Winfried Edelmann

Winfried Edelmann

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Winfried Edelmann

Publications by authors named "Winfried Edelmann"

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Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis.

G3 (Bethesda) 2019 06 5;9(6):1839-1850. Epub 2019 Jun 5.

Department of Biomedical Sciences and Center for Reproductive Genomics, Cornell University, Ithaca, NY 14853

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http://dx.doi.org/10.1534/g3.119.400074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553527PMC
June 2019

MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.

PLoS Genet 2018 10 12;14(10):e1007719. Epub 2018 Oct 12.

Section on Gene Structure and Disease, Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases,National Institutes of Health, Bethesda, MD, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200270PMC
October 2018

EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.

DNA Repair (Amst) 2017 09 10;57:98-106. Epub 2017 Jul 10.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY, 10065, USA; Department of Human Science, Georgetown University Medical Center, 3700 Reservoir Rd. NW, Washington, D.C., 20057, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584059PMC
September 2017

MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.

Cancer Res 2016 08 3;76(15):4383-93. Epub 2016 Jun 3.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2926DOI Listing
August 2016

A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.

Cancer Res 2016 07 4;76(14):4183-91. Epub 2016 Jun 4.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland. Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033673PMC
July 2016

Genomic Landscape of Colorectal Mucosa and Adenomas.

Cancer Prev Res (Phila) 2016 06 24;9(6):417-27. Epub 2016 May 24.

Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas. Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1940-6207.CAPR-16-0081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941624PMC
June 2016

Mouse models of DNA mismatch repair in cancer research.

DNA Repair (Amst) 2016 Feb 4;38:140-146. Epub 2015 Dec 4.

Department of Cell Biology, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, NY 10461, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864153004
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http://dx.doi.org/10.1016/j.dnarep.2015.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754788PMC
February 2016

Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.

Gut 2015 Dec 26;64(12):1905-12. Epub 2014 Nov 26.

Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1136/gutjnl-2014-307663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680183PMC
December 2015

Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.

Mol Carcinog 2015 Nov 11;54(11):1376-86. Epub 2014 Sep 11.

Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/mc.22213DOI Listing
November 2015

Seamless Ligation Cloning Extract (SLiCE) cloning method.

Methods Mol Biol 2014 ;1116:235-44

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1007/978-1-62703-764-8_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672941PMC
September 2014

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.

Cancer Discov 2014 May 20;4(5):592-605. Epub 2014 Feb 20.

1Department of Translational Genomics; 2Institute of Pathology; 3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne; 4Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany; and 5Michael F. Price Center, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0907DOI Listing
May 2014

Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression.

Dev Biol 2013 May 4;377(1):213-23. Epub 2013 Feb 4.

Department of Biology, McGill University, Urology Research Laboratory, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1.

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http://dx.doi.org/10.1016/j.ydbio.2013.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664362PMC
May 2013

Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.

J Clin Invest 2012 Sep 6;122(9):3184-96. Epub 2012 Aug 6.

Department of Medicine, Genetic Medicine, Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI62110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428084PMC
September 2012

AIDing antibody diversity by error-prone mismatch repair.

Semin Immunol 2012 Aug 14;24(4):293-300. Epub 2012 Jun 14.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.smim.2012.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422444PMC
August 2012

SLiCE: a novel bacterial cell extract-based DNA cloning method.

Nucleic Acids Res 2012 Apr 12;40(8):e55. Epub 2012 Jan 12.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1093/nar/gkr1288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333860PMC
April 2012

Effect of caloric intake on Western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer.

Nutr Cancer 2012 Apr 22;64(3):401-8. Epub 2012 Mar 22.

Department of Medicine (Gastroenterology and Hepatology), Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1080/01635581.2012.660672DOI Listing
April 2012

Mismatch-mediated error prone repair at the immunoglobulin genes.

Biomed Pharmacother 2011 Dec 24;65(8):529-36. Epub 2011 Oct 24.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave-Chanin 404, Bronx, NY 10461, United States.

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http://dx.doi.org/10.1016/j.biopha.2011.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235044PMC
December 2011

Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.

Cancer Prev Res (Phila) 2011 May 24;4(5):684-93. Epub 2011 Mar 24.

Department of Molecular Virology, Immunology & Medical Genetics, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991477PMC
May 2011

Msh6 protects mature B cells from lymphoma by preserving genomic stability.

Am J Pathol 2010 Nov 7;177(5):2597-608. Epub 2010 Oct 7.

Cell Biology Department, Chanin 403, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://dx.doi.org/10.2353/ajpath.2010.100234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966815PMC
November 2010

PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13384-9. Epub 2010 Jul 12.

Department of Cell Biology, and Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.1008589107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922181PMC
July 2010

An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.

Gastroenterology 2010 Mar 18;138(3):993-1002.e1. Epub 2009 Nov 18.

