Publications by authors named "Wim Timens"

100Publications

Genetic regulation of gene expression of MIF family members in lung tissue.

Sci Rep 2020 Oct 12;10(1):16980. Epub 2020 Oct 12.

Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-74121-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552402PMC
October 2020

An All-In-One Transcriptome-Based Assay to Identify Therapy-Guiding Genomic Aberrations in Nonsmall Cell Lung Cancer Patients.

Cancers (Basel) 2020 Oct 1;12(10). Epub 2020 Oct 1.

Department of Genetics, University Medical Centre Groningen, University of Groningen, 9700RB Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12102843DOI Listing
October 2020

Pellino-1 Regulates the Responses of the Airway to Viral Infection.

Front Cell Infect Microbiol 2020 31;10:456. Epub 2020 Aug 31.

Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2020.00456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488214PMC
August 2020

Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma.

Clin Exp Allergy 2020 Sep 15. Epub 2020 Sep 15.

Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cea.13732DOI Listing
September 2020

Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?

Mol Syst Biol 2020 07;16(7):e9841

Department of Pathology and Medical Biology, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/msb.20209841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383087PMC
July 2020

Immune microenvironment composition in non-small cell lung cancer and its association with survival.

Clin Transl Immunology 2020 12;9(6):e1142. Epub 2020 Jun 12.

Department of Pulmonary Diseases University Medical Center Groningen University of Groningen Groningen The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cti2.1142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291326PMC
June 2020

Combined osimertinib, dabrafenib and trametinib treatment for advanced non-small-cell lung cancer patients with an osimertinib-induced BRAF V600E mutation.

Lung Cancer 2020 08 4;146:358-361. Epub 2020 Jun 4.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lungcan.2020.05.036DOI Listing
August 2020

The Genetic Epidemiology of Pediatric Pulmonary Arterial Hypertension.

J Pediatr 2020 Oct 2;225:65-73.e5. Epub 2020 Jun 2.

Center for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.05.051DOI Listing
October 2020

Link between increased cellular senescence and extracellular matrix changes in COPD.

Am J Physiol Lung Cell Mol Physiol 2020 07 27;319(1):L48-L60. Epub 2020 May 27.

Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00028.2020DOI Listing
July 2020

SARS-CoV-2 receptor ACE2 gene expression and RAAS inhibitors.

Lancet Respir Med 2020 06 13;8(6):e50-e51. Epub 2020 May 13.

Centre for Heart Lung Innovation, University of British Colombia at St Paul's Hospital, Vancouver V6Z 1Y6, BC, Canada; Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(20)30224-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220165PMC
June 2020

Protein-altering germline mutations implicate novel genes related to lung cancer development.

Authors:
Xuemei Ji Semanti Mukherjee Maria Teresa Landi Yohan Bosse Philippe Joubert Dakai Zhu Ivan Gorlov Xiangjun Xiao Younghun Han Olga Gorlova Rayjean J Hung Yonathan Brhane Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen Jinyoung Byun Konstantin H Dragnev John K Field Lambertus Fa Kiemeney Philip Lazarus Shan Zienolddiny Stephen Lam Matthew B Schabath Angeline S Andrew Pier A Bertazzi Angela C Pesatori Nancy Diao Li Su Lei Song Ruyang Zhang Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Gary E Goodman Angela Cox Fiona Taylor Penella Woll Erich Wichmann Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Lesley M Butler Kenneth Offit Preethi Srinivasan Chaitanya Bandlamudi Matthew D Hellmann David B Solit Mark E Robson Charles M Rudin Zsofia K Stadler Barry S Taylor Michael F Berger Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens María Soler Artigas Sanjay Shete Hermann Brenner Stephen Chanock Paul Brennan James D McKay Christopher I Amos

Nat Commun 2020 05 11;11(1):2220. Epub 2020 May 11.

The Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-15905-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214407PMC
May 2020

A case report of an unusual non-mucinous papillary variant of CPAM type 1 with KRAS mutations.

BMC Pulm Med 2020 Feb 24;20(1):52. Epub 2020 Feb 24.

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1088-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041291PMC
February 2020

Circulating tumor cells in lung cancer are prognostic and predictive for worse tumor response in both targeted- and chemotherapy.

Transl Lung Cancer Res 2019 Dec;8(6):854-861

Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tlcr.2019.11.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976367PMC
December 2019

Atypical goblet cell hyperplasia occurs in CPAM 1, 2, and 3, and is a probable precursor lesion for childhood adenocarcinoma.

