Wolf Reik

Wolf Reik

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Wolf Reik

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Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

Cell Stem Cell 2019 Sep 15;25(3):388-406.e8. Epub 2019 Aug 15.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731995PMC
September 2019

Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.

Genes Dev 2019 02 28;33(3-4):194-208. Epub 2019 Jan 28.

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom.

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http://dx.doi.org/10.1101/gad.321174.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362816PMC
February 2019

Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.

Cell Rep 2019 Jan;26(4):815-824.e4

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344340PMC
January 2019

Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity.

PLoS Genet 2018 11 21;14(11):e1007766. Epub 2018 Nov 21.

Max Planck Institute for Biology of Ageing, Cologne, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1007766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281273PMC
November 2018

Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition.

Transl Psychiatry 2018 10 12;8(1):195. Epub 2018 Oct 12.

Laboratory of Translational Nutrition Biology, Department of Health Sciences and Technology, ETH Zurich, 8603, Schwerzenbach, Switzerland.

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http://dx.doi.org/10.1038/s41398-018-0243-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185972PMC
October 2018

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition.

Nat Rev Mol Cell Biol 2018 07;19(7):436-450

Epigenetics Programme, Babraham Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/s41580-018-0008-zDOI Listing
July 2018

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.

Cell Syst 2018 07;7(1):63-76.e12

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK; Epigenetics Programme, Babraham Institute, Cambridge, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066359PMC
July 2018

Defective germline reprogramming rewires the spermatogonial transcriptome.

Nat Struct Mol Biol 2018 05 30;25(5):394-404. Epub 2018 Apr 30.

MRC Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41594-018-0058-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086329PMC
May 2018

An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.

Cell Stem Cell 2017 Nov;21(5):694-703.e7

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; University of Cambridge, The Old Schools, Trinity Lane, Cambridge CB2 1TN, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678422PMC
November 2017

Single-cell epigenomics: Recording the past and predicting the future.

Science 2017 10;358(6359):69-75

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1126/science.aan6826DOI Listing
October 2017

Epigenetic resetting of human pluripotency.

Development 2017 08;144(15):2748-2763

Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK

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http://dev.biologists.org/lookup/doi/10.1242/dev.146811
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http://dx.doi.org/10.1242/dev.146811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560041PMC
August 2017

Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.

Cell Rep 2017 08;20(5):1215-1228

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Single-Cell Genomics Centre, Cambridge CB10 1SA, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554778PMC
August 2017

A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.

Nat Struct Mol Biol 2017 Jul 22;24(7):604-606. Epub 2017 May 22.

European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.

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http://dx.doi.org/10.1038/nsmb.3413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898609PMC
July 2017

Erratum to: DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.

Genome Biol 2017 05 12;18(1):90. Epub 2017 May 12.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13059-017-1233-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429579PMC
May 2017

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Cell Rep 2017 05;19(8):1503-1511

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK; Department of Haematology, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK; Stem Cell Institute, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457484PMC
May 2017

DNA methylation homeostasis in human and mouse development.

Curr Opin Genet Dev 2017 Apr 2;43:101-109. Epub 2017 Mar 2.

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2017.02.003DOI Listing
April 2017

DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.

Genome Biol 2017 Apr 11;18(1):67. Epub 2017 Apr 11.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13059-017-1189-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387360PMC
April 2017

Multi-tissue DNA methylation age predictor in mouse.

Genome Biol 2017 04 11;18(1):68. Epub 2017 Apr 11.

Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK.

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http://dx.doi.org/10.1186/s13059-017-1203-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389178PMC
April 2017

Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).

Nat Protoc 2017 03 9;12(3):534-547. Epub 2017 Feb 9.

Epigenetics Programme, Babraham Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2016.187DOI Listing
March 2017

Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase.

Nucleic Acids Res 2017 02;45(4):1703-1713

Institute of Biochemistry, Pfaffenwaldring 55, Faculty of Chemistry, University of Stuttgart, D-70569 Stuttgart, Germany.

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http://dx.doi.org/10.1093/nar/gkw1112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389507PMC
February 2017

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice.

