Wolf-Hagen Schunck

Wolf-Hagen Schunck

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Wolf-Hagen Schunck

Wolf-Hagen Schunck

Publications by authors named "Wolf-Hagen Schunck"

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59Publications

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Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts.

Cardiovasc Toxicol 2019 Aug;19(4):365-371

Experimental and Clinical Research Center, 16341, Berlin, Germany.

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http://dx.doi.org/10.1007/s12012-019-09508-xDOI Listing
August 2019

Hypoxia-reoxygenation enhances murine afferent arteriolar vasoconstriction by angiotensin II.

Am J Physiol Renal Physiol 2018 03 25;314(3):F430-F438. Epub 2017 Oct 25.

Institute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, Berlin , Germany.

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http://dx.doi.org/10.1152/ajprenal.00252.2017DOI Listing
March 2018

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases.

Pharmacol Ther 2018 03 7;183:177-204. Epub 2017 Nov 7.

Department of Gastroenterology, Diabetes, Oncology and Rheumatology, Ruppiner Kliniken, Brandenburg Medical School, Neuruppin, Germany; Lipid Clinic, Experimental and Clinical Research Centre (ECRC), Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1016/j.pharmthera.2017.10.016DOI Listing
March 2018

Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.

Prostaglandins Other Lipid Mediat 2017 Nov 23;133:93-102. Epub 2017 Apr 23.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, D-60596, Germany; German Center of Cardiovascular Research (DZHK) Partner site Rhein-Main, Frankfurt am Main, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10988823173001
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http://dx.doi.org/10.1016/j.prostaglandins.2017.04.002DOI Listing
November 2017

EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids.

J Lipid Res 2016 09 19;57(9):1608-11. Epub 2016 Jul 19.

Max Delbrueck Center for Molecular Medicine, Berlin, Germany 13125

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http://dx.doi.org/10.1194/jlr.C071084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003160PMC
September 2016

Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis.

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1534-48. Epub 2016 Jun 9.

From the Department of Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland (J.H., S.Y.-H.); Centre for R&D, Uppsala University/County Council of Gaevleborg, Gaevle, Sweden (O.L.); Institute for Pathology, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany (J.H.B.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (W.-H.S., D.M., A.H., J.-D.D., L.T., F.B.); Department of Cardiology (B.P., F.B.) and Center for Cardiovascular Research/CCR, Institute of Laboratory Medicine Clinical Chemistry and Pathobiochemistry (K.K.), Charité-Universitaetsmedizin Berlin, Berlin, Germany; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Teltow, Germany (F.J., C.M.); Institute for Diabetes and Obesity, Helmholtz Zentrum Muenchen, Munich, German Research Center for Environmental Health, Germany (M.J.); and Cologne Interventional Immunology, University Hospital of Cologne, Cologne, Germany (M.v.B.-B.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306962
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http://dx.doi.org/10.1161/ATVBAHA.115.306962DOI Listing
August 2016

Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans.

J Lipid Res 2015 Nov 23;56(11):2110-23. Epub 2015 Sep 23.

Department of Biology, Ecology, Humboldt University of Berlin, 10115 Berlin, Germany.

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http://dx.doi.org/10.1194/jlr.M061887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617398PMC
November 2015

Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease.

Adv Exp Med Biol 2015 ;851:151-87

Max Delbrueck Center for Molecular Medicine, Robert-Rössle-Str. 10, Berlin, 13125, Germany.

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http://dx.doi.org/10.1007/978-3-319-16009-2_6DOI Listing
October 2015

Epoxides Derived from Dietary Dihomo-Gamma-Linolenic Acid Induce Germ Cell Death in C. elegans.

Sci Rep 2015 Oct 21;5:15417. Epub 2015 Oct 21.

School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99614-6340, USA.

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http://dx.doi.org/10.1038/srep15417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614016PMC
October 2015

Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids.

J Pharmacol Exp Ther 2014 Dec 14;351(3):688-98. Epub 2014 Oct 14.

Department of Pharmaceutical Sciences, University of New Mexico, Albuquerque, New Mexico (L.N.A., E.F.W., M.K.W.); Lipidomix GmbH, Berlin, Germany (M.R.); and Max-Delbrück Center for Molecular Medicine, Berlin, Germany (W.-H.S.)

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http://dx.doi.org/10.1124/jpet.114.219535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244579PMC
December 2014

CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation.

Biochem J 2014 Nov;464(1):61-71

*Humboldt-Universität zu Berlin, Department of Biology, Freshwater and Stress Ecology, Späthstr. 80/81, 12437 Berlin, Germany.

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http://dx.doi.org/10.1042/BJ20140848DOI Listing
November 2014

The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein.

J Pharmacol Exp Ther 2014 Jul 24;350(1):14-21. Epub 2014 Apr 24.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University Frankfurt am Main, Germany (Y.D., T.F., R.P., I.F.); University of Texas Southwestern Medical Center, Dallas, Texas (J.R.F.); and Max-Delbrück Center for Molecular Medicine, Berlin, Germany (W.-H.S.)

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http://jpet.aspetjournals.org/content/early/2014/04/24/jpet.
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http://jpet.aspetjournals.org/content/350/1/14.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.114.21425
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http://dx.doi.org/10.1124/jpet.114.214254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062412PMC
July 2014

Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization.

Proc Natl Acad Sci U S A 2014 Jul 16;111(26):9603-8. Epub 2014 Jun 16.