Virchows Arch 2020 Jun 19;476(6):843-854. Epub 2019 Dec 19.

Diagnostic and Research Institute of Pathology, Medical University Graz, Neue Stiftingtalstrasse 6, 8036, Graz, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-019-02732-4DOI Listing
June 2020

Multicentre study on the consistency of PD-L1 immunohistochemistry as predictive test for immunotherapy in non-small cell lung cancer.

J Clin Pathol 2020 Jul 10;73(7):423-430. Epub 2019 Dec 10.

Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jclinpath-2019-205993DOI Listing
July 2020

Analysis of Released Circulating Tumor Cells During Surgery for Non-Small Cell Lung Cancer.

Clin Cancer Res 2020 Apr 26;26(7):1656-1666. Epub 2019 Nov 26.

Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-19-2541DOI Listing
April 2020

Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD.

Eur Respir J 2020 02 20;55(2). Epub 2020 Feb 20.

Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00563-2019DOI Listing
February 2020

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.

J Pathol 2020 04 3;250(5):624-635. Epub 2019 Dec 3.

University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.5364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216938PMC
April 2020

Cigarette smoke exposure alters phosphodiesterases in human structural lung cells.

Am J Physiol Lung Cell Mol Physiol 2020 01 30;318(1):L59-L64. Epub 2019 Oct 30.

University of Groningen, Department of Molecular Pharmacology, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00319.2019DOI Listing
January 2020

Current Smoking is Associated with Decreased Expression of miR-335-5p in Parenchymal Lung Fibroblasts.

Int J Mol Sci 2019 Oct 18;20(20). Epub 2019 Oct 18.

University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, 9713 GZ Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20205176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829537PMC
October 2019

Laminin α4 contributes to airway remodeling and inflammation in asthma.

Am J Physiol Lung Cell Mol Physiol 2019 12 25;317(6):L768-L777. Epub 2019 Sep 25.

University of Groningen, Department of Molecular Pharmacology, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00222.2019DOI Listing
December 2019

MiR-31-5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease.

Allergy 2020 03 23;75(3):703-706. Epub 2019 Oct 23.

Groningen Research Institute for Asthma and COPD, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14060DOI Listing
March 2020

Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors.

J Immunother Cancer 2019 07 10;7(1):173. Epub 2019 Jul 10.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30.0001, 9700, RB, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0649-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617698PMC
July 2019

Tc-HYNIC-IL-2 scintigraphy to detect acute rejection in lung transplantation patients: a proof-of-concept study.

EJNMMI Res 2019 May 10;9(1):41. Epub 2019 May 10.

Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13550-019-0511-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510740PMC
May 2019

CX Chemokine Receptor 7 Contributes to Survival of -Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor.

Cancers (Basel) 2019 Mar 30;11(4). Epub 2019 Mar 30.

Groningen Research Institute of Pharmacy, Department of Chemical and Pharmaceutical Biology, University of Groningen, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11040455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520904PMC
March 2019

Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices.

Am J Physiol Lung Cell Mol Physiol 2019 03 10;316(3):L537-L546. Epub 2019 Jan 10.

Department of Molecular Pharmacology, University of Groningen , Groningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00325.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459292PMC
March 2019

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Authors:
Victoria E Jackson Jeanne C Latourelle Louise V Wain Albert V Smith Megan L Grove Traci M Bartz Ma'en Obeidat Michael A Province Wei Gao Beenish Qaiser David J Porteous Patricia A Cassano Tarunveer S Ahluwalia Niels Grarup Jin Li Elisabeth Altmaier Jonathan Marten Sarah E Harris Ani Manichaikul Tess D Pottinger Ruifang Li-Gao Allan Lind-Thomsen Anubha Mahajan Lies Lahousse Medea Imboden Alexander Teumer Bram Prins Leo-Pekka Lyytikäinen Gudny Eiriksdottir Nora Franceschini Colleen M Sitlani Jennifer A Brody Yohan Bossé Wim Timens Aldi Kraja Anu Loukola Wenbo Tang Yongmei Liu Jette Bork-Jensen Johanne M Justesen Allan Linneberg Leslie A Lange Rajesh Rawal Stefan Karrasch Jennifer E Huffman Blair H Smith Gail Davies Kristin M Burkart Josyf C Mychaleckyj Tobias N Bonten Stefan Enroth Lars Lind Guy G Brusselle Ashish Kumar Beate Stubbe Mika Kähönen Annah B Wyss Bruce M Psaty Susan R Heckbert Ke Hao Taina Rantanen Stephen B Kritchevsky Kurt Lohman Tea Skaaby Charlotta Pisinger Torben Hansen Holger Schulz Ozren Polasek Archie Campbell John M Starr Stephen S Rich Dennis O Mook-Kanamori Åsa Johansson Erik Ingelsson André G Uitterlinden Stefan Weiss Olli T Raitakari Vilmundur Gudnason Kari E North Sina A Gharib Don D Sin Kent D Taylor George T O'Connor Jaakko Kaprio Tamara B Harris Oluf Pederson Henrik Vestergaard James G Wilson Konstantin Strauch Caroline Hayward Shona Kerr Ian J Deary R Graham Barr Renée de Mutsert Ulf Gyllensten Andrew P Morris M Arfan Ikram Nicole Probst-Hensch Sven Gläser Eleftheria Zeggini Terho Lehtimäki David P Strachan Josée Dupuis Alanna C Morrison Ian P Hall Martin D Tobin Stephanie J London