Department of Medicine/Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1053/j.gastro.2009.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862591PMC
March 2010

Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.

Proc Natl Acad Sci U S A 2010 Mar 8;107(12):5511-5. Epub 2010 Mar 8.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://www.pnas.org/content/107/12/5511.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1001223107
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http://dx.doi.org/10.1073/pnas.1001223107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851751PMC
March 2010

Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.

Carcinogenesis 2009 Nov 15;30(11):1923-6. Epub 2009 Sep 15.

Strang Cancer Research Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1093/carcin/bgp200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783002PMC
November 2009

Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas.

Proc Natl Acad Sci U S A 2009 Nov 16;106(44):18698-703. Epub 2009 Oct 16.

Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Canada.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0905965106
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http://dx.doi.org/10.1073/pnas.0905965106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773990PMC
November 2009

Involvement of Exo1b in DNA damage-induced apoptosis.

Nucleic Acids Res 2009 Jun 1;37(10):3452-63. Epub 2009 Apr 1.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1093/nar/gkp194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691832PMC
June 2009

A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.

Proc Natl Acad Sci U S A 2009 May 6;106(21):8495-500. Epub 2009 May 6.

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0903654106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677980PMC
May 2009

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.

PLoS Genet 2009 May 15;5(5):e1000482. Epub 2009 May 15.

INSERM, U781, Université Paris Descartes, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1371/journal.pgen.1000482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674216PMC
May 2009

Mouse models of colon cancer.

Gastroenterology 2009 Mar;136(3):780-98

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.12.049DOI Listing
March 2009

Perforin-mediated suppression of B-cell lymphoma.

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2723-8. Epub 2009 Feb 5.

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1073/pnas.0809008106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650333PMC
February 2009

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice.

Glycobiology 2009 Jan 10;19(1):68-75. Epub 2008 Oct 10.

Institut Jacques Monod, UMR CNRS 7592, Univ. P6 and P7, 2 Place Jussieu, 75251 Paris Cedex 5, France.

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http://dx.doi.org/10.1093/glycob/cwn105DOI Listing
January 2009

O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.

Proc Natl Acad Sci U S A 2009 Jan 5;106(2):576-81. Epub 2009 Jan 5.

Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0811991106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613938PMC
January 2009

Analysis of meiotic prophase I in live mouse spermatocytes.

Chromosome Res 2008 2;16(5):743-60. Epub 2008 Jun 2.

Department of Biomedical Sciences and Center for Reproductive Genomics, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1007/s10577-008-1224-8DOI Listing
December 2008

Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

J Immunol 2008 Dec;181(12):8450-9

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656362PMC
http://dx.doi.org/10.4049/jimmunol.181.12.8450DOI Listing
December 2008

Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.

Cancer Res 2008 Oct;68(19):7803-10

Strang Cancer Research Laboratory, Department of Medicine, Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, New York 10467, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-1209DOI Listing
October 2008

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Proc Natl Acad Sci U S A 2008 Oct 14;105(42):16248-53. Epub 2008 Oct 14.

Departments of Cell Biology and Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.0808182105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571010PMC
October 2008

Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q.

Proc Natl Acad Sci U S A 2008 Sep 3;105(37):13993-8. Epub 2008 Sep 3.

Moores Cancer Center, University of California, San Diego, School of Medicine, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0806435105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528866PMC
September 2008

MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.

PLoS Genet 2008 Sep 12;4(9):e1000186. Epub 2008 Sep 12.

Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525838PMC
September 2008

Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.

Biol Reprod 2008 Mar 5;78(3):462-71. Epub 2007 Dec 5.

Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14850, USA.

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http://dx.doi.org/10.1095/biolreprod.107.065771DOI Listing
March 2008

Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.

Proc Natl Acad Sci U S A 2008 Mar 12;105(11):4247-52. Epub 2008 Mar 12.

Department of Cell Biology and Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.0800276105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393764PMC
March 2008

Piroxicam increases colon tumorigenesis and promotes apoptosis in Mlh1 +/- /Apc1638(N/+) mice.

Anticancer Res 2007 Nov-Dec;27(6B):3807-12

Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy.

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February 2008

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.

Carcinogenesis 2006 Dec 25;27(12):2402-8. Epub 2006 May 25.

Department of Therapeutic Radiology, Yale University School of Medicine, PO Box 208040, New Haven, CT 06520-8040, USA.

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http://dx.doi.org/10.1093/carcin/bgl079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612936PMC
December 2006

Mismatch repair proteins as sensors of alkylation DNA damage.

Cancer Cell 2006 Jun;9(6):417-8

Division of Hematology/Oncology, Department of Medicine and Moores Cancer Center, University of California, San Diego, School of Medicine, 3855 Health Sciences Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.05.013DOI Listing
June 2006

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.