Genes (Basel) 2017 Feb 17;8(2). Epub 2017 Feb 17.

Centre for Ageing and Vitality, Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.3390/genes8020075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333064PMC
February 2017

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

Cell Rep 2017 01;18(5):1079-1089

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300890PMC
January 2017

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

PLoS Genet 2016 Dec 15;12(12):e1006485. Epub 2016 Dec 15.

HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157941PMC
December 2016

Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.

Dev Cell 2016 10;39(1):104-115

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064768PMC
October 2016

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

Proc Natl Acad Sci U S A 2016 10 11;113(43):12202-12207. Epub 2016 Oct 11.

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom

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http://dx.doi.org/10.1073/pnas.1608679113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086989PMC
October 2016

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.

Cell Rep 2016 09;17(1):179-192

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055476PMC
http://dx.doi.org/10.1016/j.celrep.2016.08.087DOI Listing
September 2016

Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass.

Stem Cell Reports 2016 Apr 3;6(4):437-446. Epub 2016 Mar 3.

Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 4BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834040PMC
April 2016

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity.

Genome Biol 2016 Apr 18;17:72. Epub 2016 Apr 18.

Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.

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http://dx.doi.org/10.1186/s13059-016-0944-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834828PMC
April 2016

Maternal DNA Methylation Regulates Early Trophoblast Development.

Dev Cell 2016 Jan;36(2):152-63

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.

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http://www.cell.com/developmental-cell/pdf/S1534-5807(15)008
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http://linkinghub.elsevier.com/retrieve/pii/S153458071500836
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http://dx.doi.org/10.1016/j.devcel.2015.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729543PMC
January 2016

Processive DNA demethylation via DNA deaminase-induced lesion resolution.

PLoS One 2014 15;9(7):e97754. Epub 2014 Jul 15.

DNA Editing in Immunity and Epigenetics, IFOM-Fondazione Instituto FIRC di Oncologia Molecolare, Milano, Italy; DNA Editing Lab, Clare Hall Laboratories, London Research Institute, South Mimms, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097754PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098905PMC
December 2015

Germline and Pluripotent Stem Cells.

Cold Spring Harb Perspect Biol 2015 Nov 2;7(11). Epub 2015 Nov 2.

Wellcome Trust Cancer Research UK Gurdon Institute & Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a019422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632666PMC
November 2015

5-Formylcytosine can be a stable DNA modification in mammals.

Nat Chem Biol 2015 Aug 22;11(8):555-7. Epub 2015 Jun 22.

1] Department of Chemistry, University of Cambridge, Cambridge, UK. [2] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nchembio.1848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486442PMC
August 2015

Forget the Parents: Epigenetic Reprogramming in Human Germ Cells.

Cell 2015 Jun;161(6):1248-51

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.039DOI Listing
June 2015

Prmt5: a guardian of the germline protects future generations.

EMBO J 2015 Mar 16;34(6):689-90. Epub 2015 Feb 16.

Epigenetics Programme, The Babraham Institute, Cambridge, UK The Wellcome Trust Sanger Institute, Cambridge, UK.

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http://dx.doi.org/10.15252/embj.201591054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369307PMC
March 2015

Global reorganization of the nuclear landscape in senescent cells.

Cell Rep 2015 Feb 29;10(4):471-83. Epub 2015 Jan 29.

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK; The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1016/j.celrep.2014.12.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542308PMC
February 2015

Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo.

Epigenetics Chromatin 2015 9;8(1). Epub 2015 Jan 9.

University of Saarland, FR 8.3, Biological Sciences, Genetics/Epigenetics, Campus A2.4, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1186/1756-8935-8-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304184PMC
January 2015

Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation.

Cell Rep 2014 Dec 12;9(6):1990-2000. Epub 2014 Dec 12.

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542306PMC
December 2014

Redundant mechanisms to form silent chromatin at pericentromeric regions rely on BEND3 and DNA methylation.

Mol Cell 2014 Nov 6;56(4):580-94. Epub 2014 Nov 6.

INSERM AVENIR, Institute of Human Genetics CNRS UPR1142, 141 rue de la Cardonille, 34000 Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.001DOI Listing
November 2014

Etoposide induces nuclear re-localisation of AID.

