Wolf-Dieter Ludwig

Wolf-Dieter Ludwig

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Wolf-Dieter Ludwig

Wolf-Dieter Ludwig

Publications by authors named "Wolf-Dieter Ludwig"

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[Orphan drugs from the perspective of the Drug Commission of the German Medical Association : Opportunities and challenges].

Internist (Berl) 2019 04;60(4):399-404

Arzneimittelkommission der deutschen Ärzteschaft, Herbert-Lewin-Platz 1, 10623, Berlin, Deutschland.

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http://dx.doi.org/10.1007/s00108-019-0578-7DOI Listing
April 2019

Expression of CD56 defines a distinct subgroup in childhood T-ALL with inferior outcome. Results of the ALL-BFM 2000 trial.

Br J Haematol 2018 10 20;183(1):96-103. Epub 2018 Jul 20.

Department of Haematology and Stem Cell Transplantation, Helios Klinikum Berlin Buch, Berlin, Germany.

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http://doi.wiley.com/10.1111/bjh.15503
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http://dx.doi.org/10.1111/bjh.15503DOI Listing
October 2018

IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

J Clin Oncol 2018 04 2;36(12):1240-1249. Epub 2018 Mar 2.

Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School; Petra Dörge, German Center for Infection Research, Hannover; Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein; Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel; Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital; Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin; Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg; Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany; Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic; Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo; Maria Grazia Valsecchi, University of Milano-Bicocca, Monza; Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy; Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland; Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel; Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria; Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France; and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.74.3617DOI Listing
April 2018

Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000).

J Clin Oncol 2018 01 17;36(3):244-253. Epub 2017 Nov 17.

Martin Schrappe, Kirsten Bleckmann, Anja Möricke, and Gunnar Cario, University Hospital Schleswig-Holstein, Campus Kiel, Kiel; Martin Zimmermann and Gudrun Göhring, Hannover Medical School, Hannover; Claus R. Bartram, Institute of Human Genetics, Ruprecht-Karls University, Heidelberg; Charlotte Niemeyer, University of Freiburg, Freiburg; Rita Beier, University Hospital, Essen; Wolf-Dieter Ludwig, HELIOS Medical Center Berlin-Buch, Berlin; Paul-Gerhardt Schlegel, University of Würzburg, Würzburg, Germany; Andrea Biondi, Carmelo Rizzari, Maria Grazia Valsecchi, and Valentino Conter, University of Milano-Bicocca; Andrea Biondi, Carmelo Rizzari, and Valentino Conter, Ospedale San Gerardo, Monza; Franco Locatelli, University of Pavia and Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Pediatrico Bambino Gesù; Anna Maria Testi, University La Sapienza, Rome; Elena Barisone, Regina Margherita Children's Hospital, Turin; Ottavio Ziino, Azienda di Rilievo Nazionale ad Alta Specializzazione Ospedali Civico Di Cristina, Palermo; Rosanna Parasole, Santobono-Pausilipon Children's Hospital; Fiorina Casale, University of Naples, Naples; Giuseppe Basso, University of Padova, Padova, Italy; Andishe Attarbaschi, Georg Mann, and Renate Panzer-Grümayer, St Anna Children's Hospital and Medical University of Vienna, Vienna, Austria; and Felix Niggli and Beat Schäfer, University Hospital Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1200/JCO.2017.74.4946DOI Listing
January 2018

Late Relapse of Classical Hodgkin Lymphoma: An Analysis of the German Hodgkin Study Group HD7 to HD12 Trials.

J Clin Oncol 2017 May 27;35(13):1444-1450. Epub 2017 Feb 27.

Paul J. Bröckelmann, Helen Goergen, Charlotte Kohnhorst, Bastian von Tresckow, Michael Fuchs, Peter Borchmann, and Andreas Engert, University Hospital of Cologne, Cologne; Julia Meissner, University of Heidelberg, Heidelberg; Andrea Kerkhoff, University Hospital of Münster, Münster; Wolf-Dieter Ludwig, Helios Kinikum Berlin-Buch, Berlin, Germany; Alden Moccia, Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland; and Jana Markova, University Hospital Kralovske Vinohrady, Prague, Czech Republic.

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http://ascopubs.org/doi/10.1200/JCO.2016.71.3289
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http://dx.doi.org/10.1200/JCO.2016.71.3289DOI Listing
May 2017

Drug information by public health and regulatory institutions: Results of an 8-country survey in Europe.

