Wim Timens

Wim Timens

UNVERIFIED PROFILE

Are you Wim Timens?   Register this Author

Register author
Wim Timens

Wim Timens

Publications by authors named "Wim Timens"

Are you Wim Timens?   Register this Author

100Publications

3375Reads

50Profile Views

Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors.

J Immunother Cancer 2019 Jul 10;7(1):173. Epub 2019 Jul 10.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30.0001, 9700, RB, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0649-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617698PMC
July 2019

Tc-HYNIC-IL-2 scintigraphy to detect acute rejection in lung transplantation patients: a proof-of-concept study.

EJNMMI Res 2019 May 10;9(1):41. Epub 2019 May 10.

Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13550-019-0511-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510740PMC
May 2019

Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 10;316(3):L537-L546. Epub 2019 Jan 10.

Department of Molecular Pharmacology, University of Groningen , Groningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00325.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459292PMC
March 2019

CX Chemokine Receptor 7 Contributes to Survival of -Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor.

Cancers (Basel) 2019 Mar 30;11(4). Epub 2019 Mar 30.

Groningen Research Institute of Pharmacy, Department of Chemical and Pharmaceutical Biology, University of Groningen, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11040455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520904PMC
March 2019

Essential preanalytics in PD-L1 immunocytochemistry.

Histopathology 2019 Jan 23;74(2):362-364. Epub 2018 Oct 23.

Department of Pathology and Medical Biology, University Medical Centre Groningentshow, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/his.13717
Publisher Site
http://dx.doi.org/10.1111/his.13717DOI Listing
January 2019

The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific.

Epigenetics 2017 ;12(12):1076-1091

a Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, EA10, 9713 GZ , Groningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15592294.2017.1403691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810788PMC
December 2018

Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon?

Respiration 2018;96(2):148-158. Epub 2018 May 2.

Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000488149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159827PMC
December 2018

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Eur Respir J 2018 09 6;52(3). Epub 2018 Sep 6.

Dept of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01556-2017DOI Listing
September 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers.

Cancers (Basel) 2018 Jan 4;10(1). Epub 2018 Jan 4.

Department of Genetics, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers10010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789360PMC
January 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Authors:
Victoria E Jackson Jeanne C Latourelle Louise V Wain Albert V Smith Megan L Grove Traci M Bartz Ma'en Obeidat Michael A Province Wei Gao Beenish Qaiser David J Porteous Patricia A Cassano Tarunveer S Ahluwalia Niels Grarup Jin Li Elisabeth Altmaier Jonathan Marten Sarah E Harris Ani Manichaikul Tess D Pottinger Ruifang Li-Gao Allan Lind-Thomsen Anubha Mahajan Lies Lahousse Medea Imboden Alexander Teumer Bram Prins Leo-Pekka Lyytikäinen Gudny Eiriksdottir Nora Franceschini Colleen M Sitlani Jennifer A Brody Yohan Bossé Wim Timens Aldi Kraja Anu Loukola Wenbo Tang Yongmei Liu Jette Bork-Jensen Johanne M Justesen Allan Linneberg Leslie A Lange Rajesh Rawal Stefan Karrasch Jennifer E Huffman Blair H Smith Gail Davies Kristin M Burkart Josyf C Mychaleckyj Tobias N Bonten Stefan Enroth Lars Lind Guy G Brusselle Ashish Kumar Beate Stubbe Mika Kähönen Annah B Wyss Bruce M Psaty Susan R Heckbert Ke Hao Taina Rantanen Stephen B Kritchevsky Kurt Lohman Tea Skaaby Charlotta Pisinger Torben Hansen Holger Schulz Ozren Polasek Archie Campbell John M Starr Stephen S Rich Dennis O Mook-Kanamori Åsa Johansson Erik Ingelsson André G Uitterlinden Stefan Weiss Olli T Raitakari Vilmundur Gudnason Kari E North Sina A Gharib Don D Sin Kent D Taylor George T O'Connor Jaakko Kaprio Tamara B Harris Oluf Pederson Henrik Vestergaard James G Wilson Konstantin Strauch Caroline Hayward Shona Kerr Ian J Deary R Graham Barr Renée de Mutsert Ulf Gyllensten Andrew P Morris M Arfan Ikram Nicole Probst-Hensch Sven Gläser Eleftheria Zeggini Terho Lehtimäki David P Strachan Josée Dupuis Alanna C Morrison Ian P Hall Martin D Tobin Stephanie J London

Wellcome Open Res 2018 12;3. Epub 2018 Jan 12.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/wellcomeopenres.12583.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081985PMC
January 2018

Lung tissue gene-expression signature for the ageing lung in COPD.