Wellcome Open Res 2018 12;3. Epub 2018 Jan 12.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/wellcomeopenres.12583.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081985PMC
January 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Eur Respir J 2018 09 6;52(3). Epub 2018 Sep 6.

Dept of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01556-2017DOI Listing
September 2018

Essential preanalytics in PD-L1 immunocytochemistry.

Histopathology 2019 01 23;74(2):362-364. Epub 2018 Oct 23.

Department of Pathology and Medical Biology, University Medical Centre Groningentshow, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/his.13717
Publisher Site
http://dx.doi.org/10.1111/his.13717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379696PMC
January 2019

Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon?

Respiration 2018;96(2):148-158. Epub 2018 May 2.

Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000488149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159827PMC
December 2018

Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers.

Cancers (Basel) 2018 Jan 4;10(1). Epub 2018 Jan 4.

Department of Genetics, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers10010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789360PMC
January 2018

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Eur Respir Rev 2017 Dec 6;26(146). Epub 2017 Dec 6.

University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/16000617.0073-2017DOI Listing
December 2017

Lung tissue gene-expression signature for the ageing lung in COPD.

Thorax 2017 Dec 6. Epub 2017 Dec 6.

University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2017-210074DOI Listing
December 2017

The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific.

Epigenetics 2017 ;12(12):1076-1091

a Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen , Hanzeplein 1, EA10, 9713 GZ , Groningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15592294.2017.1403691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810788PMC
December 2018

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

Sci Rep 2017 10 9;7(1):12871. Epub 2017 Oct 9.

Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-13265-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634489PMC
October 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD.

Eur Respir J 2017 05 25;49(5). Epub 2017 May 25.

Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.02538-2016DOI Listing
May 2017

CT-guided percutaneous hookwire localization increases the efficacy and safety of VATS for pulmonary nodules.

J Surg Oncol 2017 Jun 23;115(7):898-904. Epub 2017 Feb 23.

Department of Pulmonary Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jso.24589
Publisher Site
http://dx.doi.org/10.1002/jso.24589DOI Listing
June 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways.

J Allergy Clin Immunol 2017 07 19;140(1):280-283.e3. Epub 2016 Dec 19.

Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.11.020DOI Listing
July 2017

Cancer Stem Cells, Epithelial to Mesenchymal Markers, and Circulating Tumor Cells in Small Cell Lung Cancer.

Clin Lung Cancer 2016 11 8;17(6):535-542. Epub 2016 Jun 8.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2016.05.015DOI Listing
November 2016

Novel Genetic Susceptibility Loci for FEV1 in the Context of Occupational Exposure in Never-Smokers.

Am J Respir Crit Care Med 2016 09;194(6):769-72

1 University of Groningen, University Medical Center Groningen Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201603-0646LEDOI Listing
September 2016

PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.

Oncoimmunology 2016 May 16;5(5):e1131379. Epub 2016 Mar 16.

Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/2162402X.2015.1131379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910698PMC
May 2016

The Translation from Risk Allele to Biological Function in Chronic Obstructive Pulmonary Disease. What's in It for FAM13A?

Am J Respir Crit Care Med 2016 07;194(2):130-2

1 Department of Pathology and Medical Biology and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201602-0249EDDOI Listing
July 2016

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD.

Eur Respir J 2016 08 13;48(2):359-69. Epub 2016 Jul 13.