Health Policy 2017 Mar 29;121(3):257-264. Epub 2016 Dec 29.

Service de Pharmacologie Médicale et Clinique, Centre Midi-Pyrénées de Pharmacovigilance, Pharmacoépidémiologie et d'Informations sur le Médicament, Faculté de Médecine, CHU de Toulouse, France.

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http://dx.doi.org/10.1016/j.healthpol.2016.12.007DOI Listing
March 2017

[Flow-cytometric immunophenotyping in clinical diagnostics].

Dtsch Med Wochenschr 2016 Oct 17;141(21):1569-1574. Epub 2016 Oct 17.

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http://dx.doi.org/10.1055/s-0042-109432DOI Listing
October 2016

Metamizole (dipyrone)-associated agranulocytosis. An analysis of German spontaneous reports 1990-2012.

Eur J Clin Pharmacol 2015 Sep 15;71(9):1129-38. Epub 2015 Jul 15.

Drug Commission of the German Medical Association (DCGMA), Herbert-Lewin-Platz 1, 10623, Berlin, Germany,

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http://link.springer.com/10.1007/s00228-015-1895-y
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http://dx.doi.org/10.1007/s00228-015-1895-yDOI Listing
September 2015

Declaration and Handling of Conflicts of Interest in Guidelines: A Study of S1 Guidelines From German Specialist Societies From 2010-2013.

Dtsch Arztebl Int 2015 Jun;112(26):445-51

Drug Commission of the German Medical Association, Berlin, Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Department of Biometrics and Medical Informatics at the University Medical Center of the Johannes Gutenberg University Mainz, Department of Pharmacology, Klinikum Bremen-Mitte gGmbH, Department of General Practice, University Hospital Freiburg, Berlin School of Public Health, Charité, Universitätsmedizin Berlin, Department of Hematology, Oncology, and Tumor Immunology, HELIOS Klinikum Berlin-Buch.

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http://dx.doi.org/10.3238/arztebl.2015.0445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515786PMC
June 2015

Peripheral blood sCD3⁻ CD4⁺ T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma.

Hematol Oncol 2014 Mar 24;32(1):16-21. Epub 2013 Jun 24.

Department of Hematology, Oncology and Tumor Immunology, Charité-University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany; Labor Berlin Charité Vivantes GmbH, Berlin, Germany.

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http://dx.doi.org/10.1002/hon.2080DOI Listing
March 2014

[New drugs in oncology--features of clinical trials for market authorisation and arguments for the rapid implementation of independent clinical trials following approval].

Onkologie 2013 ;36 Suppl 2:17-22

Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ), Berlin, Deutschland.

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http://dx.doi.org/10.1159/000348253DOI Listing
September 2013

Does the pharmaceutical industry influence guidelines?: two examples from Germany.

Dtsch Arztebl Int 2013 Sep 2;110(35-36):575-83. Epub 2013 Sep 2.

Drug Commission of the German Medical Association, Berlin.

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http://dx.doi.org/10.3238/arztebl.2013.0575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783818PMC
September 2013

Case definition for progressive multifocal leukoencephalopathy following treatment with monoclonal antibodies.

J Neurol Neurosurg Psychiatry 2012 Sep 17;83(9):927-33. Epub 2012 Jul 17.

Department of Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany.

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http://dx.doi.org/10.1136/jnnp-2012-302478DOI Listing
September 2012

[Possibilities and limitations of stratified medicine based on biomarkers and targeted therapies in oncology].

Z Evid Fortbild Qual Gesundhwes 2012 10;106(1):11-22. Epub 2012 Jan 10.

Klinik für Hämatologie, Onkologie und Tumorimmunologie im HELIOS Klinikum Berlin-Buch.

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http://dx.doi.org/10.1016/j.zefq.2011.12.001DOI Listing
June 2012

Incidence of thyroid hormone therapy in patients treated with sunitinib or sorafenib: a cohort study.

Eur J Cancer 2012 May 28;48(7):974-81. Epub 2012 Feb 28.

German Institute for Drug Use Evaluation, DAPI, Carl-Mannich-Strasse 26, 65760 Eschborn, Germany.

