Wolfgang A Linke

Wolfgang A Linke

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Wolfgang A Linke

Wolfgang A Linke

Publications by authors named "Wolfgang A Linke"

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Cronos Titin is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function.

Circulation 2019 Oct 7. Epub 2019 Oct 7.

Department of Bioengineering, University of Washington, Seattle, WA; Department of Pathology, University of Washington, Seattle, WA; Center for Cardiovascular Biology, University of Washington, Seattle, WA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA; Department of Medicine/Cardiology, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039521DOI Listing
October 2019

Cardiac α-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy.

Circ Genom Precis Med 2019 Aug 20;12(8):e002491. Epub 2019 Aug 20.

Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine (C.F., S.D., B.S., Ellen Schulze-Bahr, S.P., G.S., A.U., Eric Schulze-Bahr), University Hospital Münster.

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http://dx.doi.org/10.1161/CIRCGEN.119.002491DOI Listing
August 2019

Posttranslational modifications of titin from cardiac muscle: how, where, and what for?

FEBS J 2019 Jun 29;286(12):2240-2260. Epub 2019 Apr 29.

Institute of Physiology II, University of Muenster, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/febs.14854
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http://dx.doi.org/10.1111/febs.14854DOI Listing
June 2019

The Translational Landscape of the Human Heart.

Cell 2019 Jun 30;178(1):242-260.e29. Epub 2019 May 30.

Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.010DOI Listing
June 2019

Titin as a force-generating muscle protein under regulatory control.

J Appl Physiol (1985) 2019 May 6;126(5):1474-1482. Epub 2018 Dec 6.

Institute of Physiology II, University of Muenster , Muenster , Germany.

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http://dx.doi.org/10.1152/japplphysiol.00865.2018DOI Listing
May 2019

Early myocardial changes induced by doxorubicin in the nonfailing dilated ventricle.

Am J Physiol Heart Circ Physiol 2019 Mar 7;316(3):H459-H475. Epub 2018 Dec 7.

Department of Surgery and Physiology, Faculty of Medicine, Unidade de Investigação Cardiovascular, Universidade do Porto , Porto , Portugal.

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https://www.physiology.org/doi/10.1152/ajpheart.00401.2018
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http://dx.doi.org/10.1152/ajpheart.00401.2018DOI Listing
March 2019

A personal tribute to Johann Caspar Rüegg (1930-2018): milestones of muscle research.

Biophys Rev 2018 Aug 9;10(4):1129-1131. Epub 2018 Jul 9.

Institute of Physiology II, University of Münster, Robert Koch Str. 27B, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s12551-018-0436-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082302PMC
August 2018

Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1.

Circ Res 2018 07 14;123(3):342-355. Epub 2018 May 14.

From the Medical Faculty, Department of Cardiovascular Physiology, Heinrich-Heine-University, Düsseldorf, Germany (A.-E.H., C.A., S.K., M.I., S.S., S.B., M.K.)

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312166DOI Listing
July 2018

Titin Gene and Protein Functions in Passive and Active Muscle.

Authors:
Wolfgang A Linke

Annu Rev Physiol 2018 02 13;80:389-411. Epub 2017 Nov 13.

Institute of Physiology II, University of Münster, 48149 Münster, Germany; email:

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http://dx.doi.org/10.1146/annurev-physiol-021317-121234DOI Listing
February 2018

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes.

J Mol Cell Cardiol 2017 12 21;113:9-21. Epub 2017 Sep 21.

Department of Cardiology and Pneumology, Universitätsmedizin Göttingen, Germany; Institute of Pharmacology and Toxicology, Technische Universität Dresden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2017.09.008DOI Listing
December 2017

CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis.

PLoS One 2017 11;12(8):e0182643. Epub 2017 Aug 11.

Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182643PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553786PMC
October 2017

Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy.

Cardiovasc Res 2017 Aug;113(10):1161-1172

Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Ullevål, Kirkeveien 166, NO-0407 Oslo, Norway.

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http://dx.doi.org/10.1093/cvr/cvx087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852536PMC
August 2017

Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes.

Biophys Rev 2017 Jun 10;9(3):225-237. Epub 2017 Apr 10.

Department of Cardiovascular Physiology, Ruhr University Bochum, MA 03/56, 44780, Bochum, Germany.

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http://dx.doi.org/10.1007/s12551-017-0263-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498327PMC
June 2017

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

Circulation 2017 May 6;135(19):1832-1847. Epub 2017 Feb 6.

From Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany (M.T., J.E.H., P.B., S.S., T.M., M.-L.C.L., E.L., F.R., S.Z., E. Wettwer, W.-H.Z.); German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany (M.T., J.E.H., P.B., S.S., T.M., M.-L.C.L., E.L., F.R., S.Z., E. Wingender, W.A.L., W.-H.Z.); Institute of Bioinformatics, University Medical Center Göttingen, Germany (S.Z., E. Wingender); Stanford Cardiovascular Institute (J.R., M.W., J.D.G., J.C.W.) and Department of Radiology (J.D.G., J.C.W.), Molecular Imaging Program, Stanford University School of Medicine, CA; The Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Technion-Israel Institute of Technology, Haifa (I.K., L.G.); Institute of Pharmacology and Toxicology, Technical University Dresden, Germany (E. Wettwer, U.R.); University Medical Center Utrecht and Hubrecht Institute, The Netherlands (P.D., L.W.v.L.); Leiden University Medical Center, The Netherlands (M.J.G.); Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Germany (S.K., K.T., G.H., W.A.L.); Center for Applied Technology, Beckman Research Institute, City of Hope, Duarte, CA (L.A.C.); Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany (A.U., W.A.L.); New Laura and Isaac Perlmutter Cancer Center at New York University Langone (T.A., B.N.); and McEwen Centre for Regenerative Medicine, Toronto, Canada (G.K.). The current address for Dr Hudson is Laboratory for Cardiac Regeneration, School of Biomedical Sciences, The University of Queensland, Australia.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501412PMC
May 2017

Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme.

MBio 2017 02 14;8(1). Epub 2017 Feb 14.

Microbial Biology, Faculty of Biology, Ruhr University Bochum, Bochum, Germany

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http://dx.doi.org/10.1128/mBio.02082-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312082PMC
February 2017

Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement.

Neurology 2016 Nov 26;87(21):2235-2243. Epub 2016 Oct 26.

From the Department of Cardiovascular Physiology (A.U., T.D., W.A.L.), Center for Rare Diseases Ruhr (A.U., G.D., A.G., T.D., R.K., M.T., C.H., W.A.L., S.H., M.V.), Department of Human Genetics (G.D., S.H.), Department of Neurology, Heimer Institute for Muscle Research, University Hospital Bergmannsheil (A.G., R.K., M.T., M.V.), and Institute for Pediatric Radiology, Katholisches Klinikum Bochum (C.H.), Ruhr University Bochum; Klinikum Kassel (A.F.), Kassel Medical School; Institute of Neuropathology (J.W.), RWTH University Hospital Aachen; and Institute of Human Genetics (L.M.-C., M.S., B.W.), Center for Molecular Medicine and Institute for Genetics, University of Cologne, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000003360DOI Listing
November 2016

Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection Fraction.

Circ Heart Fail 2016 Oct 10;9(10). Epub 2016 Oct 10.

From the Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (R.Z., G.M., Q.C., O.O., S.H., H.T., T.L., X.-L.W., H.-C.L., M.M.R.); and Department of Cardiovascular Physiology, Ruhr University Bochum, Germany (WA.L).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082983PMC
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.003238DOI Listing
October 2016

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction.

JACC Heart Fail 2016 Apr 9;4(4):312-24. Epub 2015 Dec 9.

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands; Department of Cardiovascular Physiology, Ruhr University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1016/j.jchf.2015.10.007DOI Listing
April 2016

Molecular and structural transition mechanisms in long-term volume overload.

Eur J Heart Fail 2016 04 23;18(4):362-71. Epub 2015 Dec 23.

Department of Cardiology and Pneumology, Georg-August-University, Goettingen, Germany.

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http://dx.doi.org/10.1002/ejhf.465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064674PMC
April 2016

Titin stiffness modifies the force-generating region of muscle sarcomeres.

Sci Rep 2016 Apr 15;6:24492. Epub 2016 Apr 15.

Department of Cardiovascular Physiology, Ruhr University Bochum, Germany.

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http://dx.doi.org/10.1038/srep24492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832248PMC
April 2016

Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect.

J Mol Cell Cardiol 2016 Feb 23;91:207-14. Epub 2015 Dec 23.

Erich and Hanna Klessmann Institute for Cardiovascular Research & Development (EHKI), Heart and Diabetes Center NRW, Ruhr University Bochum, D-32545 Bad Oeynhausen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.12.015DOI Listing
February 2016

Work Done by Titin Protein Folding Assists Muscle Contraction.

Cell Rep 2016 Feb 4;14(6):1339-1347. Epub 2016 Feb 4.

Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865255PMC
February 2016

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science 2015 Aug;349(6251):982-6

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/science.aaa5458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618316PMC
August 2015

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.

