Becker Wolfgang Bergmeier Christoph Bode Joshua H Bourne Helena Brown Harry R Buller Arina J Ten Cate-Hoek Vincent Ten Cate Yvonne J M van Cauteren Yam F H Cheung Audrey Cleuren Danielle Coenen Harry J G M Crijns Ilaria de Simone Sophie C Dolleman Christine Espinola Klein Delia I Fernandez Lianne Granneman Arnoud van T Hof Peter Henke Yvonne M C Henskens Jingnan Huang Lisa K Jennings Natalie Jooss Mieke Karel Danique van den Kerkhof Frederik A Klok Bram Kremers Bernhard Lämmle Avi Leader Annika Lundstrom Nigel Mackman Pier M Mannucci Zahra Maqsood Paola E J van der Meijden Marc van Moorsel Luis A Moran John Morser Manouk van Mourik Stefano Navarro Raluca A I Neagoe Renske H Olie Pauline van Paridon Jens Posma Isabella Provenzale Pieter H Reitsma Billy Scaf Leon Schurgers Jaap Seelig Agneta Siegbahn Bob Siegerink Oliver Soehnlein Eva Maria Soriano Marcin A Sowa Henri M H Spronk Robert F Storey Chukiat Tantiwong Alicia Veninga Xueqing Wang Steve P Watson Jeff Weitz Sacha S Zeerleder Hugo Ten Cate

Thromb Haemost 2020 Apr 14;120(4):538-564. Epub 2020 Apr 14.

Laboratory for Clinical Thrombosis and Hemostasis, Department of Biochemistry and Internal Medicine and Thrombosis Expert Center, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.

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April 2020

Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury.

Authors:
Jörn Karhausen Hae Woong Choi Krishna Rao Maddipati Joseph P Mathew Qing Ma Yacine Boulaftali Robert Hugh Lee Wolfgang Bergmeier Soman N Abraham

Sci Adv 2020 03 18;6(12):eaay6314. Epub 2020 Mar 18.

Department of Pathology, Duke University Medical Center, Durham, NC, USA.

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March 2020

Glanzmann thrombasthenia: genetic basis and clinical correlates.

Authors:
Juliana Perez Botero Kristy Lee Brian R Branchford Paul F Bray Kathleen Freson Michele P Lambert Minjie Luo Shruthi Mohan Justyne E Ross Wolfgang Bergmeier Jorge Di Paola

Haematologica 2020 04 5;105(4):888-894. Epub 2020 Mar 5.

Division of Pediatric Hematology Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, MO, USA

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April 2020

Therapeutic strategies for thrombosis: new targets and approaches.

Authors:
Nigel Mackman Wolfgang Bergmeier George A Stouffer Jeffrey I Weitz

Nat Rev Drug Discov 2020 05 4;19(5):333-352. Epub 2020 Mar 4.

Thrombosis & Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, Canada.

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May 2020

Desialylation of -glycans on glycoprotein Ibα drives receptor signaling and platelet clearance.

Authors:
Yingchun Wang Wenchun Chen Wei Zhang Melissa M Lee-Sundlov Caterina Casari Michael C Berndt Francois Lanza Wolfgang Bergmeier Karin M Hoffmeister X Frank Zhang Renhao Li

Haematologica 2021 01 1;106(1):220-229. Epub 2021 Jan 1.

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.

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January 2021

Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications.

Authors:
Robert H Lee Raymond Piatt Ankita Dhenge María L Lozano Verónica Palma-Barqueros José Rivera Wolfgang Bergmeier

Sci Transl Med 2019 12;11(522)

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

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December 2019

Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis.

Authors:
Stephen P Holly Nidhi Gera Putianqi Wang Alexander Wilson Ziqiang Guan Ling Lin Brian Cooley Hammodah R Alfar Ruchi G Patil Raymond Piatt Tina M Leisner Wolfgang Bergmeier Rinku Majumder Leslie V Parise

Blood Adv 2019 11;3(22):3818-3828

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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November 2019

Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides.

Authors:
Muzaddid Sarker Ardeshir Goliaei Florence Golesi Marjorie Poggi Aaron A Cook Mohammad A I Khan Brenda R Temple Lucia Stefanini Matthias Canault Wolfgang Bergmeier Sharon L Campbell

J Thromb Haemost 2020 03 30;18(3):693-705. Epub 2019 Dec 30.

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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March 2020

New insights into cytoskeletal remodeling during platelet production.

Authors:
Dorsaf Ghalloussi Ankita Dhenge Wolfgang Bergmeier

J Thromb Haemost 2019 09 16;17(9):1430-1439. Epub 2019 Jul 16.

McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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September 2019

Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection.

Authors:
Ichiro Misumi Kevin D Cook Joseph E Mitchell Makayla M Lund Sarah C Vick Robert H Lee Toru Uchimura Wolfgang Bergmeier Piotr Mieczkowski Fernando Pardo-Manuel de Villena Jenny P Y Ting Jason K Whitmire

Cell Rep 2019 04;27(5):1387-1396.e5

Department of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:

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April 2019

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease.