Thorax 2017 Dec 6. Epub 2017 Dec 6.

University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2017-210074DOI Listing
December 2017

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Eur Respir Rev 2017 Dec 6;26(146). Epub 2017 Dec 6.

University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/16000617.0073-2017DOI Listing
December 2017

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

Sci Rep 2017 10 9;7(1):12871. Epub 2017 Oct 9.

Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-13265-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634489PMC
October 2017

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways.

J Allergy Clin Immunol 2017 07 19;140(1):280-283.e3. Epub 2016 Dec 19.

Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.11.020DOI Listing
July 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

CT-guided percutaneous hookwire localization increases the efficacy and safety of VATS for pulmonary nodules.

J Surg Oncol 2017 Jun 23;115(7):898-904. Epub 2017 Feb 23.

Department of Pulmonary Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jso.24589
Publisher Site
http://dx.doi.org/10.1002/jso.24589DOI Listing
June 2017

miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD.

Eur Respir J 2017 05 25;49(5). Epub 2017 May 25.

Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.02538-2016DOI Listing
May 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Cancer Stem Cells, Epithelial to Mesenchymal Markers, and Circulating Tumor Cells in Small Cell Lung Cancer.

Clin Lung Cancer 2016 11 8;17(6):535-542. Epub 2016 Jun 8.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2016.05.015DOI Listing
November 2016

Fibulin-5 as a potential therapeutic target in COPD.

Expert Opin Ther Targets 2016 09 25;20(9):1031-3. Epub 2016 Mar 25.

a Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14728222.2016.1164696DOI Listing
September 2016

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Authors:
Gordon Fehringer Peter Kraft Paul D Pharoah Rosalind A Eeles Nilanjan Chatterjee Fredrick R Schumacher Joellen M Schildkraut Sara Lindström Paul Brennan Heike Bickeböller Richard S Houlston Maria Teresa Landi Neil Caporaso Angela Risch Ali Amin Al Olama Sonja I Berndt Edward L Giovannucci Henrik Grönberg Zsofia Kote-Jarai Jing Ma Kenneth Muir Meir J Stampfer Victoria L Stevens Fredrik Wiklund Walter C Willett Ellen L Goode Jennifer B Permuth Harvey A Risch Brett M Reid Stephane Bezieau Hermann Brenner Andrew T Chan Jenny Chang-Claude Thomas J Hudson Jonathan K Kocarnik Polly A Newcomb Robert E Schoen Martha L Slattery Emily White Muriel A Adank Habibul Ahsan Kristiina Aittomäki Laura Baglietto Carl Blomquist Federico Canzian Kamila Czene Isabel Dos-Santos-Silva A Heather Eliassen Jonine D Figueroa Dieter Flesch-Janys Olivia Fletcher Montserrat Garcia-Closas Mia M Gaudet Nichola Johnson Per Hall Aditi Hazra Rebecca Hein Albert Hofman John L Hopper Astrid Irwanto Mattias Johansson Rudolf Kaaks Muhammad G Kibriya Peter Lichtner Jianjun Liu Eiliv Lund Enes Makalic Alfons Meindl Bertram Müller-Myhsok Taru A Muranen Heli Nevanlinna Petra H Peeters Julian Peto Ross L Prentice Nazneen Rahman Maria Jose Sanchez Daniel F Schmidt Rita K Schmutzler Melissa C Southey Rulla Tamimi Ruth C Travis Clare Turnbull Andre G Uitterlinden Zhaoming Wang Alice S Whittemore Xiaohong R Yang Wei Zheng Daniel D Buchanan Graham Casey David V Conti Christopher K Edlund Steven Gallinger Robert W Haile Mark Jenkins Loïc Le Marchand Li Li Noralene M Lindor Stephanie L Schmit Stephen N Thibodeau Michael O Woods Thorunn Rafnar Julius Gudmundsson Simon N Stacey Kari Stefansson Patrick Sulem Y Ann Chen Jonathan P Tyrer David C Christiani Yongyue Wei Hongbing Shen Zhibin Hu Xiao-Ou Shu Kouya Shiraishi Atsushi Takahashi Yohan Bossé Ma'en Obeidat David Nickle Wim Timens Matthew L Freedman Qiyuan Li Daniela Seminara Stephen J Chanock Jian Gong Ulrike Peters Stephen B Gruber Christopher I Amos Thomas A Sellers Douglas F Easton David J Hunter Christopher A Haiman Brian E Henderson Rayjean J Hung

Cancer Res 2016 09 20;76(17):5103-14. Epub 2016 Apr 20.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-2980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493PMC
September 2016

Novel Genetic Susceptibility Loci for FEV1 in the Context of Occupational Exposure in Never-Smokers.