Cardiovasc Res 2015 May 12;106(2):217-26. Epub 2015 Jan 12.

Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway KG Jebsen Cardiac Research Centre and Center for Heart Failure Research, University of Oslo, Oslo, Norway.

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://cardiovascres.oxfordjournals.org/cgi/doi/10.1093/cvr/
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http://dx.doi.org/10.1093/cvr/cvv002DOI Listing
May 2015

Emerging importance of oxidative stress in regulating striated muscle elasticity.

J Muscle Res Cell Motil 2015 Feb 6;36(1):25-36. Epub 2014 Nov 6.

Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, MA 3/56, 44780, Bochum, Germany.

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http://dx.doi.org/10.1007/s10974-014-9392-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352196PMC
February 2015

Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.

Cardiovasc Res 2014 Dec 23;104(3):423-31. Epub 2014 Oct 23.

Laboratory of Physiopharmacology (Building T2), University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium

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http://dx.doi.org/10.1093/cvr/cvu223DOI Listing
December 2014

Heart failure with preserved ejection fraction.

Pflugers Arch 2014 Jun 25;466(6):1037-53. Epub 2014 Mar 25.

Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Guggenheim 9, 200 First Street, Southwest Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s00424-014-1480-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075067PMC
June 2014

Gigantic business: titin properties and function through thick and thin.

Circ Res 2014 Mar;114(6):1052-68

From the Department of Cardiovascular Physiology, Ruhr University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.301286DOI Listing
March 2014

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.

J Cell Biol 2014 Jan 13;204(2):187-202. Epub 2014 Jan 13.

Department of Cardiovascular Physiology and 2 Neurological University Clinic Bergmannsheil, Ruhr University Bochum, 44780 Bochum, Germany.

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http://dx.doi.org/10.1083/jcb.201306077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897184PMC
January 2014

Untangling regulatory networks to spot drivers and modulators of cardiac disease.

J Mol Cell Cardiol 2013 Oct 13;63:1-3. Epub 2013 Jul 13.

Dept. of Cardiovascular Physiology, Ruhr University Bochum, MA 3/56, D-44780 Bochum, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2013.07.003DOI Listing
October 2013

Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts.

Cardiovasc Res 2013 Sep 13;99(4):648-56. Epub 2013 Jun 13.

Department of Cardiovascular Physiology, Heinrich Heine University Düsseldorf, Germany.

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http://dx.doi.org/10.1093/cvr/cvt144DOI Listing
September 2013

Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function.

Biochim Biophys Acta 2013 Apr 6;1833(4):812-22. Epub 2012 Oct 6.

Dept. of Cardiovascular Physiology, Ruhr University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2012.09.012DOI Listing
April 2013

Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.

Cardiovasc Res 2013 Mar 4;97(3):464-71. Epub 2012 Dec 4.

Department of Cardiovascular Physiology, Ruhr University, MA 3/56, D-44780 Bochum, Germany.

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http://dx.doi.org/10.1093/cvr/cvs353DOI Listing
March 2013

Alteration of the beta-adrenergic signaling pathway in human heart failure.

Curr Pharm Biotechnol 2012 Oct;13(13):2522-31

Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, MA 3/56, D-44780 Bochum, Germany.

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October 2012

King of hearts: a splicing factor rules cardiac proteins.

Nat Med 2012 May 4;18(5):660-1. Epub 2012 May 4.

Department of Cardiovascular Physiology, Ruhr University Bochum, Germany.

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http://dx.doi.org/10.1038/nm.2762DOI Listing
May 2012

Conformation-regulated mechanosensory control via titin domains in cardiac muscle.

Pflugers Arch 2011 Jul 25;462(1):143-54. Epub 2011 Feb 25.

Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, MA 3/56, 44780, Bochum, Germany.

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http://dx.doi.org/10.1007/s00424-011-0938-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114084PMC
July 2011

The giant protein titin: a regulatory node that integrates myocyte signaling pathways.

J Biol Chem 2011 Mar 21;286(12):9905-12. Epub 2011 Jan 21.

Department of Cardiovascular Physiology, Ruhr University Bochum, D-44780 Bochum, Germany.

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http://dx.doi.org/10.1074/jbc.R110.173260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060543PMC
March 2011

Biomaterials: spider strength and stretchability.

Authors:
Wolfgang A Linke

Nat Chem Biol 2010 Oct;6(10):702-3

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http://dx.doi.org/10.1038/nchembio.442DOI Listing
October 2010

The giant protein titin as an integrator of myocyte signaling pathways.

Physiology (Bethesda) 2010 Jun;25(3):186-98

Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1152/physiol.00005.2010DOI Listing
June 2010

Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy.