Authors:
Camille Faes Anton Ilich Amandine Sotiaux Erica M Sparkenbaugh Michael W Henderson Laura Buczek Joan D Beckman Patrick Ellsworth Denis F Noubouossie Lantarima Bhoopat Mark Piegore Céline Renoux Wolfgang Bergmeier Yara Park Kenneth I Ataga Brian Cooley Alisa S Wolberg Nigel S Key Rafal Pawlinski

Blood 2019 06 5;133(23):2529-2541. Epub 2019 Apr 5.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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June 2019

Small GTPases in megakaryocyte and platelet biology.

Authors:
Lucia Stefanini Wolfgang Bergmeier

Platelets 2019 20;30(1):7-8. Epub 2019 Jan 20.

b Department of Biochemistry and Biophysics , University of North Carolina , Chapel Hill , NC , USA.

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March 2019

RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.

Authors:
Bing Wu Song Zhang Zengli Guo Gang Wang Ge Zhang Ling Xie Jitong Lou Xian Chen Di Wu Wolfgang Bergmeier Junnian Zheng Yisong Y Wan

Immunity 2018 11 13;49(5):886-898.e5. Epub 2018 Nov 13.

Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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November 2018

Two novel, putative mechanisms of action for citalopram-induced platelet inhibition.

Authors:
Harvey G Roweth Aaron A Cook Masaaki Moroi Arkadiusz M Bonna Stephanie M Jung Wolfgang Bergmeier Stewart O Sage Gavin E Jarvis

Sci Rep 2018 11 12;8(1):16677. Epub 2018 Nov 12.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

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November 2018

STIM1 R304W causes muscle degeneration and impaired platelet activation in mice.

Authors:
Thilini H Gamage Gjermund Gunnes Robert Hugh Lee William Edward Louch Asbjørn Holmgren Joseph D Bruton Emma Lengle Terje R Selnes Kolstad Tobias Revold Silja Svanstrøm Amundsen Knut Tomas Dalen Pål Andre Holme Geir Erland Tjønnfjord Geir Christensen Håkan Westerblad Arne Klungland Wolfgang Bergmeier Doriana Misceo Eirik Frengen

Cell Calcium 2018 12 5;76:87-100. Epub 2018 Oct 5.

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway. Electronic address:

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December 2018

Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.

Authors:
Frederic Lagarrigue Alexandre R Gingras David S Paul Andrew J Valadez Monica N Cuevas Hao Sun Miguel A Lopez-Ramirez Benjamin T Goult Sanford J Shattil Wolfgang Bergmeier Mark H Ginsberg

Blood Adv 2018 09;2(18):2358-2368

Department of Medicine, University of California, San Diego, La Jolla, CA.

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September 2018

Functional redundancy between RAP1 isoforms in murine platelet production and function.

Authors:
Lucia Stefanini Robert H Lee David S Paul Ellen C O'Shaughnessy Dorsaf Ghalloussi Christopher I Jones Yacine Boulaftali Kathryn O Poe Raymond Piatt Dan O Kechele Kathleen M Caron Klaus M Hahn Jonathan M Gibbins Wolfgang Bergmeier

Blood 2018 11 21;132(18):1951-1962. Epub 2018 Aug 21.

McAllister Heart Institute and.

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November 2018

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.

Authors:
Wolfgang Bergmeier Silvio Antoniak Edward M Conway Cécile V Denis Lindsey A George Berend Isermann Nigel S Key Sriram Krishnaswamy Wilbur A Lam David Lillicrap Jian Liu Mark R Looney José A López Coen Maas Flora Peyvandi Wolfram Ruf Anil K Sood Henri H Versteeg Alisa S Wolberg Pancras C Wong Jeremy P Wood Hartmut Weiler

Res Pract Thromb Haemost 2018 Jul 12;2(3):407-428. Epub 2018 Apr 12.

Blood Research Institute Blood Center of Wisconsin Milwaukee WI USA.

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July 2018

Phenotype analysis and clinical management in a large family with a novel truncating mutation in , the CalDAG-GEFI encoding gene.

Authors:
Amrita Desai Wolfgang Bergmeier Mathias Canault Marie-Christine Alessi David S Paul Paquita Nurden Xavier Pillois Wenche Jy Yeon S Ahn Alan T Nurden

Res Pract Thromb Haemost 2017 Jul 20;1(1):128-133. Epub 2017 Jun 20.

IHU-LIRYC Plateforme Technologique D'Innovation Biomédicale Hopital Xavier Arnozan Pessac France.

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July 2017

Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets.

Authors:
Caterina Casari David S Paul Sophie Susen Cécile Lavenu-Bombled Annie Harroche Raymond Piatt Kathryn O Poe Robert H Lee Marijke Bryckaert Olivier D Christophe Peter J Lenting Cécile V Denis Wolfgang Bergmeier

Blood Adv 2018 06;2(12):1417-1428

McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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June 2018

RAP GTPases and platelet integrin signaling.

Authors:
Lucia Stefanini Wolfgang Bergmeier

Platelets 2019 4;30(1):41-47. Epub 2018 Jun 4.

b Department of Biochemistry and Biophysics , University of North Carolina , Chapel Hill, NC, USA.

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March 2019

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI.

Authors:
Aaron A Cook Wei Deng Jinqi Ren Renhao Li John Sondek Wolfgang Bergmeier

J Biol Chem 2018 06 5;293(22):8521-8529. Epub 2018 Apr 5.

From the Departments of Biochemistry and Biophysics and

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June 2018