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http://dx.doi.org/10.1016/j.ejca.2012.01.036DOI Listing
May 2012

Apheresis-related enrichment of CD26++ T lymphocytes: phenotypic characterization and correlation with unfavorable outcome in autologous hematopoietic progenitor cell transplantation.

Transfusion 2012 Apr 26;52(4):765-76. Epub 2011 Sep 26.

GMP Development Unit, Integrated Research and Treatment Center Transplantation (IFB-Tx), Medical School Hannover, Hannover, Germany.

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http://dx.doi.org/10.1111/j.1537-2995.2011.03351.xDOI Listing
April 2012

[Clinical trials in oncology: deficits and proposals for solution].

Z Evid Fortbild Qual Gesundhwes 2011 12;105(9):657-64. Epub 2011 Feb 12.

Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ).

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http://dx.doi.org/10.1016/j.zefq.2011.01.006DOI Listing
March 2012

[Benefit-risk evaluation of new drugs as a basis for decisions on prioritization in hematology/oncology: methodical challenges and problem-solving strategies].

Onkologie 2011 17;34 Suppl 1:6-10. Epub 2011 Jan 17.

Klinik für Hämatologie, Onkologie und Tumorimmunologie, HELIOS Klinikum Berlin-Buch, Berlin, Germany.

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http://dx.doi.org/10.1159/000323064DOI Listing
July 2011

[Open questions in the drug therapy of tumors with new active substances].

Onkologie 2010 16;33 Suppl 7:6-10. Epub 2010 Sep 16.

Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ), HELIOS Klinikum Berlin-Buch, Herbert-Lewin-Platz 1, Berlin, Germany.

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http://dx.doi.org/10.1159/000320465DOI Listing
February 2011

[The relation between publication bias and clinical trials funding].

Z Evid Fortbild Qual Gesundhwes 2010 ;104(4):314-22

Arzneimittelkommission der deutschen Arzteschaft (AkdA).

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http://dx.doi.org/10.1016/j.zefq.2010.03.029DOI Listing
September 2010

[Interview -- drug legislation -- reporting unexpected adverse drug reactions].

Pneumologie 2009 Sep 17;63(9):479-80. Epub 2009 Sep 17.

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http://dx.doi.org/10.1055/s-0029-1241104DOI Listing
September 2009

[Conflicts of interest and clinical drug trials -- impact of the pharmaceutical industry and the impingement on the integrity of medical science].

Z Evid Fortbild Qual Gesundhwes 2009 ;103(3):149-54

Arzneimittelkommission der deutschen Arzteschaft, Herbert-Lewin-Platz 1, 10623 Berlin.

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http://dx.doi.org/10.1016/j.zefq.2009.02.018DOI Listing
July 2009

[Improving drug safety in Germany: an alliance between the government and the medical profession].

Z Evid Fortbild Qual Gesundhwes 2008 ;102(9):582-6; discussion 593, 606-8

Robert-Rössle-Klinik im HELIOS Klinikum Berlin-Buch, Klinik für Hämatologie, Onkologie u. Tumorimmunologie, Charité, Campus Berlin-Buch.

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http://dx.doi.org/10.1016/j.zefq.2008.09.021DOI Listing
April 2009

[Treatment recommendations from the Drug Commission of the German Medical Association].

Z Evid Fortbild Qual Gesundhwes 2008 ;102(4):245-52

Arzneimittelkommission der deutschen Arzteschaft, Berlin.

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http://dx.doi.org/10.1016/j.zefq.2008.04.005DOI Listing
December 2008

Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML.

Blood 2008 Mar 14;111(5):2899-903. Epub 2007 Dec 14.

Department of Paediatrics and Adolescent Medicine, University of Ulm, Eythstrasse 24, Ulm, Germany.

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http://dx.doi.org/10.1182/blood-2007-08-109058DOI Listing
March 2008

Differential expression of the carcinoembryonic antigen-related cell adhesion molecules panCD66, CD66a, CD66c and of sialyl-Lewis x (CD15s) on blast cells of acute leukemias.

Int J Hematol 2008 Mar 27;87(2):137-143. Epub 2008 Feb 27.

HELIOS Klinikum Berlin, Charité-University Medical School Berlin, Robert-Roessle-Clinic, Campus-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany.

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http://dx.doi.org/10.1007/s12185-008-0044-0DOI Listing
March 2008

Clinical characteristics and treatment outcome of infants with non-Hodgkin lymphoma.