J Mol Cell Cardiol 2010 May 23;48(5):910-6. Epub 2010 Feb 23.

Dept of Cardiovascular Physiology, Ruhr University Bochum, D-44780 Bochum, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2010.02.012DOI Listing
May 2010

Regulation of oscillatory contraction in insect flight muscle by troponin.

J Mol Biol 2010 Mar 25;397(1):110-8. Epub 2010 Jan 25.

EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jmb.2010.01.039DOI Listing
March 2010

Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.

Circ Heart Fail 2009 May 25;2(3):233-42. Epub 2009 Mar 25.

Department of Biochemistry, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Thoraxcenter, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.806125DOI Listing
May 2009

Titin-based mechanical signalling in normal and failing myocardium.

J Mol Cell Cardiol 2009 Apr;46(4):490-8

Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, D-48149 Muenster, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2009.01.004DOI Listing
April 2009

Functional role of the extended loop 2 in the myosin 9b head for binding F-actin.

J Biol Chem 2009 Feb 4;284(6):3663-71. Epub 2008 Dec 4.

Institute of General Zoology and Genetics, Westfalian Wilhelms-University Münster, Münster 48149, Germany.

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http://dx.doi.org/10.1074/jbc.M808338200DOI Listing
February 2009

Pulling single molecules of titin by AFM--recent advances and physiological implications.

Pflugers Arch 2008 Apr 6;456(1):101-15. Epub 2007 Dec 6.

Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, 48149 Muenster, Germany.

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http://dx.doi.org/10.1007/s00424-007-0389-xDOI Listing
April 2008

Mineralocorticoid signaling in transition to heart failure with normal ejection fraction.

Hypertension 2008 Feb 17;51(2):289-95. Epub 2007 Dec 17.

Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.099010DOI Listing
February 2008

Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway.

Circ Res 2008 Feb 20;102(4):439-47. Epub 2007 Dec 20.

Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, D-48149 Muenster, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.162719DOI Listing
February 2008

Acute and chronic ventricular-arterial coupling in systole and diastole: insights from an elderly hypertensive model.

Hypertension 2007 Sep 9;50(3):503-11. Epub 2007 Jul 9.

Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.090092DOI Listing
September 2007

Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension.

J Muscle Res Cell Motil 2006 4;27(5-7):435-44. Epub 2006 Aug 4.

Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, D-48149, Muenster, Germany.

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http://dx.doi.org/10.1007/s10974-006-9090-5DOI Listing
February 2007

Plasticity of cardiac titin/connectin in heart development.

J Muscle Res Cell Motil 2005 ;26(6-8):333-42

Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10974-005-9040-7DOI Listing
January 2007

Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity.

J Physiol 2006 Nov 24;577(Pt 1):339-52. Epub 2006 Aug 24.

Uppsala University, Department of Neuroscience, Clinical Neurophysiology, 75185 Uppsala, Sweden.

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http://dx.doi.org/10.1113/jphysiol.2006.116749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000690PMC
November 2006

Developmental changes in passive stiffness and myofilament Ca2+ sensitivity due to titin and troponin-I isoform switching are not critically triggered by birth.

Am J Physiol Heart Circ Physiol 2006 Aug 5;291(2):H496-506. Epub 2006 May 5.

Physiology and Biophysics Unit, Univ. of Muenster, Schlossplatz 5, D-48149 Muenster, Germany.

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http://dx.doi.org/10.1152/ajpheart.00114.2006DOI Listing
August 2006

Mechanical properties of cardiac titin's N2B-region by single-molecule atomic force spectroscopy.

J Struct Biol 2006 Aug 25;155(2):263-72. Epub 2006 Apr 25.

Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU, UK.

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http://dx.doi.org/10.1016/j.jsb.2006.02.017DOI Listing
August 2006

Myocardial structure and function differ in systolic and diastolic heart failure.

Circulation 2006 Apr 17;113(16):1966-73. Epub 2006 Apr 17.

Department of Physiology, Institute for Cardiovascular Research, VU Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.587519DOI Listing
April 2006

The molecular elasticity of the insect flight muscle proteins projectin and kettin.

Proc Natl Acad Sci U S A 2006 Mar 14;103(12):4451-6. Epub 2006 Mar 14.

European Molecular Biology Laboratory, D-69012 Heidelberg, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0509016103
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http://dx.doi.org/10.1073/pnas.0509016103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450192PMC
March 2006

Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles.

J Gen Physiol 2005 Nov 17;126(5):461-80. Epub 2005 Oct 17.

Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1085/jgp.200509364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266601PMC
November 2005