PLoS One 2013 4;8(12):e82110. Epub 2013 Dec 4.

Epigenetics Programme, The Babraham Institute, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082110PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852760PMC
September 2014

Resetting transcription factor control circuitry toward ground-state pluripotency in human.

Cell 2014 Sep;158(6):1254-1269

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162745PMC
September 2014

Epigenetics: Cellular memory erased in human embryos.

Nature 2014 Jul 23;511(7511):540-1. Epub 2014 Jul 23.

Epigenetics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK, and at the Centre for Trophoblast Research, University of Cambridge.

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http://dx.doi.org/10.1038/nature13648DOI Listing
July 2014

Reprogramming the methylome: erasing memory and creating diversity.

Cell Stem Cell 2014 Jun;14(6):710-9

Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051243PMC
June 2014

Regulation of lineage specific DNA hypomethylation in mouse trophectoderm.

PLoS One 2013 25;8(6):e68846. Epub 2013 Jun 25.

Epigenetics Programme, the Babraham Institute, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068846PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692478PMC
February 2014

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.

Nat Protoc 2013 Oct 5;8(10):1841-51. Epub 2013 Sep 5.

Department of Chemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2013.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919000PMC
October 2013

Robust 3D DNA FISH using directly labeled probes.

J Vis Exp 2013 Aug 15(78). Epub 2013 Aug 15.

Nuclear Dynamics Programme, The Babraham Institute.

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http://dx.doi.org/10.3791/50587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846859PMC
August 2013

Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells.

Curr Opin Cell Biol 2013 Jun 17;25(3):281-8. Epub 2013 Mar 17.

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1016/j.ceb.2013.02.013DOI Listing
June 2013

Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Proc Natl Acad Sci U S A 2013 May 2;110(21):8627-31. Epub 2013 May 2.

Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1073/pnas.1306723110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666705PMC
May 2013

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

Nature 2013 Mar 10;495(7441):370-4. Epub 2013 Feb 10.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1038/nature11925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606645PMC
March 2013

Reprogramming by cell fusion: boosted by Tets.

Mol Cell 2013 Mar;49(6):1017-8

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1016/j.molcel.2013.03.014DOI Listing
March 2013

Incomplete methylation reprogramming in SCNT embryos.

Nat Genet 2012 Sep;44(9):965-6

Epigenetics Programme, The Babraham Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.2393DOI Listing
September 2012

Shifting behaviour: epigenetic reprogramming in eusocial insects.

Curr Opin Cell Biol 2012 Jun 17;24(3):367-73. Epub 2012 Mar 17.

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom.

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http://dx.doi.org/10.1016/j.ceb.2012.02.005DOI Listing
June 2012

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.

Nat Cell Biol 2012 Jun 10;14(7):659-65. Epub 2012 Jun 10.

Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.

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http://dx.doi.org/10.1038/ncb2521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389517PMC
June 2012

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.

Science 2012 May 26;336(6083):934-7. Epub 2012 Apr 26.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

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http://dx.doi.org/10.1126/science.1220671DOI Listing
May 2012

Methylome analysis using MeDIP-seq with low DNA concentrations.

Nat Protoc 2012 Mar 8;7(4):617-36. Epub 2012 Mar 8.

University College London (UCL) Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/nprot.2012.012DOI Listing
March 2012

Uncovering the role of 5-hydroxymethylcytosine in the epigenome.

Nat Rev Genet 2011 Nov 15;13(1):7-13. Epub 2011 Nov 15.

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1038/nrg3080DOI Listing
November 2011

DNA demethylases: a new epigenetic frontier in drug discovery.

Drug Discov Today 2011 Aug 13;16(15-16):683-90. Epub 2011 May 13.

CellCentric Ltd., Chesterford Research Park, Little Chesterford, CB10 1XL, UK.

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https://www.acsu.buffalo.edu/~abagati/dropbox/New%20folder/D
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http://linkinghub.elsevier.com/retrieve/pii/S135964461100147
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http://dx.doi.org/10.1016/j.drudis.2011.05.004DOI Listing
August 2011