Br J Haematol 2007 Nov 14;139(3):443-9. Epub 2007 Sep 14.

Department of Paediatric Haematology and Oncology, St. Anna Children's Hospital, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06796.xDOI Listing
November 2007

[Editorial comment on Krege S. et al: off-label use: an unsolved problem].

Aktuelle Urol 2007 Jul;38(4):299-300

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http://dx.doi.org/10.1055/s-2007-980091DOI Listing
July 2007

In vivo expression of survivin and its splice variant survivin-2B: impact on clinical outcome in acute myeloid leukemia.

Int J Cancer 2006 Sep;119(6):1291-7

Department of Hematology and Oncology, Campus Virchow, Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/ijc.21995DOI Listing
September 2006

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.

Blood 2006 Aug 13;108(4):1151-7. Epub 2006 Apr 13.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2005-12-4956DOI Listing
August 2006

Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia.

Clin Cancer Res 2006 Aug;12(15):4553-61

Department of Pediatric Oncology/Hematology, HELIOS Klinikum Berlin, Robert-Roessle-Clinic, Laboratory for Functional Genomics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0235DOI Listing
August 2006

Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.

Blood 2006 Jun 7;107(11):4524-31. Epub 2006 Feb 7.

Universitätsklinik für Kinder-und Jugendmedizin, University of Ulm, Germany.

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http://dx.doi.org/10.1182/blood-2005-08-3305DOI Listing
June 2006

Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species.

Blood 2005 Jun 10;105(12):4767-75. Epub 2005 Feb 10.

Department of Hematology, Oncology, and Tumor Immunology, Robert-Rossle-Clinic, HELIOS Klinikum Berlin-Buch, Charité Medical School, Berlin, Germany.

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http://dx.doi.org/10.1182/blood-2004-09-3428DOI Listing
June 2005

Minimal residual disease detection by flow cytometry.

Lab Hematol 2004 ;10(3):169

Dept. of Hematology, Oncology, and Tumor Immunology, Robert-Rossle-Klinik, HELlOS Klinikum, Berlin, Charite Universitatsmedizin, Berlin, Germany.

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May 2005

[Differential diagnosis of intra- and perilienal tumors by use of a RES-specific MRI contrast agent].

Rontgenpraxis 2004 ;55(5):192-9

Klinik und Poliklinik für Strahlenheilkunde der Charité, CampusVirchow Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin.

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May 2005

Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis.

Ann Hematol 2005 Apr 6;84(4):236-44. Epub 2004 Nov 6.

Department of Hematology and Oncology, Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum, Berlin, Germany.

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http://dx.doi.org/10.1007/s00277-004-0969-1DOI Listing
April 2005

[Legal aspects of medication prescription].

Z Arztl Fortbild Qualitatssich 2005 Apr;99(2):156-60; discussion 166, 168

Robert-Rössle-Klinik im HELIOS Klinikum Berlin-Buch.

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April 2005

High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia.

Clin Cancer Res 2004 Jun;10(11):3737-44

Department of Hematology, Oncology, and Tumor Immunology, Charité, Campus Berlin-Buch, Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-03-0642DOI Listing
June 2004

[Expression and significance of apoptosis protein inhibitor survivin and XIAP, in patients with myelodysplastic syndromes and in the cell line MUTZ-1].

Zhonghua Xue Ye Xue Za Zhi 2004 Jan;25(1):26-30

The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China.

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January 2004

The prognostic significance of antigen expression in leukaemia.

Best Pract Res Clin Haematol 2003 Dec;16(4):613-28

Robert-Rössle-Clinic, Department of Haematology, Oncology and Tumour Immunology, HELIOS Clinic Berlin, Charité, Campus Berlin-Buch, Lindenberger Weg 80, D-13122, Berlin, Germany.

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http://dx.doi.org/10.1016/s1521-6926(03)00087-2DOI Listing
December 2003

Correlation of protein expression and gene expression in acute leukemia.

Cytometry B Clin Cytom 2003 Sep;55(1):29-36

Laboratory for Leukemia Diagnostics, Ludwig-Maximilians-University, University Hospital Grosshadern, Department of Internal Medicine III, Munich, Germany.

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http://dx.doi.org/10.1002/cyto.b.10025DOI Listing
September 2003