Am J Respir Crit Care Med 2016 09;194(6):769-72

1 University of Groningen, University Medical Center Groningen Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201603-0646LEDOI Listing
September 2016

Susceptibility genes for lung diseases in the major histocompatibility complex revealed by lung expression quantitative trait loci analysis.

Eur Respir J 2016 08 12;48(2):573-6. Epub 2016 May 12.

Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada Dept of Molecular Medicine, Laval University, Québec, QC, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00114-2016DOI Listing
August 2016

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD.

Eur Respir J 2016 08 13;48(2):359-69. Epub 2016 Jul 13.

University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Dept of Pulmonology, Groningen, The Netherlands These two authors contributed equally to this work.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01911-2015DOI Listing
August 2016

The Translation from Risk Allele to Biological Function in Chronic Obstructive Pulmonary Disease. What's in It for FAM13A?

Am J Respir Crit Care Med 2016 07;194(2):130-2

1 Department of Pathology and Medical Biology and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201602-0249EDDOI Listing
July 2016

PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.

Oncoimmunology 2016 May 16;5(5):e1131379. Epub 2016 Mar 16.

Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/2162402X.2015.1131379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910698PMC
May 2016

The clinical utility of reticular basement membrane thickness measurements in asthmatic children.

J Asthma 2015 14;52(9):926-30. Epub 2015 Sep 14.

a Department of Pediatric Pulmonology, Erasmus Medical Centre , Sophia Children's Hospital , Rotterdam , The Netherlands .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/02770903.2015.1025409DOI Listing
April 2016

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.

Thorax 2016 Apr 21;71(4):312-22. Epub 2016 Jan 21.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2015-206958DOI Listing
April 2016

Sexual maturation protects against development of lung inflammation through estrogen.

Am J Physiol Lung Cell Mol Physiol 2016 Jan 25;310(2):L166-74. Epub 2015 Nov 25.

University of Groningen, Department of Pharmacokinetics, Toxicology, and Targeting, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00119.2015DOI Listing
January 2016

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels.

J Allergy Clin Immunol 2015 Dec 5;136(6):1664-1672.e14. Epub 2015 Jun 5.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2015.03.042DOI Listing
December 2015

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.

Am J Physiol Lung Cell Mol Physiol 2015 Nov 28;309(10):L1112-23. Epub 2015 Aug 28.

University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands; and University of Groningen, University Medical Center Groningen, Groningen, Groningen Research Institute for Asthma Research Institute, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00077.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652154PMC
November 2015

Old dilemma: asthma with irreversible airway obstruction or COPD.

Virchows Arch 2015 Nov 14;467(5):583-93. Epub 2015 Sep 14.

Department of Pulmonology, University of Groningen, University Medical Center Groningen, PO Box 196, 9700 AD, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-015-1824-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656713PMC
November 2015

Effects of ageing and smoking on pulmonary computed tomography scans using parametric response mapping.

Eur Respir J 2015 Oct 25;46(4):1193-6. Epub 2015 Jun 25.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands Both authors contributed equally

View Article

Download full-text PDF

Source
http://erj.ersjournals.com/content/46/4/1193.full.pdf
Web Search
http://erj.ersjournals.com/lookup/doi/10.1183/09031936.00009
Publisher Site
http://dx.doi.org/10.1183/09031936.00009415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591191PMC
October 2015

Unravelling the complexity of COPD by microRNAs: it's a small world after all.

Eur Respir J 2015 Sep 6;46(3):807-18. Epub 2015 Aug 6.

University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands University of Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, The Netherlands Both authors contributed equally as last authors

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.02139-2014DOI Listing
September 2015

A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.

Am J Physiol Lung Cell Mol Physiol 2015 Apr 30;308(8):L766-75. Epub 2015 Jan 30.

University of Groningen, Department of Molecular Pharmacology, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, GRIAC, Groningen, The Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00301.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499028PMC
April 2015

Susceptibility to COPD: differential proteomic profiling after acute smoking.