University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Dept of Pulmonology, Groningen, The Netherlands These two authors contributed equally to this work.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01911-2015DOI Listing
August 2016

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Authors:
Gordon Fehringer Peter Kraft Paul D Pharoah Rosalind A Eeles Nilanjan Chatterjee Fredrick R Schumacher Joellen M Schildkraut Sara Lindström Paul Brennan Heike Bickeböller Richard S Houlston Maria Teresa Landi Neil Caporaso Angela Risch Ali Amin Al Olama Sonja I Berndt Edward L Giovannucci Henrik Grönberg Zsofia Kote-Jarai Jing Ma Kenneth Muir Meir J Stampfer Victoria L Stevens Fredrik Wiklund Walter C Willett Ellen L Goode Jennifer B Permuth Harvey A Risch Brett M Reid Stephane Bezieau Hermann Brenner Andrew T Chan Jenny Chang-Claude Thomas J Hudson Jonathan K Kocarnik Polly A Newcomb Robert E Schoen Martha L Slattery Emily White Muriel A Adank Habibul Ahsan Kristiina Aittomäki Laura Baglietto Carl Blomquist Federico Canzian Kamila Czene Isabel Dos-Santos-Silva A Heather Eliassen Jonine D Figueroa Dieter Flesch-Janys Olivia Fletcher Montserrat Garcia-Closas Mia M Gaudet Nichola Johnson Per Hall Aditi Hazra Rebecca Hein Albert Hofman John L Hopper Astrid Irwanto Mattias Johansson Rudolf Kaaks Muhammad G Kibriya Peter Lichtner Jianjun Liu Eiliv Lund Enes Makalic Alfons Meindl Bertram Müller-Myhsok Taru A Muranen Heli Nevanlinna Petra H Peeters Julian Peto Ross L Prentice Nazneen Rahman Maria Jose Sanchez Daniel F Schmidt Rita K Schmutzler Melissa C Southey Rulla Tamimi Ruth C Travis Clare Turnbull Andre G Uitterlinden Zhaoming Wang Alice S Whittemore Xiaohong R Yang Wei Zheng Daniel D Buchanan Graham Casey David V Conti Christopher K Edlund Steven Gallinger Robert W Haile Mark Jenkins Loïc Le Marchand Li Li Noralene M Lindor Stephanie L Schmit Stephen N Thibodeau Michael O Woods Thorunn Rafnar Julius Gudmundsson Simon N Stacey Kari Stefansson Patrick Sulem Y Ann Chen Jonathan P Tyrer David C Christiani Yongyue Wei Hongbing Shen Zhibin Hu Xiao-Ou Shu Kouya Shiraishi Atsushi Takahashi Yohan Bossé Ma'en Obeidat David Nickle Wim Timens Matthew L Freedman Qiyuan Li Daniela Seminara Stephen J Chanock Jian Gong Ulrike Peters Stephen B Gruber Christopher I Amos Thomas A Sellers Douglas F Easton David J Hunter Christopher A Haiman Brian E Henderson Rayjean J Hung

Cancer Res 2016 09 20;76(17):5103-14. Epub 2016 Apr 20.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-2980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493PMC
September 2016

Susceptibility genes for lung diseases in the major histocompatibility complex revealed by lung expression quantitative trait loci analysis.

Eur Respir J 2016 08 12;48(2):573-6. Epub 2016 May 12.

Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada Dept of Molecular Medicine, Laval University, Québec, QC, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00114-2016DOI Listing
August 2016

Fibulin-5 as a potential therapeutic target in COPD.

Expert Opin Ther Targets 2016 09 25;20(9):1031-3. Epub 2016 Mar 25.

a Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14728222.2016.1164696DOI Listing
September 2016

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.

Thorax 2016 Apr 21;71(4):312-22. Epub 2016 Jan 21.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2015-206958DOI Listing
April 2016

Sexual maturation protects against development of lung inflammation through estrogen.

Am J Physiol Lung Cell Mol Physiol 2016 Jan 25;310(2):L166-74. Epub 2015 Nov 25.

University of Groningen, Department of Pharmacokinetics, Toxicology, and Targeting, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00119.2015DOI Listing
January 2016

Old dilemma: asthma with irreversible airway obstruction or COPD.

Virchows Arch 2015 Nov 14;467(5):583-93. Epub 2015 Sep 14.

Department of Pulmonology, University of Groningen, University Medical Center Groningen, PO Box 196, 9700 AD, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-015-1824-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656713PMC
November 2015