Immunity 2006 Apr;24(4):393-403

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.02.011DOI Listing
April 2006

Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations.

Development 2006 Mar 1;133(5):977-87. Epub 2006 Feb 1.

Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1242/dev.02264DOI Listing
March 2006

Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events.

Nucleic Acids Res 2005 27;33(21):6733-42. Epub 2005 Nov 27.

Department of Immunology, University of Toronto, Medical Sciences Building 5265, Toronto, Canada, M5S 1A8.

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http://dx.doi.org/10.1093/nar/gki983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297709PMC
December 2005

Impaired hippocampal long-term potentiation in microtubule-associated protein 1B-deficient mice.

J Neurosci Res 2005 Oct;82(1):83-92

Skirball Institute, New York University School of Medicine, New York, USA.

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http://dx.doi.org/10.1002/jnr.20624DOI Listing
October 2005

(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition.

Nat Struct Mol Biol 2005 Aug 17;12(8):663-70. Epub 2005 Jul 17.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/nsmb965DOI Listing
August 2005

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.

Nat Genet 2005 Jul 19;37(7):750-5. Epub 2005 Jun 19.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1038/ng1587DOI Listing
July 2005

Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.

Proc Natl Acad Sci U S A 2005 Jan 7;102(3):737-42. Epub 2005 Jan 7.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center and Weill Graduate School of Medical Sciences of Cornell University, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0406212102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545532PMC
January 2005

Loss of DNA mismatch repair function and cancer predisposition in the mouse: animal models for human hereditary nonpolyposis colorectal cancer.

Am J Med Genet C Semin Med Genet 2004 Aug;129C(1):91-9

Human Genetics, Mt. Sinai School of Medicine, New York, NY, USA.

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http://doi.wiley.com/10.1002/ajmg.c.30021
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http://dx.doi.org/10.1002/ajmg.c.30021DOI Listing
August 2004

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice.

Nat Immunol 2004 Feb 11;5(2):224-9. Epub 2004 Jan 11.

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://www.nature.com/articles/ni1031
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http://dx.doi.org/10.1038/ni1031DOI Listing
February 2004

A panel of repeat markers for detection of microsatellite instability in murine tumors.

Mol Carcinog 2003 Dec;38(4):155-9

Division of Biology and Biomedical Sciences and Department of Surgery, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1002/mc.10157DOI Listing
December 2003

Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele.

Am J Pathol 2003 Nov;163(5):1757-63

Institute of Pathology, Case Western Reserve University Medical Center, 2085 Adelbert Road, Cleveland, OH 44106, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892417PMC
http://dx.doi.org/10.1016/S0002-9440(10)63535-3DOI Listing
November 2003

DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts.

J Invest Dermatol 2003 Oct;121(4):876-80

Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1046/j.1523-1747.2003.12486.xDOI Listing
October 2003

Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice.

Anticancer Res 2003 May-Jun;23(3B):2217-26

Strang Cancer Prevention Center, New York, NY 10021, USA.

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August 2003

Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations.

Carcinogenesis 2003 Mar;24(3):605-11

Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1093/carcin/24.3.605DOI Listing
March 2003

Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination.

J Immunol 2003 Feb;170(4):1620-4

Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 403, Bronx, NY 10461, USA.

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http://dx.doi.org/10.4049/jimmunol.170.4.1620DOI Listing
February 2003

Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation.

Proc Natl Acad Sci U S A 2002 Nov 4;99(23):14937-42. Epub 2002 Nov 4.

Department of Cell Biology, Biostatistics Core, Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.232579299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137523PMC
November 2002

APC-dependent suppression of colon carcinogenesis by PPARgamma.

Proc Natl Acad Sci U S A 2002 Oct 7;99(21):13771-6. Epub 2002 Oct 7.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.162480299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129773PMC
October 2002

Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium.

Oncogene 2002 Oct;21(46):7126-30

Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1.

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http://dx.doi.org/10.1038/sj.onc.1205861DOI Listing
October 2002

Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.

Hum Mol Genet 2002 Aug;11(16):1845-54

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1093/hmg/11.16.1845DOI Listing
August 2002

Mouse models for human DNA mismatch-repair gene defects.

Trends Mol Med 2002 Jul;8(7):346-53

Dept of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/s1471-4914(02)02359-6DOI Listing
July 2002

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.

Proc Natl Acad Sci U S A 2002 Jul 15;99(15):9924-9. Epub 2002 Jul 15.

Department of Medicine and Harvard Partners Center for Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.152321699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126601PMC
July 2002

Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae.

Mol Cell Biol 2002 Apr;22(7):2329-44

Department of Molecular Pharmacology, Institute for Smooth Muscle Biology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133690PMC
http://dx.doi.org/10.1128/mcb.22.7.2329-2344.2002DOI Listing
April 2002