PLoS One 2014 18;9(7):e102037. Epub 2014 Jul 18.

University of Groningen, University Medical Centre Groningen, Department of Pulmonary Diseases, Groningen Research Institute of Asthma and COPD (GRIAC), Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103835PMC
March 2015

Adverse pulmonary vascular remodeling in the Fontan circulation.

J Heart Lung Transplant 2015 Mar 16;34(3):404-13. Epub 2015 Jan 16.

Department of Pediatric Cardiology, Beatrix Children's Hospital. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healun.2015.01.005DOI Listing
March 2015

Distinct macrophage phenotypes in allergic and nonallergic lung inflammation.

Am J Physiol Lung Cell Mol Physiol 2015 Feb 12;308(4):L358-67. Epub 2014 Dec 12.

University of Groningen, University Medical Center Groningen, Department of Pathology, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, GRIAC- Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00341.2014DOI Listing
February 2015

Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study.

PLoS One 2014 24;9(3):e92498. Epub 2014 Mar 24.

Centre de Recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Quebec city, Québec, Canada; Department of Molecular Medicine, Laval University, Quebec city, Québec, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092498PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963906PMC
January 2015

Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.

J Cell Mol Med 2015 Jan 30;19(1):210-26. Epub 2014 Sep 30.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands; Department of Paediatrics, Department of Pediatric Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.12418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288364PMC
January 2015

Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.

Carcinogenesis 2014 Dec 3;35(12):2653-9. Epub 2014 Sep 3.

Institut universitaire de cardiologie et de pneumologie de Québec, Québec G1V 4G5, Canada, Department of Molecular Medicine, Laval University, Québec G1V 0A6, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgu184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247514PMC
December 2014

Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers.

PLoS One 2014 5;9(2):e87443. Epub 2014 Feb 5.

University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands ; University of Groningen, University Medical Center Groningen, GRIAC research institute, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087443PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914834PMC
November 2014

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD.

Respir Res 2014 Oct 10;15:121. Epub 2014 Oct 10.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-014-0121-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203909PMC
October 2014

Lung expression quantitative trait loci data set identifies important functional polymorphisms in the asthma-associated IL1RL1 region.

J Allergy Clin Immunol 2014 Sep 18;134(3):729-31. Epub 2014 Apr 18.

UBC James Hogg Research Centre, Heart + Lung Institute, St Paul's Hospital, Vancouver, British Columbia, Canada; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2014.02.039DOI Listing
September 2014

Effects of cigarette smoke extract on human airway smooth muscle cells in COPD.

Eur Respir J 2014 Sep 25;44(3):634-46. Epub 2014 Jun 25.

Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/09031936.00171313DOI Listing
September 2014

Interaction between Epac1 and miRNA-7 in airway smooth muscle cells.

Naunyn Schmiedebergs Arch Pharmacol 2014 Aug 4;387(8):795-7. Epub 2014 Jul 4.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands,

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00210-014-1015
Web Search
http://link.springer.com/10.1007/s00210-014-1015-z
Publisher Site
http://dx.doi.org/10.1007/s00210-014-1015-zDOI Listing
August 2014

Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2014 Jun;189(11):1439-42

1 University of Groningen Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201311-1982LEDOI Listing
June 2014

miR-638 regulates gene expression networks associated with emphysematous lung destruction.

Genome Med 2013 31;5(12):114. Epub 2013 Dec 31.

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, 72 East Concord Street Boston, MA 02118, USA ; Bioinformatics Program, Boston University, 44 Cummington Street Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gm519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971345PMC
May 2014

Eosinophilic inflammation in subjects with mild-to-moderate asthma with and without obesity: disparity between sputum and biopsies.

Am J Respir Crit Care Med 2014 May;189(10):1281-4

1 University of Groningen Groningen, The Netherlands and GRIAC Research Institute Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201310-1841LEDOI Listing
May 2014

A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke.

Am J Physiol Cell Physiol 2014 Mar 22;306(6):C585-97. Epub 2014 Jan 22.

University of Groningen, Department of Molecular Pharmacology, Groningen, The Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00183.2013DOI Listing
March 2014

Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD.

Am J Physiol Lung Cell Mol Physiol 2013 Oct 30;305(8):L582-9. Epub 2013 Aug 30.

Dept. of Pathology and Medical Biology, Univ. Medical Center Groningen, P.O. Box 30.001, 9700 RB, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00152.2013DOI Listing
October 2013