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1401191111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084420PMC
July 2014

Variations in the human soluble epoxide hydrolase gene and recurrence of atrial fibrillation after catheter ablation.

Int J Cardiol 2013 Oct 25;168(4):3647-51. Epub 2013 May 25.

Department of Cardiology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany; Experimental and Clinical Research Center, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2013.05.010DOI Listing
October 2013

CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?

Prostaglandins Other Lipid Mediat 2011 Nov 16;96(1-4):99-108. Epub 2011 Sep 16.

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1016/j.prostaglandins.2011.09.001DOI Listing
November 2011

Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples.

Prostaglandins Other Lipid Mediat 2011 Apr 12;94(3-4):81-7. Epub 2011 Jan 12.

Department of Medicine, Division Hepatology, Gastroenterology and Endocrinology, Rudolf-Virchow-Hospital, Charité University Medicine, Berlin, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S109888231100004
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http://dx.doi.org/10.1016/j.prostaglandins.2010.12.006DOI Listing
April 2011

Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids.

Biochim Biophys Acta 2011 Jan 30;1814(1):210-22. Epub 2010 Sep 30.

Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bbapap.2010.09.009DOI Listing
January 2011

Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.

Biochim Biophys Acta 2011 Jan 29;1814(1):168-74. Epub 2010 Sep 29.

Institute of Clinical Pharmacology and Toxicology, Charité, Campus Mitte, University Medicine Berlin, 10117 Berlin, Germany; Wernigeroder Str. 111, 16341 Panketal, Germany.

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http://dx.doi.org/10.1016/j.bbapap.2010.09.014DOI Listing
January 2011

Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids.

Pharmacol Rep 2010 May-Jun;62(3):536-47

Max Delbrueck Center for Molecular Medicine, Robert Roessle-Str. 10, 13125 Berlin, Germany.

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November 2010

Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease.

Circ Res 2009 Aug 16;105(4):326-34. Epub 2009 Jul 16.

Medical Clinic III, Dresden University of Technology, Fetscherstr. 74, 01307 Dresden, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.200501DOI Listing
August 2009

Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice.

Arterioscler Thromb Vasc Biol 2009 Jan 16;29(1):54-60. Epub 2008 Oct 16.

Charité Campus Buch, Franz Volhard Clinic/ECRC, Berlin, Germany.

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http://dx.doi.org/10.1161/ATVBAHA.108.171298DOI Listing
January 2009

Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans.

Arch Biochem Biophys 2008 Apr 8;472(1):65-75. Epub 2008 Feb 8.

Humboldt University at Berlin, Department of Biology, Freshwater and Stress Ecology, Spaethstr. 80/81, 12437 Berlin, Germany.

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http://dx.doi.org/10.1016/j.abb.2008.02.002DOI Listing
April 2008

The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents.

Exp Physiol 2007 Nov 3;92(6):1067-76. Epub 2007 Aug 3.

Nephrology/Hypertension Division, Franz Volhard Clinic, HELIOS Klinikum-Berlin, Campus Buch, Berlin, Germany.

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http://dx.doi.org/10.1113/expphysiol.2007.038166DOI Listing
November 2007

Human CYP1A1 variants lead to differential eicosapentaenoic acid metabolite patterns.

Biochem Biophys Res Commun 2005 Oct;336(3):779-83

Institute of Clinical Pharmacology, Charité-Universitätsmedizin Berlin, Humboldt University of Berlin, 10098 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.172DOI Listing
October 2005

Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.

Biochem Biophys Res Commun 2005 Apr;329(4):1275-81

Max Delbrück Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2005.02.103DOI Listing
April 2005

Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.

Cancer Res 2005 Apr;65(7):2972-8

Institute of Clinical Pharmacology, Charité-Campus Mitte, University Medicine Berlin, Berlin, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3543DOI Listing
April 2005

Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.

Biochem Pharmacol 2004 Apr;67(8):1445-57

Institute of Clinical Pharmacology, University Medical Center Charité, Humboldt University of Berlin, Schumannstrasse 20-21, Berlin 10098, Germany.

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http://dx.doi.org/10.1016/j.bcp.2003.12.023DOI Listing
April 2004

Human CYP1A1 allelic variants: baculovirus expression and purification, hydrodynamic, spectral, and catalytical properties and their potency in the formation of all-trans-retinoic acid.

Protein Expr Purif 2003 Apr;28(2):259-69

Institute of Clinical Pharmacology, University Medical Center Charité, Humboldt University of Berlin, 10098 Berlin, Germany.

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April 2003

P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage.

Hypertension 2002 Sep;40(3):273-9

Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Kliniken-Berlin, Medical Faculty of the Charité, Humboldt University of Berlin, Germany.

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http://dx.doi.org/10.1161/01.hyp.0000029240.44253.5eDOI Listing
September 2002

Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes. Effects of charge and nonbilayer phase propensity of the membrane.

Eur J Biochem 2002 Apr;269(7):1799-805

Institute of Clinical Pharmacology, University Medical Centrum Charité, Humboldt University of Berlin, Germany.

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http://dx.doi.org/10.1046/j.1432-1033.2002.02848.xDOI Listing
April 2002

Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators.

Hypertension 2002 Feb;39(2 Pt 2):609-13

Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic HELIOS Kliniken-Berlin, Medical Faculty of the Charité, Humboldt University of Berlin, Germany.

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http://dx.doi.org/10.1161/hy0202.103293DOI Listing
February 2002